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All Journal Nexus Pendidikan Kedokteran dan Kesehatan Nexus Kedokteran Klinik Nexus Biomedika Nexus Kedokteran Translasional Journal of Epidemiology and Public Health Indonesian Journal of Medicine Jurnal Respirasi (JR)
Leli Saptawati
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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Hubungan antara Hipoglikemi dengan Kejadian Hipotermi pada Neonatus Rujukan di RSUD Dr. Moewardi Virgiansari, Dio Dara; Hidayah, Dwi; Saptawati, Leli
Nexus Kedokteran Klinik Vol 2, No 1 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Neonatal hypoglycaemia is an avoidable cause of mortality and neurodevelopmental impairment. Hypoglicemia may develop to hypothermia as a result of metabolic thermogenesis disturbance. Hypothermia during the newborns period is widely regarded as a major contributory cause of significant morbidity and mortality in developing countries including Indonesia, about 7% prevalence of hypothermia has been reported happens on newborns.  The objective of this study was to determine the association between hypoglicemia and hypotermia in newborns. An analytic observational using cross sectional approach was used in this study. A total of eighty one newborns was selected by fixed-disease sampling. Sample of this study were the newborns who referred to Dr. Moewardi Hospital. The data were collected by the measurement of blood glucose concentration and axillary temperature of newborns. The data was analyzed using multiple logistic regression test on SPSS 16 for Windows. Hypoglycemic newborns have a risk of hypothermia 2.381 times higher than non hypoglicemic newborns after controlling some confounding factors, such as: age, birth weight, gestational age, and status of asphyxia, altough it was statistically not significant (OR = 1.98; CI = 95%; 0.54, 7.73; p = 0.305). Early neonatal age (0-7 days), low birth weight (< 2.500 gram), early gestational age (< 37 weeks), asphyxia status were also risk factors of hypothermia in newborns. There was a moderate association between hypoglicemia and hypothermia on referral newborns, altough it was statistically not significant. Hypoglycemic newborns have a higher risk of hypothermia than non hypoglicemic newborns after controlling some confounding factors, such as: age, birth weight, gestational age, and status of asphyxia. Keywords: newborns, referral, hypoglicemia, hypothermia
Hubungan antara Syok Berkepanjangan (Prolonged Shock) dengan Kematian Anak Penderita Dengue Shock Syndrome di PICU/NICU RSUD Dr.Moewardi Solehah, Rizka; Pudjiastuti, .; Saptawati, Leli
Nexus Kedokteran Klinik Vol 2, No 1 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Dengue Shock Syndrome (DSS) is severe type of dengue infection which is the major cause of mortality. In Indonesia, DSS cases increase until 53%, the number of incidence are 500.000 cases every year, and its mortality is 1-5%. DSS is caused by plasma leakage which can leading to tissue hypoperfusion. If proper and timely management of DSS had delayed, DSS may result in multiple organ dysfunction syndrome (MODS) even death. The purpose of this research is to find out whether there is the relationship between prolonged shock and mortality of children with Dengue Shock Syndrome at PICU/NICU of RSUD Dr. Moewardi. This was an analytic observational study with cross sectional approach and purposive sampling technique. A sample of 61 study subject was selected by purposive sampling technique from children who aged 0-18 years, children who suffered Dengue Shock Syndrome and treated at PICU/NICU RSUD Dr. Moewardi in June 2006 - December 2011. The data obtained from PICU/NICU and medical records section of RSUD Dr. Moewardi. Statistical analysis was using chi square test and continued by using contingency coefficient test. Patients of prolonged shock DSS have higher mortality than patients of non-prolonged shock DSS, although the relation between them is low (p = 0.005; contingency coefficient = 0,335). The mortality risk were five times greater (OR= 5; CI 95%; 1,536 – 16,273). In this study, DSS was much found in girl (59,02%), children aged 6-12 years old (52,46%), and usually who had weak condition (67,21%), and good nutritional status because this study was done at area with good nutritional status was majority in children. There were significant relationship between prolonged shock and mortality of children with Dengue Shock Syndrome at PICU/NICU of RSUD Dr. Moewardi with low rate relation. Patients with prolonged shock DSS have higher risk of mortality than patients with non-prolonged shock DSS.
Uji Efektivitas Prosedur Disinfeksi Tingkat Tinggi Endoskopi Saluran Cerna RSUD Dr. Moewardi Ramadhani, Aviaddina; Marwoto, .; Saptawati, Leli
Nexus Biomedika Vol 2, No 1 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: The risk of infection associated with gastrointestinal endoscope remains a topic of interest. This vexation may be related to reliability of the disinfecting techniques or the compliances with the guideline laid down for high-level disinfection. Gastrointestinal endoscope disinfecting techniques may vary from site to site. This study was to examine the effectiveness of gastrointestinal endoscope high-level disinfection at Rumah Sakit Umum Daerah (RSUD) Dr. Moewardi. Methods: An observational study using cross sectional design was conducted at RSUD Dr. Moewardi. Thirty samples from gastrointestinal endoscope swab after high-level disinfection process with 24 hours storage and without storage was sampled with convenience sampling technique. Data from this research were analyzed descriptively and tested using Chi square test. Results: Microorganism were detected in 11/14 samples of gastrointestinal endoscope after 24 hours storage and 3/16 samples of gastrointestinal endoscope without storage process. The microorganisms were Bacillus sp, Staphylococcus aureus, Staphylococcus non-aureus, and Clostridium sp. Significant relationship was detected between storage processes after gastrointestinal endoscope high-level disinfection with microorganism contamination. Conclusions: High-level disinfection of gastrointestinal endoscopes RSUD Dr. Moewardi was not yet effective. There was a significant relationship between gastrointestinal endoscopy storage for 24 hours with the effectiveness of high-level disinfection of gastrointestinal endoscopes. Keywords: high-level disinfection, gastrointestinal endoscope, 24 hours storage, without 24 hours storage.
Perbandingan Efektivitas Handrub Softa-Man® Dan Formula Handrub Moewardi Terhadap Angka Kuman Di RSUD Dr. Moewardi Saptawati, Leli; Marwoto, .; Jeffrey F .L, Henrikus
Nexus Biomedika Vol 2, No 1 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: Nosocomial infections are important clinical problem, indicated by many cases on the incidence of nosocomial infections. To overcome this incident, a lot of researchers have conducted variety of ways, one of them is hand hygiene. Two different kinds of hand hygiene alcohol-based products were used in this study, handrub Softa-man® and Moewardi’s handrub formula. The effectiveness of both handrub in reducing the number of bacteria was compared on health-care workers. Methods: This study was a quasi-experimental study. The study was conducted at hospital wards in Dr. Moewardi Hospital. Respondents were taken by consecutive sampling. There were two groups in this study, the group that received handrub Softa-man® and the group that received Moewardi’s handrub formula. Each group was observed for the effectiveness in reducing the number of bacteria. The data that had been collected then were analyzed using the Mann-Whitney test and followed by Wilcoxon test. Results: The results of this study showed that both groups managed to reduce the number of bacteria. Wilcoxon test result showed a difference in the number of bacteria before and after hand washing where the number of bacteria after hand washing was fewer than before hand washing. The result of Mann-Whitney test showed that there was no statistical difference in the decreased number of bacteria when both handrub were compared. Conclusions: There was no significant difference in the decreased number of bacteria between the Softa-man® handrub and Moewardi’s handrub formula usage. Keywords: Handrub’s effectiveness, Alcohol-based handrub, Softa-man®, Moewardi’s formula, Number of bacteria.
The Effectiveness of the Leaf Extract of Jati Belanda (Guazuma ulmifolia Lamk) as Dengue Antiviral In Vitro Pratiwi, Yani Dwi; Saptawati, Leli; Marufah, Siti
Nexus Kedokteran Translasional Vol 6, No 1 (2017): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Introduction: Dengue Haemorrhagic Fever is one of a serious disease in the world because it can cause death. During all these years, DHF in Indonesia only treated by symptomatic and supportive therapy. The purpose of this study was to determine the effectiveness of Jati Belanda leaf’s extracts as antiviral dengue in vitro. Methods: The method used is pure experimental research and the research design method is post test only control group design. The subject is dengue virus serotype 2 strain New GuineaC (DENV2 NGC) obtained from the Laboratory of Virology and Molecular Biology Department of Microbiology, Faculty of Medicine, University of Indonesiaand this research was started from June until November 2016. The independent variables in this study is the concentration of Jati Belanda leaf’s extracts obtained from Pharmaceutical Laboratory of Faculty Pharmacy, Gadjah Mada University and dependent variable are infectivity value and viability value. The collected data are presented in tables. Results:In concentration 40 µg/ml, the infectivity value is 12.6% and the viability value is 91.4%. Conclusions: The leaf extracts of Jati Belanda is potentially effective as antiviral dengue. Keywords: dengue, Jati Belanda extract, antivirus, DHF  
A High Incidence of Multidrug Resistant Strains as the Agents Causing Bloodstream Infection in Hospital in Indonesia Suryawati, Betty; Saptawati, Leli
Indonesian Journal of Medicine Vol 4, No 1 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Various bacteria have been identified as the agents causing bloodstream infection. Multidrug resistant (MDR) strains, such as Gram-negative pathogens producing extended-spectrum beta-lactamases (ESBL) and Methicillin-resistant S.aureus (MRSA) are potential bacterial agents causing bloodstream infection in the hospital setting. The increase of these MDR strains in bloodstream infection is alarming since there are limited antibiotic choices for treatment. This study aimed to investigate the agents causing bloodstream infection and to investigate their antibiotics susceptibility profiles. Subjects and Method: Samples were venous blood collected from patients admitted to hospital from January 2014 to December 2016. Bacteria were grown in-automated BACTEC® blood culture (BD, New Jersey, USA). The identification of MRSA strain was conducted using oxacillin susceptibility test. The bacterial identification and identification of ESBL-producing bacteria was conducted using colorimetric assay using Vitek2®system (bioMérieux).Results: The antibiotic profiles of all bacteria isolated from venous blood samples were analysed. The most bacteria isolated from the blood stream were K. pneumonia, A. baumannii, E. coli, P. Aeruginosa, E. cloacae, S. marcennes, S. haemolyticus, S. hominis, S.epidermidis, and S. aureus. Conclusions: The resistant profiles of bacteria isolated from blood stream showed that there was a high incidence of MDR bacteria, including potential ESBL-producing bacteria, carbapenemase-producing bacteria and MRSA strains.Keywords: Bloodstream Infection, Staphylococcus aureus, Extended Spectrum Betalactamase, Antibiotic Resistance.Correspondence: Betty Suryawati. Department of Microbiology, Faculty of Medicine, Universitas Sebelas Maret, Jl. Ir. Sutami No 36A, Surakarta 57126, Central Java, Indonesia. Email: betty.suryawati@staff.uns.ac.id.Indonesian Journal of Medicine (2019), 4(1): 28-34https://doi.org/10.26911/theijmed.2019.04.01.05
Risk Factors and Prognosis of Nontuberculous Mycobacteria Infection in a High Prevalence of Tuberculosis Setting Saptawati, Leli; Mashuri, Yusuf Ari; Suryawati, Betty; Harsono, Harsono; Pradiptakirana, Riska
Journal of Epidemiology and Public Health Vol 5, No 1 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: The prevalence and incidence of Non­tuberculous Mycobacteria (NTM) infections in the world in general have continued to in­cre­ase in the last two to three decades. Until now i­den­tification and testing of NTM sensitivity in Indonesia is still very difficult to do in daily health services. Thus, NTM infection is still a ne­glected case and misdiagnosis often occurs. In these conditions, one of the things that is very im­portant to help clinicians in the management of NTM infections is information about patient characteristics and how the relationship of risk factors for NTM infection with prognosis.Subjects and Method: The study was con­duc­ted retrospectively using data on the medical re­cords of patients with positive culture of NTM at the Surakarta Center for Community Lung Health (BBKPM) for 3 years (2016-2018). A total of 134 samples were selected for this study with total sampling. The dependent variable is the prognosis of infection. The independent variables were gender, age, occupation, history of inhaled corticosteroid use, antibiotic therapy, and under­lying disease. Data were analyzed using multiple logistic regression.Results: The number of samples is 143 medical records. Most of the patients in this study were male (62.90%) and aged less than 60 years (79.70%). The majority of patients work not as far­mers (80.40%). Most patients had no history of inhaled corticosteroid use (89.50%). The­ra­pe­utic factors indicate that the majority of patients receive combined antibiotic therapy (68.5%). As many as 42% of patients with NTM infection have an underlying disease. Underlying disease in patients is mostly in the form of diabetes me­l­litus (DM) in 13.3% and in the former tuber­cu­losis in 4.9%. Based on the Chi-Square test, a sig­nificant relationship was found between the­ra­peutic factors, history of inhaled corti­cos­teroid use, and type of work, and the patient's prog­no­sis. Based on mult­ivariable testing, the factor of antibiotic therapy is the most influential variable on a pa­tient's prognosis.Conclusion: Risk factors related to the patient's prog­nosis are occupation, use of inhaled cor­tico­steroids and antibiotic therapy.Keywords: Nontuberculous Mycobacteria, risk factors, prognosis, Center for Community Lung HealthCorrespondence: Leli Saptawati. Department of Microbiology, Fa­culty of Medicine, Universitas Sebelas Maret, In­do­nesia. Jl. Ir. Soetami no. 36A Kentingan Su­ra­karta, Indonesia. Email: llsapt_md@yahoo.­co.­id. Mobile: (0271) 632489.Journal of Epidemiology and Public Health (2020), 5(1): 79-87https://doi.org/10.26911/jepublichealth.2020.05.01.08
Hubungan Motivasi Berprestasi dengan Prokrastinasi Akademik pada Mahasiswa Program Studi Kedokteran Universitas Sebelas Maret Sheilla Elfira San Pambayun; Suyatmi .; Leli Saptawati
Nexus Pendidikan Kedokteran dan Kesehatan Vol 3, No 1 (2014): Nexus Pendidikan Kedokteran & Kesehatan
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Academic procrastination is an educational and psychological problem that has negative effects for students. One of the factors that influence academic procrastination is the existence of achievement motivation. Students who have a high achievement motivation level will be highly motivated to finish their homework immediately, increased their skills, and interested in challenges. This study aimed to determine the correlation between academic procrastination and achievement motivation level in Medical Student of Sebelas Maret University. Methods: This study was an observational study with cross sectional approach on October 2014 in Faculty of Medicine, Sebelas Maret University. Total sampling of 173 students were included in this study. The data were obtained using Suyatmis Achievement Motivation Scale (2002) and Ahmainis Academic Procrastination Scale. The obtained data was analyzed using Spearmans rank correlation through SPSS 20.00 for Windows. Results: This study showed the average score of achievement motivation level was 14711.20, and the average score of academic procrastination was 84.0611.86. Spearmans rank correlation test showed Spearmans correlation coefficient (r) about -0.540 with significance level = 0.000 (p < 0.05). Conclusions: There was a moderate negative correlation and statistically significant between academic procrastination and achievement motivation level in Medical Student of Sebelas Maret University. Keywords: Achievement Motivation, Academic Procrastination, Medical Students
ScreeningEffectiveness of The Extract of Sambiloto (Andrographis paniculata), Serai (Cymbopogon citrates) and Meniran (Phyllanthus niruri L.) as Dengue AntiviralIn Vitro Sarah Luthfiani; Ratih Dewi Yudhani; Leli Saptawati
Nexus Biomedika Vol 5, No 1 (2016): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Introduction: Dengue virus infection isone of the emergency infectious diseases in the world. Morbidity and mortality of dengue fever in Indonesia is relatively high.There is no specific therapy for dengue infection. The main treatment principle of dengue infection is supportive therapy such as replacement of body fluids. Indonesia has natural product which can be potential as an antiviral for dengue therapy, such as sambiloto (Andrographis paniculata), serai (Cymbopogon citrates) and meniran (Phyllanthus niruri L.). The aim of this research is to determine the effectiveness of the extract of sambiloto (Andrographis paniculata), serai (Cymbopogon citrates) and meniran (Phyllanthus niruri L.) as dengue antiviral in vitro. Methods:This study was a laboratory experimental research using dengue virus serotype 2 strain New guinea C (DENV2 NGC) which was infected into Huh-7 cell line as the subject of the research. This researchwas conducted in 2 parts. First ,inhibition test of the extract against DENV2 was assessed by the percentage of infectivity with Focus Forming Unit assay method . Second ,toxicity test of the extracts in HuH - 7 cells was assessed by the percentage of viability by MTT assay method. Effective herbs extract as a dengue antiviral was an extract that had average percentage of infectivity20% and average percentage of viability > 50%. Results: The extracts of sambiloto, serai, and meniranhad average percentage of infectivity: 53.8%; 114.4%; and 51.9%respectively. While the average percentage of viability were: 105.9%; 95.7%; and 98.6%respectively. Conclusion: The extracts of sambiloto (Andrographis paniculata), serai (Cymbopogon citrates), and meniran (Phyllanthus niruri L.) were not effective as dengue antiviral in vitro. Keywords: Andrographis paniculata, Cymbopogon citrates, Phyllanthus niruri L., DENV2 NGC,HuH-7.
Perbandingan Efektivitas Handrub Softa-Man Dan Formula Handrub Moewardi Terhadap Angka Kuman Di RSUD Dr. Moewardi Henrikus Jeffrey F .L; Leli Saptawati; . Marwoto
Nexus Biomedika Vol 2, No 1 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Nosocomial infections are important clinical problem, indicated by many cases on the incidence of nosocomial infections. To overcome this incident, a lot of researchers have conducted variety of ways, one of them is hand hygiene. Two different kinds of hand hygiene alcohol-based products were used in this study, handrub Softa-man and Moewardis handrub formula. The effectiveness of both handrub in reducing the number of bacteria was compared on health-care workers. Methods: This study was a quasi-experimental study. The study was conducted at hospital wards in Dr. Moewardi Hospital. Respondents were taken by consecutive sampling. There were two groups in this study, the group that received handrub Softa-man and the group that received Moewardis handrub formula. Each group was observed for the effectiveness in reducing the number of bacteria. The data that had been collected then were analyzed using the Mann-Whitney test and followed by Wilcoxon test. Results: The results of this study showed that both groups managed to reduce the number of bacteria. Wilcoxon test result showed a difference in the number of bacteria before and after hand washing where the number of bacteria after hand washing was fewer than before hand washing. The result of Mann-Whitney test showed that there was no statistical difference in the decreased number of bacteria when both handrub were compared. Conclusions: There was no significant difference in the decreased number of bacteria between the Softa-man handrub and Moewardis handrub formula usage. Keywords: Handrubs effectiveness, Alcohol-based handrub, Softa-man, Moewardis formula, Number of bacteria.
Co-Authors . Marwoto . Marwoto . Pudjiastuti . Pudjiastuti Arina Setyaningrum Aviaddina Ramadhani Dhani Redhono, Dhani Dio Dara Virgiansari Dwi Hidayah Dwi Hidayah Eko Setijanto Harsono Harsono Henrikus Jeffrey F .L Hutami Sri Ummiyati Maarif, Athok Shofiudin Marufah, Siti marwoto marwoto Maryani Maryani Mashuri, Yusuf Ari Mochammad Imron Awalludin Nawanindha, Natasha Pradiptakirana, Riska Pratiwi, Yani Dwi Putra, Lutfi Lafil Cahya Ratih Dewi Yudhani Ratih Puspita Febrinasari Reviono Reviono Rizka Solehah Sarah Luthfiani Sebayang, Pribadi M Sheilla Elfira San Pambayun Siti Marufah SURYAWATI, BETTY SURYAWATI, BETTY Suyatmi . Vitri Widyaningsih Yani Dwi Pratiwi Yulia Sari Yusup Subagio Sutanto