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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmiah Cendekia Eksakta

Yulias Ninik Windriati

Universitas Wahid Hasyim

Author-ID : 418565

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Mechanical Engineering Medicine & Pharmacology Public Health

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Optimasi Formula Tablet Ekstrak Daun Sirih Merah (Piper crocotum Ruiz & Pav) dengan Metode Kempa Langsung Menggunakan Desain Faktorial Sugiyono, Sugiyono; Iftitah, Aqib Ossa Eldurr; Windriyati, Yulias Ninik
Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Vol 2, No 1 (2016): Pharmauho
Publisher : Fakultas Farmasi Universitas Halu Oleo

Ekstrak daun sirih merah (Pipercrocotum, Ruiz &Pav) memiliki khasiat salah satunya adalah sebagai mukolitik. Ekstrak dalam sediaan tablet dipengaruhi eksipien dan metode pembuatan. Avicel PH 102 sebagai bahan pengisi-pengikat dan Explotab sebagai bahan penghancur dapat dikombinasikan dalam tablet dengan metode kempa langsung. Penelitian ini bertujuan untuk mencari formula optimal tablet daun sirih merah dengan metode kempa langsung menggunakan desain faktorial. Ekstrak dibuat secara perkolasi dengan etanol 70%.Tablet ekstrak daun sirih merah dibuat dalam 4 formula dengan eksipien Avicel PH 102-ExplotabÂ Â (F1 : 20%-2%, F2 : 90%-2%, F3 : 20%-8%, F4 : 90%-8%) dari bobot ekstrak menggunakan metode kempa langsung. Dilakukan optimasi menggunakan Design Expert version 8.0.6.1. Formula optimum divalidasi dan dianalisis menggunakan uji One sample T-test. Hasil penelitian menunjukkan bahwa Avicel PH 102 dan Explotab memberikan pengaruh meningkatkan kekerasan serta menurunkan kerapuhan dan waktu hancur. Interaksi keduanya memberikan pengaruh dalam menurunkan kekerasan serta meningkatkan kerapuhan dan waktu hancur. Formula optimum dengan kombinasi Avicel PH 102 sebesar 75,5% dan Explotab sebesar 2% terbukti valid.Kata kunci: Avicel, Explotab, Desain Faktorial, Kempa Langsung, Daun Sirih Merah.

DISOLUSI DAN KARAKTER FISIKOKIMIA ASAM FENOFIBRAT DALAM DISPERSI PADAT PERMUKAAN DENGAN SODIUM STARCH GLYCOLATE Yulias Ninik Windriyati; Ayu Shabrina
CENDEKIA EKSAKTA Vol 4, No 1 (2019)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.3194/ce.v4i1.2673

Asam fenofibrat merupakan antihiperlipidemia yang sangat sukar larut dalam air sehingga disolusinya ditingkatkan dengan pembentukan dispersi padat permukaan untuk meningkatkan bioavailabilitasnya. Penelitian ini bertujuan untuk mengetahui disolusi dan karakter fisikokimia asam fenofibrat dalam sistem dispersi padat permukaan dengan sodium starch glycolate. Dispersi padat permukaan dibuat dengan metode co-evaporation dan hasilnya diuji disolusi dalam medium dapar fosfat pH 6,8. Karakterisasi partikel dilakukan dengan SEM, XRD, DTA dan FTIR. Disolusi asam fenofibrat meningkat setelah berada dalam sistem dispersi padat permukaan dengan sodium starch glycolate. Foto SEM menunjukkan terjadi perubahan habit kristal setelah mengalami rekristalisasi dalam etanol 96%. Analisis XRD membuktikan terjadi penurunan kristalinitas partikel asam fenofibrat dan hasil uji DTA tidak menunjukkan transformasi polimorf dalam sistem dispersi padat permukaan. Sedangkan analisis FTIR menunjukkan tidak terjadi interaksi kimia antara asam fenofibrat dengan sodium starch glycolate. Kata kunci: asam fenofibrat, sodium starch glycolate, dispersi padat permukaan

PENGARUH VARIASI KONSENTRASI PEKTIN KULIT BUAH JERUK BALI (Citrus maxima MERR.) SEBAGAI SUSPENDING AGENT TERHADAP SIFAT FISIK SUSPENSI MAGNESIUM HIDROKSIDA yulias ninik windriyati; ika kurnaningsih; mufrod mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 1 JUNI 2008
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTSuspention is the most effective liquid dosage form for magnesium hydroxide because the compound relatively insoluble in water. Pectin as suspending agent has been used to inhibit sedimentation of suspension. The aim of this research is to know physical and chemical characteristic of pectin from Bali Citrus Peels and the influence of difference concentration of pectin and storage duration to physical characteristic of magnesium hydroxide suspensions. Pectin powder was extracted from Bali Citrus Peels with 70% ethanol. Magnesium hidroxide suspensions were made in three formulas with pectin concentration 0.75%, 1.00% and 1.25%. The suspensions was tested for their physical characteristic such as particle sizes, viscosity, sediment volume, redispersibility and fluidity (easiness to be poured) for 4 weeks. The result of this research shown that the pectin from Bali Citrus Peels can be used as suspending agent. The pectin powder has 15.26% water content, pH 3 and no amylum. The viscosity of mucilago was 33.33 cP for 0.75% concentration of pectin, 37.17 cP for 1.00%, and 40.50 cP for 1.25% respectively at the time of preparation. The difference concentration of pectin and its storage duration significantly affected particle sizes, viscosity, redispersibility and fluidity, while sediment volumes had influenced until the end of first week. Keywords: Pectin made of Bali Citrus Peels, Physical Characteristic and Suspensions

PENGEMBANGAN FILM TRANSDERMAL DILTIAZEM HCl TIPE MATRIKS DENGAN KOMBINASI POLIMER POLIVINIL ALKOHOL DAN ETIL SELULOSA SERTA PENINGKAT PENETRASI PEG 400 Yulias Ninik Windriyati; Aenul Sholikhah; Fauziah Muliawati
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI & FARMASI KLINIK VOL. 13 NO. 1 JUNI 2016
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Diltiazem hydrochloride (diltiazem HCl), a calcium channel blocker is widely used in the management of angina pectoris and hypertension. Because of its short biological half-life (3.5 h) and low oral bioavailability (40%) due to extensive hepatic metabolism leading to high frequency drug dosing. Therefore, diltiazem HCl is a suitable drug for transdermal formulation to improve bioavailability of the drug, patient’s convenience and compliance due to less frequent administration. The objective was to characterized the physicochemical properties and permeation of matrix film transdermal diltiazem HCl that prepared with polymers (PVA & EC) and PEG 400 as penetration enhancer. In this study, six formulation were prepared in different ratio of film forming polymers (5:5 & 7:3), and 15%, 20%, 25% of PEG 400. Developed transdermal film were characterized for weight uniformity, thickness, folding endurance, moisture uptake, drug content and in vitro permeation study using commercial semi permeable membrane. The crystall of drug excipient interaction were evaluated using X-ray diffraction technique. All the formulations were found to be suitable for formulating in terms of physicochemical characteristics and there was no significant differences. The in vitro skin permeation profiles showed increased flux values with increase of PEG 400 as penetration enhancer. The X-ray diffraction studies revealed that the crystallinity of the drug decreased as the proporsion of PVA in the film increased. Keywords : diltiazem HCl, PEG 400, PVA, patch transdermal, permeation

FORMULASI TABLET HISAP EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocotum Ruiz & Pav.) DENGAN PEMANIS SORBITOL-LAKTOSA-ASPARTAM Akhmad Jazuli; Yulias Ninik Windriyati; Sugiyono Sugiyono
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Perkembangan Terbaru Pemanfaatan Herbal Sebagai Agen Preventif Pada Tera
Publisher : Universitas Wahid Hasyim Semarang

ABSTRAK Sirih merah (Piper crocotum Ruiz & Pav.) adalah salah satu tanaman obat yang biasa digunakan untuk mengobati penyakit diantaranya batuk. Untuk memudahkan penggunaan maka dibuat dalam bentuk sediaan tablet hisap. Penelitian ini bertujuan untuk mengetahui sifat fisik tablet hisap ekstrak etanol daun sirih merah dengan pemanis sorbitol-laktosa-aspartam dan respon rasanya. Ekstrak daun sirih merah diperoleh secara perkolasi dengan penyari etanol 70%. Tablet hisap dibuat dengan metode granulasi basah dengan 5 formula yang mengandung pemanis sorbitol-laktosa sebagai fase internal yakni : FI (0%-82%), F II (20,5%-61,5%), F III (41%-41%), F IV (61,5%-20,5%), F V (82%-0%) dan aspartam sebagai fase eksternal sebanyak 10%. Granul diuji sifat fisiknya meliputi kecepatan alir, sudut diam, dan kompresibilitas. Tablet hisap diuji sifat fisiknya meliputi keseragaman bobot, kekerasan, kerapuhan, waktu melarut dan uji tanggapan rasa. Data tersebut dibandingkan dengan Farmakope Indonesia dan pustaka lainnya. Selain itu data sifat fisik tablet dianalisis secara statistik menggunakan uji Kruskal Wallis, dilanjutkan uji Mann Whitney dengan taraf kepercayaan 95%. Uji tanggapan rasa dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa penggunaan pemanis sorbitol-laktosa-aspartam menghasilkan tablet hisap yang memenuhi persyaratan sifat fisik tablet. Formula V dengan sorbitol-laktosa (82%-0%) dan aspartam 10% dapat diterima oleh 90% responden. Kata kunci : Ekstrak Etanol Daun Sirih Merah, Sorbitol-laktosa-aspartam, Tablet hisap,.

PERBANDINGAN DISOLUSI ASAM MEFENAMAT DALAM SISTEM DISPERSI PADAT DENGAN PEG 6000 DAN PVP yulias ninik; sugiyono sugiyono; widhi astuti; maria faizatul
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.1 JUNI 2014
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Mefenamic acid is an analgetic that insoluble in water, therefore several approaches are required to improve the dissolution and bioavailability. The aim of this research is to know the dissolution of mefenamic acid in solid dispersion system with PEG 6000 and PVP. Solid dispersion of mefenamic acid-PEG 6000 were prepared by fusion method and mefenamic acid-PVP by solvent evaporation method with contain PEG 6000 or PVP for FI (20%), FII (40%), FIII(60%), FIV (80%) and FV (100%) respectively were compared with the weight of mefenamic acid. The powder of solid dispersion systems were investigated for its recovery and dissolution in medium fosfat buffer pH 7.4 until 60 minutes. Pure mefenamic acid and the physical mixture with polimer were used as compared powders. The result of dissolution testing were revealed by Dissolution Efficiency (DE60). The result showed that both PEG 6000 and PVP can increased the dissolution of mefenamic acid from solid dispersion systems. The DE60 of mefenamic acid-PEG 6000 from FI 38,81%; FII 51,05%; FIII 62,87%; FIV 75,63%; FV 87,03%; and the physical mixture of FV 58,84% respectively. Meanwhile the DE60 mefenamic acid-PVP from FI 26,76%; FII 37,78%; FIII 45,23%; FIV 62,41%; FV 82,71%; and the physical mixture of FV 26,44% respectively. Keywords : mefenamic acid, PEG 6000, PVP, solid dispersion, dissolution

PENGARUH VARIASI KADAR AMILUM GARUT (Maranta arundinaceae Linn) SEBAGAI BAHAN PENGIKAT TERHADAP SIFAT FISIK DAN KIMIA TABLET PARASETAMOL Sugiyono Sugiyono; Pipit Murdiyani; Yulias Ninik Windriyati
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.9 No.2 Desember 2012
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Starch had a characteristic that could be used as a binder. Arrowroot starch containing amylose and amylopectin which could be used as a binder. Paracetamol had the flow properties and compactibility badly, it was necessary to make granules by wet granulation method (Voigt, 1984). This study aimed to determine the influence of variations in levels of arrowroot starch as a binder to the physical and chemical properties of paracetamol tablets. This research was conducted by mixing paracetamol with mucilago amylum arrowroot (FI: 5%, FII: 7.5%, FIII: 10%, FIV: 12.5%, and FV: 15%) and were given lactose, sifted, and dried. Granules sifted back, plus primogel and magnesium stearate. Mixed granules tested flow rate, rupose angle and tapping index . The granules was then into tablet and then their physical properties were observed, including weight uniformity, hardness, brittleness, and dissolving time.The active substance content was decided based on Farmakope Indonesia Edisi III. The data gathered were then analyzed theoretically by comparing then against what were stated in the literature and statistic cally tested by using one way ANAVA with a confidence degree of 95%, which was then furthered by using the Tuckey test. The result that the starch contained in the arrowroot could be used as a paracetamol tablet binder. Tablets of all formulas met the requirements of a good tablet physical properties. Hardness and tablet disintegration time increased with increasing levels of arrowroot starch as binder, while the fragility of the tablet decreased. Key words: arrowroot amylum, binder, Tablet parasetamol

PENGARUH PERBEDAAN KONSENTRASI EKSTRAK ETER REBUSAN DAUN SIRIH (Piper betle Linn) DALAM SEDIAAN SALEP TERHADAP SIFAT FISIK DAN DAYA ANTIBAKTERINYA yulias ninik windriyati; esti oktaria
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 2 DESEMBER 2008
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTBetle leaves has been used as antibacteria or antiseptic and was formulated in gargle. Betel leaves extractformulated in ointment in order to practical and effective to the skin. The aim of this research is to know the influenceof difference concentration of betle leaves extract in ointment to its physical properties and antibacteria effet againtsStaphylococcus aureus.Extract was obtained from leaves of the plant by decoction and continued by extraction with ether. Ointmentwere made in fine formulas with extract concentration 0.2, 0.4, 0.6, 0.8 and 1% w/w. The ointment was tested for itsphysical properties such as consisted of homogenity, viscosity, stickness and spreadibility. Antibacterial activityagaints Staphylococcus aureus was tested by diffusion method.The result of this research shown that the ointment homogenous. The difference of extract concentration had notinfluence on their viscosity and dispersive power, however had influence on their fixed time. The ointment of betleleaves extract had antibacterial activity againts Staphylococcus aureus.Keywords: Betle leaves extract, Ointment, Physical Test, antibacteri

EVALUASI IN VITRO-IN VIVO FILM TRANDERMAL DILTIAZEM HCL DENGAN PENINGKAT PENETRASI PEG 400 SEBAGAI ANTIHIPERTENSI Yulias Ninik Windriyati; Risha Fillah Fithria; Fitria Dwi Kurniawati; Ulfa Risalatul Mukaromah
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 1 Juni 2019
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTDiltiazem HCL is an antihypertensive that low oral bioavailability of 40%, so developed to transdermal preparations. A matrix type of transdermal patch of diltiazem HCl was prepared using polyvinyl alcohol and ethyl cellulose with PEG 400 as penetration enhancer. In vitro-in vivo evaluation were conducted to asses drug permeation through the skin and determine the effectiveness of transdermal film as an antihypertensive drug. Transdermal patches of diltiazem HCl were evaluated for physicochemical characteristics weight variation, thickness, folding endurance, moisture uptake, and drug content. In vitro permeation study was conducted using commercial semi permeable membrane in Franz diffusion cell. In vivo activity study was evaluated on male rat Wistar that induced NaCl with CODA non-invasive blood pressure method. Transdermal patches of diltiazem HCl were found no significant differences in terms of physicochemical characteristics. The in vitro skin permeation profiles showed increased flux values with the increase of PEG 400 as a penetration enhancer. The in vivo evaluation showed a reduction in systolic and diastolic blood pressure within one hour after the drug administration. Diltiazem HCl was able penetration into skin, absorbed in blood circulation and effective as antihypertensive via transdermal route.Keywords : antihypertension, diltiazem HCl, PEG 400, transdermal patch

PENGARUH PENGGUNAAN AMILUM BIJI DURIAN (Durio Zibethinus L.) SEBAGAI BAHAN PENGHANCUR YANG DITAMBAHKAN SECARA INTERNAL-EKSTERNAL TERHADAP SIFAT FISIK DAN KIMIA TABLET IBUPROFEN Sugiyono Sugiyono; Hilda Shofia Afriliana; Yulias Ninik Windriati
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.10 No.1 Juni 2013
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Keyword : durian seeds amylum, disintegrant, ibuprofen tablets. Amylum is a polysaccharide inside plant that was saved as a food reserves in fruit seed. One of the amylum contents is amylose, essentially insoluble in cold water but can absorb large amount of water and expand, so it can be used as a disintegrant of tablets. The aim of this research is to find out the influence of the used of durian seeds amylum as a disintegrant that be added internally-externally toward the physical and chemical properties of ibuprofen tablets.Ibuprofen tablets were prepared by wet granulation method, with levels of amylum as a disintegrant were 10% which added the intragranular-extragranular with a ratio of FI (100%:0%), FII (75%:25%), FIII (50%:50%), FIV (25%:75%), FV (0%:100%). Dried granules obtained were then tested its physical properties include flow rate, angle of repose, and compressibility. Tablets were tested in terms of physical and chemical tablets properties include weight uniformity, hardness, friability, disintegration time and active substance content of tablets. Data obtained were analyzed with a theoretical approach that is done by comparing the statistical literature and that is one way ANAVA analysis with 95% confidence level, followed by a Tuckey test.The result obtained shows that all formulation complied with the requirement of good physical and chemical properties of tablet. The added of durian seeds amylum as a tablets disintegrant with internally-externally method causes difference the physical properties of disintegration time ibuprofen tablets in significant, while at hardness and friability there is no difference in significant.

Co-Authors Aenul Sholikhah Akhmad Jazuli Aqnes Budiarti Ayu Shabrina Dewi, Riska Rosita diah pitaloka wahyuningrum Erwin Tukuru esti oktaria Fauziah Muliawati Fitria Dwi Kurniawati Hilda Shofia Afriliana Ibrahim Arifin Iftitah, Aqib Ossa Eldurr Igustin Azmi Syahida ika kurnaningsih Lies Sunarliawati M Fatchur Rochman maria faizatul mimik murrukmihadi mimik murukmihadi Mufrod Mufrod Nailatul Husna nissa ratna junita Pipit Murdiyani Ririn Lispita Wulandari risha fillah fithria Sri Febri Haryati Sugiyono Sugiyono Sugiyono Sugiyono Surti Khayatul Fata Susiana Irmawati Trisnaningrum, Nunung Ulfa Risalatul Mukaromah Uswatun Hasanah Widhi Astuti

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