AR106472A1 - Inhibidores de acc y usos de los mismos - Google Patents
Inhibidores de acc y usos de los mismosInfo
- Publication number
- AR106472A1 AR106472A1 ARP160103255A ARP160103255A AR106472A1 AR 106472 A1 AR106472 A1 AR 106472A1 AR P160103255 A ARP160103255 A AR P160103255A AR P160103255 A ARP160103255 A AR P160103255A AR 106472 A1 AR106472 A1 AR 106472A1
- Authority
- AR
- Argentina
- Prior art keywords
- membered
- ring
- independently selected
- sulfur
- nitrogen
- Prior art date
Links
- 229940121373 acetyl-coa carboxylase inhibitor Drugs 0.000 title 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 20
- 229910052760 oxygen Inorganic materials 0.000 abstract 19
- 125000005842 heteroatom Chemical group 0.000 abstract 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 18
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 17
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 17
- 229910052757 nitrogen Inorganic materials 0.000 abstract 17
- 239000001301 oxygen Chemical group 0.000 abstract 17
- 239000011593 sulfur Chemical group 0.000 abstract 17
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 16
- 229920006395 saturated elastomer Polymers 0.000 abstract 15
- 125000002950 monocyclic group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 3
- 125000002619 bicyclic group Chemical group 0.000 abstract 3
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 3
- 229910052805 deuterium Inorganic materials 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 abstract 2
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 abstract 2
- 108010018763 Biotin carboxylase Proteins 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000002837 carbocyclic group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 229930195733 hydrocarbon Natural products 0.000 abstract 2
- 150000002430 hydrocarbons Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000005605 benzo group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- -1 hydrogen halogen Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000003566 oxetanyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente solicitud proporciona compuestos útiles como inhibidores de la Acetil-CoA carboxilasa (ACC), composiciones de los mismos, y métodos de uso de la misma. Reivindicación 1: Un compuesto de fórmula (1) ó (2), o una sal farmacéuticamente aceptable, estereoisómero o mezcla de estereoisómeros del mismo, donde: X se selecciona de -O-, -S-, o -N(R)-; cada Q¹ y Q² es independientemente O ó S; R¹ es hidrógeno, halógeno, -CN, -NO₂, -R⁶, -OR, o -SR; R² es hidrógeno halógeno, -R⁶, -OR, -SR, -N(R)₂, -N(R)C(O)R, -C(O)N(R)₂, -N(R)C(O)N(R)₂, -N(R)C(O)OR, -OC(O)N(R)₂. -N(R)S(O)₂R, -S(O)₂N(R)₂, -C(O)R, -C(O)OR, -OC(O)R, -S(O)R, -S(O)₂R, o Hy; o R¹ y R² pueden opcionalmente ser tomados juntos para formar un carbociclo-monocíclico de 3 - 8 miembros opcionalmente sustituido saturado o parcialmente insaturado, o un heterociclo-, benzo-, o un anillo heteroarilo-fusionado de 5 - 6 miembros; Hy es un anillo opcionalmente sustituido seleccionado de un anillo monocíclico heterocíclico de 3 - 8 miembros saturado o parcialmente insaturado que tiene 1 - 4 heteroátomos independientemente seleccionados de nitrógeno, oxígeno y azufre; un anillo monocíclico heteroarilo de 5 - 6 miembros que tiene 1 - 4 heteroátomos independientemente seleccionados de nitrógeno, oxígeno, y azufre; un anillo bicíclico heterocíclico saturado o parcialmente insaturado de 6 - 10 miembros que tiene 1 - 5 heteroátomos independientemente seleccionados de nitrógeno, oxígeno y azufre; y un anillo bicíclico heteroarilo de 7 - 10 miembros que tiene 1 - 5 heteroátomos independientemente seleccionados de nitrógeno, oxígeno y azufre; cada R se selecciona independientemente de hidrógeno, deuterio, y un grupo opcionalmente sustituido seleccionado de C₁₋₆ alifático; un anillo carbocíclico monocíclico de 3 - 8 miembros saturado o parcialmente insaturado; fenilo; un anillo arilo bicíclico de 8 - 10 miembros; un anillo heterocíclico monocíclico de 3 - 8 miembros saturado o parcialmente insaturado que tiene 1 - 4 heteroátomos seleccionados independientemente de nitrógeno, oxígeno y azufre; un anillo heteroarilo monocíclico de 5 - 6 miembros que tiene 1 - 4 heteroátomos seleccionados independientemente de nitrógeno, oxígeno y azufre; un anillo heterocíclico bicíclico de 6 - 10 miembros saturado o parcialmente insaturado que tiene 1 - 5 heteroátomos seleccionados independientemente de nitrógeno, oxígeno y azufre; y un anillo heteroarilo bicíclico de 7 - 10 miembros que tiene 1 - 5 heteroátomos seleccionados independientemente de nitrógeno, oxígeno y azufre; L¹ es un enlace covalente, una cadena lineal o ramificado de hidrocarburo C₁₋₆ bivalente opcionalmente sustituida, o un ciclopropilenilo, ciclobutilenilo, o un grupo oxetanilo; R³ es un anillo heterocíclico monocíclico de 3 - 7 miembros saturado o parcialmente insaturado que tiene 1 - 3 heteroátomos seleccionados independientemente de N, O, S, S (O), y S(O)₂; en la que R³ está sustituido con m a instancias de R⁵; L² es un enlace covalente o una cadena lineal o ramificada hidrocarbonada bivalente C₁₋₆, donde L² está sustituido con p a instancias de -R⁷; R⁴ es hidrógeno o un anillo opcionalmente sustituido seleccionado de un anillo carbocíclico monocíclico de 3 - 10 miembros saturado o parcialmente insaturado; fenilo; un bicíclico de 6 - 10 miembros saturado, parcialmente insaturado, o un anillo arilo; un anillo heterocíclico monocíclico de 3 - 8 miembros, saturado o parcialmente insaturado que tiene 1 - 4 heteroátomos seleccionados independientemente de nitrógeno, oxígeno y azufre; un anillo de heteroarilo monocíclico de 5 - 6 miembros que tiene 1 - 4 heteroátomos seleccionados independientemente de nitrógeno, oxígeno y azufre; un anillo heterocíclico bicíclico de 6 - 10 miembros saturado o parcialmente insaturado que tiene 1 - 5 heteroátomos seleccionados independientemente de nitrógeno, oxígeno y azufre; y un anillo heteroarilo bicíclico de 7 - 10 miembros que tiene 1 - 5 heteroátomos seleccionados independientemente de nitrógeno, oxígeno y azufre; donde cada R⁴, además, puede estar opcionalmente sustituido con n instancias de -R⁸; cada instancia de R⁵ es independientemente oxo, -R⁶, -OR, -SR, -N(R)₂, -N(R)C(O)R, -C(O)N(R)₂, -N(R)C(O)N(R)₂, -N(R)C(O)OR, -OC(O)N(R)₂, -N(R)SO₂R, -SO₂N(R)₂, -C(O)R, -C(O)OR, -OC(O)R, -S(O)R, y -S(O)₂R; o dos instancias de R⁵, junto con el átomo(s) a los que están unidos, forman un anillo de 3 a 10 miembros opcionalmente sustituido saturado, parcialmente insaturado o aromático que tiene de 0 - 4 heteroátomos seleccionados independientemente de nitrógeno, oxígeno y azufre; cada R⁶ se selecciona independientemente de deuterio, y un grupo opcionalmente sustituido seleccionado de alifático C₁₋₆; un anillo carbocíclico monocíclico de 3 - 8 miembros saturado o parcialmente insaturado; fenilo; un anillo arilo bicíclico de 8 - 10 miembros; un anillo heterocíclico monocíclico de 3 - 8 miembros, saturado o parcialmente insaturado que tiene 1 - 4 heteroátomos seleccionados independientemente de nitrógeno, oxígeno y azufre; un anillo de heteroarilo monocíclico de 5 - 6 miembros que tiene 1 - 4 heteroátomos seleccionados independientemente de nitrógeno, oxígeno y azufre; un anillo heterocíclico bicíclico de 6 - 10 miembros saturado o parcialmente insaturado que tiene 1 - 5 heteroátomos seleccionados independientemente de nitrógeno, oxígeno y azufre; y un anillo heteroarilo bicíclico de 7 - 10 miembros que tiene 1 - 5 heteroátomos seleccionados independientemente de nitrógeno, oxígeno y azufre; cada instancia de R⁷ se selecciona independientemente de oxo, -R⁶, -OR, -SR, -N(R)₂, -N(R)C(O)R, -C(O)N(R)₂, -N(R)C(O)N(R)₂, -N(R)C(O)OR, -OC(O)N(R)₂, -N(R)SO₂R, -SO₂N(R)₂, -C(O)R, -C(O)OR, -OC(O)R, -S(O)R, y -S(O)₂R; cada R⁸ es independientemente halógeno, -R⁶, -OR, -SR, -N(R)₂ o deuterio; cada uno de m, n, y p es independientemente 0 - 5; e Y se selecciona de -O-, -S-, o -N (R).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562246318P | 2015-10-26 | 2015-10-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR106472A1 true AR106472A1 (es) | 2018-01-17 |
Family
ID=57233943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160103255A AR106472A1 (es) | 2015-10-26 | 2016-10-25 | Inhibidores de acc y usos de los mismos |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10179793B2 (es) |
| EP (1) | EP3368540A1 (es) |
| JP (1) | JP2018538246A (es) |
| KR (1) | KR20180067603A (es) |
| CN (1) | CN108368125A (es) |
| AR (1) | AR106472A1 (es) |
| AU (1) | AU2016344392A1 (es) |
| BR (1) | BR112018008227A2 (es) |
| CA (1) | CA3003275A1 (es) |
| EA (1) | EA201890749A1 (es) |
| IL (1) | IL258636A (es) |
| MX (1) | MX2018005292A (es) |
| SG (1) | SG11201802989QA (es) |
| WO (1) | WO2017075056A1 (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS57157B1 (sr) | 2011-11-11 | 2018-07-31 | Gilead Apollo Llc | Acc inhibitori i njihove primene |
| EP3225618B1 (en) | 2014-11-26 | 2020-05-06 | Takeda Pharmaceutical Company Limited | Bicyclic compound |
| BR112018009212B1 (pt) | 2015-11-25 | 2022-06-14 | Gilead Apollo, Llc | Método para controlar patógenos fúngicos agrícolas |
| PL3380479T3 (pl) | 2015-11-25 | 2023-05-08 | Gilead Apollo, Llc | Triazolowe inhibitory acc i ich zastosowania |
| AU2016361412A1 (en) | 2015-11-25 | 2018-05-24 | Gilead Apollo, Llc | Pyrazole ACC inhibitors and uses thereof |
| EA201890949A1 (ru) | 2015-11-25 | 2018-12-28 | Джилид Аполло, Ллс | СЛОЖНОЭФИРНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ |
| SG11201807077RA (en) * | 2016-03-02 | 2018-09-27 | Gilead Apollo Llc | Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof |
| CA3037642A1 (en) | 2016-09-23 | 2018-03-29 | Bayer Aktiengesellschaft | N 3 -cyclically substituted thienouraciles and use thereof |
| EP3571205B1 (en) | 2017-01-22 | 2023-08-30 | Sunshine Lake Pharma Co., Ltd. | Thienopyrimidine derivative and use thereof in medicine |
| WO2018161008A1 (en) * | 2017-03-03 | 2018-09-07 | Gilead Apollo, Llc | Processes for the preparation of fungicidal compounds |
| SI4122464T1 (sl) | 2017-03-28 | 2024-07-31 | Gilead Sciences, Inc. | Terapevtske kombinacije za zdravljenje bolezni jeter |
| CN110709402B (zh) * | 2017-06-15 | 2022-05-10 | 浙江海正药业股份有限公司 | 杂芳基并嘧啶酮类衍生物、其制备方法及其在医药上用途 |
| TW201910338A (zh) * | 2017-07-26 | 2019-03-16 | 大陸商南京聖和藥業股份有限公司 | 作為acc抑制劑的化合物及其應用 |
| CA3094988A1 (en) | 2018-03-30 | 2019-10-03 | Biotheryx, Inc. | Thienopyrimidinone compounds |
| EP3805230B1 (en) * | 2018-06-05 | 2024-08-07 | Medshine Discovery Inc. | Thieno[2,3-c]pyridazin-4(1h)-one derivative and application thereof |
| CA3118422A1 (en) * | 2018-11-02 | 2020-05-07 | Dow Agrosciences Llc | Compositions comprising halauxifen and other herbicides and methods thereof |
| US20220041616A1 (en) * | 2018-11-20 | 2022-02-10 | The National Institutes of Pharmaceutical R&D Co., Ltd. | Spiro compound and medical uses thereof |
| CN111484504B (zh) * | 2019-01-25 | 2024-05-10 | 南京圣和药业股份有限公司 | Acc抑制剂的光学异构体及其应用 |
| US20220152164A1 (en) * | 2019-03-22 | 2022-05-19 | Kallyope, Inc. | Gpcr combination therapies |
| EP3995498A4 (en) | 2019-07-02 | 2023-03-01 | Sunshine Lake Pharma Co., Ltd. | THIENOPYRIMIDI DERIVATIVES WITH STEREO CONFIGURATION AND THEIR USE IN MEDICINE |
| AR119594A1 (es) | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | Derivados de tienopirimidina como inhibidores acc y usos de los mismos |
| CN110746439B (zh) * | 2019-10-18 | 2020-10-30 | 南京瑞捷医药科技有限公司 | 一种噻吩并嘧啶二酮化合物的制备方法 |
| CN114787166B (zh) * | 2019-12-05 | 2023-09-19 | 漳州片仔癀药业股份有限公司 | 噻吩并[2,3-c]哒嗪-4(1H)-酮类化合物的晶型及其制备方法和应用 |
| US11578081B1 (en) | 2019-12-05 | 2023-02-14 | Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd. | Crystal form as inhibitor of ACC1 and ACC2, and preparation method therefor and use thereof |
| WO2021112213A1 (ja) * | 2019-12-05 | 2021-06-10 | 日本曹達株式会社 | ２，４－ジオキソ－１，４－ジヒドロチエノピリミジン化合物、及びそれを含有する農園芸用殺菌剤又は医療用・動物用抗真菌剤 |
| KR20230005210A (ko) * | 2020-04-08 | 2023-01-09 | 레믹스 테라퓨틱스 인크. | 스플라이싱을 조절하기 위한 화합물 및 방법 |
| US11478533B2 (en) | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
| CN113968871A (zh) * | 2020-07-25 | 2022-01-25 | 南京圣和药业股份有限公司 | 苯基取代类acc抑制剂的晶型 |
| WO2022133097A1 (en) * | 2020-12-17 | 2022-06-23 | Biogen Ma Inc. | Synthesis of compounds that modulate use-dependent voltage-gated sodium channels |
| WO2022138812A1 (ja) | 2020-12-24 | 2022-06-30 | モジュラス株式会社 | テトラヒドロチエノピリミジンスルホンアミド化合物 |
| WO2022268520A1 (de) * | 2021-06-21 | 2022-12-29 | Bayer Aktiengesellschaft | Verwendung von substituierten pyrrolidinonen oder deren salzen zur steigerung der stresstoleranz in pflanzen. |
| CN115677551A (zh) * | 2021-12-28 | 2023-02-03 | 武汉市振邦生物科技有限公司 | 一种2-氧代吡咯烷-3-甲酸乙酯的制备工艺 |
| WO2024031089A1 (en) | 2022-08-05 | 2024-02-08 | Gilead Sciences, Inc. | Sars-cov2 main protease inhibitors |
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-
2016
- 2016-10-25 AR ARP160103255A patent/AR106472A1/es unknown
- 2016-10-26 CN CN201680072737.1A patent/CN108368125A/zh active Pending
- 2016-10-26 JP JP2018521087A patent/JP2018538246A/ja active Pending
- 2016-10-26 EP EP16791253.4A patent/EP3368540A1/en not_active Withdrawn
- 2016-10-26 US US15/334,955 patent/US10179793B2/en not_active Expired - Fee Related
- 2016-10-26 MX MX2018005292A patent/MX2018005292A/es unknown
- 2016-10-26 KR KR1020187013132A patent/KR20180067603A/ko not_active Withdrawn
- 2016-10-26 CA CA3003275A patent/CA3003275A1/en not_active Abandoned
- 2016-10-26 BR BR112018008227A patent/BR112018008227A2/pt not_active Application Discontinuation
- 2016-10-26 WO PCT/US2016/058867 patent/WO2017075056A1/en not_active Ceased
- 2016-10-26 AU AU2016344392A patent/AU2016344392A1/en not_active Abandoned
- 2016-10-26 SG SG11201802989QA patent/SG11201802989QA/en unknown
- 2016-10-26 EA EA201890749A patent/EA201890749A1/ru unknown
-
2018
- 2018-04-11 IL IL258636A patent/IL258636A/en unknown
- 2018-11-27 US US16/201,571 patent/US20190330224A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3368540A1 (en) | 2018-09-05 |
| KR20180067603A (ko) | 2018-06-20 |
| MX2018005292A (es) | 2018-08-01 |
| CN108368125A (zh) | 2018-08-03 |
| IL258636A (en) | 2018-06-28 |
| WO2017075056A1 (en) | 2017-05-04 |
| AU2016344392A1 (en) | 2018-05-10 |
| EA201890749A1 (ru) | 2018-11-30 |
| US20190330224A1 (en) | 2019-10-31 |
| CA3003275A1 (en) | 2017-05-04 |
| SG11201802989QA (en) | 2018-05-30 |
| BR112018008227A2 (pt) | 2018-10-23 |
| JP2018538246A (ja) | 2018-12-27 |
| US10179793B2 (en) | 2019-01-15 |
| US20170145028A1 (en) | 2017-05-25 |
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