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EFEK EKSTRAK AIR DAN HEKSAN HERBA SURUHAN Peperomia pellucida (L) Kunth) TERHADAP PENURUNAN KADAR ASAM URAT SERUM DARAH AYAM KAMPUNG JANTAN Yunarto, Nanang
Media Penelitian dan Pengembangan Kesehatan Vol 23, No 1 Mar (2013)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | http://ejournal.litbang.depkes.go.id/index.php/MPK/article/view/3060

Abstrak Salah satu tanaman yang selama ini digunakan masyarakat sebagai pilihan obat tradisional untuk asam urat adalah suruhan (Peperomia pellucida (L) Kunth). Penelitian ini dilakukan untuk menguji efek dari ekstrak air dan heksan herba suruhan terhadap penurunan kadar asam urat serum darah pada ayam kampung jantan. 40 ayam kampung jantan dibuat hiperurisemia dengan pemberian kombinasi antara jus hati ayam 4 ml/kg BB dan urea 1 mg/kg BB selama 12 hari. Hewan uji tersebut dibagi menjadi 8 kelompok. Kelompok I sebagai kontrol negatif dengan pemberian Polivinil Pirolidon (PVP) 0,5%. Kelompok II diberi Allopurinol 10 mg/kg BB sebagai kontrol positif, kelompok III-V diberi ekstrak air 100; 200; 400 mg/Kg BB dan kelompok VI-VIII diberi ekstrak heksan 100; 200; 400 mg/Kg BB. Pemberian bahan uji mulai hari ke-13 sampai 20. Pada hari ke-15,18 dan 21 diambil serum darah hewan uji melalui vena lateralis sayap untuk diukur kadar asam uratnya serta dihitung persentase penurunan kadar asam urat . Hasil uji secara pre klinik hari ke-21, ekstrak air herba suruhan 200 mg/Kg BB mampu menurunkan kadar asam urat paling tinggi yaitu 62,49±2,80% dan penurunan kadar asam urat dengan ekstrak heksan paling tinggi hanya 19,62±3,95% pada dosis 400 mg/Kg BB. Potensi ekstrak air 200 mg/Kg BB sebanding dengan Allopurinol 10 mg/Kg BB. Ekstrak air dan heksan herba suruhan memiliki khasiat untuk menurukan kadar asam urat yang mengindikasikan bahwa kandungan kimia dalam herba suruhan dapat dikembangan menjadi obat antihiperurisemia. Kata kunci : Peperomia pellucida (L) Kunth, asam urat, uji pre klinik, ekstrak air dan heksan Abstract One of the plants that had been used by the local people as a choice of traditional medicine for gout is suruhan (Peperomia pellucida (L) Kunth). This research was conducted to examine the effects of water and hexan extract of suruhan to decrease uric acid levels in cock. 40 cock made hyperuricemia with the administration combination of chicken liver juice 4 ml / kg and urea 1 mg / kg for 12 days. The test animals were divided into 8 groups. Group I as a negative control with administration of polyvinyl pyrrolidone (PVP) 0.5%. Group II was given allopurinol 10 mg/Kg BW as a positive control, a group III-V were given water extract 100; 200; 400 mg / Kg BW and group VI-VIII were given hexane extract 100; 200; 400 mg/Kg BW. Treatment begins day 13 to 20. On day 15, 18 and 21 were taken blood serum by vena lateralis wing vein to measure levels of uric acid, and calculated the percentage reduction in uric acid levels. From the result of pre clinic study on day 21, water extract of suruhan at the dose of 200 mg/Kg BW the highest decrease uric acid level about 62,49±2,80% and the highest decrease uric acid level with hexane extract is 19,62±3,95% at the dose of 400 mg/Kg BW. Potential water extract of suruhan 200 mg / kg BW is equivalent with Allopurinol 10 mg/kg BW. Water and hexan extract of suruhan has potency to decrease uric acid level that indicating the contain some chemical constituents in suruhan that possibly lead development to antihyperuricemia drug. Keywords : Peperomia pellucida (L) Kunth, uric acid, preclinic study, water and hexan extract

Pengaruh Penyalutan Terhadap Karakteristik Fisika Kimia dan Stabilitas Tablet Fraksi Etil Asetat Daun Gambir sebagai Agen Antidislipidemia Yunarto, Nanang; Sulistyowati, Indah; Kurniatri, Arifayu Addiena; Aini, Nurul
Media Penelitian dan Pengembangan Kesehatan Vol 27, No 2 (2017)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/mpk.v27i2.5873.

Gambir (Uncaria gambir, Roxb) with the main content of catechin compounds is a major comodity that is efficacious as an antidyslipidemia agent and reduce lesion atheloschlerosis. Catechins are found most often in gambir leaf extract, but are hygroscopic in order to increase the content and its stability is made in the fraction form and formulated in the film-coated tablet preparation. Coatings will protect the gambir from environmental influences. This study aims to find out the best formula of core tablets and film-coated tablets of ethyl acetate fraction of gambir leaf extract. The granulation method used using wet granulation. Optimization of the tablets coating formulation was carried out through three different formulas with the addition of 4, 6, and 8% coatings. The core tablet and the coat were tested for physical characteristics such as weight uniformity, crushed time, hardness, and tablet fragility, chemical characteristics of active substance content and accelerated stability test. The chemical physics evaluation of tablets shows all tablets meeting physical and chemical requirements. Accelerated stability test result obtained catechin content in the core tablets and coat membrane in the absence of loss potency more than 5%. The coated tablet has loss in potency smaller than core tablet. The greater the composition of the coating material used of coating the smaller the loss in potency of catechin content in tablets.AbstrakTanaman gambir (Uncaria gambir, Roxb) dengan kandungan utama senyawa katekin merupakan komoditas unggulan yang berkhasiat sebagai agen antidislipidemia dan mengurangi lesi aterosklerosis. Katekin ditemukan paling banyak pada ekstrak daun gambir, namun bersifat higroskopis sehingga untuk meningkatkan rendemen kandungan dan kestabilannya dibuat dalam bentuk fraksi dan diformulasikan dalam sediaan tablet salut selaput. Penyalut akan melindungi gambir dari pengaruh lingkungan. Penelitian ini bertujuan untuk mengetahui formula terbaik tablet inti dan tablet salut selaput fraksi etil asetat ekstrak daun gambir. Metode granulasi yang digunakan menggunakan granulasi basah. Optimasi formulasi penyalutan tablet dilakukan melalui tiga formula berbeda dengan penambahan bobot bahan penyalut 4, 6, dan 8%. Tablet inti dan salut dilakukan pengujian karakteristik fisika seperti keseragaman bobot, waktu hancur, kekerasan, kerapuhan tablet, karakteristik kimia berupa kadar zat aktif, dan uji stabilitas dipercepat. Evaluasi fisika kimia tablet menunjukkan semua tablet memenuhi persyaratan fisik dan kimia. Hasil uji stabilitas dipercepat diperoleh kandungan katekin dalam tablet inti maupun salut selaput tidak adanya loss in potency yang lebih dari 5%. Tablet salut memiliki loss in potency lebih kecil daripada tablet inti. Semakin besar komposisi bahan penyalut yang digunakan semakin kecil loss in potency kandungan katekin dalam tablet.

REVITALISASI PENGGUNAAN OBAT GENERIK Yunarto, Nanang
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 1, No 2 (2011): Oktober 2010 - Maret 2011
Publisher : University of Muhammadiyah Malang

The government through the Ministry of Health is very serious about revitalizing the use of generic drugs by issuing a policy that stipulated in the Regulation of the Minister of Health No. HK. 02.02/Menkes/068/1/2010 about duty to use generic drugs in government health care facilities. To maximize the use of generic drugs, it is very important to improve understanding and trust of society that generic drugs have the quality, safety and effectiveness are similar to branded drugs. Besides that, there is a lot of research and the study of generic drugs will increase the knowledge, so that health professionals, especially doctors do not hesitate to prescribe generic drugs. Quality used as a basis of reference to establish the truth of the eficacy and safety. For availability of certain products can be demonstrated in vitro. Studies of drug dissolution gave the same indication with drug bioavailability. Ideally, in vitro drug dissolution correlates bioavailability in vivo. From the research results of dissolution test generic drugs Amoxiciline 500 mg tablets, Isosorbit Dinitrat 5 mg tablets and Omeprazole capsules compared to branded drugs show no less generic drugs than branded drugs, dissolution test results even better generic drugs

REVITALISASI PENGGUNAAN OBAT GENERIK Nanang Yunarto
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 1 No. 2 (2011): Oktober 2010 - Maret 2011
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/far.v1i2.1170

The government through the Ministry of Health is very serious about revitalizing the use of generic drugs by issuing a policy that stipulated in the Regulation of the Minister of Health No. HK. 02.02/Menkes/068/1/2010 about duty to use generic drugs in government health care facilities. To maximize the use of generic drugs, it is very important to improve understanding and trust of society that generic drugs have the quality, safety and effectiveness are similar to branded drugs. Besides that, there is a lot of research and the study of generic drugs will increase the knowledge, so that health professionals, especially doctors do not hesitate to prescribe generic drugs. Quality used as a basis of reference to establish the truth of the eficacy and safety. For availability of certain products can be demonstrated in vitro. Studies of drug dissolution gave the same indication with drug bioavailability. Ideally, in vitro drug dissolution correlates bioavailability in vivo. From the research results of dissolution test generic drugs Amoxiciline 500 mg tablets, Isosorbit Dinitrat 5 mg tablets and Omeprazole capsules compared to branded drugs show no less generic drugs than branded drugs, dissolution test results even better generic drugs

Effect of Ethanolic Leaves Extract of Peperomia pellucida (L) Kunth as Antimalarial and Antioxidant Nanang Yunarto; Hanief Mulia Ar Rossyid; Lisa Andriani Lienggonegoro
Media Penelitian dan Pengembangan Kesehatan Vol 28 No 2 (2018)
Publisher : Sekretariat Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/mpk.v28i2.132

In malaria infection, the Plasmodium parasites break down hemoglobin in the host's red blood cells into toxic free heme and amino acids. Plasmodium is also capable of converting free heme to non-toxic hemozoin through a polymerization process. Malaria infection, on the other hand, also triggers the formation of free radicals that affect the pathophysiology of malaria. Suruhan leaf (Peperomia pellucida (L.)Kunth) has long been used as an antimalarial and is known to contain large flavonoids that function as antioxidants. In this study, leaf extraction, inhibitory activity of heme polymerization assay, and antioxidant activity assay were performed. Organoleptically, leaf extract obtained in the form of dry blackish green coloured extractswith a bitter taste and the typical scent of suruhan leaves. The yield of the extract obtained was 18.28%, water content was 7.73%, drying shrinkage was 9.16%, and total ash content was 0.46%. The IC50 value of inhibition activity of heme polymerization of ethanol extract of the Suruhan leaves was 0.93 mg / mL, smaller compared to chloroquine(1.48 mg / mL)while the value of IC50. antioxidant activity of ethanol extract of leaf syrup was 32.94 mg / mL compared to Vitamin C of 4 mg/mL. In conclusion,ethanolic leaves extract of suruhan has inhibitory activity of heme polymerization and antioxidant activity so that it has potentiality as antimalarial drugs

Gambir (Uncaria gambir Roxb.) as A Potential Alternative Treatment for Hyperlipidemia Nanang Yunarto; Novi Sulistyaningrum; Arifayu Addiena Kurniatri; Berna Elya
Media Penelitian dan Pengembangan Kesehatan Vol 31 No 3 (2021)
Publisher : Sekretariat Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/mpk.v31i3.4472

Gambir (Uncaria gambir Roxb.) is a member of family of Rubiaceae. In Asia including Indonesia, extracts of gambir are empirically used daily to weed out. The high content of catechin flavonoids in gambir has a pharmacological effect in the treatment of hyperlipidemia that potential to be developed into traditional medicine. This literature review aimed to examine the potency of pharmacological effect of gambir as hyperlipidemia treatment therapy based on the results of studies in silico, in vitro, in vivo pharmacological effects and its safety to provide evidence of scientific information to the community. The literatures used for analysis in this study including evidence-based articles on both pharmacology and safety which are available in Pubmed and Google Scholar. The results showed a very strong potency of gambir plants in the treatment of hyperlipidemia with catechin as bioactive compounds. In silico study revealed mechanism action of catechin as antihyperlipidemic using 2 pathways, inhibition of the enzyme HMG-CoA reductase and increase the LDL receptors. In vitro studies of catechin are able to inhibit lipid absorption in the intestine through inhibition of pancreatic lipase activity, lipid hydrolysis and emulsification, micelle cholesterol deposition. Pre-clinical tests on animals showed that the ethyl acetate fraction of gambir leaves was able to reduce the levels of total cholesterol, triglycerides, LDL and increase blood plasma HDL. The long-term use of gambir leaves has been proven to be safe, not mutagenic, no hematological, clinical biochemical abnormalities and no abnormalities in the vital organs of the animal models. Abstrak Gambir (Uncaria gambir Roxb) adalah tumbuhan perdu dari suku Rubiaceae. Di Asia termasuk Indonesia, secara empiris ekstrak gambir digunakan sehari-hari untuk menyirih. Kandungan flavonoid katekin yang tinggi dalam gambir memiliki efek farmakologi dalam pengobatan hiperlipidemia yang berpotensi untuk dikembangkan menjadi obat tradisional. Kajian literatur ini bertujuan untuk mengkaji potensi farmakologi gambir sebagai terapi pengobatan hiperlipidemia berdasarkan hasil studi efek farmakologi in silico, in vitro, in vivo efek farmakologi dan keamanannya, sehingga memberikan bukti informasi ilmiah kepada masyakarat. Literatur yang digunakan dalam proses review meliputi literatur dengan berbasis bukti baik farmakologi maupun keamanan yang tersedia di Pubmed dan Google Scholar. Hasil kajian menunjukkan potensi yang sangat kuat dari tanaman gambir dalam pengobatan hiperlipidemia dengan katekin sebagai senyawa bioaktif utama. Studi in silico menunjukkan mekanisme aksi katekinsebagai antihiperlipidemia menggunakan dua jalur yaitu penghambatan enzim HMG-CoA reduktase dan peningkatan reseptor LDL. Studi in vitro katekin mampu menghambat penyerapan lipid di usus melalui penghambatan aktivitas lipase pankreas, hidrolisis lipid dan emulsifikasi, serta pengendapan kolesterol misel. Studi in vivo menunjukkan fraksi etil asetat daun gambir mampu menurunkan kadar kolesterol total, trigliserida, LDL dan meningkatkan HDL plasma darah. Penggunaan daun gambir dalam jangka panjang terbukti aman, tidak mutagen, tidak ditemukan kelainan hematologi, biokimia klinis dan tidak menyebabkan kelainan organ vital hewan uji.

VALIDATION OF SPECTROPHOTOMETRY METHOD FOR DETERMINATION OF (+)-CATECHIN IN ETHYL ACETATE FRACTION OF GAMBIR EXTRACT (Uncaria gambir Roxb.) Nanang Yunarto; Uud Nourma Reswandaru; Indah Sulistyowati; Indhira Oliffia Prameswari; Qotrunnada Linggar Pinanditi; Tri Madesa Patadungan
Jurnal Tumbuhan Obat Indonesia Vol 14 No 2 (2021): Jurnal Tumbuhan Obat Indonesia
Publisher : Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jtoi.v14i2.4846

ABSTRACT Gambir leaves (Uncaria gambir Roxb.) is a plant that has been widely used by people for traditional medicine. The main compound of gambir extract is a (+)-catechin that has been proven as anti-dental plaque, antioxidant, antibacterial, and antihyperlipidemic. This study aims to validate a method for the quantitative determination of catechin in ethyl acetate fraction of gambir extract based on spectrophotometry. The validation was conducted by measuring the linearity, accuracy, and ruggedness of the method that fulfills the requirements along with the limit of detection (LoD) and limit of quantification (LoQ) determination. Determining the precision (based on %RSD and CV), 100 ppm of catechin were made to 7 replicates while accuracy was evaluated by calculating the recovery. The ruggedness of the method is determined by analyzing it on a different day. The linearity was determined by assessing the r-value on the relation between the absorbance curve and standard series concentration. The LoD and LoQ could be calculated based on the standard curve equation. The results showed the method fulfilled the linearity requirement with R 0.9996; had precision in 1.23% RSD; had accuracy in the range of 100.80% to 101.64%; the method ruggedness was not significantly different; had 3.85 ppm of LoD and 12.84 ppm of LoQ. The validation method showed a valid result, and the method can be used for routine analysis on the measurement of catechin in ethyl acetate fraction of gambir extract. Keywords: Catechin, Uncaria gambir, Method Validation, Spectrophotometry ABSTRAK Daun gambir (Uncaria gambir Roxb.) merupakan tanaman yang telah banyak dimanfaatkan masyarakat dalam pengobatan tradisional. Senyawa utama ekstrak gambir adalah (+)-katekin yang telah terbukti sebagai anti plak gigi, antioksidan, antibakteri, dan antihiperlipidemia. Penelitian ini bertujuan untuk memvalidasi suatu metode penentuan kuantitatif katekin dalam fraksi etil asetat ekstrak gambir secara spektrofotometri. Validasi dilakukan dengan mengukur linearitas, akurasi, dan kekasaran metode yang memenuhi persyaratan beserta penetapan Limit of Detection (LoD) dan Limit of Quantification (LoQ). Penentuan presisi (berdasarkan %RSD dan CV), 100 ppm katekin dibuat 7 ulangan sedangkan akurasi dievaluasi dengan menghitung perolehan kembali. Kekasaran metode ditentukan dengan menganalisisnya pada hari yang berbeda. Linearitas ditentukan dengan mengukur nilai r pada hubungan antara kurva absorbansi dan konsentrasi seri standar. Berdasarkan persamaan kurva standar, maka LoD dan LoQ dapat dihitung. Hasil penelitian menunjukkan metode memenuhi syarat linearitas dengan R 0,9996; memiliki presisi di 1,23% RSD; memiliki akurasi pada kisaran 100,80% sampai dengan 101,64%; kekasaran metode tidak berbeda nyata; memiliki 3,85 ppm LoD; dan 12,84 ppm LoQ. Validasi menunjukkan hasil yang valid, dan metode tersebut dapat digunakan untuk analisis rutin pada pengukuran katekin dalam fraksi etil asetat ekstrak gambir. Kata kunci: Catechin, Uncaria gambir, Validasi Metode, Spektrofotometri

Uji Stabilitas Fisik Formula Body scrub Kombinasi Ekstrak Daun Gambir (Uncaria gambir (Hunter) Roxb) dan Daun Nilam (Pogostemon cablin (Blanco) Benth.) Yunarto, Nanang; Furqon, Ainun; Reswandaru, Uud Nourma; Sari, Diah Permata
Edu Masda Journal Vol 7, No 2 (2023): Edu Masda Journal Volume 7 Nomor 2
Publisher : STIKes Kharisma Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52118/edumasda.v7i2.161

Excessive accumulation of dead skin cells can cause skin problems. This can cause premature aging caused by oxidative stress in the body due to free radicals. So we need antioxidants to ward off free radicals. One of the natural antioxidants obtained from gambier and patchouli plants with antioxidant levels of 73.3% and an IC50 of 1.538 ppm, respectively, The purpose of this is to formulate a body scrub preparation with a combination of gambir extract (Uncaria gambir (Hunter) Roxb.) combined with patchouli (Pogostemon cablin (Blanco) Benth.) and to test the quality of research and find the preparation. The body scrub formula is made with three FI formulas; gambier leaves 15% and patchouli leaves 3%, FII; gambier leaves 20% and patchouli leaves 5%, FIII; gambier leaves 25% and patchouli leaves 7%. The process of making body scrub preparations using the emulsification method. The results showed that the three formulas were homogeneous, there was no organoleptic change, the average pH range was 6–5.6, which met the pH requirements according to SNI 16-4399-1996, and the average dispersion was 32.4–34.8. A body scrub is stable in storage temperature (40 °C ± 2 °C) for 4 weeks. The combination extract of gambier and patchouli leaves can be formulated into a body scrub preparation that is stable and meets the requirements. Body scrub Formulation II is a body scrub formulation with the best physical strength.AbstrakPenumpukan sel kulit mati yang berlebihan dapat menyebabkan permasalahan pada kulit. Hal tersebut dapat menimbulkan penuaan dini yang disebabkan adanya stress oksidatif di dalam tubuh karena radikal bebas. Sehingga diperlukan antioksidan untuk menyangkal radikal bebas. Salah satu antioksidan alami didapatkan dari tanaman gambir dan nilam dengan masing-masing kadar antioksidan 73,3% dan IC50 1,538 ppm. Tujuan dari penelitian ini untuk melakukan formulasi sediaan body scrub dengan kombinasi ekstrak gambir (Uncaria gambir (Hunter) Roxb.) yang dikombinasikan dengan nilam (Pogostemon cablin (Blanco) Benth.) dan menguji mutu fisik serta mengevaluasi stabilitas sediaanya. Formula body scrub dibuat dengan tiga formula FI; daun gambir 15% dan daun nilam 3%, FII; daun gambir 20% dan daun nilam 5%, FIII; daun gambir 25% dan daun nilam 7%. Proses pembuatan sediaan body scrub dengan metode emulsifikasi. Hasil pengamatan menunjukkan bahwa ketiga formula homogen, tidak terjadi perubahan organoleptis, rentang rata-rata pH 6-5,6 yang memenuhi syarat pH menurut SNI 16-4399-1996 dan rata-rata daya sebar 32,4-34.8. Body scrub stabil dalam penyimpanan suhu (40ºC ± 2ºC ) selama 4 minggu. Ekstrak kombinasi daun gambir dan nilam dapat diformulasikan menjadi sediaan body scrub yang stabil dan memenuhi persyaratan. Formulasi II adalah formulasi body scrub dengan stabilitas fisik yang paling baik.

Indonesian Cinnamon (Cinnamomum burmanni (Nees & T. Nees) Blume) as Promising Medicinal Resources: A Review Handayani, Aisyah; Lailaty, Intani Quarta; Rosyidah, A'liyatur; Sari, Dewi Ratih Tirto; Yunarto, Nanang; Suherman, Dadang
Jurnal Sylva Lestari Vol. 12 No. 3 (2024): September
Publisher : Department of Forestry, Faculty of Agriculture, University of Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jsl.v12i3.929

Cinnamomum burmanni (Lauraceae) is one of the Cinnamomum species native to Indonesia. Given the worldwide use of cinnamon, the famous spice derived from its bark, cinnamon is also considered to possess medicinal properties. Consequently, a comprehensive review of C. burmanni was conducted to explore its medicinal benefits. This paper reviews several studies on the traditional use of C. burmanni in Indonesia, its phytochemistry, and its pharmacological properties. Traditionally, C. burmanni is utilized not only as spices but also for medicinal purposes, food ingredients, and ritual purposes. The bark is the most commonly used part, while few other parts of the plant are used. Several phytochemical compounds of C. burmanni have been identified. C. burmanni also has been reported to exhibit a wide range of biological activities. From those studies, it can be concluded that the medicinal use of C. burmanni’s bark has been scientifically validated due to its rich content of active compounds. Furthermore, other parts of C. burmanni should be analyzed to determine their content of active compounds. Keywords: active compound, Cinnamomum burmanni, medicinal plant, spice, traditional medicine

The Pharmaceutical Availability of Gambier Leaves Bioactive Fraction Coated Tablet in Simulated Human Body Fluids Sulistyowati, Indah; Yunarto, Nanang; Aini, Nurul; Arifin, Kelik M
Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 2, AGUSTUS 2018
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v8i2.321

The widespread usage of traditional medicine either in the developed or developing countries, makes traditional medicine requirements become a major concern in terms of assuring the safety and effectiveness of treatment. WHO suggested dissolution study to support traditional medicine clinical trials. The catechins from Gambier could reduce atherosclerotic lesions case caused by elevated levels of cholesterol, LDL, and triglycerides. Catechin is hygroscopic that becoming unstable. Raising the stability, Gambier is made to a coated tablet. This study aimed to determine the condition of gambier leaves bioactive fraction coated tablet in simulated human body fluids through an in vitro testing using dissolution tester. Three formulations coated tablet with different coating percentage had been tested using dissolution tester apparatus. The test was conducted in water, acid, and buffer as dissolution medium to generate the dissolution profile. Tablet evaluation showed that the three formulations dissolved 71.25% ± 6.26 to 91.05% ±3.05 in the water, acid, and buffer dissolution medium. The gambier leaves bioactive fraction coated tablet had more than 70% pharmaceutical availability in simulated human body fluids.

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