|
US6096318A
(en)
*
|
1973-05-07 |
2000-08-01 |
The Ohio State University |
Antigenically modified HCG polypeptides
|
|
US4902506A
(en)
|
1983-07-05 |
1990-02-20 |
The University Of Rochester |
Immunogenic conjugates
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US5158769A
(en)
*
|
1984-03-07 |
1992-10-27 |
New York Blood Center, Inc. |
Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers
|
|
US5417986A
(en)
*
|
1984-03-16 |
1995-05-23 |
The United States Of America As Represented By The Secretary Of The Army |
Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
|
|
US5208036A
(en)
|
1985-01-07 |
1993-05-04 |
Syntex (U.S.A.) Inc. |
N-(ω, (ω-1)-dialkyloxy)- and N-(ω, (ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4666829A
(en)
|
1985-05-15 |
1987-05-19 |
University Of California |
Polypeptide marker for Alzheimer's disease and its use for diagnosis
|
|
US5618920A
(en)
|
1985-11-01 |
1997-04-08 |
Xoma Corporation |
Modular assembly of antibody genes, antibodies prepared thereby and use
|
|
US4713366A
(en)
|
1985-12-04 |
1987-12-15 |
The Ohio State University Research Foundation |
Antigenic modification of polypeptides
|
|
US5096706A
(en)
|
1986-03-25 |
1992-03-17 |
National Research Development Corporation |
Antigen-based treatment for adiposity
|
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US5278049A
(en)
|
1986-06-03 |
1994-01-11 |
Incyte Pharmaceuticals, Inc. |
Recombinant molecule encoding human protease nexin
|
|
US5231170A
(en)
|
1986-08-27 |
1993-07-27 |
Paul Averback |
Antibodies to dense microspheres
|
|
US5187153A
(en)
|
1986-11-17 |
1993-02-16 |
Scios Nova Inc. |
Methods of treatment using Alzheimer's amyloid polypeptide derivatives
|
|
US5223482A
(en)
|
1986-11-17 |
1993-06-29 |
Scios Nova Inc. |
Recombinant Alzheimer's protease inhibitory amyloid protein and method of use
|
|
US5220013A
(en)
|
1986-11-17 |
1993-06-15 |
Scios Nova Inc. |
DNA sequence useful for the detection of Alzheimer's disease
|
|
US4879213A
(en)
|
1986-12-05 |
1989-11-07 |
Scripps Clinic And Research Foundation |
Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse
|
|
US4912206A
(en)
|
1987-02-26 |
1990-03-27 |
The United States Of America As Represented By The Department Of Health And Human Services |
CDNA clone encoding brain amyloid of alzheimer's disease
|
|
JP3101690B2
(ja)
|
1987-03-18 |
2000-10-23 |
エス・ビィ・２・インコーポレイテッド |
変性抗体の、または変性抗体に関する改良
|
|
US4883666A
(en)
|
1987-04-29 |
1989-11-28 |
Massachusetts Institute Of Technology |
Controlled drug delivery system for treatment of neural disorders
|
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
|
US5057540A
(en)
|
1987-05-29 |
1991-10-15 |
Cambridge Biotech Corporation |
Saponin adjuvant
|
|
US5245015A
(en)
|
1991-04-26 |
1993-09-14 |
Tanox Biosystems, Inc. |
Monoclonal antibodies which neutralize HIV-1 through reaction with a conformational epitope in vitro
|
|
US5583112A
(en)
|
1987-05-29 |
1996-12-10 |
Cambridge Biotech Corporation |
Saponin-antigen conjugates and the use thereof
|
|
US5849298A
(en)
|
1987-06-24 |
1998-12-15 |
Autoimmune Inc. |
Treatment of multiple sclerosis by oral administration of bovine myelin
|
|
US5641474A
(en)
|
1987-06-24 |
1997-06-24 |
Autoimmune, Inc. |
Prevention of autoimmune diseases by aerosol administration of autoantigens
|
|
US5571500A
(en)
|
1987-06-24 |
1996-11-05 |
Autoimmune, Inc. |
Treatment of autoimmune diseases through administration by inhalation of autoantigens
|
|
EP0359783B2
(en)
|
1987-06-24 |
2002-04-17 |
Autoimmune, Inc. |
Treatment of autoimmune diseases by oral administration of autoantigens
|
|
US5571499A
(en)
|
1987-06-24 |
1996-11-05 |
Autoimmune, Inc. |
Treatment of autoimmune diseases by aerosol administration of autoantigens
|
|
US5869054A
(en)
|
1987-06-24 |
1999-02-09 |
Autoimmune Inc. |
Treatment of multiple sclerosis by oral administration of autoantigens
|
|
US5645820A
(en)
|
1987-06-24 |
1997-07-08 |
Autoimmune, Inc. |
Treatment of autoimmune diseases by aerosol administration of autoantigens
|
|
US5004697A
(en)
|
1987-08-17 |
1991-04-02 |
Univ. Of Ca |
Cationized antibodies for delivery through the blood-brain barrier
|
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
|
CA1339014C
(en)
|
1987-10-08 |
1997-03-25 |
Ronald E. Majocha |
Antibodies to a4 amyloid peptide
|
|
US5231000A
(en)
|
1987-10-08 |
1993-07-27 |
The Mclean Hospital |
Antibodies to A4 amyloid peptide
|
|
EP0382781B1
(en)
|
1987-10-23 |
1993-09-29 |
Genetics Institute, Inc. |
Composition for treating cancers characterized by over-expression of the c-fms proto-oncogene
|
|
US5089603A
(en)
|
1989-06-21 |
1992-02-18 |
Tanox Biosystems, Inc. |
Antigenic epitopes present on membrane-bound but not secreted iga
|
|
AU3056289A
(en)
|
1988-01-13 |
1989-08-11 |
Mclean Hospital Corporation, The |
Genetic constructs containing the alzheimer brain amyloid gene
|
|
US4912094B1
(en)
|
1988-06-29 |
1994-02-15 |
Ribi Immunochem Research Inc. |
Modified lipopolysaccharides and process of preparation
|
|
US5576184A
(en)
|
1988-09-06 |
1996-11-19 |
Xoma Corporation |
Production of chimeric mouse-human antibodies with specificity to human tumor antigens
|
|
EP0442926A1
(en)
|
1988-11-10 |
1991-08-28 |
Imperial Cancer Research Technology Limited |
Polypeptides
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5227159A
(en)
|
1989-01-31 |
1993-07-13 |
Miller Richard A |
Anti-idiotype antibodies reactive with shared idiotopes expressed by B cell lymphomas and autoantibodies
|
|
US5262332A
(en)
|
1989-04-05 |
1993-11-16 |
Brigham And Women's Hospital |
Diagnostic method for Alzheimer's disease: examination of non-neural tissue
|
|
AU5525090A
(en)
|
1989-04-14 |
1990-11-16 |
Research Foundation For Mental Hygiene, Inc. |
Monoclonal antibody to amyloid peptide
|
|
WO1990012871A1
(en)
|
1989-04-14 |
1990-11-01 |
Research Foundation For Mental Hygiene, Inc. |
Cerebrovascular amyloid protein-specific monoclonal antibody sv17-6e10
|
|
CA2017507C
(en)
|
1989-05-25 |
1996-11-12 |
Gary Van Nest |
Adjuvant formulation comprising a submicron oil droplet emulsion
|
|
CA2070281C
(en)
|
1989-12-20 |
2005-08-23 |
David Allen Hafler |
Improved treatment of autoimmune diseases by aerosol administration of auto antigens
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
DE69120146T2
(de)
|
1990-01-12 |
1996-12-12 |
Cell Genesys Inc |
Erzeugung xenogener antikörper
|
|
AU651097B2
(en)
|
1990-03-02 |
1994-07-14 |
Autoimmune, Inc. |
Enhancement of the down-regulation of autoimmune diseases by oral administration of autoantigens
|
|
JPH05506990A
(ja)
|
1990-04-24 |
1993-10-14 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
プロテアーゼ ネキシン―２の精製、検出、及び使用方法
|
|
US5753624A
(en)
|
1990-04-27 |
1998-05-19 |
Milkhaus Laboratory, Inc. |
Materials and methods for treatment of plaquing disease
|
|
DE69126304T2
(de)
|
1990-04-27 |
1997-09-04 |
Mcmichael, John, Delanson, N.Y. |
Verfahren und zusammensetzung zur behandlung von erkrankungen des zns hervorgerufen durch abnormales beta-amyloid-protein
|
|
GB9009548D0
(en)
|
1990-04-27 |
1990-06-20 |
Celltech Ltd |
Chimeric antibody and method
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
ES2217250T3
(es)
|
1990-06-15 |
2004-11-01 |
Scios Inc. |
Mamifero transgenico, no humano que muestra la patologia de formacion amiloides de la enfermedad de alzheimer.
|
|
EP0537247A4
(en)
|
1990-06-19 |
1993-09-08 |
Immuvax |
Nonpathogenic variant virus
|
|
GB9014932D0
(en)
|
1990-07-05 |
1990-08-22 |
Celltech Ltd |
Recombinant dna product and method
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5780587A
(en)
|
1990-08-24 |
1998-07-14 |
President And Fellows Of Harvard College |
Compounds and methods for inhibiting β-protein filament formation and neurotoxicity
|
|
WO1993012227A1
(en)
|
1991-12-17 |
1993-06-24 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
NZ239643A
(en)
*
|
1990-09-17 |
1996-05-28 |
North American Vaccine Inc |
Vaccine containing bacterial polysaccharide protein conjugate and adjuvant (c-nd-che-a-co-b-r) with a long chain alkyl group.
|
|
US6506728B2
(en)
|
1990-09-25 |
2003-01-14 |
Genentech, Inc. |
Methods using a novel neurotrophic factor, NT-4
|
|
WO1992006187A1
(en)
|
1990-09-28 |
1992-04-16 |
The Upjohn Company |
Transgenic animals with alzheimer's amyloid precursor gene
|
|
DK0553244T4
(da)
|
1990-10-05 |
2005-08-01 |
Celldex Therapeutics Inc |
Målrettet immunostimulering med bispecifikke reagenser
|
|
HUT69942A
(en)
|
1990-10-15 |
1995-09-28 |
Brigham & Womens Hospital |
Treatment of autoimmun diseases by oral administration of autoantigenes
|
|
GB9023352D0
(en)
|
1990-10-26 |
1990-12-05 |
Lynxvale Ltd |
Vaccinia vectors,vaccinia genes and expression products thereof
|
|
ES2236682T5
(es)
|
1991-01-21 |
2011-03-31 |
Elan Pharmaceuticals, Inc. |
Ensayo y modelo para la enfermedad de alzheimer.
|
|
KR100257214B1
(ko)
|
1991-03-01 |
2000-05-15 |
데스꼴롱그 티에리 |
거세되지 않은 수컷가축의 고기의 관능적 품질을 개선하기 위한 방법
|
|
US5192753A
(en)
|
1991-04-23 |
1993-03-09 |
Mcgeer Patrick L |
Anti-rheumatoid arthritic drugs in the treatment of dementia
|
|
CA2086831C
(en)
|
1991-05-08 |
1999-03-16 |
Reinhard Gluck |
Immunostimulating and immunopotentiating reconstituted influenza virosomes and vaccines containing them
|
|
EP1400536A1
(en)
|
1991-06-14 |
2004-03-24 |
Genentech Inc. |
Method for making humanized antibodies
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
US5672805A
(en)
|
1991-07-18 |
1997-09-30 |
The Regents Of The University Of California |
Transgenic mice expressing the neurotoxic C-terminus of β-amyloid precursor protein
|
|
US5434050A
(en)
|
1991-08-13 |
1995-07-18 |
Regents Of The University Of Minnesota |
Labelled β-amyloid peptide and methods of screening for Alzheimer's disease
|
|
US5837268A
(en)
|
1991-10-16 |
1998-11-17 |
University Of Saskatchewan |
GnRH-leukotoxin chimeras
|
|
AU671093B2
(en)
|
1992-01-07 |
1996-08-15 |
Elan Pharmaceuticals, Inc. |
Transgenic animal models for alzheimer's disease
|
|
US5679348A
(en)
|
1992-02-03 |
1997-10-21 |
Cedars-Sinai Medical Center |
Immunotherapy for recurrent HSV infections
|
|
ES2204900T3
(es)
|
1992-02-11 |
2004-05-01 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
Estructura inmuinogena de doble vector.
|
|
HU220357B
(hu)
|
1992-02-28 |
2001-12-28 |
Autoimmune Inc. |
Eljárás és készítmények autoimmun betegségek kezelésére bystander antigén alkalmazásával
|
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
|
US5604102A
(en)
|
1992-04-15 |
1997-02-18 |
Athena Neurosciences, Inc. |
Methods of screening for β-amyloid peptide production inhibitors
|
|
US5441870A
(en)
|
1992-04-15 |
1995-08-15 |
Athena Neurosciences, Inc. |
Methods for monitoring cellular processing of β-amyloid precursor protein
|
|
US5851787A
(en)
|
1992-04-20 |
1998-12-22 |
The General Hospital Corporation |
Nucleic acid encoding amyloid precursor-like protein and uses thereof
|
|
CA2118508A1
(en)
|
1992-04-24 |
1993-11-11 |
Elizabeth S. Ward |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
GB9209118D0
(en)
|
1992-04-28 |
1992-06-10 |
Sb 120 Amsterdam Bv |
Vaccine compositions
|
|
PT652758E
(pt)
|
1992-06-18 |
2000-04-28 |
Harvard College |
Vacinas de toxina da difteria
|
|
CA2138997C
(en)
|
1992-06-25 |
2003-06-03 |
Jean-Paul Prieels |
Vaccine composition containing adjuvants
|
|
US5837672A
(en)
|
1992-07-10 |
1998-11-17 |
Athena Neurosciences, Inc. |
Methods and compositions for the detection of soluble β-amyloid peptide
|
|
US5766846A
(en)
|
1992-07-10 |
1998-06-16 |
Athena Neurosciences |
Methods of screening for compounds which inhibit soluble β-amyloid peptide production
|
|
US6610493B1
(en)
|
1993-06-17 |
2003-08-26 |
Brigham And Women's Hospital |
Screening compounds for the ability to alter the production of amyloid-β peptide
|
|
WO1994001772A1
(en)
|
1992-07-13 |
1994-01-20 |
The Children's Medical Center Corporation |
SCREEN FOR ALZHEIMER'S DISEASE THERAPEUTICS BASED ON β-AMYLOID PRODUCTION
|
|
IL102687A
(en)
|
1992-07-30 |
1997-06-10 |
Yeda Res & Dev |
Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them
|
|
ATE174628T1
(de)
|
1992-07-31 |
1999-01-15 |
Medeva Holdings Bv |
Expression rekombinanter fusionsproteine in attenuierten bakterien
|
|
HUT71860A
(en)
|
1992-08-27 |
1996-02-28 |
Deakin Res Ltd |
Retro-, inverso-, and retro-inverso synthetic peptide analogues
|
|
US5958883A
(en)
|
1992-09-23 |
1999-09-28 |
Board Of Regents Of The University Of Washington Office Of Technology |
Animal models of human amyloidoses
|
|
AU5358494A
(en)
|
1992-10-13 |
1994-05-09 |
Duke University |
Method of inhibiting binding of amyloid precursor protein to beta-amyloid protein
|
|
DE69334337D1
(de)
|
1992-10-26 |
2010-08-26 |
Elan Pharm Inc |
Verfahren zur Identifizierung von Hemmstoffverbindungen der Freisetzung von Beta-Amyloidpeptid (BAP)
|
|
US5605811A
(en)
|
1992-10-26 |
1997-02-25 |
Athena Neurosciences, Inc. |
Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein
|
|
US5972336A
(en)
|
1992-11-03 |
1999-10-26 |
Oravax Merieux Co. |
Urease-based vaccine against helicobacter infection
|
|
US6210671B1
(en)
|
1992-12-01 |
2001-04-03 |
Protein Design Labs, Inc. |
Humanized antibodies reactive with L-selectin
|
|
AU685776B2
(en)
|
1993-01-22 |
1998-01-29 |
Sloan-Kettering Institute For Cancer Research |
Ganglioside-KLH conjugate vaccines with QS-21
|
|
US5955317A
(en)
|
1993-01-25 |
1999-09-21 |
Takeda Chemical Industries, Ltd. |
Antibodies to β-amyloids or their derivatives and use thereof
|
|
ATE239797T1
(de)
|
1993-01-25 |
2003-05-15 |
Takeda Chemical Industries Ltd |
Antikörper gegen beta-amyloid oder derivative davon und seine verwendung
|
|
US5358708A
(en)
|
1993-01-29 |
1994-10-25 |
Schering Corporation |
Stabilization of protein formulations
|
|
US5472693A
(en)
*
|
1993-02-16 |
1995-12-05 |
The Dow Chemical Company |
Family of anti-carcinoembryonic antigen chimeric antibodies
|
|
CA2115811A1
(en)
|
1993-02-17 |
1994-08-18 |
Claus Krebber |
A method for in vivo selection of ligand-binding proteins
|
|
CA2115900A1
(en)
|
1993-02-22 |
1994-08-23 |
Gerald W. Becker |
Pharmaceutical screens and antibodies
|
|
AU692152B2
(en)
|
1993-03-17 |
1998-06-04 |
Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The |
Immunogenic chimeras comprising nucleic acid sequences encoding endoplasmic reticulum signal sequence peptides and at least one other peptide, and their uses in vaccines and disease treatments
|
|
CA2158475C
(en)
|
1993-03-18 |
2009-06-02 |
Lawrence Tamarkin |
Composition and method for reducing toxicity of biologically-active factors
|
|
US5776468A
(en)
|
1993-03-23 |
1998-07-07 |
Smithkline Beecham Biologicals (S.A.) |
Vaccine compositions containing 3-0 deacylated monophosphoryl lipid A
|
|
IT1270939B
(it)
|
1993-05-11 |
1997-05-26 |
Angeletti P Ist Richerche Bio |
Procedimento per la preparazione di immunogeni e reagenti diagnostici,e immunogeni e reagenti diagnostici cosi' ottenibili.
|
|
DE69426077T3
(de)
*
|
1993-05-25 |
2004-09-02 |
Wyeth Holdings Corp. |
Adjuvantien für impfstoffe gegen das respiratorische synzitialvirus
|
|
WO1994028412A1
(en)
|
1993-05-28 |
1994-12-08 |
The Miriam Hospital |
Composition and method for in vivo imaging of amyloid deposits
|
|
ES2171454T3
(es)
|
1993-06-04 |
2002-09-16 |
Whitehead Biomedical Inst |
Proteinas de estres y sus usos.
|
|
US5464823A
(en)
|
1993-07-20 |
1995-11-07 |
The Regents Of The University Of California |
Mammalian antibiotic peptides
|
|
CA2168459C
(en)
|
1993-07-30 |
2002-10-01 |
Mohammed Anjam Khan |
Fusion proteins containing the c-terminal of tetanus toxin linked to a heterologous protein
|
|
WO1995005393A2
(en)
|
1993-08-18 |
1995-02-23 |
Morphosys Gesellschaft Für Proteinoptimierung Mbh |
Lipopolysaccharide-binding and neutralizing peptides
|
|
DK96493D0
(da)
|
1993-08-26 |
1993-08-26 |
Mouritsen Og Elsner Aps |
Fremgangsmaade til at inducere antistofresponser mod selvproteiner og autovaccine fremstillet ved fremgangsmaaden
|
|
AU707083B2
(en)
|
1993-08-26 |
1999-07-01 |
Bavarian Nordic Inc. |
Inducing antibody response against self-proteins with the aid of foreign T-cell epitopes
|
|
EP0714308A4
(en)
|
1993-08-26 |
1998-07-29 |
Univ California |
METHOD, COMPOSITIONS AND DEVICES FOR THE ADMINISTRATION OF NAKED POLYNUCLEOTIDS, WHICH ENCODE FOR BIOLOGICALLY ACTIVE PEPTIDES
|
|
WO1995006407A1
(en)
|
1993-08-30 |
1995-03-09 |
The Regents Of The University Of California |
Novel component of amyloid in alzheimer's disease and methods for use of same
|
|
WO1995007301A1
(en)
|
1993-09-07 |
1995-03-16 |
Smithkline Beecham Corporation |
Recombinant il4 antibodies useful in treatment of il4 mediated disorders
|
|
US5652334A
(en)
|
1993-09-08 |
1997-07-29 |
City Of Hope |
Method for design of substances that enhance memory and improve the quality of life
|
|
US5385887A
(en)
|
1993-09-10 |
1995-01-31 |
Genetics Institute, Inc. |
Formulations for delivery of osteogenic proteins
|
|
DE69435171D1
(de)
|
1993-09-14 |
2009-01-08 |
Pharmexa Inc |
Pan dr-bindeproteinen zur erhöhung der immunantwort
|
|
US5470951A
(en)
|
1993-09-29 |
1995-11-28 |
City Of Hope |
Peptides for antagonizing the effects of amyloid βprotein
|
|
US5858981A
(en)
|
1993-09-30 |
1999-01-12 |
University Of Pennsylvania |
Method of inhibiting phagocytosis
|
|
AU683703B2
(en)
|
1993-10-20 |
1997-11-20 |
Duke University |
Method of binding material to the beta-amyloid peptide
|
|
ATE223702T1
(de)
|
1993-10-22 |
2002-09-15 |
Genentech Inc |
Verfahren und zusammensetzungen zur mikrokapselung von adjuvantien
|
|
US5744368A
(en)
|
1993-11-04 |
1998-04-28 |
Research Foundation Of State University Of New York |
Methods for the detection of soluble amyloid β-protein (βAP) or soluble transthyretin (TTR)
|
|
US5827690A
(en)
|
1993-12-20 |
1998-10-27 |
Genzyme Transgenics Corporatiion |
Transgenic production of antibodies in milk
|
|
US5434170A
(en)
|
1993-12-23 |
1995-07-18 |
Andrulis Pharmaceuticals Corp. |
Method for treating neurocognitive disorders
|
|
US5877399A
(en)
|
1994-01-27 |
1999-03-02 |
Johns Hopkins University |
Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
|
|
DE69533583T2
(de)
|
1994-01-27 |
2005-10-06 |
Regents of the University of Minnesota, Southeast, Minneapolis |
Nicht humane, transgenische säugetiere mit sich entwickelnder neurologischer krankheit
|
|
AU692237B2
(en)
|
1994-02-03 |
1998-06-04 |
Picower Institute For Medical Research, The |
Compositions and methods for advanced glycosylation endproduct-mediated modulation of amyloidosis
|
|
AUPM411994A0
(en)
|
1994-02-25 |
1994-03-24 |
Deakin Research Limited |
Epitopes
|
|
US5795954A
(en)
|
1994-03-04 |
1998-08-18 |
Genentech, Inc. |
Factor VIIa inhibitors from Kunitz domain proteins
|
|
US6270757B1
(en)
|
1994-04-21 |
2001-08-07 |
Genetics Institute, Inc. |
Formulations for IL-11
|
|
US6372716B1
(en)
|
1994-04-26 |
2002-04-16 |
Genetics Institute, Inc. |
Formulations for factor IX
|
|
WO1995031996A1
(en)
|
1994-05-25 |
1995-11-30 |
Milkhaus Lab |
Materials and methods for treatment of plaquing diseases
|
|
US5622701A
(en)
|
1994-06-14 |
1997-04-22 |
Protein Design Labs, Inc. |
Cross-reacting monoclonal antibodies specific for E- and P-selectin
|
|
US5798100A
(en)
|
1994-07-06 |
1998-08-25 |
Immunomedics, Inc. |
Multi-stage cascade boosting vaccine
|
|
US6417178B1
(en)
|
1994-07-19 |
2002-07-09 |
University Of Pittsburgh |
Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits
|
|
EP0769963A4
(en)
|
1994-07-27 |
1999-07-28 |
Commw Scient Ind Res Org |
POLYEPITOPE VACCINES
|
|
PT784684E
(pt)
|
1994-09-16 |
2007-11-23 |
Cancer Res Fund Of Contra Cost |
''péptidos recontinantes derivados do anticorpo mc3 anti-ba46, métodos para a sua utilização e métodos de hmnanização de péptidos do anticorpo''
|
|
US5872005A
(en)
|
1994-11-03 |
1999-02-16 |
Cell Genesys Inc. |
Packaging cell lines for adeno-associated viral vectors
|
|
US6114133A
(en)
|
1994-11-14 |
2000-09-05 |
Elan Pharmaceuticals, Inc. |
Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-β peptide (x-≧41)
|
|
US5589154A
(en)
|
1994-11-22 |
1996-12-31 |
Rutgers, The State University Of New Jersey |
Methods for the prevention or treatment of vascular hemorrhaging and Alzheimer's disease
|
|
US5688651A
(en)
|
1994-12-16 |
1997-11-18 |
Ramot University Authority For Applied Research And Development Ltd. |
Prevention of protein aggregation
|
|
JP2000510813A
(ja)
|
1995-02-06 |
2000-08-22 |
ジェネテイックス・インスティテュート・インコーポレイテッド |
Ｉｌ−１２用処方
|
|
US5786180A
(en)
|
1995-02-14 |
1998-07-28 |
Bayer Corporation |
Monoclonal antibody 369.2B specific for β A4 peptide
|
|
US5624937A
(en)
|
1995-03-02 |
1997-04-29 |
Eli Lilly And Company |
Chemical compounds as inhibitors of amyloid beta protein production
|
|
US5817626A
(en)
|
1995-03-14 |
1998-10-06 |
Praecis Pharmaceuticals Incorporated |
Modulators of beta-amyloid peptide aggregation
|
|
US5854204A
(en)
|
1995-03-14 |
1998-12-29 |
Praecis Pharmaceuticals, Inc. |
Aβ peptides that modulate β-amyloid aggregation
|
|
US5854215A
(en)
|
1995-03-14 |
1998-12-29 |
Praecis Pharmaceuticals Incorporated |
Modulators of β-amyloid peptide aggregation
|
|
US6303567B1
(en)
|
1995-03-14 |
2001-10-16 |
Praecis Pharmaceuticals, Inc . |
Modulators of β-amyloid peptide aggregation comprising D-amino acids
|
|
EP0871755A1
(en)
|
1995-03-23 |
1998-10-21 |
Cantab Pharmaceuticals Research Limited |
Vectors for gene delivery
|
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
UA56132C2
(uk)
|
1995-04-25 |
2003-05-15 |
Смітклайн Бічем Байолоджікалс С.А. |
Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
|
|
CA2222055A1
(en)
|
1995-05-23 |
1996-11-28 |
Morphosys Gesellschaft Fur Proteinoptimierung Mbh |
Multimeric proteins
|
|
AU6113896A
(en)
|
1995-06-05 |
1996-12-24 |
Brigham And Women's Hospital |
Use of oral tolerance to suppress both th1 and th2 immune re sponses and to suppress antibody production
|
|
US5948763A
(en)
|
1995-06-07 |
1999-09-07 |
New York University |
Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits
|
|
US5910427A
(en)
*
|
1995-06-22 |
1999-06-08 |
La Jolla Institute For Allergy And Immunology |
Antigen non-specific glycosylation inhibiting factor derivatives
|
|
PT750907E
(pt)
|
1995-06-30 |
2002-08-30 |
American Cyanamid Co |
Formulacoes de vacinas estaveis para administracao parenterica metodo para a sua utilizacao e processo para a sua preparacao
|
|
JP4073955B2
(ja)
|
1995-07-07 |
2008-04-09 |
ダーウィン モレキュラー コーポレイション |
アルツハイマー病に関連する第１染色体の遺伝子および遺伝子産物
|
|
AUPN443995A0
(en)
|
1995-07-27 |
1995-08-17 |
Csl Limited |
Papillomavirus polyprotein
|
|
US6685940B2
(en)
|
1995-07-27 |
2004-02-03 |
Genentech, Inc. |
Protein formulation
|
|
US6267958B1
(en)
|
1995-07-27 |
2001-07-31 |
Genentech, Inc. |
Protein formulation
|
|
ES2176484T3
(es)
|
1995-08-18 |
2002-12-01 |
Morphosys Ag |
Bancos de proteinas/(poli)peptidos.
|
|
AU6898996A
(en)
|
1995-08-21 |
1997-03-12 |
Cytrx Corporation |
Compositions and methods for growth promotion
|
|
BR9610580A
(pt)
|
1995-09-14 |
2000-10-24 |
Univ California |
Anticorpos especìficos para prpse nativos
|
|
US5731284A
(en)
|
1995-09-28 |
1998-03-24 |
Amgen Inc. |
Method for treating Alzheimer's disease using glial line-derived neurotrophic factor (GDNF) protein product
|
|
US5985242A
(en)
|
1995-10-27 |
1999-11-16 |
Praecis Pharmaceuticals, Inc. |
Modulators of β-amyloid peptide aggregation comprising D-amino acids
|
|
US5750361A
(en)
|
1995-11-02 |
1998-05-12 |
The Regents Of The University Of California |
Formation and use of prion protein (PRP) complexes
|
|
AU705688B2
(en)
|
1995-11-10 |
1999-05-27 |
Cytogen Corporation |
Peptides which enhance transport across tissues and methods of identifying and using the same
|
|
WO1997018855A1
(en)
|
1995-11-21 |
1997-05-29 |
Eduard Naumovich Lerner |
Device for enhanced delivery of biologically active substances and compounds in an organism
|
|
WO1997021728A1
(en)
|
1995-12-12 |
1997-06-19 |
Karolinska Innovations Ab |
PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b)
|
|
US6015662A
(en)
*
|
1996-01-23 |
2000-01-18 |
Abbott Laboratories |
Reagents for use as calibrators and controls
|
|
US5770700A
(en)
|
1996-01-25 |
1998-06-23 |
Genetics Institute, Inc. |
Liquid factor IX formulations
|
|
ZA97452B
(en)
*
|
1996-01-25 |
1997-08-15 |
Trinity College Dublin |
Streptococcus equi vaccine.
|
|
US6096313A
(en)
|
1996-02-09 |
2000-08-01 |
Ludwig Institute For Cancer Research |
Compositions containing immunogenic molecules and granulocyte-macrophage colony stimulating factor, as an adjuvant
|
|
WO1997032017A1
(en)
|
1996-02-26 |
1997-09-04 |
Morphosys Gesellschaft Für Proteinoptimierung Mbh |
Novel method for the identification of nucleic acid sequences encoding two or more interacting (poly)peptides
|
|
US6150091A
(en)
|
1996-03-06 |
2000-11-21 |
Baylor College Of Medicine |
Direct molecular diagnosis of Friedreich ataxia
|
|
KR20000005120A
(ko)
|
1996-03-29 |
2000-01-25 |
스칸드레트 존 디 |
파라폭스바이러스 벡터
|
|
US5837829A
(en)
|
1996-04-02 |
1998-11-17 |
Abbott Laboratories |
9-oximesilyl erythromycin a derivatives
|
|
JP2000509022A
(ja)
|
1996-04-03 |
2000-07-18 |
アナージェン，インコーポレイテッド |
糖尿病の処置および予防のための環状ペプチドワクチン
|
|
JP2002506419A
(ja)
|
1996-04-19 |
2002-02-26 |
アメリカ合衆国 |
Ａ型肝炎ウイルスポリタンパク質の抗原反応性領域
|
|
US6284533B1
(en)
|
1996-05-01 |
2001-09-04 |
Avant Immunotherapeutics, Inc. |
Plasmid-based vaccine for treating atherosclerosis
|
|
WO1998002462A1
(en)
|
1996-07-16 |
1998-01-22 |
Morphosys Gesellschaft Für Proteinoptimierung Mbh |
Immunoglobulin superfamily domains and fragments with increased solubility
|
|
JP2000516090A
(ja)
|
1996-07-26 |
2000-12-05 |
スローン―ケッタリング インスティチュート フォー キャンサー リサーチ |
遺伝子的免疫化のための方法と試薬
|
|
US7147851B1
(en)
*
|
1996-08-15 |
2006-12-12 |
Millennium Pharmaceuticals, Inc. |
Humanized immunoglobulin reactive with α4β7 integrin
|
|
CA2183901A1
(en)
|
1996-08-22 |
1998-02-23 |
Johanna E. Bergmann |
Targets for therapy and diagnosis of alzheimer's disease and down syndrome in humans
|
|
JP2001500852A
(ja)
|
1996-08-27 |
2001-01-23 |
プレーシス ファーマスーティカルズ インコーポレイテッド |
Ｄ―アミノ酸を含むβ―アミロイドペプチド凝集のモジュレーター
|
|
US6057367A
(en)
|
1996-08-30 |
2000-05-02 |
Duke University |
Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses
|
|
US6797495B2
(en)
|
1996-11-05 |
2004-09-28 |
The Regents Of The University Of California |
Somatic cells with ablated PrP gene and methods of use
|
|
US6022859A
(en)
|
1996-11-15 |
2000-02-08 |
Wisconsin Alumni Research Foundation |
Inhibitors of β-amyloid toxicity
|
|
AU5508798A
(en)
|
1996-11-19 |
1998-06-10 |
Trustees Of The University Of Pennsylvania, The |
Diagnostic and therapeutic reagents for alzheimer's disease
|
|
US6962984B2
(en)
|
1996-12-05 |
2005-11-08 |
Nihon University |
IgA nephropathy-related DNA
|
|
US20030068316A1
(en)
|
1997-02-05 |
2003-04-10 |
Klein William L. |
Anti-ADDL antibodies and uses thereof
|
|
US6218506B1
(en)
|
1997-02-05 |
2001-04-17 |
Northwestern University |
Amyloid β protein (globular assembly and uses thereof)
|
|
ES2191286T3
(es)
|
1997-03-03 |
2003-09-01 |
Boehringer Ingelheim Pharma |
Moleculas pequeñas, utiles en el tratamiento de enfermedades inflamatorias.
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
US5798102A
(en)
|
1997-03-04 |
1998-08-25 |
Milkhaus Laboratory, Inc. |
Treatment of cardiomyopathy
|
|
US6057098A
(en)
|
1997-04-04 |
2000-05-02 |
Biosite Diagnostics, Inc. |
Polyvalent display libraries
|
|
NZ337765A
(en)
|
1997-04-09 |
2001-09-28 |
Mindset Biopharmaceuticals Usa |
Recombinant antibodies having specificity for beta-amyloid N-terminus and C-terminus and use in treating Alzheimer's Disease
|
|
US20020086847A1
(en)
|
1997-04-09 |
2002-07-04 |
Mindset Biopharmaceuticals (Usa) |
Recombinant antibodies specific for beta-amyloid ends, DNA encoding and methods of use thereof
|
|
US8173127B2
(en)
|
1997-04-09 |
2012-05-08 |
Intellect Neurosciences, Inc. |
Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof
|
|
US6787319B2
(en)
|
1997-04-16 |
2004-09-07 |
American Home Products Corp. |
β-amyloid peptide-binding proteins and polynucleotides encoding the same
|
|
EP1003531B1
(en)
|
1997-05-20 |
2007-08-22 |
Ottawa Health Research Institute |
Processes for preparing nucleic acid constructs
|
|
CA2635352C
(en)
|
1997-06-13 |
2012-09-11 |
Genentech, Inc. |
Stabilized antibody formulation
|
|
AU8269898A
(en)
|
1997-06-27 |
1999-01-19 |
Regents Of The University Of California, The |
Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor
|
|
IT1293511B1
(it)
|
1997-07-30 |
1999-03-01 |
Gentili Ist Spa |
Anticorpi monoclonali catalitici ad attivita' proteasica per la lisi selettiva della componente proteica di placche e aggregati correlati
|
|
DE69842048D1
(de)
|
1997-08-01 |
2011-01-27 |
Max Planck Gesellschaft |
Zusammensetzung und verfahren zum nachweis von krankheiten in zusammenhang mit der bildung von amyloid-ähnlichen fibrillen oder protein-aggregaten
|
|
WO1999006587A2
(en)
|
1997-08-01 |
1999-02-11 |
Morphosys Ag |
Novel method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex
|
|
CA2302522C
(en)
|
1997-08-29 |
2010-08-17 |
Antigenics Llc |
Compositions comprising the adjuvant qs-21 and polysorbate or cyclodextrin as excipient
|
|
US6175057B1
(en)
|
1997-10-08 |
2001-01-16 |
The Regents Of The University Of California |
Transgenic mouse model of alzheimer's disease and cerebral amyloid angiopathy
|
|
US6710226B1
(en)
|
1997-12-02 |
2004-03-23 |
Neuralab Limited |
Transgenic mouse assay to determine the effect of Aβ antibodies and Aβ Fragments on alzheimer's disease characteristics
|
|
US7179892B2
(en)
|
2000-12-06 |
2007-02-20 |
Neuralab Limited |
Humanized antibodies that recognize beta amyloid peptide
|
|
US7964192B1
(en)
*
|
1997-12-02 |
2011-06-21 |
Janssen Alzheimer Immunotherapy |
Prevention and treatment of amyloidgenic disease
|
|
US7790856B2
(en)
*
|
1998-04-07 |
2010-09-07 |
Janssen Alzheimer Immunotherapy |
Humanized antibodies that recognize beta amyloid peptide
|
|
US20080050367A1
(en)
*
|
1998-04-07 |
2008-02-28 |
Guriq Basi |
Humanized antibodies that recognize beta amyloid peptide
|
|
US6761888B1
(en)
|
2000-05-26 |
2004-07-13 |
Neuralab Limited |
Passive immunization treatment of Alzheimer's disease
|
|
US6750324B1
(en)
|
1997-12-02 |
2004-06-15 |
Neuralab Limited |
Humanized and chimeric N-terminal amyloid beta-antibodies
|
|
US6905686B1
(en)
|
1997-12-02 |
2005-06-14 |
Neuralab Limited |
Active immunization for treatment of alzheimer's disease
|
|
US6787523B1
(en)
|
1997-12-02 |
2004-09-07 |
Neuralab Limited |
Prevention and treatment of amyloidogenic disease
|
|
US6913745B1
(en)
|
1997-12-02 |
2005-07-05 |
Neuralab Limited |
Passive immunization of Alzheimer's disease
|
|
TWI239847B
(en)
|
1997-12-02 |
2005-09-21 |
Elan Pharm Inc |
N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
|
|
US6923964B1
(en)
|
1997-12-02 |
2005-08-02 |
Neuralab Limited |
Active immunization of AScr for prion disorders
|
|
EP1033998B1
(en)
|
1997-12-03 |
2005-10-19 |
Neuralab, Ltd. |
Suppressing beta-amyloid-related changes in alzheimer's disease
|
|
CN1283991A
(zh)
|
1997-12-03 |
2001-02-14 |
藤泽药品工业株式会社 |
软质颗粒状药剂以及它的制造方法
|
|
FR2777015B3
(fr)
|
1998-02-23 |
2000-09-15 |
Financ De Biotechnologie |
Procede et moyens pour l'obtention de modeles cellulaires et animaux de maladies neurodegeneratives
|
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
US20050059802A1
(en)
|
1998-04-07 |
2005-03-17 |
Neuralab Ltd |
Prevention and treatment of amyloidogenic disease
|
|
US20050059591A1
(en)
|
1998-04-07 |
2005-03-17 |
Neuralab Limited |
Prevention and treatment of amyloidogenic disease
|
|
ES2230848T3
(es)
|
1998-04-28 |
2005-05-01 |
Smithkline Beecham Corporation |
Anticuerpos monoclonales con inmunogenicidad reducida.
|
|
NO314086B1
(no)
|
1998-05-08 |
2003-01-27 |
Gemvax As |
Peptider og farmasöytiske sammensetninger inneholdende disse, nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slike DNA-sekvenser samt anvendelse av disse for fremstilling avfarmasöytiske preparater til
|
|
WO1999060021A2
(en)
|
1998-05-19 |
1999-11-25 |
Yeda Research And Development Co. Ltd. |
Use of activated t cells, nervous system-specific antigens for treating disorders of the nevrous system
|
|
US20030147882A1
(en)
|
1998-05-21 |
2003-08-07 |
Alan Solomon |
Methods for amyloid removal using anti-amyloid antibodies
|
|
DE69942274D1
(de)
|
1998-05-21 |
2010-06-02 |
Univ Tennessee Res Foundation |
Methoden zur amyloidentfernung mit anti-amyloid-antikörper
|
|
US6432710B1
(en)
*
|
1998-05-22 |
2002-08-13 |
Isolagen Technologies, Inc. |
Compositions for regenerating tissue that has deteriorated, and methods for using such compositions
|
|
US6727349B1
(en)
|
1998-07-23 |
2004-04-27 |
Millennium Pharmaceuticals, Inc. |
Recombinant anti-CCR2 antibodies and methods of use therefor
|
|
SK4272001A3
(en)
|
1998-10-05 |
2003-02-04 |
Pharmexa As |
Methods for therapeutic vaccination
|
|
WO2000023082A1
(en)
|
1998-10-19 |
2000-04-27 |
Yeda Research And Development Co. Ltd. |
Treatment of systemic lupus erythematosus by down-regulating the autoimmune response to autoantigens
|
|
US7112661B1
(en)
*
|
1998-10-30 |
2006-09-26 |
The Research Foundation Of State University Of New York |
Variable heavy chain and variable light chain regions of antibodies to human platelet glycoprotein Ib alpha
|
|
GB2348203B
(en)
|
1998-11-04 |
2002-06-19 |
Imp College Innovations Ltd |
Solube beta-forms of prion proteins, methods of preparation and use
|
|
NZ513056A
(en)
|
1999-01-19 |
2004-01-30 |
Upjohn Co |
Gamma-irradiation sterilized polyethylene packaging
|
|
EP1146898A1
(en)
|
1999-01-22 |
2001-10-24 |
Matthew John During |
Vaccine-mediated treatment of neurological disorders
|
|
US7629311B2
(en)
*
|
1999-02-24 |
2009-12-08 |
Edward Lewis Tobinick |
Methods to facilitate transmission of large molecules across the blood-brain, blood-eye, and blood-nerve barriers
|
|
US7282570B2
(en)
|
1999-04-20 |
2007-10-16 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
ATE384077T1
(de)
|
1999-05-05 |
2008-02-15 |
Neurochem Int Ltd |
Stereoselektive antifibrillogene peptide
|
|
US6787637B1
(en)
*
|
1999-05-28 |
2004-09-07 |
Neuralab Limited |
N-Terminal amyloid-β antibodies
|
|
UA81216C2
(en)
|
1999-06-01 |
2007-12-25 |
|
Prevention and treatment of amyloid disease
|
|
PE20010212A1
(es)
|
1999-06-01 |
2001-02-22 |
Neuralab Ltd |
Composiciones del peptido a-beta y procesos para producir las mismas
|
|
AU780474B2
(en)
|
1999-06-16 |
2005-03-24 |
Boston Biomedical Research Institute Incorporated |
Immunological control of beta-amyloid levels in vivo
|
|
CA2377382A1
(en)
*
|
1999-07-01 |
2001-01-11 |
Scios, Inc. |
Prevention and treatment of amyloid-associated disorders
|
|
MXPA02000525A
(es)
|
1999-07-15 |
2005-07-01 |
Inst Genetics Llc |
Formulaciones de il-11.
|
|
DE60043165D1
(de)
|
1999-08-04 |
2009-11-26 |
Univ Southern California |
Globularer Aufbau vom Amyloid-beta- protein und deren Verwendungen
|
|
AU784568B2
(en)
|
1999-09-03 |
2006-05-04 |
Ramot At Tel-Aviv University Ltd |
Agents and compositions and methods utilizing same useful in diagnosing and/or treating or preventing plaque forming diseases
|
|
US6294171B2
(en)
|
1999-09-14 |
2001-09-25 |
Milkhaus Laboratory, Inc. |
Methods for treating disease states comprising administration of low levels of antibodies
|
|
US6824780B1
(en)
*
|
1999-10-29 |
2004-11-30 |
Genentech, Inc. |
Anti-tumor antibody compositions and methods of use
|
|
US20020094335A1
(en)
|
1999-11-29 |
2002-07-18 |
Robert Chalifour |
Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases
|
|
MXPA02005576A
(es)
|
1999-11-29 |
2002-12-13 |
Neurochem Inc |
Vacuna para la prevencion y tratamiento de la enfermedad de alzheimer y otras enfermedades relacionadas con amiloides.
|
|
EP1237930B1
(en)
|
1999-12-08 |
2006-11-08 |
Intellect Neurosciences, Inc. |
Chimeric amyloid beta peptides
|
|
US6399314B1
(en)
|
1999-12-29 |
2002-06-04 |
American Cyanamid Company |
Methods of detection of amyloidogenic proteins
|
|
JP5025871B2
(ja)
|
2000-02-21 |
2012-09-12 |
エイチ．リュンドベック エイ／エス |
アミロイドの新規なダウン−レギュレート方法
|
|
AU783144B2
(en)
|
2000-02-21 |
2005-09-29 |
H. Lundbeck A/S |
Novel method for down-regulation of amyloid
|
|
DE1257584T1
(de)
|
2000-02-24 |
2003-05-28 |
Lilly Co Eli |
Humanisierte antikörper, die amyloid beta peptid demarkieren
|
|
AU2001253158A1
(en)
|
2000-04-05 |
2001-10-23 |
University Of Tennessee Research Corporation |
Methods of investigating, diagnosing, and treating amyloidosis
|
|
ES2309064T3
(es)
|
2000-04-13 |
2008-12-16 |
Corixa Corporation |
Composiciones inmunoestimulantes que comprenden un fosfato de aminoalquil glucosaminida y qs-21.
|
|
AU2001274873B2
(en)
|
2000-05-22 |
2006-10-05 |
New York University |
Synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid beta for induction of an immune response to amyloid beta and amyloid deposits
|
|
CA2414772C
(en)
|
2000-07-07 |
2011-06-28 |
Jan Naslund |
Prevention and treatment of alzheimer's disease
|
|
US20020009445A1
(en)
|
2000-07-12 |
2002-01-24 |
Yansheng Du |
Human beta-amyloid antibody and use thereof for treatment of alzheimer's disease
|
|
EP1172378A1
(en)
|
2000-07-12 |
2002-01-16 |
Richard Dr. Dodel |
Human beta-amyloid antibody and use thereof for treatment of alzheimer's disease
|
|
US20030092145A1
(en)
|
2000-08-24 |
2003-05-15 |
Vic Jira |
Viral vaccine composition, process, and methods of use
|
|
AU9063801A
(en)
|
2000-09-06 |
2002-03-22 |
Aventis Pharma Sa |
Methods and compositions for diseases associated with amyloidosis
|
|
IT1319277B1
(it)
|
2000-10-24 |
2003-09-26 |
Chiesi Farma Spa |
Proteine di fusione utili per il trattamento di immunizzazione dellamalattia di alzheimer.
|
|
IL139308A0
(en)
|
2000-10-26 |
2001-11-25 |
Marikovsky Moshe |
Peptides from amyloid precursor protein which inhibit tumor growth and metastasis
|
|
DE60128138T2
(de)
*
|
2000-11-02 |
2008-01-03 |
Cornell Research Foundation, Inc. |
In vivo multiphoton diagnostische detektion und bilddarstellung einer neurodegenerativen erkrankung
|
|
ATE355374T1
(de)
|
2000-11-27 |
2006-03-15 |
Praecis Pharm Inc |
Therapeutische agentien und methoden ihrer verwendung zur behandlung von amyloidogenen erkrankungen
|
|
PE20020574A1
(es)
|
2000-12-06 |
2002-07-02 |
Wyeth Corp |
Anticuerpos humanizados que reconocen el peptido amiloideo beta
|
|
US7700751B2
(en)
|
2000-12-06 |
2010-04-20 |
Janssen Alzheimer Immunotherapy |
Humanized antibodies that recognize β-amyloid peptide
|
|
WO2002060920A2
(en)
|
2000-12-27 |
2002-08-08 |
Board Of Regents, University Of Texas System |
Prion isomers, methods of making, methods of using, and compositions and products comprising prion isomers
|
|
WO2002059621A2
(en)
|
2001-01-24 |
2002-08-01 |
Bayer Corporation |
Regulation of transthyretin to treat obesity
|
|
DE60121729T2
(de)
|
2001-04-19 |
2007-11-29 |
Dr. Hermann Schätzl |
Prion Proteindimere für Impfungen
|
|
EP1385544B1
(en)
|
2001-04-30 |
2008-09-24 |
Eli Lilly And Company |
Humanized antibodies
|
|
EP2165714B1
(en)
|
2001-04-30 |
2013-10-23 |
Eli Lilly And Company |
Humanized antibodies recognizing the beta-amyloid peptide
|
|
US6906169B2
(en)
|
2001-05-25 |
2005-06-14 |
United Biomedical, Inc. |
Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide
|
|
GB0113179D0
(en)
|
2001-05-31 |
2001-07-25 |
Novartis Ag |
Organic compounds
|
|
WO2003000714A2
(en)
|
2001-06-22 |
2003-01-03 |
Panacea Pharmaceuticals, Inc. |
Compositions and methods for preventing protein aggregation in neurodegenerative diseases
|
|
MXPA04000747A
(es)
|
2001-07-25 |
2004-07-08 |
Protein Desing Labs Inc |
Formulacion farmaceutica liofilizada estable de anticuerpos igg.
|
|
US20030135035A1
(en)
|
2001-08-09 |
2003-07-17 |
Mark Shannon |
Human ZZAP1 protein
|
|
CA2451998A1
(en)
|
2001-08-17 |
2003-02-27 |
Eli Lilly And Company |
Anti-a.beta. antibodies
|
|
WO2003015691A2
(en)
|
2001-08-17 |
2003-02-27 |
Eli Lilly And Company |
RAPID IMPROVEMENT OF COGNITION IN CONDITIONS RELATED TO A$g(b)
|
|
WO2003016467A2
(en)
|
2001-08-17 |
2003-02-27 |
Eli Lilly And Company |
Use of antibodies having high affinity for soluble ass to treat conditions and diseases related to ass
|
|
US20030082191A1
(en)
|
2001-08-29 |
2003-05-01 |
Poduslo Joseph F. |
Treatment for central nervous system disorders
|
|
US6907297B2
(en)
|
2001-09-28 |
2005-06-14 |
Ethicon, Inc. |
Expandable intracardiac return electrode and method of use
|
|
US7781413B2
(en)
|
2001-10-31 |
2010-08-24 |
Board Of Regents, The University Of Texas System |
SEMA3B inhibits tumor growth and induces apoptosis in cancer cells
|
|
IL161677A0
(en)
|
2001-11-08 |
2004-09-27 |
Protein Design Labs |
Stable liquid pharmaceutical formulation of igg antibodies
|
|
EP1572894B1
(en)
|
2001-11-21 |
2016-04-13 |
New York University |
Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid beta, prion protein, amylin, alpha synuclein, or polyglutamine repeats for induction of an immune response thereto
|
|
WO2003051374A2
(en)
|
2001-12-17 |
2003-06-26 |
New York State Office Of Mental Health |
SEQUESTRATION OF Aβ IN THE PERIPHERY IN THE ABSENCE OF IMMUNOMODULATING AGENT AS A THERAPEUTIC APPROACH FOR THE TREATMENT OR PREVENTION OF BETA-AMYLOID RELATED DISEASES
|
|
AR038568A1
(es)
|
2002-02-20 |
2005-01-19 |
Hoffmann La Roche |
Anticuerpos anti-a beta y su uso
|
|
WO2003072736A2
(en)
|
2002-02-21 |
2003-09-04 |
Duke University |
Reagents and treatment methods for autoimmune diseases
|
|
MY139983A
(en)
*
|
2002-03-12 |
2009-11-30 |
Janssen Alzheimer Immunotherap |
Humanized antibodies that recognize beta amyloid peptide
|
|
US7132100B2
(en)
|
2002-06-14 |
2006-11-07 |
Medimmune, Inc. |
Stabilized liquid anti-RSV antibody formulations
|
|
EP2338510A1
(en)
|
2002-07-19 |
2011-06-29 |
Novartis Pharma AG |
Vaccine compositions containing amyloid beta1-6 antigen arrays
|
|
WO2004013172A2
(en)
|
2002-07-24 |
2004-02-12 |
Innogenetics N.V. |
Fragments of beta-amyloid as targets for vaccination against alzheimer disease
|
|
EP1545582A4
(en)
|
2002-10-01 |
2008-09-17 |
Univ Northwestern |
DIFFUSIBLE DERIVATIVES DERIVED FROM AMYLOID BETA (ADDL), ADDL SUBSTITUTE, ADDL BINDING MOLECULES, AND USES THEREOF
|
|
US20060019850A1
(en)
*
|
2002-10-31 |
2006-01-26 |
Korzenski Michael B |
Removal of particle contamination on a patterned silicon/silicon dioxide using dense fluid/chemical formulations
|
|
FR2846667B1
(fr)
|
2002-11-06 |
2004-12-31 |
Pasteur Institut |
Fragments variables d'anticorps de camelides a chaine unique diriges contre le peptide beta-amyloide 1-42 et leurs applications pour le diagnostic et le traitement des maladies neuroagregatives
|
|
AU2003293543A1
(en)
|
2002-12-13 |
2004-07-09 |
Abgenix, Inc. |
System and method for stabilizing antibodies with histidine
|
|
NZ567324A
(en)
|
2003-02-01 |
2009-08-28 |
Wyeth Corp |
Active immunization to generate antibodies to soluble A-beta
|
|
ATE468886T1
(de)
|
2003-02-10 |
2010-06-15 |
Applied Molecular Evolution |
Abeta-bindende moleküle
|
|
MXPA05010555A
(es)
|
2003-04-04 |
2006-03-09 |
Genentech Inc |
Formulaciones de proteina y anticuerpo de alta concentracion.
|
|
EP1480041A1
(en)
|
2003-05-22 |
2004-11-24 |
Innogenetics N.V. |
Method for the prediction, diagnosis and differential diagnosis of Alzheimer's disease
|
|
TWI306458B
(en)
|
2003-05-30 |
2009-02-21 |
Elan Pharma Int Ltd |
Humanized antibodies that recognize beta amyloid peptide
|
|
WO2005002444A1
(en)
*
|
2003-07-07 |
2005-01-13 |
Agency For Science, Technology And Research |
Method and apparatus for extracting third ventricle information
|
|
WO2005014041A2
(en)
|
2003-07-24 |
2005-02-17 |
Novartis Ag |
Use of an amyloid beta dna vaccine for the treatment and/or prevention of amyloid diseases
|
|
WO2005026211A2
(en)
|
2003-09-05 |
2005-03-24 |
Eli Lilly And Company |
Anti-ghrelin antibodies
|
|
CA2445743A1
(en)
*
|
2003-10-08 |
2005-04-08 |
The University Of British Columbia |
Methods for modulating neuronal responses
|
|
KR101157694B1
(ko)
|
2003-12-17 |
2012-06-20 |
와이어쓰 엘엘씨 |
면역원성 펩티드 캐리어 컨쥬게이트 및 이의 제조 방법
|
|
JP4696079B2
(ja)
|
2003-12-17 |
2011-06-08 |
ヤンセン アルツハイマー イミュノセラピー |
Ａβ免疫原性ペプチド担体結合物およびそれの製造方法
|
|
US20050214222A1
(en)
*
|
2004-02-13 |
2005-09-29 |
Mckinnon Stuart J |
In vivo imaging of amyloid plaques in glaucoma using intravenous injectable dyes
|
|
AU2005224091B2
(en)
|
2004-03-15 |
2012-02-02 |
Janssen Pharmaceutica, N.V. |
Novel compounds as opioid receptor modulators
|
|
AU2005270026A1
(en)
*
|
2004-07-02 |
2006-02-09 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Use of thioflavin radiolabeled derivatives in amyloid imaging for assessing anti-amyloid therapies
|
|
MX2007000998A
(es)
|
2004-07-30 |
2007-07-11 |
Rinat Neuroscience Corp |
Anticuerpos dirigidos peptido beta-amiloide y procedimientos que usan los mismos.
|
|
CN101027674A
(zh)
|
2004-09-23 |
2007-08-29 |
诺和诺德公司 |
自我照管支持设备
|
|
AU2005294131A1
(en)
|
2004-10-05 |
2006-04-20 |
Wyeth |
Methods and compositions for improving recombinant protein production
|
|
WO2006047670A2
(en)
|
2004-10-26 |
2006-05-04 |
Wyeth |
Methods for assessing antibodies to neurodegenerative disease-associated antigens
|
|
WO2006066233A1
(en)
|
2004-12-15 |
2006-06-22 |
Neuralab Limited |
An immunoprecipitation-based assay for predicting in vivo efficacy of beta-amyloid antibodies
|
|
US7625560B2
(en)
|
2004-12-15 |
2009-12-01 |
Janssen Alzheimer Immunotherapy |
Humanized antibodies that recognize beta amyloid peptide
|
|
CA2589017A1
(en)
*
|
2004-12-15 |
2006-06-22 |
Neuralab Limited |
Amyloid beta antibodies for use in improving cognition
|
|
WO2006066118A2
(en)
|
2004-12-15 |
2006-06-22 |
Neuralab Limited |
Contextual fear test for predicting efficacy of alzheimer immunotherapeutic treatment
|
|
EP1838348B1
(en)
|
2004-12-15 |
2013-06-26 |
Janssen Alzheimer Immunotherapy |
Humanized amyloid beta antibodies for use in improving cognition
|
|
PA8661401A1
(es)
|
2005-01-28 |
2006-09-08 |
Wyeth Corp |
Formulaciones del liquido polipeptido estabilizado
|
|
GT200600031A
(es)
*
|
2005-01-28 |
2006-08-29 |
|
Formulacion anticuerpo anti a beta
|
|
EP1879613B1
(en)
|
2005-05-05 |
2011-11-30 |
Merck Sharp & Dohme Corp. |
Peptide conjugate compositions and methods for the prevention and treatment of alzheimer's disease
|
|
ZA200710330B
(en)
|
2005-06-17 |
2009-12-30 |
Wyeth Corp |
Methods of purifying FC region containing proteins
|
|
JP2009502786A
(ja)
|
2005-07-18 |
2009-01-29 |
メルク エンド カムパニー インコーポレーテッド |
アルツハイマー病を治療するためのスピロピペリジンβ−セクレターゼ阻害剤
|
|
JP2009516654A
(ja)
|
2005-11-10 |
2009-04-23 |
ロスキャンプ リサーチ， エルエルシー |
Ａ−ベータペプチドによる血管新生の調節
|
|
JP5103466B2
(ja)
*
|
2006-03-30 |
2012-12-19 |
グラクソ グループ リミテッド |
アミロイド‐βペプチドに対する抗体
|
|
WO2010044803A1
(en)
|
2008-10-17 |
2010-04-22 |
Elan Pharma International Limited |
Treatment of amyloidogenic diseases
|
|
US8784810B2
(en)
*
|
2006-04-18 |
2014-07-22 |
Janssen Alzheimer Immunotherapy |
Treatment of amyloidogenic diseases
|
|
EP2046833B9
(en)
|
2006-07-14 |
2014-02-19 |
AC Immune S.A. |
Humanized antibody against amyloid beta
|
|
CA2680762A1
(en)
|
2007-03-12 |
2008-09-25 |
National Institute Of Radiological Sciences |
Pet visualization of amyloid-associated neuroinflammation in the brain
|
|
US8003097B2
(en)
*
|
2007-04-18 |
2011-08-23 |
Janssen Alzheimer Immunotherapy |
Treatment of cerebral amyloid angiopathy
|
|
US20080292625A1
(en)
|
2007-04-18 |
2008-11-27 |
Sally Schroeter |
Prevention and treatment of cerebral amyloid angiopathy
|
|
DK2182983T3
(da)
|
2007-07-27 |
2014-07-14 |
Janssen Alzheimer Immunotherap |
Behandling af amyloidogene sygdomme med humaniserede anti-abeta antistoffer
|
|
JO3076B1
(ar)
*
|
2007-10-17 |
2017-03-15 |
Janssen Alzheimer Immunotherap |
نظم العلاج المناعي المعتمد على حالة apoe
|
|
DK2237803T3
(da)
*
|
2007-12-28 |
2015-10-05 |
Prothena Biosciences Ltd |
Behandling og profylakse af amyloidose
|
|
JP5771525B2
(ja)
|
2008-09-18 |
2015-09-02 |
セダーズ−シナイ メディカル センター |
アルツハイマー病を検出するための光学的方法
|
|
US20130084245A1
(en)
|
2010-02-25 |
2013-04-04 |
Wyeth Llc |
Pet monitoring of a-beta-directed immunotherapy
|
|
EP2560681A4
(en)
|
2010-04-22 |
2013-09-25 |
Janssen Alzheimer Immunotherap |
USE OF TAU FOR MONITORING IMMUNOTHERAPY
|