AR106806A1 - Inhibidores triazol de acc y usos de los mismos - Google Patents

Inhibidores triazol de acc y usos de los mismos

Info

Publication number
AR106806A1
AR106806A1 ARP160103601A ARP160103601A AR106806A1 AR 106806 A1 AR106806 A1 AR 106806A1 AR P160103601 A ARP160103601 A AR P160103601A AR P160103601 A ARP160103601 A AR P160103601A AR 106806 A1 AR106806 A1 AR 106806A1
Authority
AR
Argentina
Prior art keywords
membered
sulfur
oxygen
nitrogen
independently selected
Prior art date
Application number
ARP160103601A
Other languages
English (en)
Inventor
Marcel Leit De Moradei Silvana
C Harriman Geraldine
robert greenwood Jeremy
Ghosh Shomir
Original Assignee
Gilead Apollo Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Apollo Llc filed Critical Gilead Apollo Llc
Publication of AR106806A1 publication Critical patent/AR106806A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
    • C12Y604/01002—Acetyl-CoA carboxylase (6.4.1.2)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Microbiology (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente solicitud provee compuestos de triazol útiles como inhibidores de Acetil CoA Carboxilasa (ACC), composiciones de los mismos y métodos para su uso. Reivindicación 1: Un compuesto de fórmula (1), o una sal farmacéuticamente aceptable o sal agrícolamente aceptable del mismo, en donde: X es -O-, -S-, o -NR-; R¹ es hidrógeno, C₁₋₄ alifático opcionalmente sustituido con 1 - 4 halógeno, -OR, -SR, -N(R)₂, -N(R)C(O)R, -C(O)N(R)₂, -N(R)C(O)N(R)₂, -N(R)C(O)OR, -OC(O)N(R)₂, -N(R)S(O)₂R, -S(O)₂N(R)₂, -C(O)R, -C(O)OR, -OC(O)R, -S(O)R, o -S(O)₂R; cada instancia de R², R⁶, R⁷, y R⁸ es independientemente oxo; halógeno; -CN; -OR; -Rᵃ; -SR; -N(R)₂; -N(R)C(O)R; -C(O)N(R)₂; -N(R)C(O)N(R)₂; -N(R)C(O)OR; -OC(O)N(R)₂; -N(R)S(O)₂R; -S(O)₂N(R)₂; -C(O)R; -C(O)OR; - OC(O)R; -S(O)R; o -S(O)₂R; cada R es independientemente hidrógeno o Rᵃ; cada Rᵃ es independientemente un grupo opcionalmente sustituido seleccionado de C₁₋₆ alifático, un anillo carbocíclico monocíclico saturado o parcialmente insaturado de 3 - 8 miembros, fenilo, un anillo carbocíclico aromático bicíclico de 8 - 10 miembros, un anillo heterocíclico monocíclico saturado o parcialmente insaturado de 4 - 8 miembros que tiene 1 - 2 heteroátomos independientemente seleccionados de nitrógeno, oxígeno, o azufre, un anillo heteroaromático monocíclico de 5 - 6 miembros que tiene 1 - 4 heteroátomos independientemente seleccionados de nitrógeno, oxígeno, o azufre, o un anillo heteroaromático bicíclico de 8 - 10 miembros que tiene 1 - 5 heteroátomos independientemente seleccionados de nitrógeno, oxígeno, o azufre; L¹ es un enlace covalente; una cadena de hidrocarburo de 1 - 6 miembros lineal o ramificada bivalente; ciclopropilenilo; ciclobutilenilo; u oxetanilenilo; L² es un enlace covalente o una cadena de hidrocarburo de 1 - 6 miembros lineal o ramificada bivalente; en donde L² está sustituido por n instancias de R⁹; R³ es -OR, -C(O)OR, -N(R)C(O)OR, -OC(O)N(R)₂, -C(O)N(R)OR, -C(O)NH₂, -C(O)NHRᵃ, -C(O)N(Rᵃ)₂, o -C(O)Hy; Hy es un anillo heterocíclico monocíclico de 3 - 8 miembros saturado o parcialmente insaturado que tiene 1 - 2 heteroátomos independientemente seleccionados de nitrógeno, oxígeno, o azufre, un anillo heteroaromático monocíclico de 5 - 6 miembros que tiene 1 - 4 heteroátomos independientemente seleccionados de nitrógeno, oxígeno, o azufre, o un anillo heteroaromático bicíclico de 8 - 10 miembros que tiene 1 - 5 heteroátomos independientemente seleccionados de nitrógeno, oxígeno, o azufre; en donde Hy está sustituido por p instancias de R⁶; R⁴ se selecciona de un anillo carbocíclico monocíclico de 3 - 8 miembros saturado o parcialmente insaturado, un anillo heterocíclico monocíclico saturado o parcialmente insaturado de 4 - 8 miembros que tiene 1 - 2 heteroátomos independientemente seleccionados de nitrógeno, oxígeno, o azufre, fenilo, un anillo arilo bicíclico de 8 - 10 miembros, un anillo heteroaril monocíclico de 5 - 6 miembros que tiene 1 - 4 heteroátomos independientemente seleccionados de nitrógeno, oxígeno, o azufre, y un anillo heteroarilo bicíclico de 8 - 10 miembros que tiene 1 - 4 heteroátomos independientemente seleccionados de nitrógeno, oxígeno, o azufre; en donde R⁴ está sustituido por q unidades de R⁷; cada R⁵ es independientemente hidrógeno, C₁₋₄ alifático, un anillo carbocíclico monocíclico saturado o parcialmente insaturado de 3 - 8 miembros, un anillo heterocíclico monocíclico saturado o parcialmente insaturado de 4 - 8 miembros que tiene 1 - 2 heteroátomos independientemente seleccionados de nitrógeno, oxígeno, o azufre, fenilo, un anillo arilo bicíclico de 8 - 10 miembros, un heteroarilo monocíclico de 5 - 6 miembros que tiene 1 - 4 heteroátomos independientemente seleccionados de nitrógeno, oxígeno, o azufre, o un anillo heteroarilo bicíclico de 8 - 10 miembros que tiene 1 - 4 heteroátomos independientemente seleccionados de nitrógeno, oxígeno, o azufre; en donde cada R⁵ está sustituido con r unidades de R⁸; cada R⁹ es independientemente oxo o -OR⁵; m es 0, 1, 2, ó 3; n es 0, 1, ó 2; p es 0, 1, 2, 3, ó 4; q es 0, 1, 2, 3, 4, ó 5; y r es 0, 1, 2, 3, ó 4.
ARP160103601A 2015-11-25 2016-11-24 Inhibidores triazol de acc y usos de los mismos AR106806A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562259966P 2015-11-25 2015-11-25

Publications (1)

Publication Number Publication Date
AR106806A1 true AR106806A1 (es) 2018-02-21

Family

ID=57530850

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160103601A AR106806A1 (es) 2015-11-25 2016-11-24 Inhibidores triazol de acc y usos de los mismos

Country Status (18)

Country Link
US (3) US20170166584A1 (es)
EP (1) EP3380479B1 (es)
JP (1) JP2018536661A (es)
KR (1) KR20180082557A (es)
CN (1) CN108349994B (es)
AR (1) AR106806A1 (es)
AU (1) AU2016361428A1 (es)
BR (1) BR112018010453B1 (es)
CA (1) CA3005900C (es)
CL (1) CL2018001360A1 (es)
CO (1) CO2018005369A2 (es)
EA (1) EA201890926A1 (es)
ES (1) ES2939977T3 (es)
MX (1) MX2018006287A (es)
PL (1) PL3380479T3 (es)
PT (1) PT3380479T (es)
SI (1) SI3380479T1 (es)
WO (1) WO2017091617A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS57157B1 (sr) 2011-11-11 2018-07-31 Gilead Apollo Llc Acc inhibitori i njihove primene
EP3099677A4 (en) 2014-01-31 2017-07-26 Dana-Farber Cancer Institute, Inc. Diaminopyrimidine benzenesulfone derivatives and uses thereof
US10793571B2 (en) 2014-01-31 2020-10-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
EP3347021A4 (en) 2015-09-11 2019-07-24 Dana-Farber Cancer Institute, Inc. CYANOTHIENOTRIAZOLDIAZEPINE AND USES THEREOF
RU2018112953A (ru) 2015-09-11 2019-10-14 Дана-Фарбер Кэнсер Инститьют, Инк. Ацетамидтиенотриазолодиазепины и пути их применения
AR106472A1 (es) 2015-10-26 2018-01-17 Gilead Apollo Llc Inhibidores de acc y usos de los mismos
EA201890949A1 (ru) 2015-11-25 2018-12-28 Джилид Аполло, Ллс СЛОЖНОЭФИРНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ
AU2016361412A1 (en) 2015-11-25 2018-05-24 Gilead Apollo, Llc Pyrazole ACC inhibitors and uses thereof
MX2018006499A (es) 2015-11-25 2018-08-01 Dana Farber Cancer Inst Inc Inhibidores de bromodominio bivalentes y usos de los mismos.
BR112018009212B1 (pt) 2015-11-25 2022-06-14 Gilead Apollo, Llc Método para controlar patógenos fúngicos agrícolas
PL3380479T3 (pl) 2015-11-25 2023-05-08 Gilead Apollo, Llc Triazolowe inhibitory acc i ich zastosowania
SG11201807077RA (en) 2016-03-02 2018-09-27 Gilead Apollo Llc Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof
EP3571205B1 (en) 2017-01-22 2023-08-30 Sunshine Lake Pharma Co., Ltd. Thienopyrimidine derivative and use thereof in medicine
WO2018161008A1 (en) * 2017-03-03 2018-09-07 Gilead Apollo, Llc Processes for the preparation of fungicidal compounds
CN110431143B (zh) * 2017-03-24 2022-08-12 浙江海正药业股份有限公司 杂芳基并嘧啶酮类衍生物及其制备方法和用途
SI4122464T1 (sl) 2017-03-28 2024-07-31 Gilead Sciences, Inc. Terapevtske kombinacije za zdravljenje bolezni jeter
CN111201234A (zh) * 2017-07-17 2020-05-26 南京瑞捷医药科技有限公司 新型化合物及其作为acc抑制剂的用途
JP2021008403A (ja) * 2017-09-26 2021-01-28 日本曹達株式会社 １，３，５，６−テトラ置換チエノ［２，３−ｄ］ピリミジン−２，４（１Ｈ，３Ｈ）ジオン化合物および農園芸用殺菌剤
CN110950884B (zh) * 2018-09-27 2024-03-26 上海翰森生物医药科技有限公司 含二并环类衍生物抑制剂、其制备方法和应用
WO2020092239A1 (en) 2018-10-29 2020-05-07 Gilead Apollo, Llc Processes for the preparation of fungicidal compounds
EP3669652A1 (en) * 2018-12-21 2020-06-24 Bayer AG Active compound combination
CN111484504B (zh) * 2019-01-25 2024-05-10 南京圣和药业股份有限公司 Acc抑制剂的光学异构体及其应用
EP3995498A4 (en) * 2019-07-02 2023-03-01 Sunshine Lake Pharma Co., Ltd. THIENOPYRIMIDI DERIVATIVES WITH STEREO CONFIGURATION AND THEIR USE IN MEDICINE
AR119594A1 (es) 2019-08-09 2021-12-29 Gilead Sciences Inc Derivados de tienopirimidina como inhibidores acc y usos de los mismos
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
EP4146205A4 (en) 2020-05-05 2024-05-29 Nuvalent, Inc. HETEROAROMATIC MACROCYCLIC ETHERS AS CHEMOTHERAPEUTIC AGENTS
IL297832A (en) 2020-05-05 2023-01-01 Nuvalent Inc Macrocyclic heteroaromatic chemotherapeutic agents
CN113968871A (zh) * 2020-07-25 2022-01-25 南京圣和药业股份有限公司 苯基取代类acc抑制剂的晶型
JP2024120189A (ja) * 2021-07-20 2024-09-05 日産化学株式会社 チエノウラシル化合物及び有害生物防除剤
TW202320768A (zh) 2021-10-01 2023-06-01 美商努法倫特公司 雜芳族大環醚化合物之固體形式、醫藥組成物及製備
CN118894803B (zh) * 2024-09-29 2024-12-27 济南康和医药科技有限公司 一种吲哚布芬的合成方法

Family Cites Families (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3060084A (en) 1961-06-09 1962-10-23 Du Pont Improved homogeneous, readily dispersed, pesticidal concentrate
US3299566A (en) 1964-06-01 1967-01-24 Olin Mathieson Water soluble film containing agricultural chemicals
US3325503A (en) 1965-02-18 1967-06-13 Diamond Alkali Co Polychloro derivatives of mono- and dicyano pyridines and a method for their preparation
US3296272A (en) 1965-04-01 1967-01-03 Dow Chemical Co Sulfinyl- and sulfonylpyridines
US4144050A (en) 1969-02-05 1979-03-13 Hoechst Aktiengesellschaft Micro granules for pesticides and process for their manufacture
US3920442A (en) 1972-09-18 1975-11-18 Du Pont Water-dispersible pesticide aggregates
US4172714A (en) 1976-12-20 1979-10-30 E. I. Du Pont De Nemours And Company Dry compactible, swellable herbicidal compositions and pellets produced therefrom
GB2095558B (en) 1981-03-30 1984-10-24 Avon Packers Ltd Formulation of agricultural chemicals
DE3338292A1 (de) 1983-10-21 1985-05-02 Basf Ag, 6700 Ludwigshafen 7-amino-azolo(1,5-a)-pyrimidine und diese enthaltende fungizide
CA1249832A (en) 1984-02-03 1989-02-07 Shionogi & Co., Ltd. Azolyl cycloalkanol derivatives and agricultural fungicides
US5304732A (en) 1984-03-06 1994-04-19 Mgi Pharma, Inc. Herbicide resistance in plants
BR8600161A (pt) 1985-01-18 1986-09-23 Plant Genetic Systems Nv Gene quimerico,vetores de plasmidio hibrido,intermediario,processo para controlar insetos em agricultura ou horticultura,composicao inseticida,processo para transformar celulas de plantas para expressar uma toxina de polipeptideo produzida por bacillus thuringiensis,planta,semente de planta,cultura de celulas e plasmidio
DE3545319A1 (de) 1985-12-20 1987-06-25 Basf Ag Acrylsaeureester und fungizide, die diese verbindungen enthalten
ATE57390T1 (de) 1986-03-11 1990-10-15 Plant Genetic Systems Nv Durch gentechnologie erhaltene und gegen glutaminsynthetase-inhibitoren resistente pflanzenzellen.
US4670560A (en) 1986-04-28 1987-06-02 Ortho Pharmaceutical Corporation Thienopyrimidine-2,4-dione derivatives and intermediates thereof
CN1050538A (zh) 1986-05-02 1991-04-10 施托福化学公司 杀真菌性吡啶基亚胺组合物及杀真菌方法
ES2011602T3 (es) 1986-08-12 1994-07-16 Mitsubishi Chem Ind Derivados de piridinacarboxamida y su uso como fungicidas.
FR2629098B1 (fr) 1988-03-23 1990-08-10 Rhone Poulenc Agrochimie Gene chimerique de resistance herbicide
US5180587A (en) 1988-06-28 1993-01-19 E. I. Du Pont De Nemours And Company Tablet formulations of pesticides
EP0374753A3 (de) 1988-12-19 1991-05-29 American Cyanamid Company Insektizide Toxine, Gene, die diese Toxine kodieren, Antikörper, die sie binden, sowie transgene Pflanzenzellen und transgene Pflanzen, die diese Toxine exprimieren
JPH02225485A (ja) 1989-02-27 1990-09-07 Taiho Yakuhin Kogyo Kk チエノピリミジン―３―酢酸誘導体
EP0392225B1 (en) 1989-03-24 2003-05-28 Syngenta Participations AG Disease-resistant transgenic plants
DK0777964T3 (da) 1989-08-30 2002-03-11 Kynoch Agrochemicals Proprieta Fremgangsmåde til fremstilling af et doseringssystem
EP0427529B1 (en) 1989-11-07 1995-04-19 Pioneer Hi-Bred International, Inc. Larvicidal lectins and plant insect resistance based thereon
AU628229B2 (en) 1989-11-10 1992-09-10 Agro-Kanesho Co. Ltd. Hexahydrotriazine compounds and insecticides
PL167613B1 (pl) 1990-03-12 1995-09-30 Du Pont Granulowana kompozycja rozpuszczalna lub dyspergowalna w wodzie PL
CA2083948C (en) 1990-06-25 2001-05-15 Ganesh M. Kishore Glyphosate tolerant plants
DE69122201T2 (de) 1990-10-11 1997-02-06 Sumitomo Chemical Co Pestizide Zusammensetzung
JP2828186B2 (ja) 1991-09-13 1998-11-25 宇部興産株式会社 アクリレート系化合物、その製法及び殺菌剤
UA48104C2 (uk) 1991-10-04 2002-08-15 Новартіс Аг Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника
DE4322211A1 (de) 1993-07-03 1995-01-12 Basf Ag Wäßrige, mehrphasige, stabile Fertigformulierung für Pflanzenschutz-Wirkstoffe und Verfahren zu ihrer Herstellung
JP3811196B2 (ja) 1993-08-26 2006-08-16 武田薬品工業株式会社 エンドセリン拮抗剤、チエノピリミジン誘導体およびその製造法
TW276256B (es) 1993-08-26 1996-05-21 Takeda Pharm Industry Co Ltd
US5530195A (en) 1994-06-10 1996-06-25 Ciba-Geigy Corporation Bacillus thuringiensis gene encoding a toxin active against insects
EP0846119B1 (en) 1995-08-17 2002-11-13 Takeda Chemical Industries, Ltd. Thienopyrimidine derivatives, their production and use as endothelin antagonists
JPH09110873A (ja) 1995-08-17 1997-04-28 Takeda Chem Ind Ltd チエノピリミジン誘導体、その製造法および用途
US5773704A (en) 1996-04-29 1998-06-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Herbicide resistant rice
AU2407997A (en) 1996-04-30 1997-11-19 Takeda Chemical Industries Ltd. Combined use of gnrh agonist and antagonist
JP2007302703A (ja) 1996-04-30 2007-11-22 Takeda Chem Ind Ltd 医薬組成物
DE69736841T2 (de) 1996-07-17 2007-02-01 Michigan State University, East Lansing Imidazolinon-herbizid-resistente zuckerrüben-pflanzen
US5773702A (en) 1996-07-17 1998-06-30 Board Of Trustees Operating Michigan State University Imidazolinone herbicide resistant sugar beet plants
DE19650197A1 (de) 1996-12-04 1998-06-10 Bayer Ag 3-Thiocarbamoylpyrazol-Derivate
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6984644B2 (en) 1997-05-28 2006-01-10 Astrazeneca Ab Treatment of skin disorders using thieno[2,3-D]pyrimidinediones
SE9702001D0 (sv) 1997-05-28 1997-05-28 Astra Pharma Prod Novel compounds
PL193553B1 (pl) 1997-09-18 2007-02-28 Basf Ag Pochodne benzamidoksymu, benzamidoksymy, zastosowanie pochodnych benzamidoksymu i środek grzybobójczy
DE19750012A1 (de) 1997-11-12 1999-05-20 Bayer Ag Isothiazolcarbonsäureamide
BR9813376A (pt) 1997-12-04 2001-06-19 Dow Agrosciences Llc Composição fungicidas e métodos e compostos para a preparação das mesmas
DE19754082A1 (de) 1997-12-05 1999-06-10 Knoll Ag Methode zur Bekämpfung der Fettleibigkeit
US6348643B1 (en) 1998-10-29 2002-02-19 American Cyanamid Company DNA sequences encoding the arabidopsis acetohydroxy-acid synthase small subunit and methods of use
US6576631B1 (en) 1998-11-17 2003-06-10 Kumiai Chemical Industry Co., Ltd. Pyrimidinylbenzimidazole and triazinylbenzimidazole derivatives and agricultural/horticultural bactericides
IT1303800B1 (it) 1998-11-30 2001-02-23 Isagro Ricerca Srl Composti dipeptidici aventi elevata attivita' fungicida e loroutilizzo agronomico.
JP3417862B2 (ja) 1999-02-02 2003-06-16 新東工業株式会社 酸化チタン光触媒高担持シリカゲルおよびその製造方法
AU770077B2 (en) 1999-03-11 2004-02-12 Dow Agrosciences Llc Heterocyclic substituted isoxazolidines and their use as fungicides
CA2369981A1 (en) 1999-04-09 2000-10-19 Cell Therapeutics, Inc. Therapeutic compounds for inhibiting interleukin-12 signaling and methods for using same
US6586617B1 (en) 1999-04-28 2003-07-01 Sumitomo Chemical Takeda Agro Company, Limited Sulfonamide derivatives
UA73307C2 (uk) 1999-08-05 2005-07-15 Куміаі Кемікал Індастрі Ко., Лтд. Похідна карбамату і фунгіцид сільськогосподарського/садівницького призначення
DE10021412A1 (de) 1999-12-13 2001-06-21 Bayer Ag Fungizide Wirkstoffkombinationen
WO2001054501A2 (en) 2000-01-25 2001-08-02 Syngenta Participations Ag Herbicidal composition
US6376548B1 (en) 2000-01-28 2002-04-23 Rohm And Haas Company Enhanced propertied pesticides
IL167958A (en) 2000-02-04 2010-11-30 Sumitomo Chemical Co 2-thio 3-hydroxypyridine derivatives
BR0110410A (pt) 2000-04-28 2003-07-01 Basf Ag Uso do gene ahas 2 mutante x112 de milho e herbicidas de imidazolinona para seleção de mudas transgênicas de monocotiledÈneas de milho, arroz e trigo resistentes aos herbicidas de imidazolinona
AU2001285900B2 (en) 2000-08-25 2005-02-17 Syngenta Participations Ag Novel insecticidal toxins derived from bacillus thuringiensis insecticidal crystal proteins
EP1322614A2 (en) 2000-09-18 2003-07-02 E. I. du Pont de Nemours and Company Pyridinyl amides and imides for use as fungicides
US6815556B2 (en) 2000-11-17 2004-11-09 Dow Agrosciences Llc Compounds having fungicidal activity and processes to make and use same
EP1370562A1 (en) 2001-02-14 2003-12-17 Warner-Lambert Company LLC Thieno[2,3-d]pyrimidindione derivatives as matrix metalloproteinase inhibitors
JP5034142B2 (ja) 2001-04-20 2012-09-26 住友化学株式会社 植物病害防除剤組成物
DE10136065A1 (de) 2001-07-25 2003-02-13 Bayer Cropscience Ag Pyrazolylcarboxanilide
AR037228A1 (es) 2001-07-30 2004-11-03 Dow Agrosciences Llc Compuestos del acido 6-(aril o heteroaril)-4-aminopicolinico, composicion herbicida que los comprende y metodo para controlar vegetacion no deseada
FR2828196A1 (fr) 2001-08-03 2003-02-07 Aventis Cropscience Sa Derives de chromone a action fongicide, procede de preparation et application dans le domaine de l'agriculture
ES2417012T3 (es) 2001-08-09 2013-08-05 Northwest Plant Breeding Co. Plantas de trigo que exhiben resistencia aumentada a los herbicidas de imidazolinona
WO2003014356A1 (en) 2001-08-09 2003-02-20 University Of Saskatchewan Wheat plants having increased resistance to imidazolinone herbicides
AU2002319037B2 (en) 2001-08-09 2008-05-29 University Of Saskatchewan Wheat plants having increased resistance to imidazolinone herbicides
US7655658B2 (en) 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
CN1543455B (zh) 2001-08-17 2012-07-11 三井化学Agro株式会社 3-苯氧基-4-哒嗪醇衍生物以及含有它的除草剂组合物
US7230167B2 (en) 2001-08-31 2007-06-12 Syngenta Participations Ag Modified Cry3A toxins and nucleic acid sequences coding therefor
AR037856A1 (es) 2001-12-17 2004-12-09 Syngenta Participations Ag Evento de maiz
AU2002354251A1 (en) 2001-12-21 2003-07-09 Nissan Chemical Industries, Ltd. Bactericidal composition
TWI327462B (en) 2002-01-18 2010-07-21 Sumitomo Chemical Co Condensed heterocyclic sulfonyl urea compound, a herbicide containing the same, and a method for weed control using the same
DE10204390A1 (de) 2002-02-04 2003-08-14 Bayer Cropscience Ag Disubstituierte Thiazolylcarboxanilide
CN1642599A (zh) 2002-02-27 2005-07-20 辉瑞产品公司 Acc抑制剂
KR100818540B1 (ko) 2002-03-05 2008-04-01 신젠타 파티서페이션즈 아게 Ｏ-사이클로프로필-카복스아닐리드 및 이를 포함하는 살진균 조성물
EP1551218B1 (en) 2002-07-10 2017-05-17 The Department of Agriculture, Western Australia Wheat plants having increased resistance to imidazolinone herbicides
AU2003253165A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Pyrimidine fused bicyclic metalloproteinase inhibitors
GB0227966D0 (en) 2002-11-29 2003-01-08 Syngenta Participations Ag Organic Compounds
WO2004060058A2 (en) 2003-01-06 2004-07-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Herbicides inhibiting the action of plant acetyl-coa carboxylase for use as pesticides.
EP1591446B1 (en) 2003-01-29 2013-03-06 Takeda Pharmaceutical Company Limited Thienopyrimidine compounds and use thereof
WO2004083193A1 (ja) 2003-03-17 2004-09-30 Sumitomo Chemical Company, Limited アミド化合物およびこれを含有する殺菌剤組成物
PL1633875T3 (pl) 2003-05-28 2012-12-31 Basf Se Rośliny pszenicy o zwiększonej tolerancji na herbicydy imidazolinonowe
MXPA06002155A (es) 2003-08-29 2007-01-25 Inst Nac De Technologia Agrope Plantas de arroz que tienen una tolerancia incrementada a los herbicidas de imidazolinona.
TWI355894B (en) 2003-12-19 2012-01-11 Du Pont Herbicidal pyrimidines
EA009883B1 (ru) 2004-03-10 2008-04-28 Басф Акциенгезельшафт 5, 6-диалкил-7-амино-триазолопиримидины, способ их получения и их применение для борьбы с патогенными растениями, а также содержащие их средства
US9487519B2 (en) 2004-03-10 2016-11-08 Basf Se 5,6-Dialkyl-7-aminotriazolopyrimidines, their preparation and their use for controlling harmful fungi, and compositions comprising these compounds
CA2564813A1 (en) 2004-06-03 2005-12-22 E.I. Du Pont De Nemours And Company Fungicidal mixtures of amidinylphenyl compounds
JP2008502625A (ja) 2004-06-18 2008-01-31 ビーエーエスエフ　アクチェンゲゼルシャフト Ｎ−（オルト−フェニル）−１−メチル−３−トリフルオロメチルピラゾール−４−カルボキシアニリドおよびそれらの殺菌剤としての使用
US20080108686A1 (en) 2004-06-18 2008-05-08 Basf Aktiengesellschaft N-(Ortho-Phenyl)-1-Methyl-3-Difluoromethylpyrazole-4-Carboxanilides And Their Use As Fungicides
US7947691B2 (en) 2004-07-21 2011-05-24 Athersys, Inc. Cyclic n-hydroxy imides as inhibitors of flap endonuclease and uses thereof
GB0418048D0 (en) 2004-08-12 2004-09-15 Syngenta Participations Ag Method for protecting useful plants or plant propagation material
DE102005007160A1 (de) 2005-02-16 2006-08-24 Basf Ag Pyrazolcarbonsäureanilide, Verfahren zu ihrer Herstellung und sie enthaltende Mittel zur Bekämpfung von Schadpilzen
DE502006001074D1 (de) 2005-02-16 2008-08-21 Basf Se 5-alkoxyalkyl-6-alkyl-7-amino-azolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
DE102005009458A1 (de) 2005-03-02 2006-09-07 Bayer Cropscience Ag Pyrazolylcarboxanilide
MY143535A (en) 2006-01-13 2011-05-31 Dow Agrosciences Llc 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides
EP1983832A2 (en) 2006-02-09 2008-10-29 Syngeta Participations AG A method of protecting a plant propagation material, a plant, and/or plant organs
CA2644996A1 (en) 2006-03-02 2007-09-13 Cv Therapeutics, Inc. A2a adenosine receptor antagonists
JPWO2008143262A1 (ja) 2007-05-21 2010-08-12 武田薬品工業株式会社 複素環化合物およびその用途
WO2010050445A1 (ja) 2008-10-27 2010-05-06 武田薬品工業株式会社 二環性化合物
US8623880B2 (en) 2009-03-23 2014-01-07 Glenmark Pharmaceuticals S.A. Fused pyrimidine-dione derivatives as TRPA1 modulators
DK2519527T3 (da) 2009-12-29 2014-01-27 Poxel Thieno[2,3-b]pyridindion-aktivatorer af ampk og terapeutiske anvendelser deraf
EP2569450A4 (en) 2010-05-14 2013-12-25 Univ Rochester COMPOSITIONS AND METHODS FOR TARGETING A3G: RNA COMPLEXES
JP5826848B2 (ja) 2010-09-02 2015-12-02 モンサント テクノロジー エルエルシー 線虫を防除する新規組成物および方法
RS57157B1 (sr) 2011-11-11 2018-07-31 Gilead Apollo Llc Acc inhibitori i njihove primene
EP2994139B1 (en) 2013-05-10 2019-04-10 Gilead Apollo, LLC Acc inhibitors and uses thereof
JP6417402B2 (ja) * 2013-05-10 2018-11-07 ギリアド アポロ， エルエルシー Ａｃｃ阻害剤及びその使用
AU2014262547A1 (en) 2013-05-10 2015-11-26 Gilead Apollo, Llc ACC inhibitors and uses thereof
JP6417401B2 (ja) * 2013-05-10 2018-11-07 ギリアド アポロ， エルエルシー Ａｃｃ阻害剤及びその使用
TWI652012B (zh) 2013-05-20 2019-03-01 杜邦股份有限公司 殺真菌吡唑的固態形式
WO2015003881A1 (en) * 2013-07-08 2015-01-15 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
WO2015007451A1 (en) 2013-07-15 2015-01-22 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
AR106472A1 (es) 2015-10-26 2018-01-17 Gilead Apollo Llc Inhibidores de acc y usos de los mismos
MX2018006499A (es) 2015-11-25 2018-08-01 Dana Farber Cancer Inst Inc Inhibidores de bromodominio bivalentes y usos de los mismos.
DK3888658T3 (da) 2015-11-25 2024-03-18 Effector Therapeutics Inc Eif4-a-inhiberende forbindelser og fremgangsmåder relateret dertil
BR112018009212B1 (pt) 2015-11-25 2022-06-14 Gilead Apollo, Llc Método para controlar patógenos fúngicos agrícolas
AU2016361412A1 (en) 2015-11-25 2018-05-24 Gilead Apollo, Llc Pyrazole ACC inhibitors and uses thereof
PL3380479T3 (pl) 2015-11-25 2023-05-08 Gilead Apollo, Llc Triazolowe inhibitory acc i ich zastosowania
EA201890949A1 (ru) 2015-11-25 2018-12-28 Джилид Аполло, Ллс СЛОЖНОЭФИРНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ
US10131670B2 (en) 2016-12-16 2018-11-20 Cystic Fibrosis Foundation Therapeutics, Inc. Bicyclic heteroaryl derivatives as CFTR potentiators

Also Published As

Publication number Publication date
CA3005900A1 (en) 2017-06-01
PT3380479T (pt) 2023-03-13
ES2939977T3 (es) 2023-04-28
SI3380479T1 (sl) 2023-04-28
WO2017091617A1 (en) 2017-06-01
US10800791B2 (en) 2020-10-13
JP2018536661A (ja) 2018-12-13
US20200017519A1 (en) 2020-01-16
KR20180082557A (ko) 2018-07-18
EA201890926A1 (ru) 2018-12-28
EP3380479B1 (en) 2022-12-07
CN108349994A (zh) 2018-07-31
BR112018010453A8 (pt) 2019-02-26
US20170166584A1 (en) 2017-06-15
EP3380479A1 (en) 2018-10-03
AU2016361428A1 (en) 2018-05-24
US20190241582A1 (en) 2019-08-08
CA3005900C (en) 2023-10-31
CN108349994B (zh) 2021-06-22
CL2018001360A1 (es) 2018-08-24
CO2018005369A2 (es) 2018-05-31
PL3380479T3 (pl) 2023-05-08
BR112018010453B1 (pt) 2022-06-14
BR112018010453A2 (pt) 2018-11-21
MX2018006287A (es) 2018-09-07

Similar Documents

Publication Publication Date Title
AR106806A1 (es) Inhibidores triazol de acc y usos de los mismos
AR106798A1 (es) Inhibidores pirazol de acc y usos de los mismos
AR106799A1 (es) Inhibidores éster de acc y usos de los mismos
AR096241A1 (es) Inhibidores de acc y usos de los mismos
AR096242A1 (es) Inhibidores de acc y usos de los mismos
AR119698A2 (es) Compuesto amida n-urea sustituida derivado de aminoácido
AR106472A1 (es) Inhibidores de acc y usos de los mismos
AR096243A1 (es) Inhibidores de acc y usos de los mismos
AR102177A1 (es) Compuestos de heteroarilo como inhibidores de btk y usos de los mismos
AR099995A1 (es) Piridilamidinas fungicidas
AR111419A1 (es) Compuestos fusionados de indazol piridona como antivirales
AR096979A1 (es) Derivados de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
AR111407A1 (es) Compuestos inhibidores de ask1 y usos de los mismos
AR098136A1 (es) Compuestos de heteroarilo como inhibidores de btk y usos de los mismos
ES2721268T3 (es) Compuestos de pirazolo[1,5-a]pirimidina-5,7-diamina como inhibidores de CDK y su uso terapéutico
AR090587A1 (es) Compuestos triciclicos sustituidos con actividad hacia los receptores ep1
AR107694A1 (es) Heteroarilos inhibidores de pad4
AR100806A1 (es) Inhibidores de fosfatidilinositol 3-quinasa
AR103138A1 (es) Compuestos de heteroarilo como inhibidores de la irak y usos de los mismos
AR096330A1 (es) Derivados del bipirazol como inhibidores jak
AR091273A1 (es) Inhibidores de pirimidinil tirosina quinasa
AR087760A1 (es) Heterociclilaminas como inhibidores de pi3k
AR089774A1 (es) Derivados de indolizina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
AR100809A1 (es) Inhibidores de fosfatidilinositol 3-quinasa
AR100810A1 (es) Inhibidores de fosfatidilinositol 3-quinasa

Legal Events

Date Code Title Description
FG Grant, registration