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Hubungan antara Hipoglikemi dengan Kejadian Hipotermi pada Neonatus Rujukan di RSUD Dr. Moewardi Virgiansari, Dio Dara; Hidayah, Dwi; Saptawati, Leli
Nexus Kedokteran Klinik Vol 2, No 1 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Neonatal hypoglycaemia is an avoidable cause of mortality and neurodevelopmental impairment. Hypoglicemia may develop to hypothermia as a result of metabolic thermogenesis disturbance. Hypothermia during the newborns period is widely regarded as a major contributory cause of significant morbidity and mortality in developing countries including Indonesia, about 7% prevalence of hypothermia has been reported happens on newborns.Â The objective of this study was to determine the association between hypoglicemia and hypotermia in newborns. An analytic observational using cross sectional approach was used in this study. A total of eighty one newborns was selected by fixed-disease sampling. Sample of this study were the newborns who referred to Dr. Moewardi Hospital. The data were collected by the measurement of blood glucose concentration and axillary temperature of newborns. The data was analyzed using multiple logistic regression test on SPSS 16 for Windows. Hypoglycemic newborns have a risk of hypothermia 2.381 times higher than non hypoglicemic newborns after controlling some confounding factors, such as: age, birth weight, gestational age, and status of asphyxia, altough it was statistically not significant (OR = 1.98; CI = 95%; 0.54, 7.73; p = 0.305). Early neonatal age (0-7 days), low birth weight (< 2.500 gram), early gestational age (< 37 weeks), asphyxia status were also risk factors of hypothermia in newborns. There was a moderate association between hypoglicemia and hypothermia on referral newborns, altough it was statistically not significant. Hypoglycemic newborns have a higher risk of hypothermia than non hypoglicemic newborns after controlling some confounding factors, such as: age, birth weight, gestational age, and status of asphyxia. Keywords: newborns, referral, hypoglicemia, hypothermia

Hubungan Anemia Dengan Hipotermia Pada Neonatus Di RSUD Dr. Moewardi Ardiningsih, .; Hidayah, Dwi; Sulaeman, Endang Sutisna
Nexus Kedokteran Klinik Vol 2, No 2 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Based on data from Departemen Kesehatan Republik Indonesia (2007), one of the causes of death in the first 24 hours of life is hypothermia. Hypothermia is caused by the reduction of heat production. The production of heat in of neonates are strongly associated with the supply of oxygen. Anemia is bodyâs condition with haemoglobin levels below normal score according to age and gender. The oxygen supply to tissues is reduced if haemoglobin level is decreased, causing the reduction of heat production. The aim of this research is to know about the association between anemia and hypothermia on neonates. Methods: This is an observational analytic research with cross sectional design. This research was done in RSUD Dr.Moewardi. The samples were the neonates who were treated in the High Care Unit (HCU) of neonates in RSUD Dr.Moewardi on the 3rd until 15th of March 2013. Dependent variable was hypothermia, and the independent variable was anemia. The neonatesâ haemoglobin levels were measured then the neonatesâ temperature were observerd every 3 hours for 24 jam. The data were analyzed using fisher test, because the requirements of chi-square test were not met. Result: The results from fisher test were p = 0,225. Conclusion: The analysis showed there was not association between anemia and hypothermia in this research. Keyword: anemia, hypothermia, neonates

Hubungan Pola Konsumsi Makanan Dengan Status Gizi Siswa Di Madrasah Ibtidaiyah Swasta (Mis) Pontianak Hidayah, Dwi; Hastuti, Lidia; Wardani, Nuniek Setyo
Jurnal Keperawatan dan Kesehatan Vol 8 No 1 (2017): JK2
Publisher : Sekolah Tinggi Ilmu Keperawatan Muhammadiyah Pontianak

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Latar belakang: Menciptakan sumber daya manusia yang bermutu, perlu ditata dengan memperhatikan kesehatan anak. Salah satu unsur penting kesehatan adalah masalah gizi. Status gizi dipengaruhi oleh pola konsumsi makan dan penyakit infeksi. Anak usia sekolah memiliki masa pertumbuhan dan perkembangan fisik untuk itu diperlukan status gizi yang optimal. Tujuan : Mengetahui hubungan pola konsumsi makanan dengan status gizi siswa di Madrasah Ibtidaiyah Swasta (MIS) Pontianak. Metode penelitian : Jenis penelitian bersifat analitik dengan menggunakan deskriptif analitik dengan pedekatan Cross Sectional. Teknik pengambilan sampel menggunakan teknik random sampling dengan jumlah sampel 42 orang. Analisa data bivariat menggunakan Uji Chi Square. Hasil Penelitian : Hasil dari penelitian dari 42 responden menunjukkan bahwa sebagian besar sampel memiliki pola konsumsi makanan baik sebanyak 25 orang (59,5%), anak yang pola konsumsi makanan kurang baik sebanyak  17 orang (40,5%) dan sebagian besar mempunyai gizi baik sebanyak sebanyak 37 orang (85,7%) dan anak yang berstatus gizi kurang baik sebanyak 6 orang (14,3%). Data yang diperoleh di uji statistik, didapatkan hasil bahwa nilai uji p <? (0,202 > 0,05 Kesimpulan : Penelitian ini dapat disimpulkan bahwa terdapat hubungan pola konsumsi makanan dengan status gizi di Madrasah Ibtidaiyah Swasta (MIS) Pontianak.

Difference of Calcium Levels in Infants with Low Birth Weight Nugraha, Sandi; Salimo, Harsono; Hidayah, Dwi
Indonesian Journal of Medicine Vol. 5 No. 2 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Hypocalcemia is a condition that can cause serious disorders, especially in newborns. The occurrence of hypocalcemia is an event that often occurs in babies born that can be caused due to late parathyroid hormone function in calcium metabolism in the baby's body. Hypocalcemia is often associated with hypotension and disorders of the heart rhythm, symptoms that are often seen are apnea, tachycardia, lethargy, vomiting, and gastrointestinal disorders. This study aimed to analyze differences in calcium level between low birth weight infants.Subjects and Method: A cross sectional study was conducted at Dr Moewardi Hospital, Surakarta, Central Java, from December 2016 to April 2017. A sample of 158 LBW children was selected using consecutive sampling. The dependent variable is a decrease in calcium levels. The independent variable is low birth weight babies. Data collected by medical records. Data were analyzed using multiple logistic regression.Results: Calcium level ≥1.13 mmol/L (OR= 0.30; 95% CI= 0.15 to 0.57; p <0.001), no seizures (OR= 0.20; 95% CI= 0.06 to 0.64; p = 0.004), and QoTC (OR= 0.20; 95% CI= 0.07 to 0.572; p= 0.003) decreased the risk of low birth weight.Conclusion: Calcium level ≥1.13, no seizures, and QoTC decrease the risk of low birth weight.Keywords: low birth weight, hypocalcemiaCorrespondence: Sandi Nugraha. Department of Pediatrics, Universitas Sebelas Maret/ Dr. Moewardi Hospital, Surakarta. Phone/Fax.0271-633348. Email:sssandinugraha@gmail.comIndonesian Journal of Medicine (2020), 05(02): 131-136https://doi.org/10.26911/theijmed.2020.05.02.06

Comparison Neutrophil to Lymphocyte Count Ratio with C-Reactive Protein as a Predictor for Neonatal Sepsis Nugroho, Irfan Dzakir; Hidayah, Dwi; Salimo, Harsono
Indonesian Journal of Medicine Vol. 6 No. 2 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Accurate early detection of bacteriemia plays an important role in the treatment and prognosis of infected neonates, but is constrained by the limitations of specific sepsis markers for detecting bacteriemia. NLCR or neutrophil to lymphocyte count ratio in adult population shows a more sensitive parameter in predicting infection and has the advantage of being economical and widely available. The role of NLCR in the neonatal population has not been widely studied. The purpose of this study was to analyze NLCR versus CRP as a predictor of neonatal sepsis.Subjects and Method: This study take analytic observatinal with diagnostic test approach to subject with sepsis risk factor and neonatal sepsis at dr. Moewardi hospital from April until May 2017. Characteristics data as gestational age, gender, birth weight, IT ratio, leucocyte count, neutrophil and lymphocyte count, NLCR, CRP and blood culture. Data presented descriptively and statistical analysis was performed.Results: No significant correlation between subject’s characteristics and neonatal sepsis. NLCR with cutoff point for 2.22 has sensitivity, specificity, positive and negative predictive value for 87.5%, 75%, 70% and 90%, respectively. CRP with cutoff point for 0.25 has sensitivity, specificity, positive and negative predictive value for 83.3%, 55.6%, 55.6% and 83.3% respectively. While IT-rasio has sensitivity, specificity, positive and negative predictive value for 29.2%, 91.7%, 70% and 66%, respectively.Conclusion: NLCR has a satisfactory predictive value for neonatal sepsis that widely available and economic predictor alternative with cutoff point for 2.22.Keywords: NLCR, CRP, predictor, neonatal sepsisCorrespondence: Irfan Dzakir Nugroho. Masters Program in Family Medicine, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta, Central Java.Indonesian Journal of Medicine (2021), 06(01): 112-118https://doi.org/10.26911/theijmed.2021.06.02.02

Hubungan Bayi Kecil Masa Kehamilan (KMK) dan Usia Kehamilan dengan Kejadian Stunting pada Bayi Usia 24-60 Bulan di RSUD Dr. Moewardi Miftachuljannah, Regita Ayu; Hidayah, Dwi; Setyawan, Sigit
Plexus Medical Journal Vol. 3 No. 3 (2024): Juni
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v3i3.1586

Pendahuluan: Stunting masih menjadi masalah kesehatan masyarakat yang menjadi perhatian di Indonesia. Bayi kecil masa kehamilan (KMK) dan usia kehamilan merupakan beberapa faktor risiko stunting namun hubungannya dengan kasus stunting pada bayi usia 24-60 bulan masih sedikit diteliti. Penelitian ini memiliki tujuan untuk mengetahui kaitan bayi kecil masa kehamilan (KMK) dan usia kehamilan dengan kejadian stunting pada bayi umur 24-60 bulan di Rumah Sakit Umum Daerah Dr. Moewardi. Metode: Penelitian ini memakai desain studi analitik dan pendekatan case control dengan jumlah sampel sebanyak 60 anak berusia 24-60 bulan di RSUD Dr. Moewardi pada tahun 2022. Pengambilan sampel menggunakan metode purposive sampling. Data diambil dari rekam medis dan dilakukan analisis data menggunakan software SPSS dengan analisis bivariat (uji Chi-square) dan uji multivariat (uji regresi logistik). Hasil: Dari hasil analisis statistik didapatkan bahwa ada hubungan yang signifikan antara bayi KMK dengan kejadian stunting (p = 0,018 dan OR 6.00), bayi KMK memiliki risiko 6 kali lebih tinggi terjadi stunting daripada bayi non KMK (sesuai masa kehamilan/SMK dan besar sesuai masa kehamilan/BMK). Usia kehamilan juga memiliki hubungan yang signifikan dengan stunting (p = 0,010 dan OR 4,07), usia preterm mempunyai risiko 4.07 kali lebih besar daripada bayi aterm. Kesimpulan: Terdapat hubungan yang signifikan antara bayi kecil masa kehamilan dan usia kehamilan dengan kejadian stunting pada usia 24-60 bulan. Bayi kecil masa kehamilan memiliki pengaruh lebih kuat daripada usia kehamilan dalam kejadian stunting pada bayi usia 24-60 bulan.

The Efficacy of Melatonin in Neonatal Sepsis with Respiratory Distress: A Randomized Controlled Study Hidayah, Dwi; Nur Irfani Agita
Journal of Maternal and Child Health Vol. 9 No. 5 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/thejmch.2024.09.05.03

Background: Neonatal sepsis is a significant condition worldwide, contributing to high morbidity and mortality, especially in developing countries such as Indonesia. Neonatal sepsis can rapidly progress to respiratory distress. Melatonin, an effective antioxidant and free radical scavenger, may be an adjuvant therapy. This study aimed to evaluate the efficacy of melatonin in neonatal sepsis with respiratory distress. Subjects and Method: A double-blind randomized controlled study was conducted on 42 neonatal sepsis with respiratory distress diagnosed with clinical and laboratory criteria. The subjects were randomly allocated into treatment and control groups, receiving a single dose of oral melatonin 20 mg and a placebo, respectively. The dependent variables were improvement of suplementation in oxygenation and ventilator, outcome, and hospital length of stay. The independent variables was suplementation melatonin The oxygen supplementation and ventilation support were measured at baseline and 72 hours after therapy. We analyzed all data with SPSS 25 using independent t test and determined the significance level at p < 0.050. Results: Seven of the 21 subjects in the treatment group experienced decreased oxygen supplementation and ventilation support, which was statistically significant (p = 0.009). While the outcome for both groups was the same proportion, it was statistically not significant (p = 1.000). Conclusion: Melatonin administration significantly decreased oxygen supplementation and ventilation support.

Platelet lymphocyte ratio (PLR), neutrophil lymphocyte ratio (NLR), and diastolic dysfunction as neonatal sepsis mortality predictors in preterm neonates Tampy, Safitri Tia; Hidayah, Dwi; Lilijanti, Sri
Paediatrica Indonesiana Vol. 65 No. 3 (2025): May 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.3.2025.216-23

Background Neonatal sepsis is a significant challenge in neonatal care, particularly among preterm neonates who are highly vulnerable due to their underdeveloped immune systems. Traditional markers for predicting the outcomes of neonatal sepsis, such as procalcitonin and C-reactive protein, are not always available all across places. Objective To evaluate the predictive value of platelet lymphocyte ratio (PLR), neutrophil lymphocyte ratio (NLR), and diastolic dysfunction for neonatal sepsis mortality in preterm neonates. Methods A prospective cohort study was conducted in 42 preterm neonates with neonatal sepsis admitted to Dr. Moewardi Hospital. The PLR and NLR were collected at two time points: the first blood specimen was drawn within the first 24 hours of life and the second was collected 72 hours later. Diastolic function was assessed by echocardiography performed within 48–72 hours after the diagnosis of sepsis. Mortality during treatment was recorded as the dependent variable. The relationships among these variables were analyzed with bivariate and multivariate analyses, and the significance level was set at P<0.05. Results Of 42 subjects, 57.1% died. Increased NLR and diastolic dysfunction were significantly associated with an increased risk of mortality (OR=3.64; P=0.049 and OR=25.0; P<0.001, respectively), while PLR was not. Multivariate analysis revealed that diastolic dysfunction remain a significant independent predictor of mortality (adjusted OR=28.9;P=0.001), whereas NLR did not maintain statistical significance (P=0.093). Conclusion Diastolic dysfunction was an independent predictor of mortality in preterm neonatal sepsis. The NLR and PLR did not associate with mortality in preterm neonatal sepsis. Rigorous monitoring of cardiovascular function is crucial in the management of neonatal sepsis.

Maternal Atopy Diathesis on The Newborn’s Skin Acidity and Hydration Putri, Osdatilla Esa; Widhiati, Suci; Mawardi, Prasetyadi; Kusumawardani, Arie; Mulianto, Nurrachmat; Hidayah, Dwi; Endraputra, Pristiawan
Jurnal Ners Vol. 9 No. 4 (2025): OKTOBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i4.50222

Background: Atopic diathesis, a hereditary predisposition to allergic disorders such as atopic dermatitis, asthma, and allergic rhinitis, is more strongly transmitted maternally. Maternal atopy may influence neonatal skin barrier development, but evidence on its effect on neonatal skin pH and hydration is limited. Methods: This cross-sectional study was conducted at Dr. Moewardi General Hospital, Surakarta, Indonesia, between March–April 2025. Neonates (28–41 weeks gestation), <24 hours old, and delivered by cesarean section were included. Skin pH was measured on the volar forearm and axilla using a calibrated pH meter, and hydration (water and oil content) was assessed with a Skin Tester. Maternal atopy diathesis was classified by the Erlangen Atopy Score (EAS). Results: Twenty-nine neonates were enrolled, comprising 12 with and 17 without maternal atopy. No significant association was found between maternal atopy and neonatal hydration (water: p = 0.460; oil: p = 0.997) or skin pH (p = 0.876). Conclusion: Maternal atopy diathesis was not associated with neonatal skin pH or hydration in the first 24 hours of life. Early neonatal skin physiology appears to be influenced more by intrinsic maturation than maternal atopic status. Longitudinal studies are needed to assess potential delayed effects.

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