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All Journal Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Folia Medica Indonesiana Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Jurnal Ilmiah Kedokteran Wijaya Kusuma Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Kesehatan Islam : Islamic Health Journal Indonesian Journal of Anesthesiology and Reanimation (IJAR) Jurnal Layanan Masyarakat (Journal of Public Service) Indian Journal of Forensic Medicine & Toxicology International Islamic Medical Journal Idarotuna : Jurnal of Administrative Science Jurnal Widya Medika

Achmad Basori, Achmad

3Departement Pharmacology, Faculty Of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Author-ID : 627752

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Hypolipidemic Effects of Rosa Damascena Mill. Extract in Streptozotocin-induced Diabetic Rats Tamam Jauhar; Bilqis Inayatillah; Maftuchah Rochmanti; Achmad Basori
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14461

Background: Diabetes mellitus is a chronic hyperglycemic condition with a lot of complication which canlead to death. Vascular complication in diabetes commonly caused by dyslipidemia which characterizedby decreased HDL, elevated LDL, Cholesterol and Triglyceride. Rosa damascena- an ornamental plantthoughts to have anti-hyperglycemia and antioxidant effects because of its large amount of polyphenoliccomponents . This study analyzed hypolipidemic activity properties of an ethanol extract of Rosa damascenaby measuring the lipid profile using various doses. Methods: This research is experimental study withrandomized post-test only control group design. Twenty male Wistar rats divided into 5 groups; The groupswere Healthy Control Group (HCG), Diabetes Group (DG), and Extract Group: P1 (250 mg/kgBW), P2(500 mg/kgBW), P3 (1000 mg/kgBW). All treatment groups were injected by single-dose streptozotocin50 mg/kgBW to induce diabetes, and given the Rosa damascena ethanolic extract oral treatment for 2weeks. Statistical results showed that Rosa damascena significantly decrease cholesterol (58.2±15.19), LDL(11±2.44) optimally in dose 250 mg/KgBW and triglyceride (96.7±44.2) optimally in dose 500 mg/kgBWafter 14 days. Conclusion: Rosa damascena extract seems to be great candidate for anti-hyperlipidemicdrugs.

Proses Penyembuhan Luka Ditinjau dari Aspek Mekanisme Seluler dan Molekuler Nova Primadina; Achmad Basori; David S Perdanakusuma
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 3, No 1 (2019)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v3i1.2198

ABSTRACTWound is the discontinue of the anatomical structure of the body tissue, the healing phase consists of 3 stages, they are the inflammatory phase, which is divided into early inflammation, and late inflammation that occurs from day 0 to day 5 after injury. The Proliferation phase, which includes three main processes, namely: Neoangiogenesis, fibroblast formation and re-epithelialization, occurs from day 3 to day 21 after injury. Maturation phase occurs from day 21 to 1 year after injury which aims to maximize the strength and structural integrity of new tissue fillings, epithelial growth and scar tissue formation. These three phases influence each other and many cells and cytokines play a role in each phase. The amount of research on the wound healing process to achieve satisfactory results with a shorter time than the nominal phase results in a theory of the process of wound healing that is increasingly detailed which will be explained from the aspects of cellular and molecular mechanisms.Keywords : wound healing, wound healing process, wound healing mechanism, cellular mechanism of wound healing, molecular mechanism of wound healingCorrespondence to : novaprimadina@fk.um-surabaya.ac.id ABSTRAKLuka adalah terputusnya kontinuitas struktur anatomi jaringan tubuh, dimana fase penyembuhannya terdiri dari 3 tahap yaitu Fase Inflamasi yang dibagi menjadi early inflammation (Fase haemostasis), dan late inflammation yang terjadi sejak hari ke 0 sampai hari ke 5 pasca terluka. Fase Proliferasi, yang meliputi tiga proses utama yakni: Neoangiogenesis, pembentukan fibroblast dan re-epitelisasi, terjadi dari hari ke-3 sampai hari ke-21 pasca terluka. Fase Maturasi terjadi mulai hari ke-21 sampai 1 tahun pasca luka.yang bertujuan untuk memaksimalkan kekuatan dan integritas struktural jaringan baru pengisi luka, pertumbuhan epitel dan pembentukan jaringan parut. Ketiga fase ini saling mempengaruhi satu sama lain dan banyak sel dan sitokin yang berperan didalam setiap fase. Banyaknya penelitian tentang proses penyembuhan luka untuk mencapai hasil yang memuaskan dengan waktu yang lebih singkat dari fase nomal menghasilkan teori proses penyembuhan luka yang semakin detail yang akan dijelaskan dari aspek mekanisme seluler dan molekuler.Kata kunci :penyembuhan luka, proses penyembuhan luka, mekanisme penyembuhan luka, mekanisme seluler penyembuhan luka, mekanisme molekuler penyembuhan lukaKorespondensi : novaprimadina@fk.um-surabaya.ac.id

Effects of Ginger Extract (Zingiber officinale L) on Glycogen Levels Liver on Mice with Hyperglycaemia Nenny Triastuti; Achmad Basori; Sunarni Zakaria
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 1, No 01 (2017)
Publisher : Universitas Muhammadiyah Surabaya

This study aims to prove the effect of ginger extract on rat liver glycogen levels in hyperglycemic. The design of this study is the post-test only control group design with independent variables (free) include a high-fat diet, injections of streptozotocin, the ethanol extract of ginger doses of 300, 400, 500 mg / kg and the dependent variable (dependent) include blood glucose levels ( GTTO II), glycogen levels. Based on this study, the results of different test GTTO end shows significant differences between negative control group and a positive control, a positive control and P1. Besides, also, there is a significant difference between P1 to P2. This suggests that, dosing higher ginger extract can increase the amount of glycogen levels to near normal. Effect of ginger extract on levels of glycogen in the liver of mice were exposed to a high-fat diet and STZ

PENGARUH FAKTOR-FAKTOR MANAJEMEN PROYEK TERHADAP KINERJA PROYEK DENGAN BURNOUT SEBAGAI VARIABEL PEMODERASI Achmad Basori; Zeplin Jiwa Husada Tarigan
Prosiding SNST Fakultas Teknik Vol 1, No 1 (2017): PROSIDING SEMINAR NASIONAL SAINS DAN TEKNOLOGI 8 2017
Publisher : Prosiding SNST Fakultas Teknik

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.981 KB)

Dalam kegiatan suatu proyek, perencanaan dan pengendalian segabai acuan bagi manajemen dalam pelaksanaan proyek. Tujuan penelitian adalah upaya peningkatan kinerja proyek melalui peran manajemen proyek dalam melaksanakan fungsi pengendalian waktu, biaya, dan kualitas dengan memperhatikan kondisi burnout pekerja untuk efisiensi dan peningkatan kualitas. Sampel penelitian adalah pekerja proyek Citi 9 Gempol. Teknik sampling yang digunakan adalah proportionate stratified random sampling. Dengan sampel penelitian ini berjumlah 112 pekerja dan cara pengambilan sampel menggunakan kuesioner. Teknik analisis menggunakan Regresi Linier Berganda dan Moderated Regresion Analysis (MRA). Hasil analisis menunjukkan bahwa nilai R2 model regresi linier berganda sebesar 47,7%. Dengan hasil uji hipotesis diketahui bahwa pengendalian waktu, pengendalian biaya, dan pengendalian kualitas berpengaruh signifikan terhadap kinerja proyek. Sedangkan R2 model regresi moderating sebesar 55,3%. Dengan hasil uji hipotesis diketahui bahwa variabel burnout memoderasi negatif pengaruh pengendalian waktu, pengendalian biaya, dan pengendalian kualitas terhadap kinerja proyek.Kata Kunci: Burnout, Kinerja Proyek, Pengendalian Waktu, Pengendalian Biaya, dan Pengendalian Kualitas.

Effect of Papaya Seed Extract (Carica papaya Linn.) on Glucose Transporter 4 (GLUT 4) Expression of Skeletal Muscle Tissue in Diabetic Mice Induced by High Fructose Diet Devyani Diah Wulansari; Achmad Basori; Suhartati Suhartati
Majalah Obat Tradisional Vol 22, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Ethnobotany surveys show that papaya seeds are widely used as herbs for the management of some diseases such as abdominal discomfort, pain, malaria, diabetes, obesity, and infection. This research was conducted to analyze the effect of papaya seed extract on GLUT4 expression on skeletal muscle tissue of DM type II model induced by high fructose diet. This study used 24 animals, divided into 4 groups of negative control group, treated with papaya seed extract 100 mg / kgBB, 200 mg / kgBW and 300 mg / kgBW, was adapted for 14 days then induced by fructose solution 20% Orally with a dose of 1.86 grams / kgBB for 56 days. The treatment group was given papaya seed extract in accordance with the dose of each group for 14 days. GDP levels was measured using a spectrophotometer. Skeletal muscle tissue is used on the gastrocnemius part. GLUT4 expression was measured through a Immunoreactive Score (IRS) method with immunohistochemical staining using GLUT4 polyclonal antibodies. Comparative test results showed that there were significant differences between groups (p <0.05) in final GDP variables and GLUT4 expression. Pearson correlation test results show that the value p = 0.001, meaning there is a significant relationship between GLUT4 expression with final GDP levels. The result of simple linear regression analysis showed that p = 0,000 (<0,05), meaning that dose of papaya seed extract had a significant influence on GLUT4 expression.

PHARMACODYNAMICS STUDY OF ETHANOL EXTRACT OF CYCLEA BARBATA (MIERS.) LEAVES ON SRF AND COX-2 GASTRIC MICE WITH NSAID GASTROPATHY Florence Pribadi; Suhartati Suhartati; Achmad Basori
Indonesian Journal of Pharmacy Vol 28 No 3, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Epidemiology of NSAIDs gastropathy is increasing as increase number of usage. From arthritis to cardiovascular events and cancer prevention, the versatility of NSAIDs is not questioned. However, no dose of NSAIDs is safe. No matter low dose, or single use, NSAIDs will cause gastric damage upto 3-7 days after use. In inflammation and healing process of gastropathy there are various proteins involved, but treatment with COX-2 and SRF are associated with an immediate healing and better quality of gastric mucosa. Cyclea barbata (miers.) has been declared as functional food for preventing and treatment gastropathy yet, its mechanism of actions have not yet clearly discovered. Hence the aim of this study is to analyze the effects of Cyclea barbata (miers.) ethanol extract to COX-2 and SRF in gastric tissue, in time series basis. Laboratory mice was induced with aspirin to produce gastropathy and then treated with Cyclea barbata (miers.) extract for 1, 3, 7, 10 or 14 days. Gastric tissue then harvested and analysed with elisa procedure to determine tissue SRF and COX-2 level. Treatment was proven to increase COX-2 and SRF higher than control group. This concludes one of Cyclea barbata (miers.) mechanism for NSAIDs gastropathy is by increasing tissue COX-2 and SRF.

USAHA PRODUKSI JAMU TERSTANDAR DI PEDESAAN (VILLAGE JAMOE CENTRE) SECARA AGROINDUSTRI MELALUI TEKNOLOGI 6 M SIMPLISIA MENUJU MASYARAKAT SEHAT CERDAS Sunarni Zakaria; Wurlina Wurlina; Achmad Basori; Nurina Hasanatuludhiyah; Dewa Ketut Meles
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 1 No. 1 (2017): Jurnal Layanan Masyarakat
Publisher : Universitas Airlangga

Herbal medicine business is sideline business for mothers largely. Education and training participants of Ipteks bagi Masyarakat (IbM) event not to be organized professionally. The purposes of IbM program are: 1) improve the knowledge of herbal medicine plants 2) improve skilss in selecting, drying , mixing , grinding and make simplicia (6M) 3) increase the eﬃcacy and instant herbal production (dry form) and 4) to develop human resources in the processing of herbs. Methods of IbM program is cooperating with UMKM to held Ipteks bagi Masyarakat (IbM) on knowledge of medicinal plants. Education and training to participants of UMKM business groups that the eﬃcacy of medicinal plants used by the community, how to make retrieval and instant empon- empon and technology of 6 M simplicia. Results IbM activity is a member of UMKM has already implement 1) manufacture in sorting bulbs between the leaves, stems and roots 2) apply the harvest time of toga 3) ways to avoid losing the drying properties 4) herbal packs are labeled (powder or in capsules) and increased income herbal vendors . It is suggested that activities of IbM held continuously every year to monitor the development of UMKM in order to be become the center of herbs by involving students to create new entrepreneurs. AbstrakBisnis obat herbal merupakan usaha sampingan bagi ibu sebagian besar. Peserta pelatihan dan pelatihan Ipteks bagi Masyarakat (IbM) tidak diorganisir secara profesional. Tujuan program IbM adalah: 1) meningkatkan pengetahuan tanaman jamu 2) memperbaiki skill dalam memilih, mengeringkan, mencampur, menggiling dan membuat simplisia (6M) 3) meningkatkan khasiat dan produksi jamu instan dan 4) untuk mengembangkan sumber daya manusia dalam pengolahan tumbuhan. Metode program IbM bekerja sama dengan UMKM untuk menyelenggarakan Ipteks bagi Masyarakat (IbM) tentang pengetahuan tanaman obat. Pendidikan dan pelatihan kepada peserta kelompok usaha UMKM bahwa khasiat tanaman obat yang digunakan oleh masyarakat, bagaimana membuat teko dan teko empuk dan teknologi 6 M simplicia. Hasil Kegiatan IbM adalah anggota UMKM yang telah menerapkan 1) pembuatan dalam memilah umbi antara daun, batang dan akar 2) mengaplikasikan waktu panen toga 3) cara menghindari kehilangan sifat pengeringan 4) bungkusan herbal diberi label (bedak atau dalam kapsul) dan meningkatkan pendapatan penjual herbal. Disarankan agar kegiatan IbM terus dilakukan setiap tahun untuk memantau perkembangan UMKM agar bisa menjadi pusat tanaman obat dengan melibatkan siswa untuk menciptakan wirausaha baru.

Manajemen Dana Zakat, Infaq dan Shodaqah (Zis) pada Badan Amil Zakat Nasional Lumajang Ziaulhaq Fathulloh; Achmad Basori; Mokhamad Saiful Hasan
Idarotuna : Journal of Administrative Science Vol. 3 No. 1 (2022): May
Publisher : Program Study Office Adminstrative of Akademi Komunitas Teknologi Syarifuddin Lumajang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54471/idarotuna.v3i1.31

Zakat, infaq dan shadaqah sumber dana potensial yang dapat dimanfaatkan sebagai upaya mewujudkan kesejahteraan rakyat. Pelaksanaan ibadah zakat melibatkan sejumlah kegiatan yang berkaitan dengan manajemen pengelolaan harta benda sejak perencanaan, pengorganisasian, pelaksanaan, dan pengawasan terhadap pengumpulan dan pendistribusian. Oleh sebab itu pelaksanaan ibadah zakat, infaq dan shadaqah tersebut memerlukan suatu manajemen yang baik sehingga dapat meningkatkan masyarakat dan fungsi zakat, infaq dan shadaqah dalam mewujudkan kesejahteraan dan keadilan sosial. Adapun rumusan masalah penelitian ini adalah: 1. Bagaimana manajemen pengelolaan dana zakat, infaq dan shadaqah pada BAZNAS Kabupaten Lumanjang? 2. Apakah faktor pendukung dan penghambat dalam meningkatkan kesejahteraan masyarakat? Sedangkan tujuan penelitian ini untuk mengetahui bagaimana manajemen pengelolaaan dana zakat, infaq dan shadaqah pada BAZNAS Kabupaten Lumajang, untuk mengetahui bagaimana faktor pendukung dan penghambat dalam meningkatkan kesejahteraan masyarakat di BAZNAS Kabupaten Lumanjang. Jenis penelitian ini merupakan penelitian lapangan dan kepustakaan dengan menggunakan pendekatan kualitatif deskriptif. Teknik pengumpulan data pada penelitian ini yaitu: wawancara, observasi dan dokumentasi. Sumber data terdiri dari data primer dan sekunder. Hasil penelitian manajemen pengelolaan dana ZIS di Baznas Kabupaten Lumajang sudah dilaksanakan sesuai program yang telah direncanakan, yaitu: Dhuafa Mandiri, Senyum Dhuafa, Pendidikan dan Dakwah, Sosial dan Kesehatan. Namun manajemen pengawasan masih kurang efektif dan efesien dalam berjalannya program dhuafa mandiri. Faktor pendukung dalam mensejahterakan mustahiq di Baznas Kabupaten Lumajang yaitu: pendistribusian dana ZIS sudah sesuai dengan syariat fiqih yaitu disalurkan ke 8 golongan (asnaf), Baznas Kabupaten Lumajang mempunyai yayasan sekolah Ibtidaiyah dan program terhadap anak yatim yang terlantar agar mendapatkan dan meringankan pendidikan.

Efek Pemberian Ekstrak Etanol Daun Jarak Merah (Jatropha gossypiifolia L.) terhadap Kadar Glukosa Darah Puasa, Kadar Insulin Serum dan HOMAIR pada Model Tikus DM Tipe 2 Nugroho Wibisono; Achmad Basori; Suhartati
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 11 No. 2 (2022): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v11i2.19225

Abstract. Jatropha gossypiifolia L. is a medicinal plant from theEuphorbiaceae family. Jatropha gossypiifolia L. leaves have somemedicinal properties, but their effect on antidiabetics mechanisms isstill unclear. Jatropha gossypiifolia leaves have some activecompounds such as alkaloid, flavonoid, phenol, saponins, tannins,steroid, terpenoid, and triterpenoid. The presentstudy was designedto analyze effect of Jatropha gossypiifolia leaves extract activecompounds on fasting blood glucose levels, serum insulin levels andHOMA-IR. The design of thisresearch istrue experimental with posttest only control group design with independent variables includinga high-fat diet, streptozotocin injections, Jatropha gossypiifolia L.leaves extract in doses of 60, 120, dan 240 mg/kg and dependentvariables including fasting blood glucose levels, serum insulin levels,and HOMA-IR. Based on this study, there were a significantlydifferent between fasting blood glucose levels and HOMA-IR controlgroups than the extract groups. It can be concluded that Jatrophagossypiifolia L. leaves extract has effect on fasting blood glucoselevels, serum insulin levels and HOMA-IR on DM type 2 rat models.

Profile Hemodynamics (Blood Pressure And Heart Rate) Changes in The Use of Adrenaline in Cesarean Section With Spinal Anesthesia at Dr Soetomo Surabaya Hospital Ainur Rahmah; Arie Utariani; Achmad Basori
Indonesian Journal of Anesthesiology and Reanimation Vol. 2 No. 1 (2020): Indonesian Journal of Anesthesiology and Reanimation (IJAR)
Publisher : Faculty of Medicine-Universitas Airlangga

Introduction: spinal anesthesia block is one of anesthesia technique that aims to block motor nerves resulting in paresis or anesthesia and paralysis or loss of muscle function in myotomes that are the same level as blocked dermatomes. Caesarean section is one of the surgical actions that are often performed mainly in birth cases. Besides that, the mechanism of the effects of giving birth to the operation of type B autonomic caesarean section autonomic nerve pronglion nerve which results in a decrease in the resistance of peripheral veins and peripheral vasodilatation which results in an imbalance in hemodynamics especially in blood pressure and heart rate and cause of hypotension. Vasopressor, fluid therapy, vasoconstrictor are given to reduce the toxicity of local anesthesia and to overcome hypotension. Objective: To determine hemodynamic changes (blood pressure and pulse) in spinal anesthesia block surgery patients with caesarean section at Dr Soetomo Hospital. Material and Method: This research is descriptive with a retrospective from January - March 2018, the sample taken with total sampling from secondary data from the central medical record at RSUD Dr. Soetomo. Results and Discussion: 68 samples were obtained from inclusion and exclusion criteria there was a change in blood pressure and pulse in patients with caesarean section with spinal anesthesia block with the addition of vasoconstrictors. There was a decrease in average systolic pressure 13.25, diastole 18.25 and pulse 4.5 and in no increase. There was a decrease in average systolic pressure 11.9286, diastole 13.8929 and pulse 5.6429 and no addition of p> 0.05 the two are not significantly different. Conclusion: addition of adrenaline to spinal anesthesia in caesarean section patients was not cause significant hemodynamic (blood pressure and heart rate) changes.

Co-Authors Acrivida Mega Charisma Ahmad Yudianto Ainur Rahmah Arif Rahman Nurdianto Arista Wahyu Ningsih Bilqis Inayatillah Budi Utomo David S Perdanakusuma Devyani Diah Wulansari Dhihintia Jiwangga Eddy Bagus Wasito Fery Setiawan Florence Pribadi Heribertus Agustinus B Tena Isnaeni Isnaeni Jenny Sunariani Kartuti Debora, Kartuti Maftuchah Maftuchah Meles, Dewa Ketut Mokhamad Saiful Hasan Nenny Triastuti Nova Primadina Nugroho Wibisono Nurina Hasanatuludhiyah Paul L Tahalele Rochmanti, Maftuchah Rochmanti Suhartati Suhartati Suhartati Suhartati Suhartati Sunarni Zakaria Sunarni Zakaria Tamam Jauhar Utariani, Arie Wiwin Retnowati Wurlina, W Yuani Setiawati Zeplin Jiwa Husada Tarigan Ziaulhaq Fathulloh

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