Article Per Year (5 Year)
p-Index From 2020 - 2025
1.431
P-Index
This Author published in this journals
All Journal Indonesian Journal of Chemistry Jambura Journal of Chemistry Molekul: Jurnal Ilmiah Kimia Acta Chimica Asiana Empowerment: Jurnal Pengabdian Masyarakat Jurnal ADAM : Jurnal Pengabdian Masyarakat Molekul: Jurnal Ilmiah Kimia Jurnal Komunitas Farmasi Nasional
Ihsanul Arief
Akademi Farmasi Yarsi Pontianak
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Transportation Veterinary Other

Published : 10 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 10 Documents
Search

 1 
DESIGN OF LOW CYTOTOXICITY DIARYLANILINE DERIVATIVES BASED ON QSAR RESULTS: AN APPLICATION OF ARTIFICIAL NEURAL NETWORK MODELLING Ihsanul Arief; Ria Armunanto; Bambang Setiaji; Muhammad Fachrie
Molekul Vol 11, No 2 (2016)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (587.967 KB) | DOI: 10.20884/1.jm.2016.11.2.242

Abstract

Study on cytotoxicity of diarylaniline derivatives by using quantitative structure-activity relationship (QSAR) has been done. The structures and cytotoxicities of  diarylaniline derivatives were obtained from the literature. Calculation of molecular and electronic parameters was conducted using Austin Model 1 (AM1), Parameterized Model 3 (PM3), Hartree-Fock (HF), and density functional theory (DFT) methods.  Artificial neural networks (ANN) analysis used to produce the best equation with configuration of input data-hidden node-output data = 5-8-1, value of r2 = 0.913; PRESS = 0.069. The best equation used to design and predict new diarylaniline derivatives.  The result shows that compound N1-(4′-Cyanophenyl)-5-(4″-cyanovinyl-2″,6″-dimethyl-phenoxy)-4-dimethylether benzene-1,2-diamine) is the best-proposed compound with cytotoxicity value (CC50) of 93.037 μM.
STUDY ON ANTI-HIV ACTIVITY OF DIARYLANILINE DERIVATIVES USING QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR) Ihsanul Arief; Ria Armunanto; Bambang Setiaji
Indonesian Journal of Chemistry Vol 13, No 2 (2013)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (296.485 KB) | DOI: 10.22146/ijc.21295

Abstract

Study on anti-HIV activity of diarylaniline derivative compounds by using quantitative structure-activity relationship (QSAR) has been done. The compounds structure and their anti-HIV activities were obtained from literature. Molecular and electronic parameters were calculated by Austin Model 1 (AM1), Parameterized Model 3 (PM3), Hartree-Fock (HF), and density functional theory (DFT) methods. QSAR analysis was performed using multilinear regression method. The result shows that HF method can produce the best model as follows:log EC50 = 46.418 + (99.360 × qC4) - (67.189 × qC9) - (278.869 × qC15) + (782.466 × qC19) - (127.463 × qO7)n = 20; r2 = 0.815; SEE = 0.393; Fcal/Ftab = 4.185; PRESS = 2.160Those model can predict a good inhibitory activity (log EC50) value of -0.3359 to compound N1-(4′-Cyanophenyl)-5-(4″-cyanovinyl-2″,6″-dimethyl-phenoxy)-4-hydroxyethylbenzene-1,2-diamine).
Profil ADME dari Entitas Molekul Baru yang Disetujui oleh FDA Tahun 2021: Suatu Kajian In Silico Ihsanul Arief; Hairunnisa Hairunnisa
Jambura Journal of Chemistry Vol 4, No 2 (2022): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v4i2.15257

Abstract

Aspek farmakokinetik dan farmakodinamik yang diwakili oleh sifat adsorpsi, distribusi, metabolisme, ekskresi (ADME) merupakan syarat penting suatu obat dapat menuju targetnya. Pada tahun 2021, food and drug administration (FDA) menyetujui 35 senyawa entitas molekul baru (EMB) untuk digunakan sebagai obat di masyarakat. Pada penelitian ini dikaji profil ADME dari senyawa-senyawa EMB tersebut yang meliputi kelarutan, GI absorption, BBB permeant, Lipinski rule of five, bioavailibility score dan synthetic accessibility. Struktur senyawa diperoleh dari basis data Pubchem dan kemudian dihitung profil ADME-nya melalui server SwissADME. Hasil yang diperoleh menunjukkan bahwa sebagian besar senyawa memenuhi persyaratan terkait sifat ADME terutama untuk obat-obat yang diadminitrasikan lewat oral.
Identification of Active Compound from Mitragyna speciosa Leave as Antiinflammation Agent: In Silico Study. Ihsanul Arief; Erwan Kurnianto
Acta Chimica Asiana Vol. 5 No. 2 (2022)
Publisher : The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v5i2.139

Abstract

The study aims to identify the most responsible compound for the antiinflammation activity from Mitragyna speciosa leaves. Seventeen compounds previously reported to have been isolated from the leave were virtually screened against human 5-lipoxygenase protein and analyzed according to their binding energies. The native ligand used was arachidonic acid, and mitragynine was found to be the strongest binding compound (Pubchem ID: 3034396). In addition, ADMET profiling shows that mitragynine was not violating Lipinski’s rule of five and was not toxic.
SOSIALISASI ASPEK KEAMANAN DALAM PENGGUNAAN OBAT HERBAL BAGI ANGGOTA PKK DESA PAL IX KABUPATEN KUBU RAYA Ihsanul Arief; Husnani; Athiah Masykuroh
Jurnal ADAM : Jurnal Pengabdian Masyarakat Vol 2 No 1 (2023): Vol. 2 No. 1 Edisi Februari 2023
Publisher : Institut Pendidikan Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37081/adam.v2i1.1320

Abstract

Bangsa Indonesia secara turun temurun dari generasi ke generasi telah mengenal dan juga menggunakan tanaman yang dimanfaatkan sebagai obat tradisional untuk menanggulangi masalah kesehatan. Pada umumnya penggunaan obat tradisional dinilai lebih aman daripada penggunaan obat modern. Hal ini disebabkan karena obat tradisional memiliki efek samping yang relatif lebih sedikit daripada obat modern. Akan tetapi tetap diperlukan ketepatan penggunaan obat tradisional untuk meminimalisir efek sampingnya, yakni: kebenaran obat, ketepatan dosis, ketepatan waktu penggunaan, ketepatan cara penggunaan, tidak disalahgunakan, dan ketepatan pemilihan obat untuk penyakit tertentu. Oleh karena itu, dilakukan sosialisasi tentang keamanan penggunaan obat herbal kepada masyarakat agar dapat terhindar dari efek yang tidak diinginkan. Hasil yang diperoleh menunjukkan adanya peningkatan pemahaman masyarakat yang signifikan (p < 0,005) antara sebelum dan sesudah dilakukan sosialisasi.
An Insight of Cryptocarya Secondary Metabolites as Anticancer P388: Study of Molecular Docking and ADMET Properties Herlina Rasyid; Riska Mardiyanti; Ihsanul Arief; Wahyu Dita Saputri
Molekul Vol 18 No 1 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.1.6364

Abstract

Secondary metabolites isolated from Cryptocarya was known to have various activity especially their cytotoxicity in P388 cell. There were two species of Cryptocarya studied in this research that were Cryptocarya konishii and Cryptocarya lucida. In both species, 8 isolate compounds had bioactivity as anticancer in P388 cells. This study aimed to know the binding affinity and ADMET properties of each isolated compound through P-glycoprotein substrate since this protein was reported to be responsible for the inhibition of P388 cells. Molecular docking was performed using AutoDock4 and AutoDockTools software to know the binding energy and interaction of isolate compounds against the P-glycoprotein substrate. ADMET properties calculation was done using the pkCSM web server for all compounds. Molecular docking results showed that Kurzichalcolactone B (7) isolated from C. lucida had the lowest binding energy. It resulted in the highest total intermolecular energy from the contribution of van der Waals and hydrogen bond energy. The lowest binding energy is indicating the stable interaction of ligand and substrate. Calculation of ADMET properties resulted that some of the isolate compounds fulfilling the minimum standard parameters in ADMET properties.
Pelatihan Membuat Sabun Transparan Bunga Telang Anggota PKK Desa PAL IX Sungai Kakap Kubu Raya Athiah Masykuroh; Husnani; Ihsanul Arief
Empowerment: Jurnal Pengabdian Masyarakat Vol. 2 No. 4 (2023): JULI 2023
Publisher : Pusat Riset Manajemen dan Publikasi Ilmiah Serta Pengembangan Sumber Daya Manusia Sinergi Cendikia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55983/empjcs.v2i4.409

Abstract

The workshop on making butterfly pea transparent soap (Clitoria ternatea) was carried out with the aim of increasing the insight of PKK members of Pal IX Village, Sungai Kakap District, Kubu Raya Regency on how to use butterfly pea flowers. As we know the urban society’s interest in the butterfly pea flower was increasing nowadays. It can be seen from the increasing public interest in buying butterfly pea plants in commercial nurseries. Interesting flowers and it’s benefits for traditional medicine causes this plant in demand by the public. Transparent soap has a finer foam compared to opaque soap which is not transparent. The methods  used in this workshop were lectures and surveys by distributing questionnaires  to find out how far the level of knowledge of respondents  had changed after attending  the workshop in the form of pre-test and post-test questionnaires which were distributed before and after the training was carried out. After the workshop of making transparent butterfly pea soap, the knowledge of members of PKK Desa pal IX Sungai Kakap Kubu Raya about butterfly pea flowers and the possibility of making transparent soap preparations has been increased.
UJI AKTIVITAS ANTIHIPERGLIKEMIA EKSTRAK ETANOL KULIT BATANG SENGKUANG Dracontomelon dao (Blanco) Merr & Rolfe TERHADAP MENCIT PUTIH (Mus musculus) JANTAN GALUR SWISS WEBSTER inderiyani inderiyani; Sulastri Herdaningsih; Ihsanul Arief Arief
Jurnal Komunitas Farmasi Nasional Vol. 2 No. 2 (2022): Jurnal Komunitas Farmasi Nasional
Publisher : Akademi Farmasi Yarsi Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes mellitus (DM) is a serious chronic disease that occurs when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. Sengkuang Dracontomelon dao (Blanco) Merr & Rofle has the potential as an alternative treatment for DM because it contains secondary metabolites in the form of alkaloids, tannins and flavonoids which have antihyperglycemic properties. This study aims to determine the antihyperglycemic activity of sengkuang stem bark against male white mice. Sengkuang bark is processed into simplicia and then macerated using 96% ethanol as a solvent. Then the extract was used to test antihyperglycemic activity by measuring initial glucose levels with a glucose test strip and given a test solution in the form of 0.5% Na.CMC suspension; glibenclamide 65 mg/kgbb; ethanol extract of sengkuang stem bark dose of 100 mg/kgbb; 200 mg/kgbb and 400 mg/kgbb. Then the test animals were induced with glucose 75 gram/kgbb and blood glucose levels were measured at 0, 30, 60, 90, 120, 150 and 180 minutes. The results showed that the ethanol extract of sengkuang bark at a dose of 400 mg/kgbb had activity as antihyperglycemic indicated by a significant difference with the negative control group. Keywords : Antihyperglycemia, diabetes mellitus, ethanol extract of sengkuang bark, Dracontomelon dao (Blanco) Merr & Rofle
The Potential of Paku Gajah (Angiopteris evecta) as Antitumor Through In Vitro and In Silico Studies Rasyid, Herlina; Asmirah, Asmirah; Firdausiah, Syadza; Arief, Ihsanul; Soekamto, Nunuk Hariani
Molekul Vol 19 No 2 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.2.10644

Abstract

ABSTRACT. Paku gajah (Angiopteris evecta) is one of the largest ferns which has been used empirically by the Dayak tribe of Kalimantan, Indonesia as a traditional medicine to treat various diseases, one of which is tumors. This research aims to determine the potential utilization of A. evecta stem extract as an antitumor by secondary metabolites analysis, toxicity and antitumor assay. The methods used in this study were gradual maceration using three solvents (n-hexane, ethyl acetate, and methanol), phytochemical screening, toxicity test, antitumor activity assay with the Alamarblue method, Liquid Chromatography-Mass Spectrometry (LC-MS) analysis, and molecular docking analysis. This study indicated that A. evecta stem extract contained secondary metabolites such as flavonoids, saponins, tannins, and steroids. The ethyl acetate and methanol were found as toxic extracts with LC50 130.67 and 314.31 µg/mL, respectively. In line with the toxicity, the antitumor activity of the ethyl acetate extract was the highest with an IC50 of 240.94 µg/mL and phytochemical analysis revealed the presence of violanthin and angiopteroside in the extract. Molecular docking showed that the binding energy and inhibition constants of violanthin and angiopteroside against receptors were higher than standard ligand F82. The interaction between violanthin and the receptor results five hydrogen-bond (H-bond) with Lys920, Cys919, Asp1046, and Leu840, while the angiopteroside produces four H-bonds with Leu836, Leu834, and Arg831. Keywords: Antitumor, molecular docking, paku gajah (Angiopteris evecta).
Studi Molecular Docking Senyawa Isoniazid Termodifikasi pada Sintase Asam Mikolat Dinding Sel Mycobacterium Tuberculosis Buannata, Jordi; Wijianto, Bambang; Arief, Ihsanul
Acta Chimica Asiana Vol. 7 No. 2 (2024)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v7i2.173

Abstract

Using the isoniazid in antituberculosis therapy can lead to mutations in the KatG and inhA genes of Mycobacterium tuberculosis, resulting in the development of resistance and necessitating modifications to the isoniazid compound. This study aims to assess the potential and level of toxicity of modified compounds, namely 4-pyridine carboxylic acid, pyridine aldehyde, and methyl pyridine, on the mycolic acid receptor through a molecular docking approach. PyRx was employed for the docking process using a protocol with an exhaustiveness of 106 and a center grid box at X=42.424, Y=22.4321, and Z=46.6391. Additionally, the ProTox-II website was used to determine the toxicity level of the test compounds. The results obtained from this research consist of the respective affinity values of the test compounds: -6, -5.4, and -5.2 kcal/mol. The toxicity levels of the test compounds are as follows: class 5, class 4, and class 4. All test compounds interact with amino acids on the target protein, specifically with residue numbers Histidine (HIS A:8), Phenylalanine (PHE A:142) through hydrogen bonding, Leucine (LEU A:95) through pi-Sigma (π) bonding, and Valine (VAL A:12) through pi-Alkyl (π) bonding. In conclusion, the 4-pyridine carboxylic acid compound exhibits potential as a promising drug candidate but comes with a high level of toxicity
Co-Authors . Asmirah Athiah Masykuroh Bambang Setiaji Bambang Setiaji Bambang WIJIANTO Buannata, Jordi Hairunnisa Hairunnisa Herdaningsih, Sulastri Herlina Rasyid Husnani, Husnani Inderiyani, Inderiyani Kurnianto, Erwan Muhammad Fachrie Nunuk Hariani Soekamto Rasyid, Herlina Ria Armunanto Ria Armunanto Riska Mardiyanti Syadza Firdausiah Wahyu Dita Saputri