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All Journal Current Biochemistry Folia Medica Indonesiana Journal of Natural Sciences and Mathematics Research Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Biotek Jurnal Keperawatan Terpadu (Integrated Nursing Journal) Poltekita : Jurnal Ilmu Kesehatan Jurnal Ners Jurnal Kolaboratif Sains Jurnal Pijar MIPA Jurnal Medical Laboratory Jurnal Ilmiah Pengabdian dan Inovasi Jurnal Multidisiplin Sahombu PCJN Pharmaceutical and Clinical Journal of Nusantara BIOCITY: Journal of Pharmacy Bioscience and Clinical Community

Kresnapati, I Nyoman Bagus Aji

Universitas Bumigora

Author-ID : 5804655

Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Ethanol Extract of Marigold Flower (Tagetes Erecta L.) Decreases The Total Cholesterol, Low Density Lypoprotein (LDL), Malondialdehyde (MDA), and Apoliprotein B (APOB) on Hyperlipidemia Rat Models I Nyoman Bagus Aji Kresnapati; Siti Khaerunnisa; Indri Safitri
Folia Medica Indonesiana Vol. 57 No. 3 (2021): September
Publisher : Universitas Airlangga

This study aimed to determine the effect of ethanol extract of gemitir flower (Tagetes erecta L.) on total cholesterol levels, Low-Density Lipoprotein C (LDL), Malondialdehyde (MDA), Apolipoprotein B (ApoB). Forty-eight Rattus norvegicus were randomly divided into 6 groups, groups were given standard feed (K-) and 5 groups of hyperlipidemia models (K +, P1, P2, P3, P4) were given High Fat Diet (HFD) for 35 days. On the 36th day, the total cholesterol levels were checked through the tail of Rattus norvegicus, and from day 37 to day 50 were given a normal diet (K-), HFD (K +), simvastatin 10 mg/kgBW (P1), ethanol extract of gemitir flowers (Tagetes erecta L.) 200 (P2), 400 BW (P3), and 800 mg/kgBW (P4). On day 51, the total cholesterol, LDL-C, MDA, and ApoB blood serum levels were checked. The results showed total cholesterol, Low-Density Lipoprotein (LDL), Malondialdehyde (MDA), and Apolipoprotein B (ApoB) given ethanol extract of gemitir flowers 200 and 400 mg/kgBW (P2) had a significant reduction (P < 0.05). Giving ethanol extract of gemitir flower (Tagetes erecta L.) could reduce levels of total cholesterol, LDL, MDA, and Apo B.

UJI EVALUASI FITOKIMIA TUMBUHAN HERBAL BERDASARKAN INFORMASI EMPIRIS PADA MASYARAKAT LOMBOK Nurul Indriani; MUHAMMAD EKA PUTRA RAMANDHA; I Nyoman Bagus Aji Kresnapati
Jurnal Medical Laboratory Vol. 2 No. 1 (2023): Januari: Jurnal MedLab
Publisher : Sekolah Tinggi Ilmu Kesehatan Kesetiakawanan Sosial Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/medlab.v2i1.131

Tujuan dari penelitian ini adalah untuk mengetahui potensi tumbuhan khas sasak dapat dijadikan bahan pengobatan atau obat alternatif oleh masyarakat. Uji yang dilakukan yaitu uji kulaitatif yaitu skrining fitokimia. Skrining dilakukan untuk mengetahui kandungan, alkaloid, flavonoid, terpenoid, tanin dan saponin. Penelitian ini merupakan penelitian dasar atau penelitian permulaan untuk menseleksi kandungan-kandungan obat dalam tumbuhan khas sasak. Preparasi sampel dilakukan pengeringan untuk mengurangi kadar air, dan masing-masing tumbuhan obat dilakukan maserasi dengan pelarut metanol 96% selama 2 x 24 jam. Ekstrak kental dilakukan pengujian menggunakan reagen menghasilkan warna tertentu. Hasil penelitian yaitu seluruh tumbuhan obat yang diuji berpotensi dijadikan obat dan dapat digunakan sebagai saran pengobatan oleh masyarakat.

Sosialisasi Meningkatkan Kesadaran Pentingnya Menabung Sejak Dini di TK Yarsi Mataram Puspita Ayu, Baiq Dinda; Aryani , R . Ayu Ida; I Nyoman Bagus Aji Kresna; Ana Rahmatyar; Muhammad Haris Nasri
Jurnal Ilmiah Pengabdian dan Inovasi Vol. 1 No. 2 (2022): Jurnal Ilmiah Pengabdian dan Inovasi (Desember)
Publisher : Insan Kreasi Media

The service program is one of the obligations of the implementation of the tri dharma of higher education that must be carried out. The Bumigora University service team has successfully carried out service at Yarsi Mataram Kindergarten. This result is to increase awareness of the importance of saving from an early age, the team provides socialization through playing and singing, storytelling (media storytelling) which in the story adds to the benefits of saving for children in the future, and quizzes. Teaching the importance of saving from an early age can shape children's character, children will be more responsible for the money they have, can save more, introduce the value of money later on, children will be able to distinguish which are priority needs and which are not.

Aktivitas Antimikroba Ekstrak Etanol Daun Sirsak (Annona muricata L) Terhadap Bakteri Gram Negatif Eschericia coli I Nyoman Bagus Aji Kresnapati; Sri Winarni Sofya
Jurnal Ners Vol. 7 No. 1 (2023): APRIL 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v7i1.12996

Sirsak (Annona muricata L) merupakan salah satu tanaman herbal yang bermanfaat bagi kesehatan, diantaranya dimanfaatkan sebagai antimikroba. Penelitian ini bertujuan menguji kandungan senyawa fenolik yang memiliki aktivitas antimikroba bakteri gram negatif Eschericia coli. Daun-daun yang telah dikeringkan di ekstraksi maserasi dengan dilarutkan dengan pelarut etanol 96% selama 3x24 jam. Hasil maserat pertama dan kedua di pekatkan dengan rotary evaporator. Hasil ekstrak di tes fitokimia untuk mengetahui kandungan senyawa fenolik pada daun sirsak. Uji aktivitas antimikroba dilakukan dengan metode difusi sumuran sebanyak 4 lubang pada media yang telah di inokulasi bakteri gram negatif Eschericia coli yang masing-masing lubang terdiri lubang A disuspensi etanol 96%, lubang B antibiotik standar 0,5 %, lubang C ekstrak etanol daun sirsak (EtDS 0,5%) dan lubang D EtDS 1%. Hasil penelitian berupa daerah jernih disekitar sumuran yang diameternya di ukur dengan penggaris. Hasil penelitian berupa rerata diameter antara kelompok A, B, C, dan D yang kemudian di bandingkan zona yang lebih luas dan kekuatan aktivias zona hambatnya. Hasil penelitian menunjukkan diantara 4 kelompok perlakuan, lubang sumuran yang di suspensi antibiotik 0,5% (A) memiliki diameter zoba hambat lebih luas dengan diameter 19,5 mm, kemudian EtDS 1% (D) 11,35 mm, EtDS 0,5% (C) 6,49 dan Et (A) 1,25 mm. Hasil penelitian menunjukkan aktivitas ekstrak etanol daun sirsak 1% (D) berpotensi sebagai antimikroba bakteri gram negatif Eschericia coli, namun tidak lebih efektif dibandingkan antibiotik standar 0,5%.

Familiar Edible Flowers in Indonesia I Nyoman Bagus Aji Kresnapati; Muhammad Eka Putra Ramandha; Nurul Indriani
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 01 (2022): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

Flowers besides being used as ornamental plants, they can also be consumed. Flowers that can be consumed are called Edible Flowers. Edible flowers in general can be consumed directly, usually in tea or can be served in the form of processed food. Edible flowers contain phytochemical compounds such as anthocyanins, flavonoids, phenolics, carotenoids which are useful as antioxidants. Indonesia is rich in biodiversity with a variety of plant species that can grow, including edible flowers. There is diversity, but only a few edibles that can grow and are familiar to Indonesian people will be reviewed in this article.

PERBEDAAN KADAR LIKOPEN PADA SAUS TOMAT YANG DIPRODUKSI SECARA TRADISIONAL DAN MODERN Bagus Aji Kresnapati; Baiq Yulia Hasni Pratiwi; Lalu Busyairi Muhsin
Jurnal Ilmu Kedokteran dan Kesehatan Vol 10, No 6 (2023): Volume 10 Nomor 6
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v10i6.10023

Abstrak: Perbedaan Kadar Likopen Pada Saus Tomat yang Diproduksi Secara Tradisional dan Modern. Likopen merupakan karotenoid yang mengandung pigmen dan dijumpai pada tumbuhan berwarna merah seperti pepaya, semangka, anggur merah, aprikot dan tomat. Likopen juga terdapat pada produk olahan tomat yang melalui proses pemanasan seperti saus tomat, sehingga lebih mudah diserap tubuh dibandingkan dengan tomat segar. Berdasarkan proses pembuatannya, saos tomat dibedakan 2 macam, saos tomat yang diproduksi secara modern dalam skala industri besar dan saos tomat tradisional yang diproduksi secara sederhana dalam skala industri rumahan. Salah satu kualitas saus tomat ditentukan oleh jumlah likopen yang terkandung di dalamnya. Tinggi rendahnya kadar likopen dapat menentukan tinggi rendahnya kualitas dan kuantitas tomat yang digunakan dalam pembuatan saus tomat. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan kadar likopen pada saus tomat yang diproduksi secara tradisional dan yang diproduksi secara modern. Penelitian ini merupakan penelitian observasional analitik yang bertujuan untuk mengetahui perbedaan kadar likopen pada saus tomat tradisional dan modern. Hasil penelitian menunjukkan kadar likopen tertinggi pada saus tomat tradisional sebesar 3,90 mg/100 g dan terendah 0,55. mg /100 gram; kadar likopen tertinggi saus tomat modern 9,56 mg/100 g dan terendah 5,80 mg/100 g. Rerata kadar likopen saos tomat tradisional 2,54 mg/100 g dan saus tomat modern 7,75 mg/100 g. Hasil di analisis dengan menggunakan uji statistik Independent T-test yang menunjukkan adanya perbedaan yang bermakna antara kadar likopen yang dihasilkan dengan cara tradisional dan cara modern (p=0,000<0,05).

Anemia Megaloblastik: Sebuah Tinjauan Pustaka I Ketut Wisnuaji Jayawardhana; I Nyoman Bagus Aji Kresnapati
Biocity Journal of Pharmacy Bioscience and Clinical Community Vol 1 No 1 (2022): Biocity: Journal of Pharmacy Bioscience and Clinical Community
Publisher : Department of Pharmacy, Bumigora University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30812/biocity.v1i1.2422

Anemia megaloblastik merupakan anemia yang ditandai dengan membesarnya eritroblast di sumsum tulang sehingga menganggu pematangan inti sel dan pembelahan sel eritrosit. Kelainan utamanya disebabakan karena defisiensi vitamin B-12 dan asam folat sehingga sintesis DNA terganggu. Diagnosis anemia megaloblastik dilakukan melalui anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang. Pengobatannya dilakukan berdasarkan etiologi yang mendasari. Semakin cepat didiagnosis, prognosisnya akan semakin baik. Penting untuk mengenali, mencegah, dan mengobati anemia megaloblastik.

Optimasi Ekstrak Daun Pecut Kuda Menggunakan Simplex Centroid Design: Kajian Sitotoksisitas : Optimization of horse leaf extraction using simplex centroid desaign: cytotoxicity study Sri Winarni Sofya; Eka Nurul Qomaliyah; Bagus Aji Kresnapati; I Made Kawi Widana; I Gusti Nyoman Hari Satwika
Jurnal Kolaboratif Sains Vol. 7 No. 3: MARET 2024
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v7i3.4963

Abstrak: Tanaman pecut kuda dapat mengurangi radang tenggorokan, amandel, batuk, pilek. Adapun potensi bioaktivitas tanaman pecut kuda diantaranya sebagai antioksidan, antibakteri, antiinflamasi. Senyawa kimia yang terdapat pada pecut kuda antara lain flavonoid, fenol, saponin, glikosida, tanin dan steroid. Senyawa tersebut memiliki karakteristik semipolar-polar sehingga untuk pemisahan senyawa menggunakan pelarut semipolar-polar. Metode pemisahan senyawa pada penelitian ini menggunakan metode maserasi. Pelarut yang digunakan berupa etanol,n-heksan dan etil asetat dan proses optimasi pelarut tersebut dapat dilakukan dengan salah satu teknik pada response surface mixture yaitu Simplex centroid design. Hasil optimasi dianalisis berdasarkan yield ekstraksi yang akan dilanjutkan dengan menentukan nilai konsentrasi bunuh minimum (LC50) sitotoksisitas yang diperoleh dari pengujian sitotoksisitas akut pada larva Artemia salina Leach setelah diberi perlakukan dan didiamkan selama 24 jam. Uji sitotoksisitas dilakukan pada ekstrak dengan nilai %yield ekstrak tertinggi yakni ekstrak etanol (kode EE). Nilai LC50 dari semua ekstrak menunjukan potensi toksik. LC50 yang diperoleh pada ekstrak etanol sebesar 343,094 g/mL. sehingga diperoleh informasi bahwa ekstrak etanol daun pecut kuda memiliki sitoksisitas aktif dan potensi bioaktivitas yang tinggi. Nilai LC50 < 1000 ?g/ml berbanding lurus dengan potensi antiproliferasi dan antibakteri begitupun juga dengan inhibisi enzimatis alpha-Glukosidase dan alpha-amilase dalam penelitian antidiabetes secara In Vitro, sehingga pengujian lanjutan terkait potensi ekstrak etanol daun pecut kuda sebagai antiproliferasi, antibakteri, uji inhibisi enzimatis alpha-Glukosidase dan alpha-amilase menjadi target penelitian lanjutan. Abstract: Horsewhip can reduce sore throats, tonsils, coughs and colds. The potential bioactivity of the horsewhip plant includes antioxidant, antibacterial and anti-inflammatory properties. Chemical compounds found in horse whip include flavonoids, phenols, saponins, glycosides, tannins and steroids. This compound has semipolar-polar characteristics so that the separation of the compound uses a semipolar-polar solvent. The method for separating compounds in this research uses the maceration method. The solvents used are ethanol, n-hexane and ethyl acetate and the solvent optimization process can be carried out using one of the response surface mixture techniques, namely Simplex centroid design. The optimization results were analyzed based on the extraction yield which will be followed by determining the minimum kill concentration (LC50) cytotoxicity value obtained from acute cytotoxicity testing on Artemia salina Leach larvae after being treated and left for 24 hours.Cytotoxicity test was carried out on the extract with the highest extract yield value, namely the ethanol extract (code EE). The LC50 value of all extracts showed toxic potential. The LC50 obtained from the ethanol extract was 343.094 g/mL. Thus, information was obtained that the ethanol extract of horse whip leaves has active cytotoxicity and high bioactivity potential. The LC50 value < 1000 ?g/ml is directly proportional to the antiproliferative and antibacterial potential as well as the enzymatic inhibition of alpha-glucosidase and alpha-amylase in in vitro antidiabetic research, so further testing is related to the potential of horsewhip leaf ethanol extract as antiproliferative, antibacterial, inhibition test Enzymatic alpha-Glucosidase and alpha-amylase are the targets of further research.

Omega-3 Fatty Acids and Vitamin D Combination Affected TG Levels in Rattusnorvegicus with Limited Fat Intake I Gede Angga Adnyana; I Nyoman Bagus Aji Kresnapati; I Putu Bayu Agus saputra; Maruni Wiwin Diarti; Yunan Jiwintarum
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 3 (2023): November
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i3.2248

Vitamin D is a group of secosteroids that have fat-soluble properties. Vitamin D regulates calcium absorption, bone growth and remodeling, and regulates metabolic processes and immunity. Omega-3 fatty acids are a type of polyunsaturated fatty acids (PUFAs) that are essential fatty acids for humans. Omega-3 fatty acids have various positive effects on health, especially cardiovascular-related ones. This study aims to determine the effect of omega-3 fatty acid and vitamin D combination on the TG/HDL-C ratio in high fat fed Rattus norvegicus. The research design is experimental study with a post-test-only control group design. This study used 24 male rats aged 3–4 months with a body weight of 250–300 grams which were divided into four groups; negative control group, positive control group; treatment group one; and treatment group two. The high-fat diet (HFD) is an additional (emulsion) feed added to standard feed with increased fat composition. The results showed that increased triglyceride (TG) levels of 83.40 mg/dL and HDL levels of 62.60 mg/dL after consumed high-fat diet. There was a significant decrease in TG levels of 54.15 mg/dL (p=0.026) and a decrease in HDL of 53.00 mg/dL (p>0.05, α=0,05) after administration of Omega-3 and Vitamin D combination. Conclusions in this study is the intake Omega-3 and Vitamin D combination has a positive effect on TG levels. Still, this positive effect must be accompanied by limiting the fat intake to the body. Meanwhile, combining Omega-3 and Vitamin D did not significantly affect HDL levels.

Effectiveness of Bay Leaf Decoction (Syzygium polyanthum) on Reducing Blood Glucose Levels in Paok Motong, Masbagik, East Lombok Nadi Kurniawan; Rozikin; I Putu Bayu Agus Saputra; Sabariah; I Nyoman Bagus Aji Kresnapati
Current Biochemistry Vol. 10 No. 2 (2023)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.10.2.2

One disease that correlates with blood glucose levels is diabetes mellitus (DM). According to Basic Health Research (RISKESDAS), in Indonesia by 2030 there will be an increase of up to 21.3 million people suffering from diabetes mellitus. However, nowadays most people are afraid of the side effects of using the drugs they consume and are turning to herbal therapy to lower blood glucose levels. Bay leaves have the benefit of treating diabetes mellitus, hypercholesterolemia, hypertension, diarrhea and gastritis. Phytochemical analysis shows that bay leaves contain essential oils, tannins, flavonoids and terpenoids. The aim of the research was to determine the effect of bay leaf boiled water on reducing blood glucose levels. The research was an experimental One Group Pretest Post-test Design, namely the research subjects had their blood glucose levels measured before (pre-test) and after being given bay leaf boiled water (post-test). 41 respondents in Paok Motong Barat village, Masbagik District, East Lombok Regency had their Blood Glucose Levels (GDS) measured before (pre-test) and after (post-test) giving 300 mL of bay leaf boiled water. Paired Test Statistical Analysis was used to determine the difference in pretest and posttest blood glucose levels given bay leaf boiled water. The results of the study showed that there was a significant decrease in blood glucose levels (p= 0.001) by 15.22 mg/dL to 179.27 mg/dL before administering bay leaf decoction amounting to 194.49 mg/dL. The conclusion is that there is a significant effect (p=0.001) of giving boiled bay leaves on reducing blood glucose levels. The suggestion for this research is to increase the number of respondents in the research as well as examination variables such as fasting blood glucose

Co-Authors Akmi, Alfarizi Muzaifa Ana Rahmatyar Anida, Rizki Putri Ayu Dwi Anjani, Desak Sri Ayu Aryani , R . Ayu Ida Baiq Dinda Puspita Ayu Baiq Yulia Hasni Pratiwi Eka Nurul Qomaliyah I GEDE ANGGA ADNYANA I Gede Angga Adnyana I Gusti Nyoman Hari Satwika I Ketut Wisnuaji Jayawardhana I Made Kawi Widana I Nengah Satria Wirananda I Putu Bayu Agus Saputra Indri Safitri Jayawardhana, I Ketut Wisnuaji Maruni Wiwin Diarti Maruni Wiwin Diarti Muchsin, Lalu Busyairi Mudawil Qulub Muhammad Eka Putra Ramandha Muhammad Haris Nasri Muhsin, Lalu Busyairi Nadi Kurniawan Novitarini Novitarini, Novitarini Nurul Indriani Ramadhani, Muhammad Wisda Pradja Rozikin Sabariah Sabariah Salsabila Yunita Kurniawan Siti Khaerunnisa Sofya, Sri Winarni Sri Winarni Sofya Yunan Jiwintarum Yunan Jiwintarum

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