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All Journal Science and Technology Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) JPP Jurnal Kesehatan Poltekkes Palembang Gema Wiralodra Jurnal Sibermas (Sinergi Pemberdayaan Masyarakat) Indonesian Journal of Pharmaceutical Education Jurnal Kolaboratif Sains JHTS Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Jurnal Kesehatan Farmasi Jurnal Medika: Medika Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) Journal of Community and Clinical Pharmacy Journal of Pharmacology and Natural Products
Ariani H. Hutuba
Universitas Negeri Gorontalo
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Potensi Antioksidan Masker Gel Peel-Off dari Ekstrak Buah Tomat A. Mu’thi Andy Suryadi; Juliyanty Akuba; Fika Nuzul Ramadhani; Ariani H. Hutuba
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.14299

Abstract

Tomatoes are well-known as the source of antioxidants due to the content of lycopene, i.e., a potential free radical inhibitor. Gel peel-off masks are among the chemical products containing antioxidants. The objective of this study is to formulate and examine the antioxidant activity of the gel peel-off mask made of tomato (Solanum Lycopersicum L.) extract using the DPPH method. The first step of the study was extracting tomato fruits by macerating the fruits using alcohol solvents 96%. The obtained thick extract was used as the material of the gel mask; the percentage of the extract comprised 3% (F1), 5% (F2), and 7% (F3), and it used PVA basis 11% and viscolam 3%. According to the result, the gel peel-off masks meet the requirements of physical and storage stability evaluation. The result of the antioxidant test reveals that the IC50 value of the three masks is F1 189.22 µg/mL, F2 89.34 µg/mL, and F3 36.77 µg/mL. Further, the result of T-Test reveals that P-value = 0.019 (α = 0.05), indicating a difference in the result of the antioxidant test of the three formulae in day one (t0) and day 28 (t28).
Standarisasi Mutu Tanaman Herbal Aur-Aur (Commelina longifolia L.) dan Tanaman Bungango (Flueggea virosa Royle) Andi Makkulawu; A. Mu’thi Andy Suryadi; Muhammad Taupik; Mahdalena Sy. Pakaya; Ariani. H Hutuba
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.16044

Abstract

In the developing materials for traditional medicines, it is necessary to standardize the quality of plant materials. Tuhus, quality, stability, and safety. This study aims to determine several standardization parameters and determine the flavonoid content of the 70% ethanol fraction of aur-aur leaves (Commelina longifolia L.) and bungango leaves (Flueggea virosa Royle) to ensure that the fractions have quality and measurable parameter values. The fraction was standardized with two parameters, thus specific and non-specific, and flavonoid content test using UV-Vis spectrophotometry method. The results of phytochemical screening, the fraction containing flavonoid compounds is 70% ethanol fraction. Standardization of specific parameters showed the organoleptic results of both aur-aur (Commelina longifolia L.) and bungango (Flueggea virosa Royle) leaf fractions in the form of a semi-solid viscous fraction, black in color, and characteristic odor. The content of water soluble extract and ethanol soluble extract of aur-aur (Commelina longifolia L.) leaf fraction were 22.84%, ethanol soluble extract 25.03%, while the fraction of Bungango (Flueggea virosa Royle) leaf was 30.70%. and 27.31%. Standardization of non-specific parameters showed the results of water content 21.40%, total ash content 8.92%, acid insoluble ash content 0.043%, drying shrinkage 10.48%. The results of non-specific standardization of bungango leaves (Flueggea virosa Royle) showed a moisture content of 14.45%, a total ash content of 9.62%, an acid insoluble ash content of 1.31%, a drying shrinkage of 10.64%. The results for the analysis of the flavonoid content of the 70% ethanol fraction of aur-aur leaves and bungango leaves were carried out at a wavelength of 438.36 nm. The total flavonoid content was calculated by the standard linear equation of quercetin, namely y= 0.0648x + (-0.0232) with a correlation coefficient (r2) = 0.9948 with the total flavonoid content of aur-aur leaf and bungango leaf each of 3.57. % and 9.578%.
Formulasi Dan Evaluasi Fisik Sediaan Mouthwash Ekstrak Etanol Kulit Buah Matoa (Pometia Pinnata) Nur Ain Thomas; Mahdalena Sy. Pakaya; Ariani H. Hutuba; Yayah Rachmatiyah
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.15538

Abstract

Matoa peels contained phenolic, saponin, tannin, flavonoid and terpenoid which functions as anti-bacterias to Streptococcus mutans that can cause dental caries and active ingridients for mouthwash preparations. Mouthwash is a solution to be used as a cleansing agent that can improve mouth hygiene, esthetics and breath freshness. This study aimed to identify the etanol extract of Matoa peels to be formulated mouthwash preprations and its physical evalutions. This study employed methods that includes peels extraction, extract phytochemical screening, mouthwash preparation productions and mouthwash preparations evluations consisting of organoleptic, pH and viscosity test. The testing was conducted in day 0, 7, 14, 21 and 28. The findings revealed formula 2 as the best formula with 10% of glycerin concentration.
Analysis of Hydroquinone Content in Whitening Cream Circulating in Gorontalo City Using Uv-Vis Spectrophotometry Jauria; Kostiawan Sukamto; Ariani Hutuba
Journal of Health, Technology and Science (JHTS) Vol. 3 No. 2 (2022): Journal of Health, Technology and Science (JHTS)
Publisher : LPPM Universitas Bina Mandiri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (402.813 KB) | DOI: 10.47918/jhts.v2i4.283

Abstract

This study aims to determine the content of hydroquinone in whitening cream circulating in the city of Gorontalo and to determine the level of hydroquinone in bleaching cream circulating in the city of Gorontalo. This research method is a designmixed methods, which is a rare research by combining two forms of approach in research, namely qualitative and quantitative. This study began with a qualitative analysis using FeCl3 and Benedict's reagents so that the results were obtained that from 8 samples of whitening cream (A, B, C, D, E, F, G, H) there were 2 samples of whitening cream containing hydroquinone, namely cream A and C. then continued with a quantitative test using UV VIS spectrophotometry. The result is that sample A contains 41,976 mg/g and sample C 28,430 mg/g then proceeds with the validation of the analytical method, the validation parameters include linearity, limit of detection (LOD) and limit of quantification (LOQ). carried out with the value of the correlation coefficient R = 0.9999 and LOD = 18.642 PPM, LOQ = 62.142 PPM.
Variasi Konsentrasi Bahan Pengikat Dari Pati Biji Durian (Durio Zibethinus)Terhadap Mutu Fisik Pada Formulasi Tablet Hisap Vitamin C Nur Ain Thomas; Fika Nuzul Ramadhani; Juliyanti Akuba; Ariani H. Hutuba
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.4317

Abstract

Starch of durian (Durio Zibethinus) seed is an accessible potential material to be utilized as binding agent in tablet. This study attempts to discover the influence of starch concentrate of durian seed in different percentages, i.e., 20%, 25%, and 30%, as binding agent towards the physical quality (by conducting tests i.e. weight uniformity test, hardness test, friability test, dissolution test, and organoleptic evaluation) towards vitamin C lozenges tablet formulation. Three formulae with different durian seed concentrate variation of F1 (20%), F2 (25%), and F3 (30%) were applied during the formulation of vitamin C lozenges. The result indicates that F2 and F3 formulae fulfilled all the test conducted, while the F1 formula only passed the weight uniformity test, taste response test, and organoleptic test. Based on the results of the study, F3 fulfilled all evaluations carried out, namely F3 4.07 kg hardness test, 0.30% friability test, 443.3 seconds dissolution test. F2 hardness test 3.79 kg, fragility test 0.34% solubility test 402 seconds. F1 hardness test 3.17 kg, fragility test 1.33%, soluble time test, 302.3 seconds. the conclusion obtained from the ANOVA-One way test is that there is a significant disintegration time difference of all formulas and continued by the Post-Hoct test to see the comparison of each formula with a confidence level (95%).
Pembuatan Serbuk Jahe Herbal ( SEJA) Untuk Pencegahan Stunting Di Desa Lomaya Ariani Hutuba; Madania Madania; Ayu Rofia Nurfadillah
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 2, No 1 (2023): Volume 2, Edisi 1, 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (540.202 KB) | DOI: 10.3731/phar.soc.v2i1.18595

Abstract

Stunting atau terhambatnya pertumbuhan tubuh merupakan salah satu bentuk kekurangan gizi. Zat gizi ini kemudian digunakan sebagai sumber energi bagi tubuh, meningkatkan pertumbuhan dan perkembangan serta memperbaiki jaringan tubuh. Pencegahan stunting dapat dilakukan dengan menjaga daya tahan tubuh dan konsumsi makanan yang bergizi dan mengkonsumsi senyawa bioaktif yang memiliki aktivitas imunomodulator/immune booster. Senyawa bioaktif seperti gingerol, zingeron, shogaol, dan gingerin yang terdapat pada jahe (Zingiber officinale) memiliki khasiat yang besar untuk meningkatkan daya tahan tubuh. Daya tahan tubuh tidak hanya mencegah agar tidak mudah terserang penyakit, namun juga mempercepat penyembuhan dan pemulihan dari sakit. Dalam kegiatan penyuluhan dan pelatihan pengolahan jahe, peserta dapat merasakan manfaat secara langsung untuk bisa mengolah jahedan dikonsumsi mandiri. Metode yang digunakan dalam kegiatan ini adalah metode penyuluhan dan pelatihan pembuatan serbuk jahe herbal. Hasil yang diperoleh dari kegiatan ini adalah masyarakat antusias mengikuti kegiatan ini dan masyarakat mendapatkan pengetahuan baru mengenai jahe.
Edukasi Tentang Vaksin Covid-19 Pada Masyarakat Desa Buata, Bone Bolango, Provinsi Gorontalo Teti Sutriyati Tuloli; Robert Tungadi; Ariani Hutuba; Zulfiayu Sapiun
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 1, No 2 (2022): Vol 1 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (515.114 KB) | DOI: 10.3731/phar.soc.v1i2.16814

Abstract

The World Health Organization (WHO) has declared COVID-19 as a Global Pandemic so must be handled in accordance with the legislation. Vaccination is the most effective and efficient public health effort in preventing some dangerous infectious diseases. Even though, it is undeniable that there are still many community groups who refuse vaccination due to a lack of public knowledge regarding the Covid-19 vaccine. This community service Program aims to increase public knowledge about Covid-19 through education with leaflets and and direct socialization to the Buata village community, Botupinge District, Bone Bolango Regency. The results of the Service Implementation show that the Buata village community is very interested in the information conveyed about Covid-19. This is indicated by the presence of various questions about what is the definition of a vaccine, what are the types of Covid-19 vaccines, and what are the side effects of the Covid-19 vaccine. This question has been answered properly and clearly so that the community feels satisfied and very enthusiastic during the implementation of community service programme.
Analisis Kandungan Flavanoid Daun Sambang Darah (Excoecaria cochinchinensis L) Ariani H. Hutuba; A. Mu'thi Andy Suryadi; Faramita Hiola
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.7157

Abstract

Flavonoids are chemical compounds derived from plants which are a group of secondary metabolites. Flavonoids Flavonoid compounds are polyphenolic compounds that have 15 carbon atoms arranged in a C 6 -C 3 -C 6 configuration, namely two aromatic rings connected by 3 carbon atoms that can or cannot form a third ring. Flavonoids are widely distributed in angiosperms, gymnosperms, and pteridopites. These flavonoids provide physiological and pharmacological effects on living things. The purpose of this study was to identify the flavonoid compounds present in the leaf extract of the blood sambang plant (Excoecaria cochinchinensis L). In this study, a multilevel maceration extraction was used using n-hexane, ethyl acetate and methanol solvents and then the filtrate was evaporated using an evaporator. Positive phytochemical screening results indicated the presence of flavonoids in methanol extract and negative in n-hexane and ethyl acetate extracts. From the methanol extract, TLC was carried out with an eluent ratio of methanol ethyl acetate (8: 2), it was obtained the separation of two stains where one of the stains had the same Rf value as the Rf value of flavonoids, then performed a UV-Vis spectrophotometric analysis resulting in three absorption wavelengths, namely band I (350 nm) and band II (255 nm and 267 nm). the spectrum obtained is a class of flavone compounds.
Isolasi, Karakterisasi, dan Uji Antioksidan Fungi Endofit dari Tanaman Batang Kunyit (Curcuma domestica Val.,) Mahdalena Sy. Pakaya; Nur Ain Thomas; Hamsidar Hasan; Ariani H. Hutuba; Grasela Mbae
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.20341

Abstract

Endophytic fungi live in mutualistic symbiosis and can produce secondary metabolites similar to their host. This research aims to isolate, characterize, and test the antioxidant activity of secondary metabolites from turmeric stems. This research is experimental research where the method used for endophytic fungi isolation is the direct planting method, and antioxidant activity is tested using qualitative and quantitative methods with DPPH (1.1-diphenyl-2-picylhydrazyl). One fungal isolate was obtained with the fungal isolate code (BK). Based on macroscopic and microscopic characterization, the BK fungal isolate indicates the Deuteromycota class's characteristics. The qualitative antioxidant test results indicate that the fraction of BK endophytic fungal isolate indicates antioxidant activity, indicated by the yellow color against a purple background on the TLC plate observed under visible light. The respective ICso values for the ethyl acetate and n-hexane fractions were 52.989 µg/ml and 89.725 µg/ml, categorized as strong antioxidants. The methanol fraction had an ICso value of 119.02 µg/ml, categorized as moderate, while the pure supernatant fraction had an ICso value of 156.86 µg/ml, categorized as weak antioxidant activity.
Kajian in Silico Daun Sungkai (Peronema canescens) dalam Menghambat Enzim lanosterol 14-α demethylase Jamur Candida albicans Nurul Istiqomah; Safitri Fatikasari; Ariani H. Hutuba
Indonesian Journal of Pharmaceutical Education Vol 3, No 1 (2023): Januari-April 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i1.19135

Abstract

Candida albicans (C. albicans) is a fungus that causes candidiasis. C. albicans has the enzyme Lanosterol 14- α demethylase. Lanosterol 14-α-demethylase has bioactivity in converting lanosterol to ergosterol, a special sterol found in fungal membranes, which mediates membrane permeability and fluidity. One way to treat candidiasis is to use traditional medicinal plants. Sungkai (Peronema canescens) can be used as an anti-fungal medicine. Drug development efforts can be done using the In silico method. Objectives of this study was to determine the interaction between terpenoid, flavonoid, and phenol compounds in Sungkai leaves against Lanosterol 14-α demethylase in Candida albicans. The research design used was a pre-experimental one-shot case study. Toxtree software was used to test the toxicity of compounds. Test for compound potency using the Pass Online webserver. Docking molecular using PyRx software. Visualization of docking results using Discovery Studio 2019 Software. Physicochemical test of compounds using Lipinski Test. The results showed that the compounds that had a low risk of toxicity were butanoic, catechol, guaiacol, hydroquinone, isopropanol, methanoic acid, palmitic acid, and phytol. Compounds that have anti-fungal activity based on Pharma-expert analysis are butanoic acid, genkwanin, guaiacol, hydroquinone, isopropanol, palmitic acid, and phytol. Compounds that have hydrogen bonds and binding affinity value 10 and RMSD value 2 are butanoic acid, catechol, genkwanin, guaiacol, hydroquinone, isopropanol, methanoic acid, palmitic acid, and quinic acid compounds. These compounds are thought to inhibit the Lanosterol 14-alpha demethylase enzyme in C. albicans. Compounds that comply with Lipinski's rules are anthocyanin and genkwanin compounds. The groups of compounds found in Sungkai leaves that have antifungal activity are the terpenoids, flavonoids, and phenols.
Co-Authors A. Mu'thi Andy Suryadi A. Mu'thi Andy Suryadi A. Mu’thi Andy Suryadi A. Mu’thi Andy Suryadi Abdulkadir, Widi Susanti Andi Makkulawu Andy Suryadi, A. Mu'thi Asral Kelvin Sahrain Ayu Rofia Nurfadillah Datu, Novanza L.M.N Djafar, Lisa Dr. Apt. Hamsidar Hasan S.Si.,M.Si Ekaria Revalya Malopo Erwin Purwanto Faradila Ratu Cindana Mo'o Fika Nuzul Ramadhani Grasela Mbae Hamsidar Hasan Hiola, Faramita Jauria Julianty Akuba Kaino, Ratni Khairun nisha Samsi Kostiawan Sukamto, Kostiawan La Ode Aman Lahay, Astiara Madania, Madania Mahdalena Sy Pakaya mahdalena sy. pakaya Maku, Mohamad Aditya Manno, Mohamad Reski Moh. Rivai Nakoe Mohamad Adam Mustapa Mohamad Aprianto Paneo Muhammad Taupik Muhammad Taupik Nasrun Pakaya Nur Ain Thomas Nur Rasdianah Nurul Istiqomah Payuyu, Alifia Robert Tungadi Safitri Fatikasari Sapiun, Zulfiayu Selvi Marcellia Sukmaty Damiti Suryadi, A. Mu'thi Andy Teti Sutriyati Tuloli Tri Septian Maksum Widy Susanti Abdulkadir Wiwit Zuriati Uno Yambese, Alpiani Yayah Rachmatiyah Zulkifli B. Pomalango