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All Journal Medula JFL : Jurnal Farmasi Lampung Jurnal Mandala Pengabdian Masyarakat Indonesian Journal of Pharmacy and Natural Product
Ramadhan Triyandi
Universitas Lampung
Biochemistry, Genetics & Molecular Biology Chemistry Education Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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PENGARUH FRAKSI AIR DAUN KEDONDONG BANGKOK (Spondias dulcis) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA MENCIT PUTIH JANTAN Ramadhan Triyandi; Nopiyansyah Nopiyansyah; Robi Wira Pratama
JFL : Jurnal Farmasi Lampung Vol. 7 No. 2 (2018): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (408.56 KB) | DOI: 10.37090/jfl.v7i2.55

Abstract

Ambarella Bangkok fruit (Spondias dulcis) is fruits from Anacardiaceae family. Ambarella plant is known containing secondary metabolite compounds such as alkaloid, flavonoid, saponin and tannin. Flavonoid is a polyphenol compound which work as antioksdant. Ambarela Bangkok leaf containing rich antioksidant which can be use as prevention of cancer, heart disease, cholesterol, diabetes, and premature aging. The purpose of this research is to look effect from water fraction from Ambarela leaf (spondias dulcis) to decrease diabetes disease from white male mice. In this research ambarela leaf is extracted by maseration with 70% alcohol. After the extract obtained then fractionation prosen be held. From the fraction wich ocurred, then made three variant of dose those are 175.5 mg/kgW, 351 mg/kgW and 702 mg/kgW. From those three dose, the 702mg/ kgW dose has the best effect from another dose. Positive control used glibenclamide and negative control used aquadest. The result of this research shows that water fraction from Ambarela leaf can decrease diabetes desease from the white male mice. The the greater fraction concentration, the greater the concentration of the fraction then the decrease of blood glucose level in mice is getting better. The 702mg/kgW dose has an average value of decline 94.3 mg/Dl. The result of analisys shows that watter fraction of ambarella Bangkok leaf can decrease the blood glucose level in male white mice. Key word : Spondias dulcis, water fraction of Ambarela leaf , Blood glucose level
Pemanfaatan Kulit Labu (Cucurbita Moschata Durch) Sebagai Minuman Herbal Pada Masyarakat Desa Negeri Katon-Provinsi Lampung Asep Sukohar; Andi Nafisah Tendri Adjeng; Nur Fitriana Muhammad Ali; Zulpakor Oktoba; Endah Ambarwati; Ihsanti Dwi Rahayu; Afriyani Afriyani; Ramadhan Triyandi
Jurnal Mandala Pengabdian Masyarakat Vol. 3 No. 2 (2022): Jurnal Mandala pengabdian Masyarakat
Publisher : Progran Studi Farmasi STIKES Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1420.645 KB) | DOI: 10.35311/jmpm.v3i2.101

Abstract

Antioksidan berperan penting dalam melindungi tubuh akibat efek radikal bebas yang menyebabkan menurunnya sistem imun, kanker, dan penyakit degeneratif seperti diabetes dan jantung. Salah satu sumber antioksidan alami adalah kulit Labu (Cucurbita moschata Durch) namun pemanfaatannya belum optimal dan masih sering dianggap limbah. Daerah yang banyak membudidayakan tanaman Labu adalah Desa Negeri Katon Kecamatan Negeri Katon Kabupaten Pesawaran, Provinsi Lampung. Pemanfaatan limbah kulit Labu belum optimal dikarenakan masyarakat tersebut belum memahami kandungan serta manfaat yang bisa diperoleh dari kulit Labu. Kegiatan ini merupakan salah satu bentuk pengabdian yang bertujuan untuk mengoptimalkan penggunaan kulit Labu sebagai sumber antioksidan adalah dengan memanfaatkannya menjadi produk sediaan teh. Melalui Pengabdian Kepada Masyarakat Desa Binaan (PKMDB) ini masyarakat dibimbing untuk meningkatkan pemanfaatan kulit Labu berupa pengetahuan dasar mengenai manfaat kulit labu sebagai antioksidan dalam menangkal radikal bebas, penyiapan bahan baku sampel kulit Labu. Pelaksanaan Kegiatan pengabdian kepada masyarakat menggunakan metode berupa memberi penyuluhan (ceramah dan tanya jawab), Pemberian questionare untuk mengukur efektifitas pengetahuan masyarakat sebelum dan setelah penyuluhan (pre dan post-test). Setelah pemberian materi dan pendampingan pembuatan sediaan teh Kulit Labu hasil kegiatan menunjukkan bahwa pengetahuan warga meningkat saat kembali mengisi kuesioner yang sama dan berbeda cukup besar dibandingkan sebelumnya. Sehingga melalui adaanya kegiatan pengabdian masyarakat ini dapat disimpulkan bahwa Kegiatan Pengabdian Masyarakat Di Desa Negeri Katon Kecamatan Negeri Katon Kabupaten Pesawaran mampu menambah wawasan dan memberi kontribusi mengenai manfaat dan pemanfaatan kulit Labu (Cucurbita moschata Durch).
Merokok Sebagai Faktor Risiko Terjadinya Solusio Plasenta Sherly Melvinia Malia; Nurul Islamy; Ramadhan Triyandi
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.564

Abstract

Placental abruption is the separation of the placenta before the time of delivery arrives. Placental abruption is one of the causes of bleeding during labor. Placental abruption is rare in vaginal delivery. In 1.000 births as many as 228 thousand mothers die. Bleeding is the highest cause of maternal death with a proportion of 27%. The most common causes of antepartum bleeding include placenta previa, placental abruption, and other causes such as marginal sinus bleeding, cervicitis, vasa previa, infection, and genital trauma. Placental abruption occurs when the mother's blood vessels detach from the placenta, this causes bleeding between the lining of the uterus and the placenta. There are various risk factors that can cause placental abruption, namely age, parity, alcohol consumption, cocaine consumption, and smoking. it can cause decreased blood flow to the placenta. This occurs due to changes in vasoactive substances such as prostacyclin and nitric oxide, or also due to endothelial cell damage. Nicotine in cigarettes also has a vasoconstrictive effect that can occur in the uterine arteries and umbilical arteries and increases the concentration of hemoxihemoglobin which interferes with oxygenation. The ensuing hypoxia causes microinfarction of the clotting placenta which gives rise to necrotic foci These necrotic foci then develop and cause placental abruption.
Pengetahuan dan Persepsi Apoteker Terhadap Penggunaan Obat Off-Label di Indonesia: Pharmacist's Knowledge and Perception of Off-Label Drugs Use in Indonesia Dwi Aulia Ramdini; Sarmoko; Ihsanti Dwi Rahayu; Muhammad Iqbal; Ramadhan Triyandi; Dika Pramita Destiani
Indonesian Journal of Pharmacy and Natural Product Vol. 6 No. 01 (2023): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (487.807 KB) | DOI: 10.35473/ijpnp.v6i01.2219

Abstract

Off-label drugs are generally used in clinical practice but require close monitoring by health workers, especially pharmacists. Pharmacists need knowledge regarding the potential benefits and dangers of off-label medications to ensure the safety of drug users. This study aims to determine pharmacists' knowledge and perceptions of using off-label drugs in Indonesia. The study design used in this study was a cross-sectional study with an analytic observational approach using off-label drug-related questionnaires conducted online. Results of this study a total of 174 pharmacist respondents filled out a complete questionnaire with the result that 86% of the respondents had good knowledge regarding off-label drugs, and the rest were classified as poor (14%). Pharmacist respondents said they focused on safety (96.55%), efficacy (86.55%), medication history (72.99%), cost efficiency (61.49%), and also the target population (32.76%) in the use of off-label drugs. Based on factor analysis, the experience of preparing off-label drugs was significantly related to respondents' knowledge (p=0.041). In contrast, the factors of gender (p=0.777), age (p=0.677), last education (p=0.801), and years of service (p=0.541) there is no significant relationship. Conclusions of this study is The majority of pharmacist respondents in this study had good knowledge regarding the use of off-label drugs and agreed that pharmacists play an important role in monitoring the side effects of off-label use. In addition, almost all pharmacist respondents perceived that drug safety was the dominant factor for the consideration of off-label drug use. ABSTRAK Obat off-label umumnya digunakan dalam praktik klinis, namun dalam penggunaannya diperlukan pemantauan yang ketat oleh tenaga kesehatan, khususnya oleh apoteker. Pengetahuan terkait manfaat dan bahaya obat off-label diperlukan apoteker dalam menjamin keamanan dan keselamatan penggunaan obat. Penelitian ini bertujuan untuk mengetahui pengetahuan dan persepsi apoteker terhadap penggunaan obat off-label di Indonesia. Metode penelitian yang digunakan adalah studi cross-sectional dengan pendekatan observasional analitik melalui penggunaan kuesioner terkait obat off-label yang dilakukan secara online. Hasil penelitian sebanyak 174 responden apoteker terdapat 86% responden memiliki pengetahuan yang baik terkait obat off-label, dan sebagian lainnya tergolong kurang baik (14%). Responden apoteker menyatakan memiliki fokus terhadap faktor keamanan (96,55%), kemanjuran (86,55%), riwayat pengobatan (72,99%), efisiensi biaya (61,49%), dan target populasi (32,76%) dalam penggunaan obat off-label. Berdasarkan analisis faktor, pengalaman menyiapkan obat off-label berhubungan signifikan terhadap pengetahuan responden (p=0,041), sedangkan faktor jenis kelamin (p=0,777), umur (p=0,677), pendidikan terakhir (p=0,801), dan masa kerja (p=0,541) tidak terdapat hubungan signifikan. Kesimpulan penelitian ini adalah mayoritas responden apoteker memiliki pengetahuan yang baik terkait penggunaan obat off-label dan menyetujui bahwa apoteker berperan penting dalam monitoring efek samping penggunaan off label. Selain itu, hampir keseluruhan responden apoteker memiliki persepsi dimana faktor pertimbangan penggunaan obat off-label yang dominan adalah faktor terkait keamanan obat.
Co-Authors Afriyani Afriyani Ali, Nur Fitriana Muhammad Andi Nafisah Asep Sukohar Dika Pramita Destiani Dwi Aulia Ramdini Endah Ambarwati Ihsanti Dwi Rahayu Muhammad Iqbal Nopiyansyah, Nopiyansyah Nurul Islamy Oktoba, Zulpakor Robi Wira Pratama Sarmoko Sarmoko Sherly Melvinia Malia