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Soy-Ipoghurt as an antidiabetic on hiperglicemic animal modelling Rattus norvegicus I Putu Dedy Arjita; Dhika Juliana Sukmana; Hardani Hardani; Diani Sri Hidayati; I Putu Bayu Agus Saputra
AcTion: Aceh Nutrition Journal Vol 8, No 2 (2023): June
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v8i2.909

Treatment of Diabetes Mellitus (DM) is generally through optimizing a balanced diet. Soybeans and sweet potatoes have good antioxidants and can be developed as healthy foods for people with diabetes. Soybeans and sweet potatoes are processed into Soy-yoghurt. This study aims to determine the potential of soy yogurt as an antidiabetic in experimental animals, Rattus norvegicus induced by hyperglycemia, using Streptozotocin. This study used a experiment design with a total of 40 experimental animals. The research was conducted at the Medica Farma Husada Polytechnic Laboratory, Mataram, in 2022. The experimental animals that Streptozotocin (STZ) induced were then given Soy-yogurt orally at 3 ml and 3.5 ml doses. Experimental animals' Fasting Blood Glucose (FBG) levels were measured weekly using a Glucometer, while body weight (BW) was measured every three days. The results obtained were then analyzed statistically using the ANOVA test. The test results showed that there was a significant difference in blood sugar levels (p<0,05) in fasting given soy but no difference in BW (p>0,05). This study concludes that the provision of soybeans can affect the level of FBG of the experimental animals but does not affect the BW of the experimental animals.

PTEN: The Potential Therapeutic Target of Diabetes Mellitus Ni Made Wiasty Sukanty; I Putu Bayu Agus Saputra; Lina Yunita
Poltanesa Vol 24 No 1 (2023): June 2023
Publisher : P2M Politeknik Pertanian Negeri Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51967/tanesa.v24i1.2004

Diabetes mellitus is a metabolic disease characterized by high blood glucose levels. The cause of glucose control failure is decreased insulin production by pancreatic β-cells and insulin resistance. Both lead to the obstacle of glucose uptake into cells. The mechanism of glucose uptake into cells is crucial in carbohydrate metabolism. This mechanism aims to produce energy in the form of ATP. The main signaling pathway after the process of glucose uptake is the PI3K/Akt pathway. This pathway involves many proteins activated by phosphorylation mechanisms. One of the proteins involved in this pathway is PTEN, a PI3K regulator. PTEN activity can dephosphorylate PI3K so that the insulin signaling pathway becomes blocked and glucose cannot be uptaken into cells. It causes blood glucose levels to increase. The role of PTEN in inhibiting the PI3K/Akt pathway seems to be a crucial matter to observe. By inhibiting PTEN activity, the insulin signaling pathway is expected to work properly. We have searched, read, analyzed, and summarized various studies regarding the potential of PTEN to reduce diabetes mellitus cases. In some research articles, the use of active compounds and therapy using stem cells to inhibit PTEN activity has shown good progress in the insulin signaling pathway. Based on these, it can be an option to make PTEN a target for diabetes mellitus therapy.

PTEN: The Potential Therapeutic Target of Diabetes Mellitus Ni Made Wiasty Sukanty; I Putu Bayu Agus Saputra; Lina Yunita
Poltanesa Vol 24 No 1 (2023): June 2023
Publisher : P2M Politeknik Pertanian Negeri Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51967/tanesa.v24i1.2004

Diabetes mellitus is a metabolic disease characterized by high blood glucose levels. The cause of glucose control failure is decreased insulin production by pancreatic β-cells and insulin resistance. Both lead to the obstacle of glucose uptake into cells. The mechanism of glucose uptake into cells is crucial in carbohydrate metabolism. This mechanism aims to produce energy in the form of ATP. The main signaling pathway after the process of glucose uptake is the PI3K/Akt pathway. This pathway involves many proteins activated by phosphorylation mechanisms. One of the proteins involved in this pathway is PTEN, a PI3K regulator. PTEN activity can dephosphorylate PI3K so that the insulin signaling pathway becomes blocked and glucose cannot be uptaken into cells. It causes blood glucose levels to increase. The role of PTEN in inhibiting the PI3K/Akt pathway seems to be a crucial matter to observe. By inhibiting PTEN activity, the insulin signaling pathway is expected to work properly. We have searched, read, analyzed, and summarized various studies regarding the potential of PTEN to reduce diabetes mellitus cases. In some research articles, the use of active compounds and therapy using stem cells to inhibit PTEN activity has shown good progress in the insulin signaling pathway. Based on these, it can be an option to make PTEN a target for diabetes mellitus therapy.

Noni (Morinda Citrifolia) Ethanol Extract Lowered Blood Glucose Levels, Increased Glutathione Peroxidase Activity, And Decreased Malondialdehyde in White Rats Model of Diabetes I Putu Dedy Arjita; I Putu Bayu Agus Saputra; Dhika Juliana Sukmana
Jurnal Penelitian Pendidikan IPA Vol 9 No 12 (2023): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i12.6076

Diabetes mellitus can increase oxidative stress and damage cells. Noni fruit has antibacterial, antifungal, antitumor, analgesic, hypotensive, and anti-inflammatory benefits, can boost immunity, and has antioxidant content. Noni contains phenolic compounds (anthraquinones, acuities, asperulosides, and scopoletin), organic acids (capric and caprylic acids), and alkaloids (xeronine). The effect of noni ethanol extract can significantly reduce blood glucose (P<0.05) of the T2 group (177.00Â±137.78) and T3 (159.40Â±86.53) when compared to the C+ group (511.00Â±131.45). The T1 group (387.40Â±170.06) had no significant difference (P>0.05) when compared to the C+ group (511.00Â±131.45), but there was a decrease in the average yield at T1 (387.40Â±170.06). Serum malondialdehyde (MDA) examination showed a significant decrease (p<0.05) in T1 (1188.32Â±93.41), while in T2 (1385.35Â±38.65) and T3 (1460.32Â±42.51) was not significant (p<0.05). Examination of serum glutathione peroxidase (GPX) showed a significant decrease in T1 (119.97Â±37.45), there was a decrease in GPX levels, while in the T2 group (236.14Â±6.05) and T3 (185.24Â±43.07), there was no decrease. Noni ethanol extract can lower blood glucose levels, reduce Malondialdehyde levels, and prevent increased activity of the enzyme glutathione peroxidase. Flavonoid compounds in noni ethanol extract can avoid increased blood glucose and reduce free radicals formed due to hyperglycemia conditions. Â

Physical Activity and Smoking Habits are Closely Related to Cardiovascular Endurance in Farmers Deny Sutrisna Wiatma; Reksa Samoedra; I Putu Bayu Agus Saputra; Bayu Setia
Indonesian Journal of Global Health Research Vol 6 No 1 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i1.2721

In 2019, there were 523 million cases of cardiovascular disease which caused the deaths of 18.6 million people. In this manner, some major issue should be considered, high cardiovascular endurance, for example. Relatively, high cardiovascular endurance can reduce the incidence of cardiovascular disease by 40% to 70%. Objective to nalyzing the relationship between physical activity and smoking habits among farmers in Pandan Wangi Village. The method used is quantitative research with cross-sectional design involving 108 respondents. The respondents were selected by a simple random sampling technique. Data in this study were collected using GPAQ for physical activity variables, Brinkman index questionnaire for smoking variables, and Harvard step test for cardiovascular endurance variables. Meanwhile, Spearman rank test was used in the data analysis. The research shows that the characteristics of respondents were dominated by male (64.8%) within 36-45 years old age range group (52.8%). In addition, most of the respondents were non-smoker category (62.0%), had a high level of physical activity (52.8%), and a very good level of cardiovascular endurance (27.8%). Bivariate analysis shows that there is a significant relationship between physical activity (p-value = 0.005) and smoking behavior (p-value = 0.047) on cardiovascular endurance among farmers in Pandan Wangi Village. There is a significant relationship between physical activity and smoking habits on cardiovascular endurance among farmers in Pandan Wangi Village.

Hubungan Lama Sakit, Tingkat Pendidikan, Motivasi Pasien, dan Dukungan Keluarga dengan Kepatuhan Diet Pasien Diabetes Melitus Tipe II di Rumah Sakit Daerah (RSD) Mangusada Kabupaten Badung Bali Putu Agi Abhimana Manutama; I Putu Dedy Arjita; I Putu Bayu Agus Saputra; Mamang Bagiansah
MAHESA : Malahayati Health Student Journal Vol 4, No 6 (2024): Volume 4 Nomor 6 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i6.14470

ABSTRACT Diabetes mellitus is a non-infectious disease that has become one of the health threats worldwide. Dietary adherence has a very important function in the management of DM. factors that can affect the dietary adherence of DM patients, namely education, knowledge, motivation, family support, and length of suffering. To analyze the relationship of length of illness, education level, patient motivation, and family support with dietary compliance of Type II DM patients at RSD Mangusada Badung Regency Bali. Observational analytic quantitative research with simple random sampling research design with a sample size of 92 respondents. Data were analyzed by Chi-Square test and Spearman Rank test with a significance value limit (p-value) <0.05. The results showed that the majority of respondents were 51-60 years old 44 (47.8%), the majority of respondents were male 48 (52.2%), 78 (84.8%) complied with the diet, the length of illness without complications 42 (45.7%), higher education 35 (38%), good patient motivation 75 (81.5%), good family support 71 (77.2%). Bivariate analysis showed that there was a significant relationship between length of illness with dietary compliance (p=0.048), education level with dietary compliance (p=0.015), patient motivation with dietary compliance (p=0.001), and family support with dietary compliance (p=0.009). Length of illness, education level, patient motivation, and family support are associated with dietary adherence of Type II DM patients at Mangusada Hospital, Badung Regency, Bali. Keywords: Diabetes Melitus, Dietary Compliance, Long Illness, Level Of Education, Patient Motivation, Family Support ABSTRAK Diabetes melitus merupakan penyakit non-infeksi yang menjadi salah satu ancaman kesehatan di seluruh dunia. Kepatuhan diet memiliki fungsi yang sangat penting dalam pengelolaan DM. faktor-faktor yang dapat mempengaruhi kepatuhan diet pasien DM, yaitu pendidikan, pengetahuan, motivasi, dukungan keluarga, dan lama menderita. Menganalisis hubungan lama sakit, tingkat pendidikan, motivasi pasien, dan dukungan keluarga dengan kepatuhan diet pasien DM Tipe II di RSD Mangusada Kabupaten Badung Bali. Penelitian kuantitatif analitik observasional dengan desain penelitian simple random sampling dengan besar sampel 92 responden. Data di analisis dengan uji Chi-Square dan uji Rank Spearman dengan batas nilai signifikansi (p-value) <0,05. Hasil penelitian menunjukkan mayoritas responden berusia 51-60 tahun 44 (47,8%), responden mayoritas berjenis kelamin laki-laki 48 (52,2%), patuh menjalani diet 78 (84,8%), lama sakit tanpa komplikasi 42 (45,7%), pendidikan tinggi 35 (38%), motivasi pasien baik 75 (81,5%), dukungan keluarga baik 71 (77,2%). Analisis bivariat menunjukkan terdapat hubungan yang signifikan antara lama sakit dengan kepatuhan diet (p=0,048), tingkat pendidikan dengan kepatuhan diet (p=0,015), motivasi pasien dengan kepatuhan diet (p=0,001), dan dukungan keluarga dengan kepatuhan diet (p=0,009). Lama sakit, tingkat pendidikan, motivasi pasien, dan dukungan keluarga berhubungan dengan kepatuhan diet pasien DM Tipe II di RSD Mangusada Kabupaten Badung Bali. Kata Kunci: Diabetes Melitus, Kepatuhan Diet, Lama Sakit, Tingkat Pendidikan, Motivasi Pasien, Dukungan Keluarga

Hubungan Anemia, Usia Ibu dan Paritas dengan Kejadian Berat Badan Lahir Rendah di RSUD Patut Patuh Patju Bintang Yuniar Musviratunnisah; Ananta Fittonia Benvenuto; I Putu Bayu Agus Saputra; Fachrudi Hanafi
MAHESA : Malahayati Health Student Journal Vol 4, No 6 (2024): Volume 4 Nomor 6 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i6.14437

ABSTRACT Low Birth Weight (LBW) are all newborns with a birth weight of less than 2,500 grams regardless of gestational age. Causes of LBW are multifactorial, such as maternal factors, fetal factors, environmental factors and socio-economic factors. This study aims to determine the relationship between anemia, age and parity with the incidence of LBW at Patut Patuh Patju Hospital. This research is an analytical observational research with a case-control design. The sample population in this study was all newborn babies at the Patut Patuh Patju Regional Hospital for the period January-December 2022, totaling 1.297 with 230 samples taken by purposive sampling with a 1:1 ratio of which 115 were cases and 115 controls. Data analysis for this research is univariate analysis and bivariate analysis with the chi-square statistical test. The results of this research showed that there was a significant relationship between anemia and the incidence of LBW (p-value of 0.000 and an OR of 17.5). There was a significant relationship between maternal age and the incidence of LBW (p-value of 0.000 and OR 6.1). There was a significant relationship between maternal parity and the incidence of LBW (p-value of 0.017 and OR 1.9). There was a significant relationship between anemia, age and parity with the incidence of low birth weight (LBW) at Patut Patuh Patju Hospital. Keywords: LBW, Anemia, Age, Parity, Infants ABSTRAK Berat Badan Lahir Rendah (BBLR) merupakan salah satu penyumbang Angka Kematian Bayi (AKB) tertinggi didunia. BBLR adalah semua bayi baru lahir dengan berat saat lahir kurang dari 2.500 gram tanpa memandang usia gestasi. Penyebab terjadinya BBLR bersifat multifaktorial, seperti faktor ibu, faktor janin, faktor lingkungan serta faktor sosial ekonomi. Penelitian ini bertujuan untuk mengetahui hubungan anemia, usia ibu dan paritas dengan kejadian BBLR di RSUD Patut Patuh Patju Kabupaten Lombok Barat. Jenis penelitian observasional analitik dengan pendekatan case-control. Populasi pada penelitian ini adalah seluruh bayi baru lahir di RSUD Patut Patuh Patju periode Januari-Desember tahun 2022 yang berjumlah 1.297 dengan 230 sampel yang diambil dengan purposive sampling dengan perbandingan 1:1 dimana 115 sampel sebagai kasus dan 115 kontrol. Analisis data penelitian ini adalah analisis univariat dan analisis bivariat dengan uji statistik chi-square. Hasil penelitian ini menunjukan bahwa terdapat hubungan yang signifikan antara anemia dengan kejadian BBLR (p-value=0,000 dan OR 17,5). Terdapat hubungan yang signifikan antara usia ibu dengan kejadian BBLR (p-value 0,000 dan OR 6,1). Terdapat hubungan yang signifikan antara paritas ibu dengan kejadian BBLR (p-value 0,017 dan OR 1,9). Terdapat hubungan yang signifikan antara anemia, usia ibu dan paritas dengan kejadian BBLR di RSUD Patut Patuh Patju. Kata Kunci: BBLR, Anemia, Usia Ibu, Paritas, Bayi

Omega-3 Fatty Acids and Vitamin D Combination Affected TG Levels in Rattusnorvegicus with Limited Fat Intake I Gede Angga Adnyana; I Nyoman Bagus Aji Kresnapati; I Putu Bayu Agus saputra; Maruni Wiwin Diarti; Yunan Jiwintarum
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 3 (2023): November
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i3.2248

Vitamin D is a group of secosteroids that have fat-soluble properties. Vitamin D regulates calcium absorption, bone growth and remodeling, and regulates metabolic processes and immunity. Omega-3 fatty acids are a type of polyunsaturated fatty acids (PUFAs) that are essential fatty acids for humans. Omega-3 fatty acids have various positive effects on health, especially cardiovascular-related ones. This study aims to determine the effect of omega-3 fatty acid and vitamin D combination on the TG/HDL-C ratio in high fat fed Rattus norvegicus. The research design is experimental study with a post-test-only control group design. This study used 24 male rats aged 3–4 months with a body weight of 250–300 grams which were divided into four groups; negative control group, positive control group; treatment group one; and treatment group two. The high-fat diet (HFD) is an additional (emulsion) feed added to standard feed with increased fat composition. The results showed that increased triglyceride (TG) levels of 83.40 mg/dL and HDL levels of 62.60 mg/dL after consumed high-fat diet. There was a significant decrease in TG levels of 54.15 mg/dL (p=0.026) and a decrease in HDL of 53.00 mg/dL (p>0.05, α=0,05) after administration of Omega-3 and Vitamin D combination. Conclusions in this study is the intake Omega-3 and Vitamin D combination has a positive effect on TG levels. Still, this positive effect must be accompanied by limiting the fat intake to the body. Meanwhile, combining Omega-3 and Vitamin D did not significantly affect HDL levels.

Potensi senyawa turunan flavonoid dalam menjadi inhibitor enzim HMG-Coa reductase kandidat obat h I Putu Bayu Agus Saputra; I Putu Dedy Arjita
Jurnal Penelitian Pendidikan IPA Vol 10 No 5 (2024): May
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i5.6237

Cardiovascular disease (CVD) is a disease that causes death in the world. Behavioral risk factors are crucial in dealing with CVD disease. High levels of cholesterol in the blood are associated with hypercholesterolemia. It can increase the risk of CVD disease. The HMG-CoA reductase enzyme is an enzyme that plays a role in cholesterol synthesis. It will convert the HMG-CoA compound into the mevalonate. Inhibition of this enzyme can reduce cholesterol synthesis because it inhibits the formation of mevalonate, which is the initial stage of cholesterol synthesis. Herbal compounds are compounds produced by plants. It has good benefits for the body. Flavonoid compounds can be beneficial for health. Molecular docking is a method used to determine the binding affinity and interaction values of the enzyme protein interaction with the ligand to be bound. The results of Apigenin binding affinity values is -7.7 kcal/mol, Luteolin is -8 kcal/mol, Quercetin is -8.2 kcal/mol, Kaempferol is -7.4 kcal/mol, Phloretin is -6.8 kcal/mol, Chalconaringenin is -6.9 kcal/mol, Cyanidin is -7.9 kcal/mol, Delphinidin is -7.8 kcal/mol, Hesperetin is -7.7 kcal/mol, Narigenin is -7.8 kcal/mol, Daidzein is -6.8 kcal/mol, Genistein is -7 kcal/mol, Rutin is -9.2 kcal/mol, Taxifolin is -8 kcal /mol, Diosmetin is -7.6 kcal/mol, and its native ligand Rosuvastatin is -8.5 kcal/mol. Flavonoid derivative compounds can bind to the HMG-CoA reductase enzyme. They can be candidates for antihyperlipidemia drugs.

Effectiveness of Bay Leaf Decoction (Syzygium polyanthum) on Reducing Blood Glucose Levels in Paok Motong, Masbagik, East Lombok Nadi Kurniawan; Rozikin; I Putu Bayu Agus Saputra; Sabariah; I Nyoman Bagus Aji Kresnapati
Current Biochemistry Vol. 10 No. 2 (2023)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.10.2.2

One disease that correlates with blood glucose levels is diabetes mellitus (DM). According to Basic Health Research (RISKESDAS), in Indonesia by 2030 there will be an increase of up to 21.3 million people suffering from diabetes mellitus. However, nowadays most people are afraid of the side effects of using the drugs they consume and are turning to herbal therapy to lower blood glucose levels. Bay leaves have the benefit of treating diabetes mellitus, hypercholesterolemia, hypertension, diarrhea and gastritis. Phytochemical analysis shows that bay leaves contain essential oils, tannins, flavonoids and terpenoids. The aim of the research was to determine the effect of bay leaf boiled water on reducing blood glucose levels. The research was an experimental One Group Pretest Post-test Design, namely the research subjects had their blood glucose levels measured before (pre-test) and after being given bay leaf boiled water (post-test). 41 respondents in Paok Motong Barat village, Masbagik District, East Lombok Regency had their Blood Glucose Levels (GDS) measured before (pre-test) and after (post-test) giving 300 mL of bay leaf boiled water. Paired Test Statistical Analysis was used to determine the difference in pretest and posttest blood glucose levels given bay leaf boiled water. The results of the study showed that there was a significant decrease in blood glucose levels (p= 0.001) by 15.22 mg/dL to 179.27 mg/dL before administering bay leaf decoction amounting to 194.49 mg/dL. The conclusion is that there is a significant effect (p=0.001) of giving boiled bay leaves on reducing blood glucose levels. The suggestion for this research is to increase the number of respondents in the research as well as examination variables such as fasting blood glucose

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