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All Journal Indonesian Journal of Pharmaceutical Science and Technology MEDISAINS Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas Acta Pharmaciae Indonesia : Acta Pharm Indo Majalah Farmaseutik Jurnal Penelitian Farmasi Indonesia Abdimas Umtas : Jurnal Pengabdian kepada Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Mandala Pharmacon Indonesia HERBAPHARMA : Journal of Herb Farmacological BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal Farmagazine journal of Basic Medical Veterinary Journal of Fundamental and Applied Pharmaceutical Science JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Clavia: Journal of Law Jurnal Farmasi Sains dan Praktis Mandala of Health : A Scientific Journal Jurnal Global Ilmiah Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian

Hamzah, Hasyrul

Fakultas Farmasi, Universitas Muhammadiyah Kalimantan Timur

Author-ID : 1813460

Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Efficacy of Thymol and Eugenol Against Polymicrobial Biofilm Hamzah, Hasyrul; Tunjung Pratiwi, Sylvia Utami; Hertiani, Triana
Indonesian Journal of Pharmacy Vol 29 No 4, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Biofilms associated with human infection have high levels of pathogenicity due to their resistance to antibiotics. The discovery of an active antibiofilm agent against polymicrobial biofilms is a necessary consequence for coping with biofilm-related infections. Thymol and Eugenol are essential oils that have potential as antibacterial and antifungal. This study aimed to determine the effectiveness of thymol and eugenol inhibits C. albicans, P. Aeruginosa, E. coli S. aureus and polymicrobial biofilm. Biofilm formation inhibition assay and biofilm degradation assay of thymol and eugenol were determined using microtiter broth method.The antibiofilm efficacy of thymol and eugenol towards polymicrobial biofilms were analyzed by calculating minimum biofilm inhibitor concentration (MBIC50) and minimum biofilm eradication concentration (MBEC50) values. The data were analyzed using Statistical Package for the Social Sciences (SPSS) with 95% confidence level. Thymol and eugenol showed inhibitory activity against the formation of mono and polymicrobial biofilms of the microbial tested.The result also demonstrated an evidence of activity of thymol and eugenol in breaking down mono and polymicrobial biofilm. Therefore, thymol and eugenol serves as a potential source for new antibiofilm drugs towards polymicrobial biofilm.

KARAKTERISASI BAKTERI ASAM LAKTAT (BAL) DARI FERMENTASI TAPE SINGKONG: CHARACTERIZATION OF LACTIC ACID BACTERIA (LAB) FROM FERMENTATION OF CASSAVA TAPE Widya Rahmah; Erika Nandini; Sylvan Septian Ressandy; Hasyrul Hamzah
Jurnal Penelitian Farmasi Indonesia Vol. 10 No. 1 (2021): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v10i1.1166

Indonesia is famous for its wide variety of fermented traditional foods. The type of traditional fermented food that is often found is cassava tape which is made from carbohydrate food using yeast which belongs to the lactic acid bacteria (LAB) group. This study aims to isolate and characterize LAB as probiotics from fermented cassava tape food. The research methods used were the manufacture of sample suspensions, isolation, and purification of microbes, observation of the morphology of the colonies, gram staining of bacterial isolates, acid resistance test, and bile salt resistance test. Based on the results of research from 4 types of samples with different dilutions, macroscopic tests on all samples had irregular colony edge shapes with 3 types of samples of umbonate colony elevation and 1 spreading sample, as well as 2 samples of umbonate colony shape and 2 others spreading. In the microscopic test, all samples belonged to the Gram-positive bacteria group and were rod-shaped. Meanwhile, in the characteristic test of probiotic isolates against pH and bile salts using MRSB medium with two different pH variations, namely pH 2.5 and pH 3, the results showed that there were deposits on the growth of the isolates where the acidity test stated that LAB had met all the test requirements. probiotics. However, in the bile salt resistance test, all isolates grew more optimally on a medium containing 1% ox bile compared to 5% concentration. Therefore, cassava tape can be used as a source of lactic acid bacteria as probiotics.

The Inhibition Activity of Tannin on the Formation of Mono-Species and Polymicrobial Biofilm Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans Hasyrul Hamzah; Triana Hertiani; Sylvia Utami Tunjung Pratiwi; Titik Nuryastuti
Majalah Obat Tradisional Vol 24, No 2 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Biofilm acts as the mediator for infection nowadays. Approximately, more than 80% infection incidents are biofilm-formation related. Biofilm as bacteria's defense system is more difficult to eradicate by antibiotic; therefore, pathogen bacteria on their biofilm forms can make serious problems for human health. The invention of a new candidate for polymicrobial biofilm can be an essential challenge to be studied, in order to prevent infections related to biofilm. Tannin is a polyphenol compound with anti-bacterial and anti-fungal potential. This study aims to acknowledge the effectiveness of tannin in inhibition and degradation of C. albicans, P. aeruginosa, E. coli, S. aureus, and polymicrobial biofilm. The assay for biofilm inhibition and degradation were determined with microtiter broth method. The effectivity of tannin antibiofilm against polymicrobial biofilm were analyzed by calculating minimum biofilm inhibitory concentration (MBIC50) and minimum biofilm eradication concentration (MBEC50) values. The mechanism of action of tannin against polymicrobial biofilm was tested using scanning electron microscopy (SEM). The data were analyzed using the Statistical Package for the Social Sciences (SPSS) with a 95% confidence level. Tannin 1% gave inhibition activity of mono-species biofilm formation S. aureus in the middle phase and maturation of 79.04±0.01, 61.48±0.03, E. coli 74.56±0.01, 67.91±0.02, P. aeruginosa 67.32±0.05, 35.13± 0.01, C. albicans 60.62±0.01, 47.16±0.01. The results also provide evidence that tannin activity can degrade and damage the matrix of extracellular polymeric substance (EPS) polymicrobial biofilms. Hence, tannins can be a potential candidate for new antibiofilm for polymicrobial biofilm.

Pengetahuan Masyarakat di Kota Samarinda tentang Teknologi Informasi Faldi Faldi; Bambang Setiaji; Rahman Anshari; Rizky Kurniawan Syamat; Hasyrul Hamzah; Widya Rahmah
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol 7 No 1 (2022): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v7i1.2814

Human curiosity about something will always increase the level of knowledge because everything known is knowledge. Such is knowledge, along with the times, information technology has become one of the influential factors in business success because of its advantages in facilitating work in everyday life. Everything related to the process, implementation as a tool, manipulation, and information management is a function of information technology. Without the help of information technology in the business world, it can make the promotion of a product less competitive with other competitors, weaken marketing management, worsen the company's infrastructure, and experience difficulties in running the business. This activity aims to see the level of public knowledge related to information technology, which is very helpful in daily life. This service uses a descriptive survey method associated with the level of general knowledge about information technology with a measuring instrument in the form of a questionnaire distributed to the public through webinar activities with random sampling so that 290 respondents are obtained consisting of students, private workers, and so on. Based on the results, it is known that as many as 73.6% of respondents have understood how to apply information technology. As many as 60% of respondents stated that information technology is fundamental in everyday life because it can facilitate all existing work. Most people in Samarinda already know how to apply and the importance of this information technology in promoting their work.

Efek Saponin Terhadap Penghambatan Planktonik dan Mono-Spesies Biofilm Candida albicans ATCC 10231 pada Fase Pertengahan, Pematangan dan Degaradasi Hasyrul Hamzah; Triana Hertiani; Sylvia Utami Tunjung Pratiwi; Titik Nuryastuti
Majalah Farmaseutik Vol 17, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v17i2.54444

Saponin merupakan salah satu jenis metabolit sekunder dari tanaman yang memiliki aktivitas antibakteri namun aktivitas antibiofilmnya terhadap C. albicans ATCC 10231 belum pernah dilaporkan. Penemuan kandidat antibiofilm baru terhadap biofilm C. albicans menjadi tantangan yang harus di atasi dalam mencegah infeksi yang berhubungan dengan biofilm. Penelitian ini bertujuan untuk mengetahui efektivitas saponin dalam menghambat dan mendegradasi C. albicans ATCC 10231. Pengujian planktonik, penghambatan biofilm dan pengujian degradasi biofilm ditentukan dengan menggunakan metode microtiter broth. efektivitas antibiofilm saponin terhadap biofilm dianalisis dengan menghitung minimum biofilm inhibitor konsentrasi (MBIC50) dan nilai minimum biofilm eradication concentration (MBEC50). Senyawa saponin 1 % memberikan aktivitas penghambatan pada fase planktonik C. albicans sebesar 79,48 % ± 0,01, fase pertengahan biofilm sebesar 56,00 % ± 0,02, fase pematangan 35,55 ± 0,03 Hasilnya juga memberikan bukti aktivitas saponin dapat mendegradasi 50 % biofilm C. albicans sebesar 51,03 ± 0,01. Oleh karena itu, senyawa saponin potensial untuk dikembangkan sebagai kandidat obat-obat antibiofilm baru terhadap biofilm C. albicans.

UJI AKTIVITAS ANTIBAKTERI INFUSA DAUN SIRIH (Piper betle L.) TERHADAP BAKTERI Escherichia coli Hasyrul Hamzah; Amrina Rossada Septilapani; Neni Frimayanti
Jurnal Penelitian Farmasi Indonesia Vol. 10 No. 2 (2021): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v10i2.1434

Research has been carried out on the antibacterial activity test of betel leaf infusion against Escherichia coli bacteria by solid dilution method. This study aims to determine the antibacterial activity of betel leaf infusion (Piper betle L.) against Escherichia coli bacteria. Bacterial control used a bacterial suspension dilution of 10-5 with a colony count of 212.33 colonies/mL and the control media showed that the media used was free from contamination. The results of the antibacterial research showed that the infusion of betel leaf had activity in inhibiting the growth of Escherichia coli bacteria at an infusion concentration of 25% with the number of colonies 188.33 colonies/mL, 50% with the number of colonies 160.66 colonies/mL, 75% with the number of colonies 137, 33 colonies/mL and 100% with the number of colonies 106.33 colonies/mL. The results of data analysis with the percentage decrease in the number of betel leaf infusion colonies against Escherichia coli bacteria that the higher the betel leaf infusion concentration, the less the number of bacterial colony growth, there was a difference marked by the difference in the number of bacterial colonies between control bacteria and the number of bacterial colonies at each concentration infusion.

POTENTIAL OF MATOA FRUIT EXTRACT (POMETIA PINNATA) AS ANTIOXIDANT SOURCE Widya Rahmah; Hasyrul Hamzah; Siti Hajar; Sylvan Septian Ressandy; Erlisa Maharani Putri
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.4240

Pometia pinnata or commonly known as matoa is a typical plant of Eastern Indonesia or Papua that grows throughout the Papua archipelago. Matoa contains alkaloids, saponins, tannins, flavonoids, phenolic compounds, terpenoids, and vitamins A, C, E which can boost the immune system. The study aims to examine whether the matoa (Pometia pinnata) has acted as a source of antioxidants where one of the functions of the antioxidants themselves is to increase the body's immune system by fighting free radicals. This study uses a narrative review approach, which is a secondary research method that does not have specific guidelines in its preparation (non-systematic review) using data collected assembled with research topics from various electronic and non-electronic libraries. Based on the results of the study using comparisons with other foods such as lime, spirulina, and carrots, it turns out that the fruit and fruit skins of Matoa contain more vitamin C. It is known that the skin of the fruit and matoa fruit contains vitamin C which works as an antioxidant to increase the body's immune system by fighting free radicals. Also, based on several studies, it is known that the extract of the stem and matoa bark obtained an IC50 value of more than 70 ppm where this value is classified as strong antioxidant activity.

Counseling on Digital Marketing in Marketing MSMEs in the Tourism Sector in the Tourism Market of the Mulawarman Museum, Kutai Kartanegara District Khalish Arsy Al Khairy Siregar; Faldi; Rahman Anshari; Hasyrul Hamzah; Jati Pratiwi; Junianda Haris Dwiagam
ABDIMAS: Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2022): ABDIMAS UMTAS: Jurnal Pengabdian Kepada Masyarakat
Publisher : LPPM Universitas Muhammadiyah Tasikmalaya

Indonesia is a country rich in cultural and tourist resources, one of which is the Kutai Kartanegara Regency, one of the regencies in East Kalimantan Province. Kutai Kartanegara Regency is rich in cultural and tourist resources. During the current epidemic, the tourist industry has had a catastrophic influence on business actors in the tourism sector, particularly in Kutai Kartanegara. According to sources, the tourism sector in Kutai Kartanegara has dropped by 80% due to the COVID-19 epidemic. The ease with which information is accessible is due to recent technology improvements that bring community convenience. One of them is the role of technical advancements, such as the existence of Digital Promotion in operating a business or business for the community, which may facilitate access to information and product marketing. Digital marketing is a beneficial method for promoting a product via information technology, with social media serving as an informational forum and chance for company actors and their consumers. The Mulawarman Museum Tourism Market was chosen as a service location based on field circumstances, business players' revenue level in the calm Mulawarman Museum Tourism Market, and a decline in income. It is intended that this service activity would give marketing solutions for MSME players in the tourist industry at the Mulawarman Museum Tourism Market.

POTENSI JAMU SEBAGAI OBAT HERBAL ASLI INDONESIA UNTUK MENINGKATKAN DAYA TAHAN TUBUH Aji Firda Lia F; Chaerul Fadly Mochtar; Diana Indri Sulistia; Sekar Ayu Kumara; Shella Carlina Tasya; Hasyrul Hamzah; Muh Irham Bakhtiar; Mochtar Luthfi; Chaerul Mundzir
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 3 No. 4 (2022)
Publisher : Universitas Majalengka

The virus that is currently endemic throughout the world is the Covid-19 virus. Covid-19, which was declared a pandemic by WHO on March 11, 2020, can enter the human body through the mucosa of the eyes, nose and mouth. The number of victims infected with the Covid-19 corona virus is increasing every day in Indonesia. One of the innovations in preventing the corona virus is the use of herbal ingredients to maintain body resistance in the New Normal period . This can keep the body healthy and fit, and can prevent and kill harmful bacteria in the body. So that the immune system will increase. Examples of the use of herbal ingredients, namely temulawak, turmeric and ginger, can be used as raw materials for herbal medicine or herbal medicine. The activity is expected to increase the knowledge of the community and students regarding the potential use of herbal medicine, an Indonesian herbal medicine to increase endurance. The method used is online via Zoom Meeting using the speaker presentation method to the participants. The results of the activity, namely consuming herbs, Indonesian herbs can help increase body resistance in the New Normal period.

PENTINGNYA VAKSINASI DALAM MEMBENTUK ADAPTIVE IMMUNITY Lysa Oktaviani Saleh; Chaerul Fadly Mochtar; Fhirda Azhari; Noor Aida; Rabiatul Adawiyah; Hasyrul Hamzah; Muh Irham Bakhtiar
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 3 No. 4 (2022)
Publisher : Universitas Majalengka

COVID-19 pertama kali diterapkan di Wuhan, yang berada di Provinsi Hubei, China pada tahun 2019. Virus mampu menular melalui partikel yang dikeluarkan oleh setiap individu pada saat bernapas ketika berada dalam jarak dekat yaitu satu meter. Tiap individu sangat mudah terinfeksi apabila menggunakan benda yang telah terinfeksi maupun bersentuhan secara langsung. Hal ini disebut dalam program vaksinasi sebagai kunci pemberantasan pandemi karena dapat menurunkan angka kematian serta mampu mengurangi kekebalan terkait COVID-19. Tujuan kegiatan pengabdian ini untuk memberikan edukasi kepada masyarakat pentingnya melakukan vaksinasi. Edukasi tersebut diharapkan kepada masyarakat mendapatkan kesadaran tentang pentingnya melakukan sebuah vaksinasi ditengah pandemi. Metode pelaksanaan dilakukan secara sistematis, dengan beberapa metode : 1) Menentukan pada peIaksanaan pengabdian masyarakat yang dilakukan secara daring dengan menggunakan aplikasi zoom meeting. 2) Menentukan peserta webinar pengabdian masyarakat juga dilakukan dengan penyebaran diaplikasi seperti pada whatsapp dan Instagram. 3) Pelaksanaan kegiatan webinar pengabdian masyarakat yang dilakukan dengan mempersentasikan materi mengenai pentingnya vaksinasi menggunakan powerpoint oleh narasumber, serta dilakukannya sesi diskusi yang dipandu oleh moderator. Hasil dari kegiatan adalah meningkatnya pengetahuan masyarakat tentang pentingnya vaksinasi untuk mengurangi resiko penularan. Semakin banyak masyarakat yang melakukan vaksinasi maka Herd Immunity akan tercapai, memungkinkan kita untuk mengurangi resiko infeksi dan mutasi dari COVID-19

Co-Authors A. Nurfitriani Abdul Rozak Agus Santosa Ahmad Faqih Aisyiyah, Novia Misnawati Aji Firda Lia F Alfin Syahrian Dwi Nugraha Amelia Wandini Amrina Rossada Septilapani Andi Suhendi Annisa Larasati Nurhidayah Anshari, Rahman Anugrah Riska Pradana Anugrah Riska Pradana Ari Nurwijayanto Arifin Nur Fahdianto Astriani, Nur Atika Aulan Syahala Ayu Faradillah Azizah, Aryantinur Badrani Abbas Al Fajri Bafadal, Mentarry Bakhtiar, Muh. Irham Bakti, Muhammad Tursina Bambang Setiaji Bambang Setiaji Bambang WIJIANTO Besan, Emma Jayanti Cahyaningrum, Putri Khaerani Chaerul Fadly Mochtar Dedi Setiawan Devi, Reni Selviana Diana Indri Sulistia Dwi Lestari Elva Hafidzah Endang Setyowati Erika Nandini Erika Nandini Erlisa Maharani Putri Fadlillah, Synta Haqqul Faldi Faldi Faldi Faradillah, Ayu Farid Adi Prasetya Farida, Norma Feti Fathiah Putri Varizza Fathur Rahman Fendy Prasetyawan Fhirda Azhari Frederika Erwina Rani Fredy Dian Kurniawan Guci Intan Kemuning Gunawan, Dede Reza Hafidzah, Elva Hendra Wahyudi Hendra Wahyudi Husna, Qur'anni Akhwatun Indra Yudhawan Indra Yudhawan Irzani, Elza Fadia Jamiatur Rasyidah Jati Pratiwi Junianda Haris Dwiagam Kamilah, Lila Zulfa Khalish Arsy Al Khairy Siregar Lila Zulfa Kamila Lutfi Chabib, Lutfi Luthfi M, Mochtar Lysa Oktaviani Saleh Lysa Oktaviani Saleh MAULANA, RIZA Muh Irham Bakhtiar Muhammad Nurul Fadel Muhammad Rusli Muhammad Subhan Muhtadi Mundzir, Chaerul Muslim, M. Rifqi Fadillah Neni Frimayanti Nila Fajrianti Nita Magfirah Ilyas Noor Aida Norma Feti Farida Novia Misnawati Aisyiyah Novy Yudhistirawati Nur Atika Astriani Nur Halimah Nur Lutfiah Damis Nur Rasdianah Perdana Priya Haresmita, Perdana Priya Phebe Hendra Pradana, Anugrah Riska Pratama, Virgiawan Yoga Putri, Erlisa Maharani Qur’anni Akhwatun Husna Rabiatul Adawiyah Rahmah, Widya Reni Selviana Devi Ressandy, Sylvan Septian Retno Wahyuningrum Rini Dwiastuti Riska Febriani Risna Aris Risna Aris Riyadh Aqilsya Amaryl Dyas Riza Maulana Rizky Kurniawan Rizky Kurniawan Syamat Rusdeni, Sofia Sabtanti Harimurti, Sabtanti Salsabila Azzahra Sari, Mely Anita Sari, Seftika Sekar Ayu Kumara Shella Carlina Tasya Sinta Ratna Dewi Sinta Ratna Dewi Siti Hajar Siti Hajar Suci Cahya Ningsih Suci Mardatilah Suhartomo, Dalri Muhammad Suriati Suriati Suwoko Suwoko Syayid Al Manar Sylvan Septian Ressandy Sylvan Septian Ressandy Sylvia Utami Tunjung Pratiwi Tasya Amanda, Putri Titik Nuryastuti Titik Nuryastuti Tomi Perdani Triana Hertiani Varizza, Fathiah Putri Virgiawan Yoga Pratama Virgiawan Yoga Pratama Wicaksari, Sifa Aulia Widya Rahmah Widya Rahmah Widya Rahmah Wirnawati Wirnawati Wirnawati, Wirnawati Yudhawan, Indra

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