JP2016160182A - Denture stabilizer - Google Patents

Abstract

Disclosed is a denture stabilizer which is excellent in adhesiveness and adhesive stability and can stably fix a denture for a long time in the oral cavity.
A denture stabilizer is blended with the following components (A) and (B):
(A) At least one adhesive component (B) hydrogen phosphate selected from the group consisting of a lower alkyl vinyl ether / maleic anhydride copolymer, a derivative thereof, and a salt thereof.
[Selection figure] None

Description

  The present invention relates to a denture stabilizer. More specifically, the present invention relates to a denture stabilizer that is excellent in adhesiveness and adhesive stability in the presence of water and can stably fix a denture in the oral cavity.

  Denture stabilizers are conventionally used by many denture wearers to fix a denture in a predetermined position in the oral cavity during non-chewing and chewing.

  Commercially available denture stabilizers are prepared by dispersing water-soluble polymers such as sodium carboxymethylcellulose and polyethylene glycol in oily bases such as liquid paraffin and petrolatum, and by densifying the water-soluble polymer swollen by moisture in the oral cavity. Ointment or cream type denture stabilizer that improves the stability of the teeth, and cushion type denture stability that plasticizes polyvinyl acetate with a solvent such as ethanol and fills the gap between the denture and the ridge mucosa and improves the stability of the denture In addition to agents, there are gel-type, powder-type, sheet-type, and tape-type denture stabilizers. In any form, it is important that when the denture is placed in the mouth, good adhesiveness is exhibited and the adhesiveness lasts for a long time.

  For this reason, many improvements have been proposed and performed for denture stabilizers. For example, denture stabilizers using lower alkyl vinyl ether / maleic anhydride copolymers, derivatives thereof, and salts thereof are conventionally known to have good tackiness when containing water (for example, patents). Patent Document 2 includes a partially neutralized alkyl vinyl ether-maleic acid or a denture stabilizer containing hydroxypropylcellulose and an anhydride copolymer that may be partially crosslinked. No. 3 discloses an improved denture stabilizer base composition containing a substantially anhydrous mixture of Na / Ca mixed salt of methyl vinyl ether-maleic acid copolymer, sodium carboxymethylcellulose and trivalent cation. Patent Document 4 further discloses a denture adhesive containing a partial salt of maleic acid or a copolymer of maleic anhydride and an alkyl vinyl ether (a cation of the salt includes zinc ions and magnesium ions) as an adhesive salt. Patent Document 5 discloses a denture stabilizer containing, in addition to a lower alkyl vinyl ether / maleic anhydride copolymer or a derivative thereof, a water-insoluble and water-swellable polymer, and an adhesive substance such as natural rubber and synthetic polymer. Is disclosed.

U.S. Patent Publication No. 3,003,988 U.S. Patent Publication No. 4,373,036 U.S. Patent Publication No. 5,006,571 Japanese National Patent Publication No. 10-506928 JP 2007-186510 A

  As described above, various denture stabilizers have been proposed that are excellent in adhesiveness and adhesive stability in the presence of water and can stably fix dentures in the oral cavity. There is a fact.

  For this reason, the main object of the present invention is to provide an improved denture stabilizer that is excellent in adhesiveness and adhesive stability in the presence of water and can be stably fixed in the oral cavity. It is to be.

  The present inventors have focused on lower alkyl vinyl ether / maleic anhydride copolymers, derivatives thereof, or salts thereof as an adhesive component in order to improve the adhesion and adhesion stability of denture stabilizers, which is a conventional problem. As a result of investigation, the above object can be achieved by using a hydrogen phosphate in combination with this, specifically, a lower alkyl vinyl ether / maleic anhydride copolymer by using a hydrogen phosphate, Found that adhesion and adhesion stability (adhesion persistence) in the presence of water of derivatives or their salts are further enhanced (improved) and actually used as a denture stabilizer in the oral cavity for fixing and fixing dentures It was confirmed that the feeling of use was improved.

  The present invention has been completed as a result of further research based on these findings, and includes the following embodiments.

(I) Denture stabilizer (I-1) Denture stabilizer containing the following components (A) and (B):
(A) At least one adhesive component (B) hydrogen phosphate selected from the group consisting of a lower alkyl vinyl ether / maleic anhydride copolymer, a derivative thereof, and a salt thereof.
(I-2) The hydrogen phosphate is at least one selected from the group consisting of sodium dihydrogen phosphate, disodium hydrogen phosphate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, and calcium hydrogen phosphate. The denture stabilizer described in (I-1).
(I-3) The denture stabilizer described in (I-1) or (I-2), wherein the ratio of the component (B) to 100 parts by weight of the component (A) is 0.5 to 40 parts by weight.
(I-4) The component (A) is contained in a proportion of 10 to 60% by weight, and the component (B) is contained in a proportion of 0.15 to 12% by weight. Denture stabilizer to do.
(I-5) The denture stabilizer described in any one of (I-1) to (I-4), which further contains a water-soluble polymer as an adhesion auxiliary component.

(II) Method for enhancing adhesion of denture stabilizer (II-1) (A) (A) At least one adhesive selected from the group consisting of lower alkyl vinyl ether / maleic anhydride copolymers, derivatives thereof, and salts thereof (B) Hydrogen phosphate is mix | blended with the denture stabilizer composition containing a component, The enhancement method of the adhesive force of a denture stabilizer characterized by the above-mentioned.
(II-2) The hydrogen phosphate is at least one selected from the group consisting of sodium dihydrogen phosphate, disodium hydrogen phosphate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, and calcium hydrogen phosphate. The enhancement method described in (II-1).
(II-3) The enhancing method according to (II-1) or (II-2), wherein the ratio of component (B) to 100 parts by weight of component (A) is 0.5 to 40 parts by weight.
(II-4) The denture stabilizer composition to be used is such that the proportion of the component (A) in the denture stabilizer 100 wt% after blending the component (B) is 10 to 60 wt%. The enhancing method according to any one of (II-1) to (II-3), which comprises the component (A).

  The denture stabilizer of the present invention comprises (A) at least one adhesive component selected from the group consisting of a lower alkyl vinyl ether / maleic anhydride copolymer, a derivative thereof, and a salt thereof; and (B) a hydrogen phosphate salt. In combination with (A) component in the presence of water and adhesion stability (adhesion persistence) is further enhanced (improved), and as a result, this is used as a denture stabilizer in the oral cavity. When it is used for mounting and fixing dentures, it is possible to obtain a good wearing feeling of dentures.

  Moreover, according to the method for enhancing the adhesiveness of the denture stabilizer of the present invention, (A) at least one adhesive component selected from the group consisting of a lower alkyl vinyl ether / maleic anhydride copolymer, a derivative thereof, and a salt thereof. The adhesiveness in the presence of water, preferably adhesive stability (adhesion persistence) can be further enhanced (improved) by using (B) hydrogen phosphate in combination. Therefore, by using this method for the preparation of denture stabilizer, it is possible to obtain a denture stabilizer capable of stably mounting and fixing a denture in the oral cavity and obtaining a good denture wearing feeling.

(I) Denture Stabilizer Denture stabilizer is a preparation used to attach and fix a denture on the ridge (gum) or upper jaw by bringing the denture into close contact with the ridge (gum) or upper jaw. is there. Also called denture adhesive. The target dentures are usually complete dentures and partial dentures.

  The denture stabilizers targeted by the present invention are not particularly limited in form, but are in the form of pastes such as cream types and gel types, powders such as powder types, and sheets (tapes) such as tape types and sheet types. Denture stabilizers having various forms of are included. Moreover, the material of the denture floor used as object is also not limited, and can be applied to both resin floors and metal floors.

The denture stabilizer of the present invention comprises the following components (A) and (B).
(A) at least one adhesive component selected from the group consisting of a lower alkyl vinyl ether / maleic anhydride copolymer, a derivative thereof, and a salt thereof;
(B) Hydrogen phosphate.

  Here, the hydrogen phosphate that is the component (B) is a component that can enhance its adhesiveness (and adhesive stability) when used in combination with the adhesive component of (A). For this reason, (B) component can be positioned as an adhesive (and adhesion stability) enhancement component of (A) adhesive component.

  Hereinafter, these components and other components that can constitute a denture stabilizer will be described.

(1) (A) Adhesive Component Lower alkyl vinyl ether / maleic anhydride copolymer, derivative or salt thereof (hereinafter referred to as “AVE / MA copolymers”) used as (A) adhesive component in the present invention. May have a property of absorbing water and dissolving slowly and exhibiting tackiness.

  Here, the lower alkyl vinyl ether / maleic anhydride copolymer is a copolymer produced by polymerizing a lower alkyl vinyl ether monomer and maleic anhydride. The copolymer can be easily hydrolyzed to an acid polymer.

  In the lower alkyl vinyl ether / maleic anhydride copolymer and the lower alkyl vinyl ether monomer that is the material thereof, the “lower alkyl group” usually includes an alkyl group having 1 to 8 carbon atoms. Preferably it is a C1-C6 alkyl group, More preferably, it is a C1-C4 alkyl group. Specific examples include a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, an isobutyl group, a t-butyl group, and a sec-butyl group. Therefore, as the lower alkyl vinyl ether / maleic anhydride copolymer, specifically, methyl vinyl ether / maleic anhydride copolymer, ethyl vinyl ether / maleic anhydride copolymer, divinyl ether / maleic anhydride copolymer, Mention may be made of propyl vinyl ether / maleic anhydride copolymers and isobutyl vinyl ether / maleic anhydride copolymers.

  A derivative of a lower alkyl vinyl ether / maleic anhydride copolymer was prepared by polymerizing a lower alkyl vinyl ether monomer and a maleic anhydride derivative, or obtained after copolymerizing a lower alkyl vinyl ether and maleic anhydride. It can be produced by derivatizing an alkyl vinyl ether-maleic anhydride copolymer.

  Here, as described above, the lower alkyl group in the lower alkyl vinyl ether can similarly include an alkyl group having 1 to 8 carbon atoms, preferably 1 to 6 carbon atoms, more preferably 1 to 4 carbon atoms. it can.

  Examples of maleic anhydride derivatives include maleic acid and maleic acid half ester. Here, as the maleic acid half ester, an ester of an alcohol having 1 to 18 carbon atoms, preferably 1 to 10 carbon atoms, more preferably 1 to 8 carbon atoms, particularly preferably 1 to 6 carbon atoms is suitably used. It can be illustrated.

  The derivative of the lower alkyl vinyl ether / maleic anhydride copolymer can be obtained by hydrolyzing, esterifying, or reacting the alkyl vinyl ether / maleic anhydride copolymer with a metal compound by a known method.

  For example, hydrolysis of the lower alkyl vinyl ether / maleic anhydride copolymer is carried out by adding 1 to 70 parts by weight, preferably 10 parts by weight of the lower alkyl vinyl ether / maleic anhydride copolymer to 100 parts by weight of water heated to 90 to 95 ° C. By adding ˜50 parts by weight, a lower alkyl vinyl ether / maleic acid copolymer can be obtained. In addition, in order to esterify the alkyl vinyl ether / maleic anhydride copolymer, alcohol is used as a reaction solvent (calculated amount of alcohol to be a 10-20% solution of half ester), and the alcohol is refluxed for several hours to 10 hours. Alkyl vinyl ether / maleic acid half ester can be obtained by reacting for several hours. In addition, the method described in Japanese Patent Publication No. 43-25982, that is, a method in which a powdery maleic anhydride / vinyl compound copolymer and a gaseous alcohol are reacted to obtain a half ester of the copolymer in a powder form. Can also be adopted. As a method for producing a copolymer of alkyl vinyl ether and maleate, a known method for producing a carboxylic acid salt can be used.

  Although not limited, in the present invention, the lower alkyl vinyl ether / maleic anhydride copolymer and its derivative are preferably those having a weight average molecular weight of 200,000 to 2.4 million. More preferably, it has a weight average molecular weight of 1 million to 2 million.

  Examples of the salt of the lower alkyl vinyl ether / maleic anhydride copolymer or derivative thereof include monovalent, divalent, and trivalent cations. Specific examples include alkali metal salts such as potassium salt and sodium salt, alkaline earth metal salts such as calcium salt and magnesium salt, zinc salt, and strontium salt. Sodium salts and calcium salts are preferred. These salts may be used alone or in combination of two. The mode of combination is not particularly limited, and examples thereof include a mixed salt containing both a sodium salt and a calcium salt, a mixed salt containing both a zinc salt and a magnesium salt, and a mixed salt containing both a zinc salt and a strontium salt. A combination of a sodium salt and a calcium salt is preferable.

  Such a lower alkyl vinyl ether / maleic anhydride copolymer, its derivatives and salts thereof are referred to as Gantrez (registered trademark, the same shall apply hereinafter) from IS Japan (International Specialty Products of Wayne, New Jersey, USA). Commercially available under the trade name. Specifically, the lower alkyl vinyl ether / maleic anhydride copolymer is available as Gantrez AN series, and the lower alkyl vinyl ether / maleic acid copolymer is available as Gantrez S series. Gantrez MS-955 can be used as a salt of a lower alkyl vinyl ether / maleic anhydride copolymer or a derivative thereof containing both sodium salt and calcium salt. In addition, the weight average molecular weight of Gantrez MS is about 1 million, and its Brookfield viscosity (mPa.S (11.1% solids aq.)) Is 700-3000.

  In the present invention, as the (A) adhesive component, the lower alkyl vinyl ether / maleic anhydride copolymer, derivative or salt thereof may be used singly or in any combination of two or more. May be used.

  As a ratio of the adhesive component (A) contained in 100% by weight of the denture stabilizer of the present invention, the total amount is usually 10 to 60% by weight, preferably 20 to 50% by weight, more preferably 25 to 35% by weight. Can be mentioned. This ratio is included in the product when the total weight of the final product (the weight excluding the support in the case of a form having a support such as a sheet type) is 100% by weight, regardless of the form of the final product. (A) means the ratio (% by weight) of the adhesive component. Hereinafter, the same applies to the blending ratio (% by weight) of (B) hydrogen phosphate, water-soluble polymer, and oil base.

(2) (B) Hydrogen phosphate salt As described above, the hydrogen phosphate salt as the component (B) is used in combination with the adhesive component (AVE / MA copolymers) of (A). It is a component that can enhance the property (and adhesion stability).

  The hydrogen phosphate used in the present invention is not particularly limited as long as it has such characteristics. Specific examples include sodium dihydrogen phosphate, disodium hydrogen phosphate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, and calcium hydrogen phosphate. These hydrogen phosphates may be used alone or in any combination of two or more in the range where the above properties are exhibited. Preferred hydrogen phosphates are disodium hydrogen phosphate and sodium dihydrogen phosphate, more preferably disodium hydrogen phosphate.

  As a ratio of (B) hydrogen phosphate to 100 parts by weight of (A) adhesive component contained in the denture stabilizer of the present invention, the effect of the present invention is exhibited by exhibiting the characteristics of the above (B) hydrogen phosphate. It may be in the range where it plays, for example, a range of 0.5 to 40 parts by weight. Preferably it is 1-20 weight part, More preferably, it is 1-10 weight part. Moreover, as a ratio of the (B) hydrogen phosphate contained in 100% by weight of the denture stabilizer of the present invention, the total amount is usually 0.15 to 12% by weight, preferably 0.3 to 6% by weight. Preferably 0.3 to 3 weight% can be mentioned.

(3) Other components In the denture stabilizer of the present invention, a water-soluble polymer can be blended in addition to the components (A) and (B) as long as the effects of the present invention are not impaired.

As a water-soluble polymer, together with the AVE / MA copolymers used as the component (A), it absorbs moisture in the oral cavity and exerts an appropriate adhesive force, contributing to the stabilization of denture fixing in the oral cavity. A thing can be mentioned suitably. In this sense, the water-soluble polymer can be positioned as an adhesive auxiliary component. Examples of the water-soluble polymer include alginic acid, alginates (for example, sodium alginate, potassium alginate, ammonium alginate, alginates, etc.), gum arabic , Tragacanth gum, locust bean gum, xanthan gum, guar gum, agar, gelatin, karaya gum, carrageenan and other natural polymer compounds; sodium carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose (cellulosic polymer), polyethylene glycol , Polyvinylpyrrolidone, polyvinyl alcohol, methyl vinyl ether, carboxyvinyl polymer, acrylamide and alcohol Examples thereof include a synthetic polymer compound such as a copolymer with crylic acid, sodium polyacrylate, and polyethylene oxide. These water-soluble polymers may be used alone or in any combination of two or more.

  Preferably, it swells when it contains water and exhibits adhesiveness and / or elasticity. Such can include alginate, karaya gum, polyethylene oxide and sodium carboxymethylcellulose. More preferred are alginate (for example, sodium alginate) and sodium carboxymethyl cellulose, and particularly preferred is sodium carboxymethyl cellulose.

  When a water-soluble polymer is used, the total amount of the water-soluble polymer blended in 100% by weight of the denture stabilizer of the present invention is usually 10 to 60% by weight, preferably 20 to 40% by weight, more. Preferably 20-30 weight% can be mentioned. Moreover, although it does not restrict | limit as a ratio with respect to 100 weight part of (A) adhesive components (AVE / MA copolymers) contained in a denture stabilizer, 10-200 weight part in total, Preferably it is 50-150 weight part More preferably, 80-120 weight part can be mentioned.

  The denture stabilizer of the present invention is further limited to an oily base, an aqueous base, a powder base, a gum base, and an excipient, as long as the effects of the present invention are not impaired, depending on the form and properties. , Emulsifiers, wetting agents, pH adjusting agents, viscosity adjusting agents, plasticizers, preservatives, bactericides, pigments, fragrances, flavoring agents, cooling agents, sweetening agents, and the like. As such carriers and additives, those conventionally used widely for denture stabilizers can be used as well.

  For example, an oily base is used as a base when preparing a denture stabilizer in a pasty form such as a cream type.

  As an oil base, the mineral oil component normally used for the non-aqueous denture stabilizer (for example, cream type) can be mentioned. For example, liquid paraffin, petrolatum, gelled hydrocarbon and the like can be mentioned.

  Specific examples of liquid paraffin include light liquid paraffin and heavy liquid paraffin. Preferred is light liquid paraffin having an average carbon number of 15 to 50, more preferably 25 to 50. As petrolatum, petrolatum usually used as a base for external use can be used, and examples thereof include yellow petrolatum, white petrolatum, and a mixture thereof. In addition, hydrophilic petrolatum blended with white petrolatum, stearyl alcohol, or cholesterol can be used. White petrolatum is preferable. As the gelled hydrocarbon, for example, polyethylene is blended at a ratio of 5 to 10 parts by weight, preferably 5.5 to 7.5 parts by weight with respect to 100 parts by weight of liquid paraffin, and the temperature at which polyethylene melts (110 to 130). And a gel-like material prepared by heating and mixing at about 0 ° C.). These mineral oil components may be used alone as an oily base, or two or more kinds may be used in any combination as an oily base.

  The proportion (total amount) of the oily base used in the cream type denture stabilizer is usually 10 to 70% by weight, preferably 20 to 60% by weight, more preferably 30 to 50% by weight in 100% by weight of the denture stabilizer. % Range.

  An aqueous base is usually used as a base when preparing an aqueous denture stabilizer (eg, gel type). Examples of the aqueous base include water, glycerin, propylene glycol and the like.

  On the other hand, when preparing powder-type denture stabilizers, water-soluble polymers are used exclusively as a base, but excipients such as lactose and starch and solvents such as ethanol are used when granulating There is also.

  The denture stabilizer of the present invention can be prepared according to conventional techniques in the art depending on the form (cream type, gel type, powder type, sheet (tape) type, etc.).

  Moreover, the usage method of the denture stabilizer of this invention can also be suitably selected according to the form (a cream type, a gel type, a powder type, a sheet | seat (tape) type etc.). For example, a paste denture stabilizer such as a cream type is used by thinly spreading and applying to the entire surface of the denture base (denture base) in contact with the gums (or upper jaw) excluding moisture. In addition, powder type denture stabilizers such as powder type are sprinkled evenly and thinly over the entire surface of the denture base (denture base) in contact with the gums (or upper jaw) with a little moisture adhering to it. It is used by. Furthermore, a sheet (tape) type denture stabilizer is used by sticking and adhering to the surface of the denture base (denture base) in contact with the gums (or upper jaw) excluding moisture. Thus, when the denture with the denture stabilizer attached is placed in the oral cavity and attached to the gum (or maxilla), the denture stabilizer absorbs the water of saliva and swells, thereby exhibiting adhesiveness. Or it is fixed stably to the upper jaw).

(II) Method for Enhancing Adhesive Strength of Denture Stabilizer The present invention relates to a method for enhancing the adhesive strength of a denture stabilizer. More specifically, it is a method for enhancing the adhesive strength of a denture stabilizer (not containing hydrogen phosphate) containing the adhesive component (AVE / MA copolymers) of (A) described above. The method is characterized in that (B) hydrogen phosphate is used in combination with (A) adhesive component.

  The adhesive component (AVE) of (A) (AVE / MA copolymers) and the (B) hydrogen phosphate compounded in combination therewith are as already described in (I). The description of is incorporated.

  The denture stabilizer composition to be used for enhancing the adhesive force is (A) an adhesive component (AVE / MA copolymers) in the denture stabilizer (final denture stabilizer) after blending (B) hydrogen phosphate. ) Is usually 10 to 60% by weight, preferably 20 to 50% by weight, and preferably contains (A) an adhesive component (AVE / MA copolymers). More preferably, the ratio (A) adhesive component (AVE / MA copolymers) in the final denture stabilizer is such that the ratio of (A) adhesive component (AVE / MA copolymers) is 25 to 35 wt%. ).

  The blending ratio of (B) hydrogen phosphate with respect to the denture stabilizer composition is not particularly limited as long as it is within a range that exhibits the effects of the present invention, but is included in the denture stabilizer composition. (A) The ratio of 0.5-40 weight part can be normally mentioned with respect to 100 weight part of total amounts of the adhesion component. Preferably it is 1-20 weight part, More preferably, it is 1-10 weight part. Moreover, the ratio of (B) hydrogen phosphate in 100 weight% of the final denture stabilizer (final denture stabilizer) containing (A) adhesive component and (B) hydrogen phosphate is 0.15-12. It is preferable to blend (B) hydrogen phosphate so as to be in weight percent. More preferably, it is 0.3-6 weight%, More preferably, it is 0.3-3 weight%.

  The denture stabilizer thus prepared is (B) a denture stabilizer that does not contain hydrogen phosphate, that is, (A) adhesive component (AVE / MA copolymers) is used in combination with (B) hydrogen phosphate. Compared with a denture stabilizer prepared without a control (control denture stabilizer), the adhesiveness in the presence of water is further enhanced. For this reason, the denture stabilizer prepared using the method of the present invention has an effect that it is excellent in adhesiveness in the oral cavity. In addition, as shown in Test Example 3 to be described later, according to the method, (B) adhesion in the presence of water (in the oral cavity) as compared with a control denture stabilizer prepared without using hydrogen phosphate in combination. Stability is further enhanced. For this reason, the denture stabilizer prepared using the method of the present invention has an effect that the adhesive stability in the oral cavity is excellent and the durability of the adhesive force is also good.

  Hereinafter, based on a test example and an Example, the structure and effect of this invention are demonstrated. However, the present invention is not limited to such test examples and examples. Unless otherwise specified,% described below means “% by weight”.

Test Example 1 Evaluation of Thickening Effect Solutions prepared by adding a mixture of (A) adhesive component and (B) hydrogen phosphate prepared in the ratios described in Tables 1 and 2 to water and stirring and dissolving them (Examples 1 to 5) , And Examples 6 to 9) Viscosity at 25 ° C. was measured using a B-type viscometer (manufactured by Brookfield) (rotor No. 2 to 4) under conditions of a rotation speed of 5 rpm and a measurement time of 1 minute. did. In addition, as a comparative test, the viscosity of the solution (Comparative Examples 1 to 3) (25 ° C.) in which the (A) adhesive component was charged into water at the ratio shown in Table 3 and stirred and dissolved was measured under the same conditions as described above. The results are shown in Tables 1 to 3, respectively.

  In this case, a methoxyethylene / maleic anhydride copolymer sodium / calcium salt (Gantrez MS-955, manufactured by ISP Japan) was used as an adhesive component. In Table 1, this is expressed as “AME / MA copolymers”.

  As shown in the table, from the comparison between the viscosity of Example 1 and the viscosity of Comparative Example 1, by using hydrogen phosphate together with the adhesive component (AME / MA copolymers, the same applies hereinafter), it depends on the adhesive component. It can be seen that the viscosity increases. This thickening effect by the combined use of hydrogen phosphate is also shown by the comparison between Examples 2 to 4 and 6 to 9 and Comparative Example 2, and the comparison between Example 5 and Comparative Example 3. Moreover, from the viscosity of Examples 2-4, it turns out that the thickening effect by hydrogen phosphate combined use becomes high with the increase in the ratio of hydrogen phosphate with respect to the adhesion component (AME / MA copolymers). .

Test Example 2 Evaluation of Viscosity and Adhesive Force (1) Preparation of Test Sample A cream type denture stabilizer composition (Examples 10 to 12 and Comparative Example 4) was prepared according to the formulation described in Table 4. Specifically, after the mineral oil component (light liquid paraffin, petrolatum) is heated and mixed, the adhesive component, hydrogen phosphate (disodium hydrogen phosphate), water-soluble polymer (carboxymethyl cellulose sodium) is added thereto, Prepared by mixing uniformly. In this case, a methoxyethylene / maleic anhydride copolymer sodium / calcium salt (Gantrez MS-955, manufactured by ISP Japan) was used as an adhesive component. In Table 2, this is expressed as “AME / MA copolymers”.

(2) Measurement of viscosity 20 times amount (weight ratio) of water is added to a container containing the denture stabilizer (Examples 10 to 12 and Comparative Example 4) prepared in (1) above, and the mixture is kneaded and dissolved. A solution for measurement was prepared. The viscosity of the solution (25 ° C.) was measured using a B-type viscometer (manufactured by Brookfield) (rotor No. 3) under the conditions of a rotation speed of 50 rpm and a measurement time of 1 minute. The results are shown in Table 4.

(3) Measurement of adhesive strength Four times (weight ratio) of water was added to the container containing the denture stabilizer (Examples 10 to 12, Comparative Example 4) prepared in (1) above, and kneaded and dissolved. A sample for measuring adhesive strength was prepared. The adhesive strength of this sample was measured by the method described below using a rheometer (CR-500DX, manufactured by Sun Science Co., Ltd.).
(A) A 15 g sample was placed in a 10 mL glass flat bottom beaker to flatten the surface.
(B) A resin adapter having a diameter of 15 mm was inserted from the sample surface to a depth of 10 mm at a speed of 50 mm / min.
(C) Immediately after insertion, the adapter was retracted at a speed of 50 mm / min. At that time, the maximum load (g weight) applied to the adapter was measured, and the adhesive force (kPa) was calculated according to the following formula.

  The results are also shown in Table 4.

  From this result, it can be seen that by using (b) hydrogen phosphate in combination with (a) pressure-sensitive adhesive component (AME / MA copolymers), the viscosity increases with viscosity. Further, it can be seen that the degree of increase increases as the blending ratio of (b) hydrogen phosphate to (a) adhesive component increases.

Test Example 3 Evaluation of Wearing Feeling About the denture stabilizers prepared in Test Example 2 (Examples 10 to 12, Comparative Example 4), wearing feelings (wearing stability and sustainability) for 6 panelists. Evaluated. Specifically, 6 denture users (over 3 years of usage history) were asked to wear dentures using each denture stabilizer and felt that the dentures were stably adhered to the gums. Each time was measured and scored according to the following criteria.

Each denture stabilizer is applied to the surface of the base of the complete denture (upper and lower jaws) in contact with the gums of the base (a total amount of 2 g) equivalent to 4 soybeans, and this is applied thinly over the entire surface. I stretched it out and put it in my mouth. In addition, each panelist was asked to evaluate the wearing feeling of each of the four types of denture stabilizers in accordance with the same standard by changing the test date.
[Evaluation criteria]
Time when it was felt that the denture was stably adhered More than 10 hours: 10 points 5 to 10 hours or less: 3 points 0 to 5 hours or less: 1 point.

  Table 5 shows the results of averaging the scores evaluated by each panel.

  As shown in Table 5, when (a) adhesive component (AME / MA copolymers) is used in combination with (b) hydrogen phosphate, adhesive stability (adhesion persistence) when actually installed in the oral cavity It can be seen that the property also increases. Further, this result correlates with the effect of increasing the adhesive strength evaluated in Test Example 2. By using hydrogen phosphate together with the adhesive component (AME / MA copolymers), the adhesive stability as well as the adhesive strength is improved. It can be seen that (adhesion persistence) is also improved (increased), and the degree of increase increases as the blending ratio of (b) hydrogen phosphate to (a) adhesive component increases.

Formulation Examples Cream type, gel type, powder type, and sheet type denture stabilizers can be produced according to the formulas shown below. The following “AME / MA copolymers” include methoxyethylene / maleic anhydride copolymer sodium / calcium salt (Gantrez MS-955), methoxyethylene / maleic anhydride copolymer (Gantrez AN-169). Any of Gantrez AN-179) can be used.

Formulation Example 1 Cream Type Denture Stabilizer The following ingredients are mixed while heating to prepare a cream denture stabilizer.
AME / MA copolymers 30 (% by weight)
Disodium hydrogen phosphate 1.5
Carboxymethylcellulose Na 25
Liquid paraffin 15
Petrolatum 28.5
Total 100.0% by weight.

Formulation Example 2 Gel Type Denture Stabilizer A gel denture stabilizer is prepared by mixing and dissolving the following ingredients while heating.
AME / MA copolymers 20 (% by weight)
Disodium hydrogen phosphate 1
Carboxymethylcellulose Na 10
Propylparaben 0.05
Water 68.95
Total 100.00% by weight.

Formulation Example 3 Powder or Granule Type Denture Stabilizer A granular denture stabilizer is prepared by mixing the following raw materials into a powder form or granulating it by a conventional method.
AME / MA copolymers 60 (wt%)
Disodium hydrogen phosphate 3
Carboxymethylcellulose Na 37
Total 100% by weight.

Formulation Example 4 Sheet Type Denture Stabilizer The following raw materials are mixed into a powder form, or granulated by granulating by a conventional method, and this is uniformly spread on a support such as a nonwoven fabric, Further, a similar support is placed thereon and integrated by thermocompression bonding or needle punching. Next, a sheet-type denture stabilizer is prepared by cutting into a desired shape according to the shape of the denture base.
AME / MA copolymers 60 (wt%)
Disodium hydrogen phosphate 3
Carboxymethylcellulose Na 37
Total 100% by weight.

Claims (4)

Denture stabilizer containing the following components (A) and (B):
(A) At least one adhesive component (B) hydrogen phosphate selected from the group consisting of a lower alkyl vinyl ether / maleic anhydride copolymer, a derivative thereof, and a salt thereof.   The hydrogen phosphate is at least one selected from the group consisting of sodium dihydrogen phosphate, disodium hydrogen phosphate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, and calcium hydrogen phosphate. The denture stabilizer described in Item 1.   The denture stabilizer according to claim 1 or 2, wherein the ratio of the component (B) to 100 parts by weight of the component (A) is 0.5 to 40 parts by weight. (A) Denture stabilizer composition comprising at least one adhesive component selected from the group consisting of a lower alkyl vinyl ether / maleic anhydride copolymer, a derivative thereof, and a salt thereof; A method for enhancing the adhesive strength of a denture stabilizer, comprising blending