DK2237803T3 - Behandling og profylakse af amyloidose - Google Patents

Behandling og profylakse af amyloidose Download PDF

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Publication number
DK2237803T3
DK2237803T3 DK08867535.0T DK08867535T DK2237803T3 DK 2237803 T3 DK2237803 T3 DK 2237803T3 DK 08867535 T DK08867535 T DK 08867535T DK 2237803 T3 DK2237803 T3 DK 2237803T3
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seq
antibody
antibodies
amyloid
variable region
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DK08867535.0T
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Dale B Schenk
Peter A Seubert
Jonathan Wall
Jose Saldanha
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Prothena Biosciences Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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Claims (5)

1. Antistof eller antigenbindende fragment, der er en humaniseret eller kimær version af antistof 2A4, hvor antistof 2A4 kan opnås fra ATCC-accessionsnum-mer PTA-9662.
2. Antistof eller antigenbindende fragment ifølge krav 1, der omfatter en variabel letkæderegion omfattende tre komplementaritetsbestemmende regioner ifølge SEQ ID NO: 168,169 og 170 og en variabel tungkæderegion, der omfatter tre komplementaritetsbestemmende regioner ifølge SEQ ID NO: 171, 172 og 173.
3. Antistof eller antigenbindende fragment ifølge krav 2, der omfatter en variabel letkæderegion omfattende en aminosyresekvens ifølge SEQ ID NO: 157.
4. Antistof eller antigenbindende fragment ifølge krav 2, der omfatter en variabel tungkæderegion omfattende en aminosyresekvens ifølge SEQ ID NO: 163.
5. Antistof eller antigenbindende fragment ifølge krav 2, der omfatter en variabel letkæderegion omfattende en aminosyresekvens ifølge SEQ ID NO: 157 og en variabel tungkæderegion omfattende en aminosyresekvens ifølge SEQ ID NO: 163.
DK08867535.0T 2007-12-28 2008-12-29 Behandling og profylakse af amyloidose DK2237803T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US754407P 2007-12-28 2007-12-28
US9593208P 2008-09-10 2008-09-10
PCT/US2008/088493 WO2009086539A2 (en) 2007-12-28 2008-12-29 Treatment and prophylaxis of amyloidosis

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DK2237803T3 true DK2237803T3 (da) 2015-10-05

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US (13) US7928203B2 (da)
EP (3) EP2730659A3 (da)
JP (3) JP5730020B2 (da)
KR (1) KR101603076B1 (da)
CN (1) CN102016059B (da)
AU (1) AU2008345022B2 (da)
BR (1) BRPI0821949B1 (da)
CA (1) CA2710984C (da)
CO (1) CO6341486A2 (da)
DK (1) DK2237803T3 (da)
EA (2) EA036059B1 (da)
ES (1) ES2544679T3 (da)
HU (1) HUE025560T2 (da)
IL (2) IL206641B (da)
MX (1) MX384227B (da)
NO (1) NO20101036L (da)
NZ (1) NZ586875A (da)
PL (1) PL2237803T3 (da)
PT (1) PT2237803E (da)
SG (2) SG187504A1 (da)
WO (1) WO2009086539A2 (da)

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