JP2016158665A - Denture stabilizer - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a denture stabilizer which has excellent adhesiveness and adhesive stability and can stably immobilize a denture in an oral cavity for a long time.SOLUTION: A denture stabilizer comprises the following (A) and (B) components: (A) at least one adhesive component selected from the group consisting of a lower alkylvinyl ether/maleic anhydride copolymer, a derivative thereof, and salt thereof and (B) zinc chloride.SELECTED DRAWING: None

Description

  The present invention relates to a denture stabilizer. More specifically, the present invention relates to a denture stabilizer that is excellent in adhesiveness and adhesive stability in the presence of water and can stably fix a denture in the oral cavity.

  Denture stabilizers are conventionally used by many denture wearers to fix a denture in a predetermined position in the oral cavity during non-chewing and chewing.

  Commercially available denture stabilizers are prepared by dispersing water-soluble polymers such as sodium carboxymethylcellulose and polyethylene glycol in oily bases such as liquid paraffin and petrolatum, and by densifying the water-soluble polymer swollen by moisture in the oral cavity. Ointment or cream type denture stabilizer that improves the stability of the teeth, and cushion type denture stability that plasticizes polyvinyl acetate with a solvent such as ethanol and fills the gap between the denture and the ridge mucosa and improves the stability of the denture In addition to agents, there are gel-type, powder-type, sheet-type, and tape-type denture stabilizers. In any form, it is important that when the denture is placed in the mouth, good adhesiveness is exhibited and the adhesiveness lasts for a long time.

  Therefore, many improvements have been proposed and performed for denture stabilizers. For example, denture stabilizers using lower alkyl vinyl ether / maleic anhydride copolymers, derivatives thereof, and salts thereof are conventionally known to have good tackiness when containing water (for example, patents). Patent Document 2 includes a partially neutralized alkyl vinyl ether-maleic acid or a denture stabilizer containing hydroxypropylcellulose and an anhydride copolymer that may be partially crosslinked. 3 discloses an improved denture stabilizer base composition containing a substantially anhydrous mixture of a methyl vinyl ether-maleic acid copolymer Na / Ca mixed salt, sodium carboxymethylcellulose and a trivalent cation. . Patent Document 4 further discloses a denture adhesive containing a partial salt of maleic acid or a copolymer of maleic anhydride and an alkyl vinyl ether (a cation of the salt includes zinc ions and magnesium ions) as an adhesive salt. Patent Document 5 discloses a denture stabilizer containing, in addition to a lower alkyl vinyl ether / maleic anhydride copolymer or a derivative thereof, a water-insoluble and water-swellable polymer, and an adhesive substance such as natural rubber and synthetic polymer. Is disclosed.

U.S. Patent Publication No. 3,003,988 U.S. Patent Publication No. 4,373,036 U.S. Patent Publication No. 5,006,571 Japanese National Patent Publication No. 10-506928 JP 2007-186510 A

  As described above, various denture stabilizers have been proposed that are excellent in adhesiveness and adhesive stability in the presence of water and can stably fix dentures in the oral cavity. There is a fact.

  For this reason, the main object of the present invention is to provide an improved denture stabilizer that is excellent in adhesiveness and adhesive stability in the presence of water and can be stably fixed in the oral cavity. It is to be.

  The present inventors have focused on lower alkyl vinyl ether / maleic anhydride copolymers, derivatives thereof, or salts thereof as an adhesive component in order to improve the adhesion and adhesion stability of denture stabilizers, which is a conventional problem. As a result of studies, it was confirmed that the above-mentioned purpose can be achieved by using zinc chloride in combination with this, specifically, by using zinc chloride in combination with the lower alkyl vinyl ether / maleic anhydride copolymer, its derivative, or those In the presence of water in the presence of salt and found that the adhesive stability (adhesion persistence) is further enhanced (improvement), actually used as a denture stabilizer in the oral cavity to fix the denture It was confirmed that the feeling improved.

  The present invention has been completed as a result of further research based on these findings, and includes the following embodiments.

(I) Denture stabilizer (I-1) Denture stabilizer containing the following components (A) and (B):
(A) At least one adhesive component (B) zinc chloride selected from the group consisting of a lower alkyl vinyl ether / maleic anhydride copolymer, a derivative thereof, and a salt thereof.
(I-2) The denture stabilizer described in (I-1), wherein the ratio of the component (B) to 100 parts by weight of the component (A) is 1 to 2.5 parts by weight.
(I-3) Denture stability described in (I-1) or (I-2) containing 10 to 60% by weight of component (A) and 0.3 to 1% by weight of component (B) Agent.
(I-4) The denture stabilizer described in any one of (I-1) to (I-3), which further contains a water-soluble polymer as an adhesion auxiliary component.

(II) Method for enhancing adhesion of denture stabilizer (II-1) (A) (A) At least one adhesive selected from the group consisting of lower alkyl vinyl ether / maleic anhydride copolymers, derivatives thereof, and salts thereof (B) Zinc chloride is mix | blended with the denture stabilizer composition containing a component, The enhancement method of the adhesive force of a denture stabilizer characterized by the above-mentioned.
(II-2) The enhancing method described in (II-1), wherein the ratio of the component (B) to 100 parts by weight of the component (A) is 1 to 2.5 parts by weight.
(II-3) The denture stabilizer composition to be used is such that the proportion of the component (A) in the denture stabilizer 100 wt% after blending the component (B) is 10 to 60 wt%. The enhancement method described in (II-1) or (II-2), which comprises the component (A).

  The denture stabilizer of the present invention comprises (A) at least one adhesive component selected from the group consisting of a lower alkyl vinyl ether / maleic anhydride copolymer, a derivative thereof, and a salt thereof, and (B) zinc chloride. By including it in combination, the adhesiveness and adhesive stability (adhesion persistence) in the presence of water of component (A) are further enhanced (improved), and as a result, this is used as a denture stabilizer in the oral cavity for dentures. When it is used for mounting and fixing, it is possible to obtain a good wearing feeling of dentures.

  Moreover, according to the method for enhancing the adhesiveness of the denture stabilizer of the present invention, (A) at least one adhesive component selected from the group consisting of a lower alkyl vinyl ether / maleic anhydride copolymer, a derivative thereof, and a salt thereof. The adhesion in the presence of water, preferably adhesion stability (adhesion persistence) can be further enhanced (improved) by using (B) zinc chloride in combination. For this reason, by using this method for the preparation of a denture stabilizer, it is possible to obtain a denture stabilizer capable of stably mounting and fixing a denture in the oral cavity and obtaining a good wearing comfort of the denture.

(I) Denture Stabilizer Denture stabilizer is a preparation used to attach and fix a denture on the ridge (gum) or upper jaw by bringing the denture into close contact with the ridge (gum) or upper jaw. is there. Also called denture adhesive. The target dentures are usually complete dentures and partial dentures.

  The denture stabilizers targeted by the present invention are not particularly limited in form, but are in the form of pastes such as cream types and gel types, powders such as powder types, and sheets (tapes) such as tape types and sheet types. Denture stabilizers having various forms of are included. Moreover, the material of the denture floor used as object is also not limited, and can be applied to both resin floors and metal floors.

The denture stabilizer of the present invention contains the following components (A) and (B).
(A) at least one adhesive component selected from the group consisting of a lower alkyl vinyl ether / maleic anhydride copolymer, a derivative thereof, and a salt thereof;
(B) Zinc chloride.

  Here, the zinc chloride as the component (B) is a component that can enhance its adhesiveness (and adhesive stability) when used in combination with the adhesive component of (A). For this reason, (B) component can be positioned as an adhesive (and adhesion stability) enhancement component of (A) adhesive component.

  Hereinafter, these components and other components that can constitute a denture stabilizer will be described.

(1) (A) Adhesive Component Lower alkyl vinyl ether / maleic anhydride copolymer, derivative or salt thereof (hereinafter referred to as “AVE / MA copolymers”) used as (A) adhesive component in the present invention. May have a property of absorbing water and dissolving slowly and exhibiting tackiness.

  Here, the lower alkyl vinyl ether / maleic anhydride copolymer is a copolymer produced by polymerizing a lower alkyl vinyl ether monomer and maleic anhydride. The copolymer can be easily hydrolyzed to an acid polymer.

  In the lower alkyl vinyl ether / maleic anhydride copolymer and the lower alkyl vinyl ether monomer that is the material thereof, the “lower alkyl group” usually includes an alkyl group having 1 to 8 carbon atoms. Preferably it is a C1-C6 alkyl group, More preferably, it is a C1-C4 alkyl group. Specific examples include a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, an isobutyl group, a t-butyl group, and a sec-butyl group. Therefore, as the lower alkyl vinyl ether / maleic anhydride copolymer, specifically, methyl vinyl ether / maleic anhydride copolymer, ethyl vinyl ether / maleic anhydride copolymer, divinyl ether / maleic anhydride copolymer, Mention may be made of propyl vinyl ether / maleic anhydride copolymers and isobutyl vinyl ether / maleic anhydride copolymers.

  A derivative of a lower alkyl vinyl ether / maleic anhydride copolymer was prepared by polymerizing a lower alkyl vinyl ether monomer and a maleic anhydride derivative, or obtained after copolymerizing a lower alkyl vinyl ether and maleic anhydride. It can be produced by derivatizing an alkyl vinyl ether-maleic anhydride copolymer.

  Here, as described above, the lower alkyl group in the lower alkyl vinyl ether can similarly include an alkyl group having 1 to 8 carbon atoms, preferably 1 to 6 carbon atoms, more preferably 1 to 4 carbon atoms. it can.

  Examples of maleic anhydride derivatives include maleic acid and maleic acid half ester. Here, as the maleic acid half ester, an ester of an alcohol having 1 to 18 carbon atoms, preferably 1 to 10 carbon atoms, more preferably 1 to 8 carbon atoms, particularly preferably 1 to 6 carbon atoms is suitably used. It can be illustrated.

  The derivative of the lower alkyl vinyl ether / maleic anhydride copolymer can be obtained by hydrolyzing, esterifying, or reacting the alkyl vinyl ether / maleic anhydride copolymer with a metal compound by a known method.

  For example, hydrolysis of the lower alkyl vinyl ether / maleic anhydride copolymer is carried out by adding 1 to 70 parts by weight, preferably 10 parts by weight of the lower alkyl vinyl ether / maleic anhydride copolymer to 100 parts by weight of water heated to 90 to 95 ° C. By adding ˜50 parts by weight, a lower alkyl vinyl ether / maleic acid copolymer can be obtained. In addition, in order to esterify the alkyl vinyl ether / maleic anhydride copolymer, alcohol is used as a reaction solvent (calculated amount of alcohol to be a 10-20% solution of half ester), and the alcohol is refluxed for several hours to 10 hours. Alkyl vinyl ether / maleic acid half ester can be obtained by reacting for several hours. In addition, the method described in Japanese Patent Publication No. 43-25982, that is, a method in which a powdery maleic anhydride / vinyl compound copolymer and a gaseous alcohol are reacted to obtain a half ester of the copolymer in a powder form. Can also be adopted. As a method for producing a copolymer of alkyl vinyl ether and maleate, a known method for producing a carboxylic acid salt can be used.

  Although not limited, in the present invention, the lower alkyl vinyl ether / maleic anhydride copolymer and its derivative are preferably those having a weight average molecular weight of 200,000 to 2.4 million. More preferably, it has a weight average molecular weight of 1 million to 2 million.

  Examples of the salt of the lower alkyl vinyl ether / maleic anhydride copolymer or derivative thereof include monovalent, divalent, and trivalent cations. Specific examples include alkali metal salts such as potassium salt and sodium salt, alkaline earth metal salts such as calcium salt and magnesium salt, zinc salt, and strontium salt. Sodium salts and calcium salts are preferred. These salts may be used alone or in combination of two. The mode of combination is not particularly limited, and examples thereof include a mixed salt containing both a sodium salt and a calcium salt, a mixed salt containing both a zinc salt and a magnesium salt, and a mixed salt containing both a zinc salt and a strontium salt. A combination of a sodium salt and a calcium salt is preferable.

  Such a lower alkyl vinyl ether / maleic anhydride copolymer, its derivatives and salts thereof are referred to as Gantrez (registered trademark, the same shall apply hereinafter) from IS Japan (International Specialty Products of Wayne, New Jersey, USA). Commercially available under the trade name. Specifically, the lower alkyl vinyl ether / maleic anhydride copolymer is available as Gantrez AN series, and the lower alkyl vinyl ether / maleic acid copolymer is available as Gantrez S series. Gantrez MS-955 can be used as a salt of a lower alkyl vinyl ether / maleic anhydride copolymer or a derivative thereof containing both sodium salt and calcium salt. In addition, the weight average molecular weight of Gantrez MS is about 1 million, and its Brookfield viscosity (mPa.S (11.1% solids aq.)) Is 700-3000.

  In the present invention, as the (A) adhesive component, the lower alkyl vinyl ether / maleic anhydride copolymer, derivative or salt thereof may be used singly or in any combination of two or more. May be used.

  As a ratio of the adhesive component (A) contained in 100% by weight of the denture stabilizer of the present invention, the total amount is usually 10 to 60% by weight, preferably 20 to 50% by weight, more preferably 25 to 35% by weight. Can be mentioned. This ratio is included in the product when the total weight of the final product (the weight excluding the support in the case of a form having a support such as a sheet type) is 100% by weight, regardless of the form of the final product. (A) means the ratio (% by weight) of the adhesive component. Hereinafter, the same applies to the blending ratio (% by weight) of (B) zinc chloride, water-soluble polymer, oil base and the like.

(2) (B) Zinc chloride As described above, the zinc chloride as the component (B) can be used in combination with the adhesive component (AVE / MA copolymers) of (A) to achieve its adhesiveness (and adhesiveness). It is a component that can enhance (stability).

  The ratio of (B) zinc chloride to 100 parts by weight of the (A) adhesive component contained in the denture stabilizer of the present invention is within a range that exhibits the effects of the present invention by exhibiting the characteristics of the above (B) zinc chloride. For example, the range of 0.1-10 weight part can be mentioned. Preferably it is 0.5-5 weight part, More preferably, it is 1-2.5 weight part. Moreover, as a ratio of the said (B) zinc chloride contained in 100 weight% of denture stabilizers of this invention, it is 0.03 to 3 weight% normally in the total amount, Preferably it is 0.15 to 1.5 weight%, more Preferably 0.3 to 1 weight% can be mentioned.

(3) Other components The denture stabilizer of this invention can mix | blend a water-soluble polymer in addition to the said (A) and (B) component, as long as the effect of this invention is not impaired.

As a water-soluble polymer, together with the AVE / MA copolymers used as the component (A), it absorbs moisture in the oral cavity and exerts an appropriate adhesive force, contributing to the stabilization of denture fixing in the oral cavity. A thing can be mentioned suitably. In this sense, the water-soluble polymer can be positioned as an adhesive auxiliary component. Examples of the water-soluble polymer include alginic acid, alginates (for example, sodium alginate, potassium alginate, ammonium alginate, alginates, etc.), gum arabic , Tragacanth gum, locust bean gum, xanthan gum, guar gum, agar, gelatin, karaya gum, carrageenan and other natural polymer compounds; sodium carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose (cellulosic polymer), polyethylene glycol , Polyvinylpyrrolidone, polyvinyl alcohol, methyl vinyl ether, carboxyvinyl polymer, acrylamide and alcohol Examples thereof include a synthetic polymer compound such as a copolymer with crylic acid, sodium polyacrylate, and polyethylene oxide. These water-soluble polymers may be used alone or in any combination of two or more.

  Preferably, it swells when it contains water and exhibits adhesiveness and / or elasticity. Such can include alginic acid, alginates (eg, sodium alginate), karaya gum, polyethylene oxide, and sodium carboxymethylcellulose. Alginic acid and sodium carboxymethyl cellulose are more preferable, and sodium carboxymethyl cellulose is particularly preferable.

  When a water-soluble polymer is used, the total amount of the water-soluble polymer blended in 100% by weight of the denture stabilizer of the present invention is usually 10 to 60% by weight, preferably 20 to 40% by weight, more. Preferably 20-30 weight% can be mentioned. Moreover, although it does not restrict | limit as a ratio with respect to 100 weight part of (A) adhesive components (AVE / MA copolymers) contained in a denture stabilizer, 10-200 weight part in total, Preferably it is 50-150 weight part More preferably, 80-120 weight part can be mentioned.

  The denture stabilizer of the present invention is further limited to an oily base, an aqueous base, a powder base, a gum base, and an excipient, as long as the effects of the present invention are not impaired, depending on the form and properties. , Emulsifiers, wetting agents, pH adjusting agents, viscosity adjusting agents, plasticizers, preservatives, bactericides, pigments, fragrances, flavoring agents, cooling agents, sweetening agents, and the like. As such carriers and additives, those conventionally used widely for denture stabilizers can be used as well.

  For example, an oily base is used as a base when preparing a denture stabilizer in a pasty form such as a cream type.

  As an oil base, the mineral oil component normally used for the non-aqueous denture stabilizer (for example, cream type) can be mentioned. For example, liquid paraffin, petrolatum, gelled hydrocarbon and the like can be mentioned.

  Specific examples of liquid paraffin include light liquid paraffin and heavy liquid paraffin. Preferred is light liquid paraffin having an average carbon number of 15 to 50, more preferably 25 to 50. As petrolatum, petrolatum usually used as a base for external use can be used, and examples thereof include yellow petrolatum, white petrolatum, and a mixture thereof. In addition, hydrophilic petrolatum blended with white petrolatum, stearyl alcohol, or cholesterol can be used. White petrolatum is preferable. As the gelled hydrocarbon, for example, polyethylene is blended at a ratio of 5 to 10 parts by weight, preferably 5.5 to 7.5 parts by weight with respect to 100 parts by weight of liquid paraffin, and the temperature at which polyethylene melts (110 to 130). And a gel-like material prepared by heating and mixing at about 0 ° C.). These mineral oil components may be used alone as an oily base, or two or more kinds may be used in any combination as an oily base.

  The proportion (total amount) of the oily base used in the cream type denture stabilizer is usually 10 to 70% by weight, preferably 20 to 60% by weight, more preferably 30 to 50% by weight in 100% by weight of the denture stabilizer. % Range.

  An aqueous base is usually used as a base when preparing an aqueous denture stabilizer (eg, gel type). Examples of the aqueous base include water, glycerin, propylene glycol and the like.

  On the other hand, when preparing powder-type denture stabilizers, water-soluble polymers are used exclusively as a base, but excipients such as lactose and starch and solvents such as ethanol are used when granulating There is also.

  The denture stabilizer of the present invention can be prepared according to conventional techniques in the art depending on the form (cream type, gel type, powder type, sheet (tape) type, etc.).

  Moreover, the usage method of the denture stabilizer of this invention can also be suitably selected according to the form (a cream type, a gel type, a powder type, a sheet | seat (tape) type etc.). For example, a paste-type denture stabilizer such as a cream type is used by applying and adhering thinly to the entire surface in contact with the gums (or upper jaw) of the denture base (denture base) excluding moisture. In addition, powder type denture stabilizers such as powder type are sprinkled evenly and thinly over the entire surface of the denture base (denture base) in contact with the gums (or upper jaw) with a little moisture adhering to it. It is used by. Furthermore, a sheet (tape) type denture stabilizer is used by sticking and adhering to the surface of the denture base (denture base) in contact with the gums (or upper jaw) excluding moisture. Thus, when the denture with the denture stabilizer attached is placed in the oral cavity and attached to the gum (or maxilla), the denture stabilizer absorbs the water of saliva and swells, thereby exhibiting adhesiveness. Or it is fixed stably to the upper jaw).

(II) Method for Enhancing Adhesive Strength of Denture Stabilizer The present invention relates to a method for enhancing the adhesive strength of a denture stabilizer. More specifically, it is a method for enhancing the adhesive strength of a denture stabilizer (not containing zinc chloride) containing the adhesive component (AVE / MA copolymers) of (A) described above.
The method is characterized by using (B) zinc chloride in combination with (A) the adhesive component.

  The adhesive component (AVE / MA copolymers) of (A) and (B) zinc chloride to be blended in combination therewith are as already described in (I), and here the description of (I) above. Is incorporated.

  The denture stabilizer composition to be used for enhancing the adhesive strength is the (A) adhesive component (AVE / MA copolymers) in the denture stabilizer (final denture stabilizer) after blending (B) zinc chloride. The ratio is usually 10 to 60% by weight, preferably 20 to 50% by weight. More preferably, the ratio (A) adhesive component (AVE / MA copolymer) is such that the proportion of (A) adhesive component (AVE / MA copolymers) in the final denture stabilizer is 25 to 35% by weight. Type).

  The blending ratio of (B) zinc chloride to the denture stabilizer composition is not particularly limited as long as it is within a range that exhibits the effects of the present invention, but is included in the denture stabilizer composition ( A) The ratio of 0.1-10 weight part can be normally mentioned with respect to 100 weight part of total amounts of an adhesion component. Preferably it is 0.5-5 weight part, More preferably, it is 1-2.5 weight part. The ratio of (B) zinc chloride in 100% by weight of the final denture stabilizer (final denture stabilizer) containing (A) the adhesive component and (B) zinc chloride is 0.03 to 3% by weight. Thus, it is preferable to blend (B) zinc chloride. More preferably, it is 0.15-1.5 weight%, More preferably, it is 0.3-1 weight%.

  The denture stabilizer thus prepared is prepared without using (B) zinc chloride in combination with (B) a denture stabilizer not containing zinc chloride, that is, (A) an adhesive component (AVE / MA copolymers). Compared to the denture stabilizer (control denture stabilizer), the adhesiveness in the presence of water is further enhanced. For this reason, the denture stabilizer prepared using the method of the present invention has an effect that it is excellent in adhesiveness in the oral cavity. In addition, as shown in Test Example 3 to be described later, according to the method, (B) adhesive stability in the presence of water (in the oral cavity) compared to a control denture stabilizer prepared without using zinc chloride in combination. Is more strengthened. For this reason, the denture stabilizer prepared using the method of the present invention has an effect that the adhesive stability in the oral cavity is excellent and the durability of the adhesive force is also good.

  Hereinafter, based on a test example and an Example, the structure and effect of this invention are demonstrated. However, the present invention is not limited to such test examples and examples. Unless otherwise specified,% described below means “% by weight”.

Test Example 1 Evaluation of Thickening Effect (A) Adhesive component and (B) Zinc chloride mixture prepared in the proportions shown in Table 1 were poured into water and dissolved by stirring (Examples 1 and 2) (25 ° C. ) Was measured using a B-type viscometer (manufactured by Brookfield) (rotor No. 2) under the conditions of a rotation speed of 20 rpm and a measurement time of 1 minute. As a comparative test, the viscosity of the solution (Comparative Examples 1 and 2) (25 ° C.) in which (A) the adhesive component was charged into water at the ratio shown in Table 3 and stirred and dissolved was measured under the same conditions as described above. The results are shown in Table 1.

  In this case, a methoxyethylene / maleic anhydride copolymer sodium / calcium salt (Gantrez MS-955, manufactured by ISP Japan) was used as an adhesive component. In Table 1, this is expressed as “AME / MA copolymers”.

  As shown in Table 1, from the relative ratios of the viscosities of Example 1 and Comparative Example 1 and Example 2 and Comparative Example 2, (a) adhesive component (AME / MA copolymers, the same applies hereinafter) ( b) It can be seen that the viscosity due to the adhesive component increases when zinc chloride is used in combination.

Test Example 2 Evaluation of Viscosity and Adhesive Strength (1) Preparation of Test Sample A cream type denture stabilizing composition (Examples 3 to 4 and Comparative Example 3) was prepared according to the formulation described in Table 2. Specifically, a mineral oil component (light liquid paraffin, petrolatum) was heated and mixed, and then an adhesive component, zinc chloride, and a water-soluble polymer (carboxymethylcellulose sodium) were added thereto and mixed uniformly. In this case, a methoxyethylene / maleic anhydride copolymer sodium / calcium salt (Gantrez MS-955, manufactured by ISP Japan) was used as an adhesive component. In Table 2, this is expressed as “AME / MA copolymers”.

(2) Measurement of viscosity 20 times amount (weight ratio) of water is added to a container containing the denture stabilizer (Examples 3 to 4 and Comparative Example 3) prepared in the above (1), and kneaded to dissolve the viscosity. A solution for measurement was prepared. The viscosity of the solution (25 ° C.) was measured using a B-type viscometer (manufactured by Brookfield) (rotor No. 3) under conditions of a rotation speed of 50 rpm and a measurement time of 1 minute. The results are shown in Table 2.

(3) Measurement of adhesive strength Four times (weight ratio) of water was added to the container containing the denture stabilizer (Examples 3 to 4 and Comparative Example 3) prepared in (1) above, and kneaded and dissolved. A sample for measuring adhesive strength was prepared. The adhesive strength of this sample was measured by the method described below using a rheometer (CR-500DX, manufactured by Sun Science Co., Ltd.).
(A) A 15 g sample was placed in a 10 mL glass flat bottom beaker to flatten the surface.
(B) A resin adapter having a diameter of 15 mm was inserted from the sample surface to a depth of 10 mm at a speed of 50 mm / min.
(C) Immediately after insertion, the adapter was retracted at a speed of 50 mm / min. At that time, the maximum load (g weight) applied to the adapter was measured, and the adhesive force (kPa) was calculated according to the following formula.

  The results are shown in Table 2.

  From this result, it can be seen that the use of zinc chloride in combination with the adhesive component (AME / MA copolymers) increases the viscosity as well as the viscosity. Moreover, it turns out that the extent of those increase becomes large as the mixture ratio of zinc chloride increases.

Test Example 3 Evaluation of Wearing Feeling About the denture stabilizers prepared in Test Example 2 (Examples 3 to 4 and Comparative Example 3), wearing feelings (wearing stability and sustainability) for 6 panelists. Evaluated. Specifically, 6 denture users (over 3 years of usage history) were asked to wear dentures using each denture stabilizer and felt that the dentures were stably adhered to the gums. Each time was measured and scored according to the following criteria.

Each denture stabilizer is applied to the surface of the base of the complete denture (upper and lower jaws) in contact with the gums of the base (a total amount of 2 g) equivalent to 4 soybeans, and this is applied thinly over the entire surface. I stretched it out and put it in my mouth. In addition, each panelist was asked to evaluate the wearing feeling of each of the four types of denture stabilizers in accordance with the same standard by changing the test date.
[Evaluation criteria]
Time when it was felt that the denture was stably adhered More than 10 hours: 10 points 5 to 10 hours or less: 3 points 0 to 5 hours or less: 1 point.

  The results of averaging the scores evaluated by each panel are shown in Table 3.

  As shown in Table 3, it can be seen that the use of zinc chloride in combination with the adhesive component (AME / MA copolymers) also increases the adhesive stability (adhesion persistence). Moreover, this result correlates with the effect of increasing the adhesive strength evaluated in Test Example 2, and by using zinc chloride in combination with the adhesive component (AME / MA copolymers), adhesive stability as well as adhesive stability (adhesiveness) It can be seen that (sustainability) is also improved (increased), and the degree of increase increases as the proportion of zinc chloride increases.

Formulation Examples Cream type, powder type, and sheet type denture stabilizers can be produced according to the formulas shown below. The following “AME / MA copolymers” include methoxyethylene / maleic anhydride copolymer sodium / calcium salt (Gantrez MS-955), methoxyethylene / maleic anhydride copolymer (Gantrez AN-169). Any of Gantrez AN-179) can be used.

Formulation Example 1 Cream Type Denture Stabilizer The following ingredients are mixed while heating to prepare a cream denture stabilizer.
AME / MA copolymers 30 (% by weight)
Zinc chloride 0.5
Carboxymethylcellulose Na 25
Liquid paraffin 15
Vaseline 29.5
Total 100.0% by weight.

Formulation Example 2 Gel Type Denture Stabilizer A gel denture stabilizer is prepared by mixing and dissolving the following ingredients while heating.
AME / MA copolymers 20 (% by weight)
Zinc chloride 0.3
Carboxymethylcellulose Na 10
Propylparaben 0.05
Water 69.65
Total 100.00% by weight.

Formulation Example 3 Powder or Granule Type Denture Stabilizer A granular denture stabilizer is prepared by mixing the following raw materials into a powder form or granulating it by a conventional method.
AME / MA copolymers 60 (wt%)
Zinc chloride 1
Carboxymethylcellulose Na 39
Total 100% by weight.

Formulation Example 4 Sheet Type Denture Stabilizer The following raw materials are mixed into a powder form, or granulated by granulating by a conventional method, and this is uniformly spread on a support such as a nonwoven fabric, Further, a similar support is placed thereon and integrated by thermocompression bonding or needle punching. Next, the denture base is combined and cut into a desired shape to prepare a sheet-type denture stabilizer.
AME / MA copolymers 60 (wt%)
Zinc chloride 1
Carboxymethylcellulose Na 39
Total 100% by weight.

Claims (3)

Denture stabilizer containing the following components (A) and (B):
(A) At least one adhesive component (B) zinc chloride selected from the group consisting of a lower alkyl vinyl ether / maleic anhydride copolymer, a derivative thereof, and a salt thereof.   The denture stabilizer according to claim 1, wherein the ratio of the component (B) to 100 parts by weight of the component (A) is 1 to 2.5 parts by weight.   (B) Zinc chloride is blended with a denture stabilizer composition containing at least one adhesive component selected from the group consisting of (A) a lower alkyl vinyl ether / maleic anhydride copolymer, derivatives thereof, and salts thereof. A method for enhancing the adhesive strength of a denture stabilizer, characterized by comprising: