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All Journal Jurnal Kesehatan Andalas Majalah Kedokteran Andalas Health and Medical Journal Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Scientific Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Sains, Teknologi dan Kesehatan
Intan, Shinta Ayu
Anatomic Pathology Department, Faculty Of Medicine, Universitas Andalas, Padang.
Biochemistry, Genetics & Molecular Biology Computer Science & IT Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Hubungan Ekspresi Survivin dengan Subtipe Molekuler Karsinoma Mammae Invasif Shinta Ayu Intan; Yenita Yenita; Tofrizal Tofrizal; RZ Nizar
Jurnal Kesehatan Andalas Vol 8, No 3 (2019): Online September 2019
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v8i3.1036

Abstract

Karsinoma mammae merupakan salah satu penyebab utama kematian pada perempuan di seluruh dunia. Karsinoma ini memiliki prognosis, respon pengobatan serta perilaku klinis yang berbeda yang disebabkan oleh karakteristik molekuler yang berbeda. Berbagai faktor prognostik telah menjadi dasar dalam pemberian terapi adjuvan (dan kelangsungan hidup). Salah satu molekul yang memiliki peran sebagai faktor prognostik adalah survivin. Tujuan penelitian adalah menentukan hubungan ekspresi survivin dengan subtipe molekuler karsinoma mammae invasif. Penelitian ini menggunakan metode analitik potong lintang. Sampel adalah 40 kasus dari sediaan blok parafin karsinoma mammae invasif yang didiagnosis histopatologi di Sentra Diagnostik Patologi Anatomik Fakultas Kedokteran Universitas Andalas Sumatera Barat periode Januari 2014-Desember 2017 serta reevaluasi subtipe molekuler yang telah diperiksa di Laboratorium Patologi Anatomik Fakultas Kedokteran Universitas Padjadjaran Bandung berdasarkan pemeriksaan imunohistokimia ER, PR, Her-2 dan Ki-67. Ekspresi survivin dinilai secara imunohistokimia ditandai dengan warna coklat pada inti dan sitoplasma sel tumor. Hasil penelitian dianalisis dengan uji Chi-square. Ekspresi survivin positif ditemukan pada 27 kasus dengan 9 sampel (33,3%) subtipe luminal, 8 sampel (29,6%) subtipe Her-2, dan 10 sampel (37%) subtipe Triple-negative. Karsinoma mammae invasif paling banyak ditemukan pada kelompok usia 50-59 tahun serta subtipe molekuler terbanyak adalah subtipe Triple-negative. Kesimpulan penelitian ini tidak terdapat hubungan bermakna antara ekspresi survivin dengan subtipe molekuler karsinoma mammae invasif (p=0,770).
Upaya Optimalisasi Pertumbuhan Anak Stunting melalui Peningkatan Pengetahuan Ibu tentang Kesehatan Keluarga Ulya Uti Fasrini; Desmawati Desmawati; Masrul Masrul; Nur Indrawaty Lipoeto; Delmi Sulastri; Fathiyyatul Khaira; Rahmani Welan; Shinta Ayu Intan; Rinaldiansyah Rinaldiansyah; Muhammad Rayyan Rifqi; Annisaul Husna; Rahmi Nurjannah
Warta Pengabdian Andalas Vol 28 No 3 (2021)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.28.3.232-238.2021

Abstract

The nutritional problem such as stunting will impact human resource quality. Various factors, including family economic problems, contributed to it, such as in Lambung Bukit Village, Pauh District in Padang City. Apart from financial issues, the mother's lack of illiteracy on child health and nurture also contributes to nutritional problems in this area. Health services that involve physical examinations, child development, nutritional problems and the mother's understanding of family health need to be carried out. Nutrition education was given together with maternal education about parenting and maternal health by the community service team from the Nutrition Science Section and Anatomical Pathology Section, Faculty of Medicine, Andalas University. Thirty mothers accompanied by their toddlers attended the activity. The service team provided five steps that participants must pass, including registration activities, anthropometric examinations, nutritional history, problem assessments, and nutritional consultations. It was hoped that both individual and group approaches would provide significant leverage for changing maternal behaviour. The mother benefited of the education provided. They requested that the team carry out this activity regularly at least once every three months, both to assess the growth and development of children and provide the knowledge about family health they need.
Kromomikosis yang menyerupai karsinoma sel skuamosa: suatu kasus jarang Shinta Ayu Intan; Salmiah Agus; Anandia Putriyuni
Majalah Kedokteran Andalas Vol 41, No 3 (2018): Published in September 2018
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v41.i3.p112-119.2018

Abstract

Kromomikosis merupakan infeksi jamur kronik yang disebabkan oleh jamur berpigmen (dematiaceous) yang masuk ke dermis dari lingkungan sekitar. Kromomikosis mengenai laki-laki dewasa dengan rentang usia antara 40-50 tahun. Predileksi paling sering yaitu di ekstremitas bawah terutama kaki. Tanah, sayur-sayuran dan bahan organik lainnya merupakan habitat normal dari jamur ini. Tujuan: Melaporkan satu kasus kromomikosis jarang. Kasus: Dilaporkan kasus pada seorang laki-laki usia 53 tahun dengan bercak berwarna keabu-abuan tanpa rasa gatal dan nyeri yang semakin bertambah besar sejak ±1 tahun yang lalu pada pergelangan kaki kiri.  Simpulan: Kromomikosis sering salah didiagnosis sebagai karsinoma sel skuamosa, konfirmasi histopatologi penting untuk menegakkan diagnosis karena pemeriksaan secara histopatologi menunjukkan gambaran khas yaitu adanya copper pennies sehingga dapat menyingkirkan diagnosis bandingnya. 
Ekspresi Protein Sitoplasmik SOCs2 pada Adenokarsinoma Kolorektal: Studi Imunohistokimia Nita Afriani Azmal; Shinta Ayu Intan; Tofrizal Tofrizal
Jurnal Kesehatan Andalas Vol 11, No 1 (2022): Online March 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i1.1982

Abstract

 Inflammatory cytokines have a role in triggering cell signals in colorectal cancer. They increase signaling pathways into cells via the Janus kinase pathway (JAK) - signal transducer and activator of transcription (STAT) -suppressor of cytokine signaling (SOCs) JAK-STAT. SOCs2 protein is a cytoplasmic protein that can inhibit activation of JAK-STAT pathway so that it prevents cascade of signals into the nucleus. This protein is thought to have decreased in adenocarcinoma colorectal. Objectives: To reveal the expression of SOCs2 protein in 37 paraffin block samples in Anatomy Pathology Department Medical Faculty Andalas University. Methods: Data were taken from medical records and histopathology was assessed by HE. SOCs2 expression was evaluated by immunohistochemistry using SOCs2 polyclonal antibody (bs-1896R). Cytoplasmic expression was counted using Image J software. Results: The average of age was 56.57 years, 21 samples (55.8%) were male, depth of invasion was mostly in the tunica muscularis (T3), and 7 cases of malignancy (18.9%) were poorly differentiated. SOCs2 expression was  5 cases (13.5%).   Conclusion: There was SOCs2 expression in a small proportion of colorectal adenocarcinoma.Keywords:  SOCs2 protein, cytoplasmic inhibitor, JAK-STAT, cell signaling
GAMBARAN KLINIKOPATOLOGI KARSINOMA PAYUDARA PADA WANITA USIA MUDA DI RSUP DR. M. DJAMIL PADANGTAHUN 2019-2021 Meimonita, Dhitia; Intan, Shinta Ayu; Myh, Etriyel
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 1 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Maret 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i1.985

Abstract

Breast cancer is a disease that is often found in women characterized by the growth of abnormal cells in the breast. Age factor in breast cancer in young women is known to have a poor prognosis. The purpose of this study was to determine the clinicalpathological description of breast carcinoma in young women at Dr. RSUP. M. Djamil Padang year 2019-2021. This is a descriptive research with a total sampling technique using secondary data in the form of medical records. The sample of this study was young female breast carcinoma patients in 2019-2021.The results showed that the age range for breast carcinoma in young women was 41-45 years (44.3%), most of the histopathological types were invasive ductal carcinoma (62.5%), with the majority of histopathological grade II (60.2%), tumor location was mostly in the upper lateral quadrant (60.2%), with the most tumor size T2 (52.3%). The conclusion of this study is that most cases of breast carcinoma in young women at Dr. M. Djamil Padang Year 2019-2021 are at a high degree so that early detection is needed in cases of breast carcinoma in women at this young age
Ekspresi Protein Sitoplasmik SOCs2 pada Adenokarsinoma Kolorektal: Studi Imunohistokimia Azmal, Nita Afriani; Intan, Shinta Ayu; Tofrizal, Tofrizal
Andalas Journal of Health Vol. 11 No. 1 (2022): Online March 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i1.1982

Abstract

 Inflammatory cytokines have a role in triggering cell signals in colorectal cancer. They increase signaling pathways into cells via the Janus kinase pathway (JAK) - signal transducer and activator of transcription (STAT) -suppressor of cytokine signaling (SOCs) JAK-STAT. SOCs2 protein is a cytoplasmic protein that can inhibit activation of JAK-STAT pathway so that it prevents cascade of signals into the nucleus. This protein is thought to have decreased in adenocarcinoma colorectal. Objectives: To reveal the expression of SOCs2 protein in 37 paraffin block samples in Anatomy Pathology Department Medical Faculty Andalas University. Methods: Data were taken from medical records and histopathology was assessed by HE. SOCs2 expression was evaluated by immunohistochemistry using SOCs2 polyclonal antibody (bs-1896R). Cytoplasmic expression was counted using Image J software. Results: The average of age was 56.57 years, 21 samples (55.8%) were male, depth of invasion was mostly in the tunica muscularis (T3), and 7 cases of malignancy (18.9%) were poorly differentiated. SOCs2 expression was  5 cases (13.5%).   Conclusion: There was SOCs2 expression in a small proportion of colorectal adenocarcinoma.Keywords:  SOCs2 protein, cytoplasmic inhibitor, JAK-STAT, cell signaling
FAKTOR-FAKTOR YANG MEMPENGARUHI SURVIVAL RATES PASIEN YANG MENDAPATKAN  RADIOTERAPI PADA KANKER OVARIUM : SYSTEMATIC REVIEW Genia, Dara Indah; Ariani, Novita; Suharti, Netti; Syamel, Muhammad; Elliyanti, Aisyah; Intan, Shinta Ayu
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 2 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Juni 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i2.1266

Abstract

Ovarian cancer is known as a silent but deadly disease (silent killer) so it is not uncommon for sufferers to end in death. Radiotherapy for ovarian cancer is indicated as adjuvant therapy for advanced stages in an effort to extend survival rate. This review aims to determine the factors that influence survival rates, local control, and toxicity leves in patients receiving radiotherapy for ovarian cancer. This research is a narrative reviw using the PRISMA method. A literature search was conducted in three databases Pubmed, CENTRAL and Science Direct in the 2013-2023 period. The specified keywords are adapted to the terms Medical Subject Headings (MeSH) and research questions using the PEO formula. Articles were selected based on predetermined inclusion and exclusion criteria. There are 9 selected primary articles and included in the narrative reflection. As many as 3 out of 9 studies stated first-line therapy in the form of total debulking surgery of lesions treated before RT as a factor that significantly influenced survival rates, 2 studies stated CA-125 levels before and after RT had a significant effect on survival rates, 2 studies explained that patients with platinum sensitivity and CCC histological subtypes had better survival rates, and 2 other literatures explained that cancer stage at diagnosis, cancer volume, and post-treatment or not after RT also significantly affected survival rates. Ovarian cancer patients who undergo radiotherapy have better survival rate than patients who do not receive radiotherapy with excellent local control and limited radiation related toxicity that is relatively well tolerated by patients
Gambaran Klinikopatologi Kanker Tiroid di RSUP Dr. M. Djamil Padang Tahun 2018 - 2020 Putra, Fachri; Kurniawati, Yulia; Hasmiwati, Hasmiwati; Khambri, Daan; Nurhayati, Nurhayati; Intan, Shinta Ayu
Jurnal Ilmu Kesehatan Indonesia Vol. 6 No. 2 (2025): Juni 2025
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v6i2.1401

Abstract

Latar Belakang: Kanker tiroid merupakan proses keganasan dari sel kelenjar tiroid yang penyebabnya belum diketahui secara pasti. Kanker tiroid termasuk jarang ditemukan dibandingkan jenis kanker lainnya, tetapi kanker tiroid merupakan keganasan endokrin yang tersering ditemukan. Objektif: Untuk mengetahui gambaran klinikopatologi kanker tiroid di RSUP Dr. M. Djamil Padang periode Januari 2018 – Desember 2020 Metode: Penelitian ini bersifat deskriptif dengan desain cross-sectional yang dilakukan di RSUP Dr. M. Djamil Padang pada tahun 2023. Sampel menggunakan rekam medis pasien kanker tiroid di RSUP Dr. M. Djamil Padang periode Januari 2018 – Desember 2020 yaitu sebanyak 35 pasien. Pengambilan data menggunakan teknik total sampling. Hasil: Penderita kanker tiroid lebih banyak ditemukan pada kelompok usia 55 – 64 tahun (34,3%), berjenis kelamin perempuan (60%), memiliki rentang IMT normal (48,6%), dan hampir semua penderita tidak memiliki riwayat keluarga yang menderita kanker (97,1%). Mayoritas merupakan single nodul (60%), dengan nodul terbanyak berukuran >4 cm (48,6%), dan sebagian besar konsistensi nodul adalah solid (74,3%). Jenis histopatologi didominasi kanker tiroid tipe papiler (80%), dan tatalaksana pembedahan yang paling banyak dilakukan yaitu total tiroidektomi (65,7%). Kesimpulan : Gambaran klinikopatologi kanker tiroid terbanyak ditemukan pada usia 55 – 64 tahun, berjenis kelamin perempuan, tidak memiliki riwayat keluarga dengan kanker, rentang IMT normal, single nodul, ukuran nodul >4 cm, solid, papiler, dan sebagian besar pembedahan berupa total tiroidektomi.
A Case Report: Langerhans Cell Histiocytosis of bone mimicking a Chronic Osteomyelitis Intan, Shinta Ayu
Health and Medical Journal Vol 7, No 2 (2025): HEME May 2025
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v7i2.1693

Abstract

Latar belakang: Langerhans cell histiocytosis adalah suatu lesi jinak pada tulang yang biasanya mengenai populasi anak dan dewasa muda.Penegakan diagnosis langerhans cell histiocytosis memiliki tantangan tersendiri karena selain kasus yang jarang, secara histopatologi langerhans cell histiocytosis memiliki gambaran seperti proses inflamasi lainnya. Kami melaporkan kasus pada anak laki-laki berusia 4 tahun dengan keluhan benjolan yang tumbuh lambat, konsistensi kenyal padat di area kepala. Hasil CT scan kepala menunjukkan Space Occupying Lesion (SOL) multipel dengan destruksi tulang os parietal kanan dan kiri. Pada gambaran histopatologi didapatkan kesan granuloma eosinofilik. Adanya dominasi sel eosinofilik, sel limfosit, sel plasma, serta sel inflamasi lainnya di tulang dapat menyebabkan misdiagnosis sebagai suatu osteomielitis kronik. Kemiripan tampilan histopatologi ini, selain meninjau kembali manifestasi klinis dan lokasi lesi maka analisis morfologi sel yang didukung oleh pemeriksaan imunohistokimia penting untuk membedakan sel histiosit Langerhans dengan sel histiosit normal lainnya. Pendekatan multidisiplin ini sangat penting untuk membuat diagnosis yang tepat sehingga dapat mengoptimalkan terapi yang diberikan.
Fine Needle Aspiration Biopsy as A Useful Diagnostic Adjunct in The Management of Ameloblastoma: A Cytology Case Report Rasfa, Rum Affida; Intan, Shinta Ayu; Hilbertina, Noza; Oktora, Meta Zulyati
Scientific Journal Vol. 4 No. 4 (2025): SCIENA Volume IV No 4, July 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i4.249

Abstract

Background: Ameloblastoma is one of the most common benign odontogenic tumors, known for its slow growth but locally invasive behavior, often leading to extensive bone destruction if not diagnosed and treated early. Preoperative diagnosis of ameloblastoma can be made by Fine Needle Aspiration Biopsy (FNAB) which is used as a guide for surgical planning. Diagnosis of ameloblastoma from cytology is challenging due to many pitfalls and differential diagnosis with other odontogenic lesions, but proper sampling and accurate diagnosis are very useful inpatient management Understanding its cytomorphological features can greatly assist in early differentiation from other maxillofacial neoplasms. This case report aims to describe the appearance of ameloblastoma on FNAB and reveal the contribution of the FNAB examination in the preoperative diagnosis of ameloblastoma so that adequate surgery can be carried out and the results are more optimal. Case report: We report a case of a tumor in the mandible of a 16-year-old man with a diagnosis of right mandibular tumor. The patient was sent for FNAB to the anatomical pathology laboratory. Preoperative cytology examination showed benign odontogenic lesions indicating ameloblastoma from FNAB. Furthermore, tumor resection was performed on the patient and histopathology tissue examination was performed with results consistent with ameloblastoma. Discussion: The FNAB procedure can be performed to establish for a pre-operative diagnosis of ameloblastoma. Cytological characteristics of ameloblastoma include basaloid cells or epithelial cells resembling ameloblasts with nuclei arranged palisade at the periphery and in the middle consisting of cells resembling stellate reticulum cells. False-negative results in the FNAB procedure can occur due to inadequate specimens or inaccurate sampling, mostly related to cystic tumors. To avoid this, FNAB tissue sampling can be performed at multiple sites and the deeper aspects of the tumor can assist in establishing an accurate preoperative diagnosis. Conclusion: The FNAB cytology is a reliable procedure for the pre-operative diagnosis of ameloblastoma. Pre-operative diagnosis of ameloblastoma can be used for planning therapy and early diagnosis of recurrence cases that can improve patient survival. The correlation between t
Co-Authors Aisyah Elliyanti Ananda, Gita Putri Anandia Putriyuni Annisaul Husna Ariani, Novita Azmal, Nita Afriani Daan Khambri Delmi Sulastri Desmawati Desmawati Etriyel Myh Fathiyyatul Khaira Genia, Dara Indah Hasmiwati Masrul Meimonita, Dhitia Muhammad Rayyan Rifqi Netti Suharti, Netti Nita Afriani Azmal Noza Hilbertina, Noza Nur Indrawaty Lipoeto Nurhayati Nurhayati Oktora, Meta Zulyati Putra, Fachri Rahmadian, Rizki Rahmani Welan Rahmi Nurjannah Rikarni Rikarni Rinaldiansyah Rinaldiansyah Rum Affida Rasfa RZ Nizar Salmiah Agus Selfi Renita Rusjdi Syamel, Muhammad Tofrizal Tofrizal Tofrizal Ulya Uti Fasrini Yenita Yenita Yulia Kurniawati