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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmiah Cendekia Eksakta Jurnal Pengabdian Masyarakat Abdimas Madani Aksiologi : Jurnal Pendidikan dan Ilmu Sosial Joong-Ki : Jurnal Pengabdian Masyarakat Joong-Ki Paramacitra : Jurnal Pengabdian Masyarakat EDUSOS: Jurnal Edukasi dan Ilmu Sosial Joong-Ki

Ibrahim Arifin

Unknown Affiliation

Author-ID : 4037072

Religion Agriculture, Biological Sciences & Forestry Humanities Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Pengujian Aktivitas Antioksidan Ekstrak Dan Fraksi Jantung Pisang Mas (Musa acuminata Colla) Menggunakan Metode DPPH Devi Nisa Hidayati; Ibrahim Arifin; Yuni Antika; Amalina Firdaus; Nur Kussamawari Ardian
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 14 No. 01 Juli 2017
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (701.906 KB)

Jantung pisang mas mengandung senyawa yang dapat menangkap radikal bebas antara lain saponin, fenol, flavonoid. Penelitian ini bertujuan untuk mengetahui adanya aktivitas antioksidan ekstrak etanol, fraksi etil asetat, dan fraksi air jantung pisang mas (Musa acuminata Colla) dengan metode DPPH (2,2-difenil-1-pikrilhidrazil). Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etanol 70%, dilanjutkan fraksinasi cair-cair menggunakan pelarut etil asetat dan air. Penentuan aktivitas antioksidan ekstrak etanol dan fraksi air dilakukan pada seri konsentrasi 5, 10, 15, 20, dan 25 μg/ml. Sedangkan untuk fraksi etil asetat digunakan konsentrasi sebesar 4, 8, 12, 16, dan 20 μg/ml. Persentase aktivitas antioksidan diperoleh dari data absorbansi. Nilai IC50 didapatkan dari regresi linier antara konsentrasi larutan seri uji dengan persentase aktivitas antioksidan. Identifikasi senyawa flavonoid dilakukan dengan metode KLT. Hasil penelitian menunjukkan bahwa ekstrak etanol dan fraksi etil asetat ekstrak etanol jantung pisang mas memiliki aktivitas antioksidan kuat, sedangkan fraksi air memiliki aktivitas antioksidan lemah. Nilai IC50 ekstrak etanol, fraksi etil asetat, dan fraksi air jantung pisang mas berturut-turut sebesar 68,742; 56,132; dan 201,151 μg/ml.

KAJIAN INTERAKSI OBAT PADA PASIEN KANKER LEHER RAHIM (Serviks Uteri) RAWAT INAP DI RSUP Dr. KARYADI SEMARANG TAHUN 2007 ibrahim arifin; nurul latifah; mustofa mustofa
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 2 DESEMBER 2008
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTCervical uterine cancer is a deadly tumor attacking the cervix uteri. In Indonesia, cervix uteri cancer constitutes the most aggresive and deadly cancer. Frequently, combinations of several different drugs are used for treating this disease. The purpose of this study was to find out the stastisticts and kind of drug interactions hospitalized in Dr. Kariadi Hospital Semarang for cervix uteri cancer in 2007. This study was a non-experimental research conducted retrospectively. The research was implemented to the medical records for cervix uteri cancer patients hospitalized in Dr. Kariadi Hospital Semarang. Data obtained were analysed with descriptive non-analytic method. The result of this study showed that 96 in-patients of cervix uteri cancer, 55 patients (57,29 %) had drug interactions, while 41 patients (42,7 %) had not drug interactions. From a total number of 149 cases, 134 cases (89,93 %) had drug interaction, while 15 cases (10,07 %) had not drug interaction. Based on the types of interactions, 6 patients (4,48%) had pharmakokinetic interactions and the other 128 patients (95,52 %) had unknown mechanism drug interactions. The most drugs producing interactions were midazolam and propofol. Key words : Drug Interactions, Cervix Uteri Cancer, Cer, Dr. Kariadi Hospital.

POTENSI RIMPANG KENCUR (Kaempferia galanga L.) SEBAGAI PENCEGAH OSTEOPOROSIS DAN PENURUN KOLESTEROL MELAUI STUDI IN-VIVO DAN IN-SILICO Sri Handayani; Fera Elia; Siti Istatoah; Erika Indah; Ibrahim Arifin
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Ethyl p-methoxycinnamate and ethyl cinnamate as a phytoestrogen in galangal root (Kaempferia galanga L.) expected to be used for replacing the Hormone Replacement Therapy on prevention osteoporosis and as anti-cholesterol in menopausal women. The purpose of this study is to explore the potential estrogenic effect of galangal root extract on prevention of osteoporosis and as an anti-cholesterol agent. In-silico test is performed to measure the molecular interactions between ethyl p-methoxycinnamate and ethyl cinnamate with estrogen receptor protein (1QKM) and in-vivo tests conducted by the ovariectomy method on female Wistar rats. Thirty female Wistar rats were divided into six treatment groups. Group I is the normal mice and the group II-VI is the ovariectomies rats. Ovariectomy surgery performed at 70 days of age rats. Group II is the baseline of ovariectomized rats. Group III rats treated with CMC-Na 0.5% (control). Group IV rats are treated with estradiol 2 μg/kg BW/day while the group V and VI rats are rats treated with galangal root ethanol extract (500 and 1.000) mg/kg BW/day. Administration of the test material was performed for 30 days. At the end of the experiment, a blood sample was taken from orbital sinus for measurement of blood lipid levels. All the rats were sacrificed for necropsy procedures. The results showed that galangal root ethanol extracts significantly decrease the cholesterol and LDL levels, and enhance the femur bone density. However, extract has not significantly effect in decrease the triglyceride and enhance the HDL levels of ovariectomized rats. There were almost the same binding energy between ethyl p-methoxycinnamate, ethyl cinnamate and 17β-estradiol on 1QKM protein with binding energy is -94.9984; -949 948 and -94.9982 respectively. Key words: Kaempferia galanga L., osteoporosis and anti-cholesterol agent, in-vivo, in-silico

UJI SITOTOKSISITAS FRAKSI n-HEKSANA EKSTRAK ETANOL HERBA ALFALFA (Medicago Sativa L.) PADA SEL T47D DAN SEL HeLa SERTA IDENTIFIKASI KANDUNGAN SENYAWA KIMIANYA sri susilowati; anggun claresa; ibrahim arifin
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.9 No.2 Desember 2012
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTBreast and cervical cancers were the high prevalency, both in the world and Indonesia. This study aimed to determine the cytotoxic activities and its potentcy of n-hexane fraction of ethanol extract alfalfa herb (Medicago sativa L.) in T47D cells and HeLa cells, also identificated its chemical compounds.Extraction was done using ethanol by soxhletation method and then followed fractionation with n-hexane. Cytotoxic assay to get the value of IC50 was carried out by using MTT assay with a series of concentration of fraction 62,5; 125; 250; 500; 1000 μg/ ml. The cytotoxic activities was determined with viability cells from absorbance ELISA reader. Identification of chemical compounds of n-hexane fraction of ethanol extract alfalfa herb was done using chemical reactan and paper chromatography and then was evaluated qualitatively.The results showed that the n-hexane fraction of ethanol extract of alfalfa herb had cytotoxic activities in T47D cells and HeLa cells. The IC50 values were 523,9 μg/ml in T47D cells and 503,5 μg/ml in HeLa cells. The chemical compounds of n-hexane fraction of ethanol extract of alfalfa herb were coumarin and flavonoid.Key words : cytotoxic assay, n-hexane fraction of ethanol extract of herb alfalfa, Medicago sativa L., T47D cells, HeLa cells, flavonoid, coumarin

UJI SITOTOKSISITAS FRAKSI ETIL ASETAT EKSTRAK ETANOL HERBA ALFALFA (Medicago sativa L.) TERHADAP SEL KANKER PAYUDARA T47D DAN SEL KANKER LEHER RAHIM (SEL HeLa) SERTA UJI KANDUNGAN SENYAWA KIMIANYA Devi Nisa Hidayati; Ibrahim Arifin; Sri Susilowati Susilowati
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peranan dan Kontribusi Herbal dalam Terapi Penyakit Degeneratif"
Publisher : Universitas Wahid Hasyim Semarang

Kanker payudara dan kanker leher rahim merupakan jenis penyakit ganas di Indonesia maupun dunia. Penelitian ini bertujuan untuk mengetahui potensi sitotoksik fraksi etil asetat dari ekstrak etanol herba alfalfa terhadap sel kanker payudara (sel T47D) dan sel kanker leher rahim (sel HeLa) serta mengetahui kandungan kimianya. Proses ekstraksi herba alfalfa dilakukan dengan metode sokletasi menggunakan pelarut etanol kemudian dilanjutkan fraksinasi secara bertingkat menggunakan n-heksan, kloroform, dietil eter dan etil asetat. Uji sitotoksisitas menggunakan metode MTT dengan seri konsentrasi fraksi uji 1000; 500; 250; 125; 62,5 µg/ml terhadap kultur sel T47D dan sel HeLa. Data berupa absorbansi sel hidup digunakan untuk menghitung persentase kehidupan sel T47D dan sel HeLa kemudian ditetapkan IC50 dengan analisis probit menggunakan SPSS 16 for Windows. Uji kandungan kimia dilakukan dengan pereaksi kimia kemudian dilanjutkan dengan kromatografi lapis tipis (KLT). Hasil penelitian menunjukkan bahwa fraksi etil asetat ekstrak etanol herba alfalfa memiliki efek sitotoksik terhadap sel T47D namun tidak memiliki efek sitotoksik pada sel HeLa. Potensi sitotoksik fraksi etil asetat ekstrak etanol herba alfalfa terhadap sel T47D yang dinyatakan dalam nilai IC50 sebesar 1893,4 µg/ml. Fraksi etil asetat dari ekstrak etanol herba alfalfa mengandung flavonoid. Kata kunci: Uji sitotoksisitas, fraksi etil asetat ekstrak etanol herba alfalfa (Medicago sativa L.), sel T47D, sel HeLa, flavonoid

EVALUASI PENGGUNAAN OBAT COMMOND COLD PADA PENGOBATAN SENDIRI DI MASYARAKAT DESA KARANGGONDANG KECAMATAN MLOGO KABUPATEN JEPARA ibrahim arifin; kristian teguh prasetyo; nanang munif yasin
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 6 NO. 1 JUNI 2009
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTCommon Cold is a resporatory disturbance symptom which well-marked by cough, sneez, clogged up nose,painful red lane, fever, and headache. Nowadays, people tend to have self medication to cope with Common Cold byconsuming free medicines and limited free medicines which sold freely in market. The aim in this research was toevaluate Common Cold medicines utilizat ion by people in Karanggondang Mlonggo Jepara.This research is a non-experimental study. Data was obtained from field survey by using quetionnaire thathave been filled by people in Karanggondang Mlonggo Jepara. The result in this research have being analized byusing descriptive non analytical method. Sample was taken proportionally with convenient sampling method.This research showed that description of self medicat ion on Karanggondang Mlonggo Jepara peple wassufferer frequency 40,25% then action that have been taken by Common Cold sufferer who tried to do selfmedication 77,75%, their reason to do self medication based on experience was 33%, basic of medicines choice ofself medication who fiitted in with certain medicines was 23,75%, informat ion source of respondents from books ormass media was 44,75%. The result of evaluation with Common Cold medicines utilization on KaranggondangMlonggo Jepara people showed that correct indication 80,06%, correct medicines 80,06%, correct patients 65,59%,correct dosage 72,67% and on guard of sleepy side effect which occur oftenly 35,69%.Key words : Medicines Utilization , Common Cold, Self-Medication, Karanggondang People

EVALUASI KERASIONALAN PENGOBATAN DIABETES MELITUS TIPE 2 PADA PASIEN RAWAT INAP DI RUMAH SAKIT BHAKTI WIRA TAMTAMA SEMARANG TAHUN 2006 ibrahim arifin; erna prasetyaningrum; tri murti andayani
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 4 NO. 1 JUNI 2007
Publisher : Universitas Wahid Hasyim Semarang

ASTRACTDiabetes melitus is metabolic disease characterized hiperglikemia that caused disparity of insulin secretion, insulin activity or both. WHO had predicted there were increasing of diabetes mellitus patients in next time, included in Indonesia. This study aim to know and evaluate the rational of in patients diabetes mellitus type 2 medication in Bhakti Wira Tamtama Hospital Semarang at 2006. This study is non experimental research that analyzed by non analytical descriptive method. Data were collected retrospectively from medical record comprised patient identity, diabetes melitus type 2 medication, and rational antidibetic usage. Data obtained were analysed with Standard of Perkeni 2006. The result of this study showed that 34 in-patient diabetes mellitus type 2 in Bhakti Wira Tamtama Hospital Semarang at 2006 were 40-50 years old (47,06%). Diabetes mellitus type 2 patients comprised 18 men and 16 women, 8 cases (23,52 %) were diabetes mellitus type 2 without additional diseases and 26 cases (76,47%) diabetes mellitus type 2 with additional diseases. Patients had diagnosis appropriate were 94,12 %, drug choise appropriate were 100 %, which biguanid metformin usage were 15 patients (46,87%). Dosis appropiate 100%, patient appropriate 100%, while drug interaction had happened to 1 case, that was antidiabetic and thiazid diuretic. Key words: Rational evaluation, diabetes mellitus type 2, Bhakti Wira Tamtama Hospital Semarang

EFEK SITOTOKSIK KOMBINASI EKSTRAK METANOL DAUN KENIKIR (Cosmos caudatus, Kunth) DAN DOKSORUBISIN TERHADAP SEL KANKER PAYUDARA T47D SECARA IN-VITRO DAN IN-SILICO Fera Elia Fita; Dewi Listianingsih; Yunita Ayu Hapsari; Raka Galih Pradana; Erika Indah Safitri; Ibrahim Arifin
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTDoxorubicin is chemotherapeutic agents used widely for breast cancer therapy. The use of doxorubicin may cause cardio toxicity and multi-drug resistance. In order to overcome this side effect, a combined therapy using the methanol extracts of kenikir leaves is developed. The purposes of this study are to measure the cytotoxic effect of methanol extracts of kenikir leaves and doxorubicin combination treatment against T47D breast cancer cell growth in-vitro and in-silico, as well as determining the optimal dose combination that produces the most potent cytotoxic effects. The extraction of kenikir leaves is performed with soxhletation method. The cytotoxicity assay on the T47D breast cancer cells is carried out using MTT assay. The result of this research shows that the value of IC50 methanol extracts of kenikir leaves is 778.05μg/mL. The treatment of the methanol extracts of kenikir leaves and doxorubicin combination treatment results in a strong synergy at the concentration 130 μg/mL (-41 nM); 195 μg/mL (-41 nM) and 130 μg/mL (-27.33 nM) with the value of Combination Index 0.2; 0.3 and 0.3 respectively. The result of in-silico test shows that the bond energies of aglycone flavonoid and quercetin glycoside on Bcl-2 are -63.3359 and -67.0414. Key words: Kenikir leaves extract, doxorubicin, T47D cells, molecular docking

OPTIMASI DAN VALIDASI METODE ANALISIS SUKROSA UNTUK MENENTUKAN KEASLIAN MADU PERDAGANGAN MENGGUNAKAN KROMATOGRAFI CAIR KINERJA TINGGI Aqnes Budiarti; Ibrahim Arifin
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Perkembangan Terbaru Pemanfaatan Herbal Sebagai Agen Preventif Pada Tera
Publisher : Universitas Wahid Hasyim Semarang

ABSTRAK Seiring dengan peningkatan penggunaan madu, berkembanglah pemalsuan madu untuk mendapatkan keuntungan. Penambahan larutan gula pasir sering dilakukan karena harganya yang relatif murah. Pemalsuan madu dengan cara seperti ini sangat merugikan masyarakat karena dapat memicu timbulnya penyakit diabetes. Kandungan sukrosa dalam madu menurut persyaratan mutu madu SNI 01-3545-2004 adalah maksimal 5%. Apabila kandungannya jauh lebih tinggi maka dapat dipastikan bahwa madu tersebut tidak asli. Metode didasarkan pada sifat glukosa yang polar sehingga dapat dianalisis menggunakan KCKT dan struktur glukosa yang mengandung kromofor sehingga dapat dideteksi menggunakan detektor UV. Analisis dilakukan dengan kolom C18 Lichrospher 100 RP-18 (100 mm x 4.6 mm ID, 5 μm). Fase gerak terdiri atas asetonitril dan aquabidest (65: 35, v/v). Fase gerak dihantarkan secara isokratik dengan laju alir 0,8 mL/menit. Detektor UV pada panjang gelombang 191 nm. Metode yang dikembangkan divalidasi berdasarkan parameter ketelitian, ketepatan, linieritas, spesivitas dan sensitivitas. Metode ini memenuhi persyaratan validasi. Ketelitian metode dievaluasi menggunakan uji repeatability yang menghasilkan nilai RSD 0,10 – 1,90%. Ketepatan metode ditentukan dengan studi perolehan kembali yang menunjukkan nilai perolehan kembali adalah 98,72 – 101,22%. Metode menghasilkan respon yang linier (r > 0,99) pada kisaran konsentrasi 30 – 90 µg/mL. Nilai LOD dan LOQ Sukrosa sebesar 2,64 µg/mL dan 8,83 µg/mL Kata kunci: sukrosa, madu perdagangan, KCKT

KAJIAN INTERAKSI OBAT PADA PASIEN PENYAKIT GAGAL JANTUNG RAWAT INAP DI RUMAH SAKIT UMUM DAERAH TUGUREJO SEMARANG TAHUN 2008 Yulias Ninik Windriyati; Erwin Tukuru; Ibrahim Arifin
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 7 NO. 2 DESEMBER 2010
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Heart failure is a pathological conditions such as abnormal heart function so that the heart can not pump blood to meet the metabolic needs of the tissues. Heart failure patients in general should be given at least four types of treatment that is, ACE inhibitors (angiotensin converting enzyme), diuretics, β- blockers, and digoxin. Providing a variety of drugs can cause drug interactions. This study aimed to verify the incidence of drug interaction in heart failure patients hospitalized in the Regional General Hospital Tugurejo Semarang. The data were collected retrospectively to medical record data in general hospital Tugurejo Semarang. Data were analyzed with descriptive non-analytic methods using Drug Interaction Facts (Tatro 2007) as a reference standard. The results of this research showed that of 90 patients who potential experience drug interactions 63 patients (70%). There are 43 cases (29.05%) of pharmacokinetic interaction, 47 cases (31.76%) of pharmacodynamic interactions and unknown mechanisms of interaction 58 cases (39.19%). Based on the level of significance there are three types of interactions have level of significance 1 (12.5%), there are 5 types of interactions have level of significance 2 (20.83%), and 3 types of interactions have level of significance 3 (12.5%), for level of significance 4 there are 6 types of interactions (25%), and 7 types of interactions with the level of significance 5 (29.17%). Drug interactions that have the highest incidence of occurrence is captopril and acetosal (33 cases), digoxin and captopril (19 cases). Key words : drug interaction, heart failure

Co-Authors Amalina Firdaus Aminuyati Andi Dewi Riang Tati Andi Dody May Putra Agustang anggun claresa Aqnes Budiarti Arifin, Jamaluddin Asmunandar Asmunandar Astri Risma Debi Ayu Shabrina Bahri, Bahri Devi Nisa Hidayati Dewi Listianingsih Dharmawan Dharmawan Eka Sitiyawati Abidin Erika Indah Erika Indah Safitri erna prasetyaningrum Ernawati S Kaseng Erwin Tukuru Fera Elia Fera Elia Fita Firdaus W Suhaeb Heroweti, Junvidya Idrianti, Nuni Imawar Khaeruddin Khaeruddin KHOIRUL ANWAR kristian teguh prasetyo Kusumarani, Anggi Dwi M. Ridwan Said Ahmad MARIA ULFAH Muhammad Ikhsan Muliana GH Mustofa Mustofa Nanang Munif Yasin Nur Kussamawari Ardian Nur Sahira BT Ambo Elo Nurhikmah nurul latifah Raka Galih Pradana Rifqi Munadhil Wal Hidayah Riyanto, Gusti Sadriani, Andi Saniya Alfa Salsabila Siti Istatoah Sri . Handayani Sri Handayani Sri Susilowati Sri Suwarni Subair, Ahmad Tri Murti Andayani Urva Fresiva Yulias Ninik Windriati Yuni Antika Yunita Ayu Hapsari

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