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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma
Arif Rahman Nurdianto
Puskesmas Trosobo
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Effects of Reproductive Health Education Using Video Animation Towards Reproductive Health Knowledge and Attitudes in 5th and 6th Elementary Grade Students in Serang City, Banten Edy Mustofa; I Made Arya Subadiyasa; Agus Sholahuddin; Arif Rahman Nurdianto
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 10, No 2 (2021): SEPTEMBER 2021
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (334.527 KB) | DOI: 10.30742/jikw.v10i2.1230

Abstract

Introduction: Adolescent reproductive health education aims to increase knowledge and attitudes about reproductive health. Therefore, an easy, inexpensive, and standardized method of education is needed in the delivery of reproductive health material to young adolescents, one of them is audiovisual media animationMethod: The research was conducted using a pre-experimental research design pretest-posttest one group design within 31 days. This study used a total sample of 180 subjects, furthermore, the data were analyzed using Structural Equation Modeling (SEM).Result: Education with reproductive health animated videos increased knowledge about reproductive health immediately after education was given (P = 0.002), but after 31 days, it did not affect (P = 0.171). Education with animated videos did not affect the subjects’ attitude immediately after education was carried out (P = 0.802) but had an effect after 31 days from the start of education (P = 0.031). After analyzing the correlation including other confounding variables (R square), it was found that the effect of education with animated videos towards the increasing knowledge of reproductive health was 14.9%, and 8.4% towards changes in subject attitudes.Discussion: Health education with video animation increases knowledge, but the phenomenon of attitudes such as dating still occurs even the subjects’ knowledge have increased.Conclusion: Reproductive health education using animated videos increases knowledge but does not change attitudes in reproductive health
Efek Proteksi dari Terapi Oksigen Hiperbarik terhadap Ekspresi Bcl-2 Miometrium Rattus norvegicus Bunting yang Terinfeksi oleh Tachyzoite Toxoplasma gondii Arif Rahman Nurdianto; Aryati Aryati; Mohammad Guritno Suryokusumo; Mufasirin Mufasirin
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v9i1.730

Abstract

Hyperbaric Oxygen Therapy (HBOT) can increase oxygen delivery to tissues and stimulate the formation of H2O2 as a secondary messenger for phosphorylation of nuclear factor kappa beta (NF-kB) which plays an important role in the transcription of the anti apoptotic gene. This study aimed to determine the effects of Hyperbaric Oxygen Therapy (HBOT) in enhancing the expressions of Bcl-2 in the myometrium of pregnant rats infected by Toxoplasma gondii. This study was an experimental study with a randomized control group of post-test only and designed by 37 pregnant Rattus norvegicus Sprague Dawley. Randomly, the rats were divided into four groups. Group A is infected pregnant rats that exposed by 10 sessions of HBOT 2.4 ATA in 3x30 minutes. Group B is non-infected pregnant rats and exposed by 10 sessions of HBOT 2.4 ATA in 3x30 minutes. Group C is infected pregnant rats without any exposure. Group D is non-infected pregnant rats without any exposure. Each infected pregnant rat was given a 103 tachyzoite of T.gondii by intraperitoneal injection. Bcl-2 expressions were measured through immunohistochemistry. All data were analyzed using ANOVA test through SPSS 21 program application. There was a significant difference in Bcl-2 expression between Group A and Group C because p<α (p<0.017). HBOT can increase the expression of Bcl-2 from infected and not infected rat myometrium, in the provision of HBOT 2.4 ATA for 3x30 minutes, twice a day for 5 days.
Molecular Toxicology of Organophosphate Poisoning Fery Setiawan; Arif Rahman Nurdianto; Heribertus Agustinus B Tena; Ahmad Yudianto; Jenny Sunariani; Achmad Basori; Acrivida Mega Charisma
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 1 (2022): MARET 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v11i1.1596

Abstract

The use of organophosphates (pesticides and other compounds to eradicate pests), currently, to increase the fulfillment of the population's consumption needs has a double-edged sword effect, on the one hand it can increase the need for food to be consumed by the population. The negative effect that can arise is the safety of organophosphate drugs which can contaminate the soil and water sources around the place where organophosphate drugs are used. The negative effects of organophosphates are associated with the effects of xenobiotics on humans who consume them. Xenobiotics are associated with toxicdynamic effects where organophosphates cause irreversible inhibition of the enzyme acetylcholinesterase (ACh). ACh is one of the main enzymes in the nervous system that terminates impulse conduction through the hydrolysis process of acetylcholine enzymes. Acetylcholinesterase is a specific molecular target of organophosphate pesticides. The inhibition of the Ach enzyme causes the inhibition of the acetylcholine enzyme which is normally always hydrolyzed by the Ach enzyme and is a specific biological marker of pesticide poisoning. Inhibition of ACh will cause the accumulation of the enzyme acetylcholine, resulting in negative effects of organophosphate poisoning which can lead to death. In this paper, the authors collect from various sources related to the study of molecular toxicology toxidynamic effects of drug safety and organophosphate poisoning. The results of this review article show that organophosphate poisoning is associated with irreversible inhibition of the acetylcholinesterase enzyme which results in death in the individual concerned.
Co-Authors Achmad Basori, Achmad Acrivida Mega Charisma Agus Sholahuddin Ahmad Yudianto Aryati Aryati Edy Mustofa Fery Setiawan Heribertus Agustinus B Tena I Made Arya Subadiyasa Jenny Sunariani Mohammad Guritno Suryokusumo Mufasirin