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Potensi Interaksi Obat-Obat pada Resep Polifarmasi: Studi Retrospektif pada Salah Satu Apotek di Kota Bandung Sulastri Herdaningsih; Ahmad Muhtadi; Nurul Annisa
Indonesian Journal of Clinical Pharmacy Vol 5, No 4 (2016)
Publisher : Universitas Padjadjaran

Resep polifarmasi sangat umum terjadi dalam peresepan pasien rawat jalan maupun rawat inap di setiap fasilitas kesehatan. Polifarmasi dapat meningkatkan risiko terjadinya interaksi obat-obat atau Drug-drug Interactions (DDI’s) yang sebagian besar akan menimbulkan dampak merugikan dalam terapi pasien. Tujuan dari studi ini yaitu untuk menilai potensi DDI’s pada resep rawat jalan di salah satu apotek di kota Bandung. Data diproses melalui www.drugs.com database atau Drug Interactions Checker. Studi ini memaparkan prevalensi dan mengklasifikasikan jenis interaksi potensial berdasarkan level interaksi yaitu mayor, moderat dan minor. Total resep rawat jalan periode Januari–Maret 2014 adalah sebanyak 352 lembar resep yang didalamnya terdapat sebanyak 1.111 R/. Dari total keseluruhan jumlah lembar resep, terdapat 197 (55,97%) lembar resep yang masuk dalam kriteria inklusi. Sebanyak 121 lembar resep terdapat DDI’s potensial sebesar 34,38%. Keseluruhan DDI’s potensial yang terjadi adalah sebanyak 194 interaksi. DDI’s potensial mayor sebanyak 25 (12,89%), moderat sebanyak 134 (69,07%) dan minor 35 (8,04%). DDI’s terbanyak terdapat dalam kategori mayor dan moderat yang membutuhkan perhatian lebih dan tindakan pencegahan terhadap DDI’s potensial yang mungkin terjadi oleh dokter dan apoteker untuk memaksimalkan efektivitas terapi pasien.Kata kunci: Interaksi obat-obat, pasien rawat jalan, resep polifarmasiPotential of Drug-Drug Interaction in Polypharmacy Prescription: Retrospective Study on a Drugstore in Bandung Abstract Polypharmacy prescription very commonly occurs on prescribing the outpatient and inpatient in every health facility. Polypharmacy may increase the risk of Drug-drug Interactions (DDI’s) which mostly causes harm impact in the patient’s therapy. The aim of this study was to measure the potential of DDI’s on the outpatient prescription in one of the drugstore in Bandung. The data was processed through www. drugs.com database or Drug Interactions Checker. This study described the prevalence and classification of potential interactions based on interaction level of major, moderate, and minor. The number of outpatient prescription on January–March 2014 was 352 sheets of prescriptions with 1.111 R/. From overall numbers of prescriptions, there were 197 (55.97%) sheets of prescriptions on inclusion criteria. In 121 prescriptions, there were 34.38% of DDI’s potential. All of DDI’s potential occurs was 194 interactions. The major DDI’s potential of 25 (12.89%), moderate of 134 (69.07%) and minor of 35 (8.04%). The most of DDI’s found in major and moderate level need more attention and prevention aid against DDI’s potential that may occur by doctors and pharmacists to maximize the effectiveness of patient’s therapy.Keywords: Drug-drug Interactions (DDI’s), outpatient, polypharmacy prescription

AKTIVITAS ANTIPIRETIK EKSTRAK ETANOL DAUN MENGKUDU (Morinda citrifolia L.) TERHADAP TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR WISTAR YANG DIINDUKSI PEPTON 5% Sulastri Herdaningsih; Fenny Oktaviyeni; Ismi Utari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 3 No 2 (2019)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Telah dilakukan penelitian tentang uji aktivitas antipiretik ekstrak etanol daun mengkudu (Morinda citrifolia L.) yang telah diketahui memiliki senyawa flavonoid sebagai antipiretik. Penelitian ini bertujuan untuk menguji aktivitas antipiretik ekstrak etanol daun mengkudu (Morinda citrifolia L.) terhadap tikus putih jantan (Rattus norvegicus) galur wistar yang diinduksi pepton 5% serta menentukan konsentrasi yang paling baik terhadap aktivitas antipiretik ekstrak etanol daun mengkudu (Morinda citrifolia L.). Hewan uji yang digunakan sebanyak 20 ekor, yang dibagi menjadi 5 kelompok dengan 4 replikasi yaitu kontrol negatif (suspensi Na.CMC 1%), kontrol positif (suspensi parasetamol) dan kelompok uji ekstrak etanol daun mengkudu (Morinda citrifolia L.) dengan konsentrasi 0,018 g/ 200 g BB Tikus, 0,036 g/ 200 g BB Tikus, dan 0,072 g/ 200 g BB Tikus. Data yang diperoleh dianalisis dengan menggunakan uji anova dan LSD. Hasil penelitian menunjukkan bahwa pada konsentrasi 0,072 g/ 200 g BB Tikus ekstrak etanol daun mengkudu (Morinda citrifolia L.) memiliki aktivitas antipiretik setara dengan suspensi parasetamol sebagai kontrol positif dengan persen daya antipiretik sebesar 80% dan nilai p value 0,703 (p>0,05).

FORMULASI SEDIAAN SIRUP EKSTRA ETANOL DAUN ILER (Coleus atropurpureus (L.) Benth) DAN UJI AKTIVITAS MUKOLITIK SECARA IN VITRO Sulastri Herdaningsih; Dian Kartikasari
Jurnal Insan Farmasi Indonesia Vol 5 No 1 (2022): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v5i1.925

Syrup is an oral liquid preparation containing sakarosa. The study aimed to test whether iler leaf extract (Coleus atropurpureus (L.) Benth) could be formulated as a syrup preparation then tested for physical properties and mucolytic activity. The experimental method used to test the mucolytic activity of iler leaf extract syrup in vitro is to measure the viscosity of duck egg whites added to the test solution every 15 minutes, namely at the 0th, 15th, 30th, 45th and 60th minutes. Testing of mucolytic activity was carried out on iler leaf extract syrup with concentrations of 3%, 4.5% and 6%, positive control of acetylcysteine 0.2% and negative control of aquades. The results showed that iler leaf extract syrup at concentrations of 3%, 4.5% and 6% can be formulated as syrup preparations and is able to significantly decrease the viscosity of duck egg whites compared to negative control.

Consumption Time of Captopril Influenced the Outcomes of Patients with Stage 1 Hypertension Sulastri Herdaningsih; Ahmad Muhtadi; Keri Lestari
Pharmacology and Clinical Pharmacy Research Vol 2, No 1
Publisher : Universitas Padjadjaran, Indonesia

Differences in drugs consumption time may affect its absorption and metabolism in the bodywhich could lead to differences in its efficacy. For hypertension patients, one of the mostfrequently used drugs for lowering blood is captopril. However, information regarding theinfluence of consumption time on captopril efficacy was limited. Therefore, this study wasconducted to compare the efficacy of captopril in lowering blood pressure when administeredbefore and after meal. This was an experimental study with two treatment groups,conducted at Dr. Soedarso General Hospital, Pontianak, Indonesia, during April-June 2015.Statistical analysis was performed using Mann-Whitney, Exact-Fisher, and T-test. We foundout that the reduction of systolic blood pressure in group who consumed captopril beforeand after meal was 30 mmHg and 25 mmHg, respectively (p<0.05). The similar reduction indiastolic bloos pressure was observed in both groups (10 mmHg, p>0.05). In conclusion, itis recommended to take captopril on an empty stomach since it showed better efficacy whenadministered before meal compared to after meal consumption.Keywords: hypertension, captopril, absorption

SOSIALISASI PENYAKIT TIDAK MENULAR (PTM) DAN PEMERIKSAAN KESEHATAN PADA KELOMPOK PENGAJIAN AL HUDA DI RT/RW 001/032 KOTA PONTIANAK Sulastri Herdaningsih
Jurnal Buletin Al-Ribaath Vol 15, No 1 (2018): Buletin Al-Ribaath
Publisher : Universitas Muhammadiyah Pontianak

ABSTRACTAchieving the improvement of public health through a complete health care, it is necessary to joint efforts from all levels of society. In order for health status to be more equitable, it is deemed necessary to pay attention to areas / groups of people who need more health knowledge. Having previously studied the health status of Al Huda lecturers in RT / RW 001/032 Pontianak City, it is found that many who experience Non-Communicable Diseases (PTM), including, Hypertension, Diabetes Millitus, Cholesterol, and Uric Acid, so it needs to be given counseling and health checks on Hypertension, Diabetes Millitus, Cholesterol and Uric Acid. Academy of Pharmacy YARSI Pontianak as a Higher Education Institution has an important role in devoting themselves to the community contained in the Tri Darma of Higher Education Participate in improving public health status in the form of community service in the form of health socialization and health examination. After the socialization and checking of health, it was found out that the community understood Non-Communicable Disease, the community understood how to use the correct health monitoring tool, the highest prevalence of gout disease with 92% percentage. Keywords: socialization, health examination, Al Huda study

FORMULATION AND PHYSICAL PROPERTIES TEST OF NANO CREAM PREPARATION PURIFIED EXTRACT OF KENIKIR LEAF (ETDK) AND TAMPOI FRUIT PEEL EXTRACT (EKBT) Ika Ristia Rahman; Sulastri Herdaningsih
Jurnal Ilmiah Farmako Bahari Vol 12, No 2 (2021): Jurnal Ilmiah Farmako Bahari
Publisher : Fakultas MIPA Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jfb.v12i2.1218

This research has been conducted under the title “formulation and physical properties test of nano cream preparations purified extract of Kenikir leaf (ETDK) and Tampoi fruit peel extract (EKBT)”. This study has formulated a nano cream with a purified extract of Kenikir leaf (ETDK), Tampoi fruit peel extract (EKBT), and a combination of ETDK and EKBT. This study aims to determine the purified extract of Kenikir leaves. The purified extract of Tampoi fruit peel can be formulated as nano cream preparations and to determine the physical parameters (organoleptic test, homogeneity, pH, type of nano cream, spreadability, adhesion, and particle size) for the result of the nano cream. The results of the organoleptic test were described and the physical properties of the nano cream were analyzed by using Excel application. Organoleptic testing of the combination of ETDK and EKBT nano cream formula gave a reddish-white color with an aqueous consistency. The ETDK nano cream formula gave a white bone colour with a watery consistency. In contrast, the nano cream formula with EKBT gave a brownish white colour with a watery consistency. It gives a distinctive smell of extract. The third test of nano cream formulas showed that the physical properties of this nano cream preparation met the standard requirements for physical tests. Test the physical properties that meet the pH requirements, type of nano cream, spreadability, adhesion, and particle size, and all three formulas produced an average particle of less than 300nm.

AKTIVITAS MUKOLITIK EKSTRAK DAUN ILER (Coleus atropurpureus [L.] benth.) SECARA IN VITRO Sulastri Herdaningsih; Dian Kartikasari
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 18, No 2 (2021): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Cough is a protective physiological mechanism to stimulate and cleanse the respiratory system of foreign objects that can cause infection. Traditional cough treatment is preferred because of the relatively low side ffects compared tochemical drugs. In some areas, Iler leaves are used as cough medicine. The purpose of this study was to determine the mucolytic activity of ethanol extract of Iler leaves on duck egg white which was added to the test solution every 15 minutes, namely at minutes 0,15,30,45, and 60. Viscosity measurements were carried out in the positive control group, negative control group, 3% group, 4,5% group and 6% group. The results obtained showed that Iler leaves extract was able to significantly reduce the viscosity of duck egg whites compare to the negative control. The ethanol extract of Iler leaves has mucolytic activity against duct egg white in vitro at a concetnration range of 3-6%.

FORMULASI SEDIAAN SIRUP EKSTRA ETANOL DAUN ILER (Coleus atropurpureus (L.) Benth) DAN UJI AKTIVITAS MUKOLITIK SECARA IN VITRO Sulastri Herdaningsih; Dian Kartikasari
Jurnal Insan Farmasi Indonesia Vol 5 No 1 (2022): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v5i1.925

Syrup is an oral liquid preparation containing sakarosa. The study aimed to test whether iler leaf extract (Coleus atropurpureus (L.) Benth) could be formulated as a syrup preparation then tested for physical properties and mucolytic activity. The experimental method used to test the mucolytic activity of iler leaf extract syrup in vitro is to measure the viscosity of duck egg whites added to the test solution every 15 minutes, namely at the 0th, 15th, 30th, 45th and 60th minutes. Testing of mucolytic activity was carried out on iler leaf extract syrup with concentrations of 3%, 4.5% and 6%, positive control of acetylcysteine 0.2% and negative control of aquades. The results showed that iler leaf extract syrup at concentrations of 3%, 4.5% and 6% can be formulated as syrup preparations and is able to significantly decrease the viscosity of duck egg whites compared to negative control.

Edukasi Pertolongan Pertama pada Cedera Luka di Sekolah Dasar Daerah Perbatasan Kalimantan Barat Suhaimi Fauzan; Faisal Kholid Fahdi; Yoga Pramana; Mita; Sulastri Herdaningsih; Herman
Jurnal Abdimas Mahakam Vol. 7 No. 02 (2023): Juli
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24903/jam.v7i02.2237

Abstrak Background: Siswa merupakan seseorang yang sedang belajar dengan tingkat rasa ingin tahu dan mencoba hal baru yang tinggi. Karakteristik ini dapat berpotensi mengalami timbulnya kecelakaan baik ketika sedang bermain, belajar, atau olahraga. Hasil observasi kepada tenaga pengajar menunjukkan bahwa masih sering terjadi cedera di SDN 12 Entikong. Tingkat pengetahuan yang rendah berpotensi menimbulkan kesalahan saat memberikan pertolongan pertama. Metode: Program ini merupakan program pengabdian kepada masyarakat guna memberikan edukasi kesehatan kepada siswa SDN 12 Entikong menggunakan metode ceramah dan pembekalan buku saku. Para siswa akan diberikan lembar evaluasi pre-post test. Hasil evaluasi akan diolah secara statistik (paired sample t test) guna mengetahui pengaruh edukasi kesehatan. Hasil: Rata-rata tingkat pengetahuan siswa sebelum diberikan edukasi adalah 59,5, sementara setelah diberikan edukasi sebesar 78,0. Uji statistik menunjukkan nilai p=0,000. Kesimpulan: PKM ini memberikan dampak peningkatan pengetahuan pada kalangan pelajar tentang penanganan cedera luka. PKM ini secara tegas menunjukkan bahwa ada pengaruh edukasi pertolongan pertama pada cedera luka di SDN daerah perbatasan Kalimantan Barat. Kata Kunci: Edukasi, Kesehatan, Cedera, Pendidikan, Siswa

Islamic Self-Healing on Increasing Patient Self-Efficacy Suhaimi Fauzan; Muhammad Ibnu Khatan; Mita Mita; Fauzan Alfikrie; Sulastri Herdaningsih; Herman Herman
Jurnal Keperawatan Komprehensif (Comprehensive Nursing Journal) Vol. 9 No. 3 (2023): JURNAL KEPERAWATAN KOMPREHENSIF (COMPREHENSIVE NURSING JOURNAL)
Publisher : STIKep PPNI Jawa Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33755/jkk.v9i3.456

Aims: Hemodialysis is one of kidney replacement therapy that is mostly performed by patients with chronic kidney failure. Changes in various physical and psychological conditions that cause CKD patients on hemodialysis will find excessive stressors. One of the alternative and complementary therapies to achieve self-healing is mind body and spirit therapy. The human aspect is an integral part of a number of therapies such as prayer, health, and yoga. Objective: Determine the effect of Islamic self healing n the level of self-efficacy in chronic kidney failure patients undergoing hemodialysis Methods: This research was quasi-experimental pretest-posttest with control group design. The samples were collected approximately 40 by randomly sampling during 12-26 July 2022. The population in this study was all patients who underwent hemodialysis routinely at a RSUD dr. Soedarso. The self-efficacy was measured by the chronic kidney disease (CKD) self-efficacy instrument: development and psychometric evaluation. The analysis technique in this study was sample paired t test and Mann Whitney test. Result: The results of this study indicate that most of the respondents are female (65%), have an average age of 51 years, and have the last elementary school education as much as 68%. The results of the sample paired t test in the control group were (0.40), the intervention group (0.002). Then the results of the Mann Whitney test on the efficacy value after 4 weeks of intervention showed a sig. 0.000. Conclusion: This can be done with the interdisciplinary involvement of care and psychological teams. It is recommended that spiritual therapy be included in the treatment program by health professionals, included in teaching programs, and used on a personal level for nurses and hemodialysis patients.

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