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All Journal Jurnal Kedokteran Brawijaya e-Journal Pustaka Kesehatan Dentika Dental Journal Jurnal Pangan dan Agroindustri STOMATOGNATIC- Jurnal Kedokteran Gigi ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva UNEJ e-Proceeding Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Journal of Dentomaxillofacial Science Warta Pengabdian Padjadjaran Journal of Dental Researchers and Students Jurnal Material Kedokteran Gigi Indonesian Journal of Life Sciences Odonto dental journal Jurnal Penelitian The Indonesian Journal of Health Science

Zahreni Hamzah

Bagian Biomedik, Fakultas Kedokteran Gigi, Universitas Jember, Indonesia

Author-ID : 3302201

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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SIFAT OSTEOINDUKTIF SILIKA AMORPHOUS SEKAM PADI : OSTEOINDUCTIVITY OF AMORPHOUS SILICA FROM RICE HUSK Didin Erma Indahyani; Zahreni Hamzah; Izzata Barid
Dentika: Dental Journal Vol. 16 No. 2 (2011): Dentika Dental Journal
Publisher : TALENTA

Currently, bone graft is recommended to improve and support the biological repair of bone defects properly. Bone graft was found to cause death in the donor area, long pain, infection, cosmetic deformity, hematoma, the amount of blood loss, injury or damage to the nervous in the donor area. Synthetic bone graft material was developed as a scaffold that serves to template the formation of bone. The ideal scaffold should be biodegradable, osteoconductive and osteoinductive. During there graft materials have not optimally provide the morphological, mechanical properties, biocompatibility and biodegradation, and osteoinductive-osteoinductive. Silica is proven to support and promote primary osteoblast growth, synthesis of matrix proteins, collagen type I, so that it can cause bone formation. Rice husk contains of silica is high enough. Because of abundant material and its potential in bone formation, needs to be done research on silica from rice husk in the manufacture of synthetic bone graft. The purpose of this study was to analyze the amorphous silica from waste rice husks as synthetic bone graft material (scaffold), especially against osteoblasts proliferation. Type of study was an experimental laboratory. This research was conducted by isolating the amorphous silica from rice husk. Primary osteoblast cultures derived from calvaria rats aged 2 days, growing in Alpha Modified Eagle Medium (α-MEM) (as negative control), α-MEM that in condition with 58S silica (as positive control group) and α-MEM condition with silica from rice husk (as treatment group). Osteoblast proliferation was observed with Quick Cell Proliferation Assay Kit for 7 and 14 days. The result showed that the rice husk silica was significantly (p <0.05) osteoinductive, osteoblast cultures demonstrated that its proliferation was higher in the groups that were implanted in the culture medium condition with 58S silica. In conclusion, rice husk amorphous silica is potentially osteoinductive scaffold for synthetic bone graft material.

Hubungan antara keparahan gingivitis dan indeks massa tubuh (IMT) pada lanjut usiaCorrelation between severity of gingivitis and body mass index (BMI) of elderly Lisa Wahyu Zelda Federika; Zahreni Hamzah; Niken Probosari
Padjadjaran Journal of Dental Researchers and Students Vol 4, No 2 (2020): Oktober 2020
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v4i2.28867

Pendahuluan: Tingginya prevalensi gingivitis merupakan masalah kesehatan rongga mulut yang membutuhkan perhatian khusus, terutama pada kaum lanjut usia (lansia). Gingivitis dapat terjadi karena penumpukan plak pada daerah yang tidak digunakan mengunyah sehingga terjadi penurunan saliva yang menyebabkan self-cleansing tidak bekerja pada sisi tersebut. Mekanisme tersebut menyebabkan terganggunya status gizi lansia, karena pada kondisi gingivitis terjadi penurunan kemampuan mastikasi sehingga terjadi pembatasan diet dan berkurangnya asupan nutrient oleh tubuh yang menyebabkan terjadinya penurunan Indeks Massa Tubuh (IMT) pada lansia. Tujuan penelitian menganalisis hubungan antara keparahan gingivitis dengan Indeks Massa Tubuh (IMT) pada lansia. Metode: Jenis penelitian observasi analitik korelasional dengan pendekatan cross sectional study. Subjek penelitian lansia dengan kelompok usia mulai dari pra lansia 45-59 tahun, lansia 60-74 tahun, dan usia lanjut 75 tahun keatas, yang mengisi informed consent dan bersedia menjadi subjek penelitian, minimal memiliki 2 gigi indeks yang dapat diperiksa dengan probing depth 3<x<5 mm. Pengambilan data dilakukan dengan pemeriksaan gingivitis menggunakan klasifikasi pengukuran Gingival Index (GI) oleh Loe dan Silness tahun 1963, kemudian dilakukan pengukuran Indeks Massa Tubuh (IMT) menggunakan kalsifikasi berdasarkan WHO tahun 2000. Data yang terkumpul, ditabulasi dan diuji dengan korelasi Pearson. Hasil: Hasil analisis hubungan antara Gingival Index (GI) dengan Indeks Massa Tubuh (IMT) didapatkan koefisien korelasi (r) sebesar -0,247 dengan p=0,002 (p<0,05). Simpulan: Terdapat hubungan antara keparahan gingivitis dengan IMT pada lansia. Semakin bertambahnya usia pada lansia menunjukkan peningkatan pada Gingival Index dan penurunan Indeks Massa Tubuh.Kata kunci: Lansia, gingival Index (GI), indeks massa tubuh (IMT) ABSTRACTIntroduction: The high prevalence of gingivitis is an oral health problem that requires special attention, especially in the elderly. Gingivitis can occur due to plaque buildup in areas that are not used for chewing, resulting in a decrease in the salivary volume, which causes self-cleansing to not work on the area. This mechanism disrupts the nutritional status of the elderly because decreasing mastication ability caused by gingivitis, which resulting in dietary restrictions and reduced of nutrients intake, thus causes a decrease in the Body Mass Index (BMI) of the elderly. The purpose of this study was to determine the relationship between the severity of gingivitis and Body Mass Index (BMI) of the elderly. Methods: This research was an observational analytic study, correlational with a cross-sectional approach. The subjects of this study were elderly with age groups ranging from youngest-old (45-59 years old), middle-old (60-74 years old), and oldest-old (over 75 years old), who filled out informed consent and willing to participate as research respondents, and at least having two index teeth that could be examined with a probing depth of 3 < x < 5 mm. Data were collected by examining the gingivitis using the Gingival Index (GI) measurement with the classification of Loe and Silness, then the measurement of Body Mass Index (BMI) was performed using classifications based on WHO 2000. Afterwards, data was collected, tabulated, and analysed with the Pearson correlation test. Results: The results of the analysis of the relationship between the Gingival Index (GI) and Body Mass Index (BMI) obtained correlation coefficient (r) of -0.247 with p = 0.002 (p < 0.05). Conclusion: There is a relationship between the severity of gingivitis and the BMI of the elderly. Increasing age of the elderly will also increase the GI and decrease the BMI.Keywords: Elderly, gingival index (GI), body mass index (BMI).

THE PROGRESSIVE LOW CHRONIC INFLAMMATION ON ORAL TISSUES IN ELDERLY Zahreni Hamzah; Dyah Indartin; Zahara Meilawaty
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Aging is a normal process, as inevitable biologicalphenomenon. Generally, this process characterizedby a decrease in the ability of resolution,regeneration, and reparation of cell and tissues, So,those cells and tissues cannot function properly andits will grow up and die.(1) WHO reports that thepopulation of elderly people worldwide increases by1.7% annually, whereas the population of peopleaged ≥ 65 years old increases by 2.5%. WHOclassified the elderly based on their chronologic/biologic state in 4 groups: (1) the middle age ranged45-59 years old, (2) the older/elderly age ranged 60-74 years old, (3) the advanced old age ranged 75-90years old, and (4) the very old age over 90 years old.Generally, elders ≥ 65 years old have healthproblems as effects of aging process. That meansthey need to have a special concern about theirhealth condition include in dental care.(2,3)Low, systemic and progressive chronic inflammationin elderly age is called inflammaging. This conditioncan occur as the effects of injury on cells andtissues.(4,5) There are some factors that cause injuryon cells, such as; hypoxia, chemical materials (toxins,drugs), physical agents (mechanical trauma,temperature, sudden changes in atmosphericpressure, radiation, electrical potency), microbiologyagents (virus, microbes, fungi), immune systemdisorder, genetic disorder, or malnutrition. Whenthe cells got injuries, there are some possibilityreactions on cells and tissues, e.g. retrogressivereaction, progressive reaction; and adaptationreaction. The main cause and the response towardsinflammaging that linked to illness are stillunknown.(6)

[RETRACTED] IMPACT PSYCHOLOGICAL AND PSYCHO-PHYSICAL WORK DISTRESS ON TOOTH MOBILITY IN RAT MODEL (ARTICLE RETRACTED FROM IBSC PROCEEDING) Zahreni Hamzah; Suhartono Taat Putra; Elyana Asnar STP
UNEJ e-Proceeding 2016: Proceeding The 1st International Basic Science Conference
Publisher : UPT Penerbitan Universitas Jember

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Retracted under author request.

ROLE OF CHEMOATTRACTANT CHEMOKINE (SDF-1/CXCR4) IN BONE MARROW NICHE Dyah Indartin Setyowati; Zahreni Hamzah
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Bone marrow is the pioneer for studying stem cells.The basic concept of stem cells obtained by studyinghematopoietic stem cells. Although how theinteraction of HSCs with the local environmentnecessary for the maintenance of stem cells can notbe fully explained ( Compston, 2002; Iwasaki andSuda., 2010). Studies of HSCs aims to study thehabits of these cells in a population of cellscontained in bone marrow . So far little is knownabout the interaction of the bone marrow niche. Thestudy was conducted using a culture system thatlimited done in a sustainable way to prove theinteraction of the bone marrow niche. From theseresults can then be identified subset of osteoblasts (N-Cadherin + CD 45-) that physically attaches to theHSCs in the BM . ( Tong Yin , 2006)Bone marrow consist of hematopoietic cells arewrapped by the bone structure. Hematopoietic cellsdevelop in the bone cavity and retained in the bonemarrow until they have matured, then released intothe vascular system ( Yin and Li , 2006). Most cells ofhaemopoietic can be found next to the endostealsurface of the bone, which layer is primarilyosteoblasts. Osteoblasts is one type of bone cell thatserves to reform or bone formation. HSCs are stemcells that are known to differentiate into osteoclasts.Osteoclasts are the cells of bone that serves to boneresorption. Their physical proximity betweenosteoblasts and which HSCs are parent cellsosteoclasts, as well as the identification of N -Cadherin / β - Catenin adherent complex betweenthe two prove their relationship or communicationbetween these cells. Osteoblast cells not only play arole in bone formation, but as osteoblast niche inthe bone marrow also, contribute to themaintenance of HSCs that are stem cells osteoclasts(Yin and Li , 2006 ; Tong Yin , 2006 ).There are two main types of stem cells areembryonic and adult stem cells . Pluripotentembryonic stem cells derived from the inner cellmass of blastocysts and has the ability to be a threeembryonic germ layers , namely ectoderm ,endoderm , and mesoderm (Li and Xie , 2005). Atbirth, adult stem cells including GSCs and SSCs willoccupy and live in a special microenvironment,called a niche (Li and Sie., 2005)Niche is different depending on the type of tissue ororgan. Structurally niche supported by the cells andtheir interactions molecular signals that preparedand provided to form a microenvironment for stemcells. Niche hypothesis has actually been describedby Scofield in 1978 ( Li and Sie , 2005; Yin and Li ,2006) . Stem cell niche is supported by manysignaling and adhesion molecules involved in theinteraction of the stem cell niche, accounted diversecharacteristics for each niche function ( figure 1 )that is; SDF -1/CXCR4 , SCF/c - Kit, Jagged/Notch,angiopoietin-1/ Tie2 ( Ang-1/Tie2 ), and Ca2 + -sensing receptor ( Yin and Li, 2006). Most studiesconducted to know and understand the molecularmechanisms of interaction and behavior of stemcells. Understanding the interaction and behavior ofstem cells in the bone marrow niche is veryimportant to understand the eventsosteoclastogenesis, especially how osteoclastprecursor cells can be recruited from niche thenmobile until homing (Kollet et al , 2007). Research isusually conducted in diseases associated with theaccumulation of osteoclasts or osteoclast progenitorcells that causes pathological osteolysis , such as ;benign bone tumors and bone metastases cancer (Kollet et al , 2007; Jennifer , 2009).

ROLE OF REACTIVE OXYGEN SPECIES ON DEVELOPMENTS OF OSTEOCLASTOGENESIS IN AGING Dyah Indartin Setyowati; Zahreni Hamzah; Zahara Meilawaty
UNEJ e-Proceeding 2016: Proceeding The 1st International Basic Science Conference
Publisher : UPT Penerbitan Universitas Jember

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Osteogenesis is a process of development which is perfectly controlled by a number of extrinsic and instrinsic factors that consists of hormones, growth factors, cytokines produced in the bone marrow micro environment, due to process of molecules adhesion that mediate by the interaction of cells and cell-matrix, osteoblasts-specific signaling proteins and transcription factors (TFs). Recently, research explained that adherence osteoclasts on the bone surface and secretion of protons into an extracellular compartment between osteoclasts and bone surface together with the production of Reactive Oxygen Species (ROS) involved in the complex process of bone resorption. Superoxide role in the activation and transcription NF-κB factor is to increase osteoclastogenesis. Furthermore, it is alleged that ROS is involved in both differentiation of osteoclasts and osteoblast cell. Aging and diseases which associated with aging is a result of ROS that cause damage was reported increase with age. This review, which is dedicated to geriatric physicians, geriatric dentistry or gerodontology reviews ROS-related osteoclastogenesis in aging and as the basic of the research to determine benefit of ROS through NADPH oxidase activation in the osteopetrotic case.

Saliva as a future potential predictor for various periodontal diseases Zahreni Hamzah
Dental Journal (Majalah Kedokteran Gigi) Vol. 44 No. 2 (2011): June 2011
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: There are many diagnostic biomarkers have been found in saliva. Saliva contains a wide variety of proteins, including bacteria and products, enzymes, inflammatory mediators and host response modifiers, products of tissue breakdown. Purpose: The purpose of the study was studied current development of diagnostic biomarkers in saliva that will lead to the development of simple and accurate diagnostic tools for periodental disease. Reviews: Specifically, the salivary biomarkers divided for three aspects of periodontitis i.e. inflammation, collagen degradation and bone turnover, correlated with clinical features of periodontal disease. The diagnostic biomarkers is in saliva, such as enzyme, immunoglobulin, cytokines, bacteria and bacterial products, hormones. For the past two decades, oral health researchers have been developing salivary diagnostic tools to monitor oral diseases. Conclusion: The indicators of acute periodontitis can detect with ß-glucuronidase and AST, IL-1β, and MMP-8, whereas indicators for chronic periodontitis can detect with ALP. The indicators for collagen degradation and bone turnover suggest ICTP, fibronectin fragments, and osteonectin. The indicators of severity of periodontitis especially can be predict by B. forsythus.Latar belakang: Banyak biomarker telah ditemukan dalam saliva. Saliva terdiri dari berbagai protein unik meliputi bakteri dan produk bakteri, enzim, mediator inflamasi dan modifikasi respon host (immunoglobulin, sitokin), produk kerusakan jaringan (telopeptida kolagen, osteokalsin, proteoglikan, fragmen fibronectin). Tujuan: Mengkaji biomarker dalam saliva untuk pengembangan metode diagnostik sederhana dan akurat untuk penyakit periodontal. Tinjauan Pustaka: Secara khusus, biomarker saliva pada periodontitis dibagi dalam tiga aspek yaitu inflamasi, dan degradasi kolagen serta pergantian tulang. Biomarker diagnostik dalam saliva, meliputi enzim, imunoglobulin, sitokin, bakteri dan produk-produk bakteri, hormon. Selama dua dekade terakhir, para peneliti kesehatan mulut telah mengembangkan alat diagnostik melalui saliva yang tepat untuk memonitor beberapa penyakit periodontal. Kesimpulan: Indikator periodontitis akut dapat dideteksi dengan β-glucuronidase dan AST, IL-1β,dan MMP-8, whereas indikator untuk periodontitis kronis dapat dideteksi dengan ALP. Indikator untuk degradasi kolagen dan penggantian tulang dideteksi melalui ICTP, fibronectin fragments, dan osteonectin. Sedang indikator untuk keparahan periodontitis terutama dapat diprediksi melalui B. forsythus.

The influence of functional tooth units on body mass index in the elderly of the Jember Regency Jevina Sicilia Ahliawan; Zahreni Hamzah; Mei Syafriadi
Dental Journal (Majalah Kedokteran Gigi) Vol. 53 No. 3 (2020): September 2020
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v53.i3.p144-148

Background: Tooth loss can disrupt the mastication process. Mastication disorders limit the amount of food a person consumes, affecting nutrition. The number of functional tooth units (FTUs) can affect nutritional status, measured using the body mass index (BMI). Purpose: The purpose of this study is to analyse the effect of the number of FTUs on the BMI in the elderly. Methods: This research was conducted in four villages in the Jember Regency. The number of subjects was 189, aged 45 years and over. The number of FTUs was calculated based on the anterior and posterior teeth that have contact with the antagonist and the BMI using the BMI formula. The data was analysed using a linear regression test; the level of significance is 0.005. Results: A simple linear regression test showed that there was significant correlation between FTU and BMI (p=0.366). Conclusion: The number of FTUs affects BMI; the higher the number of FTUs, the greater the BMI.

Oral health profile of the elderly people in the Pandalungan community Amandia Dewi Permana Shita; Zahreni Hamzah; Zahara Meilawaty; Tecky Indriana; Ari Tri Wanodyo Handayani; Dyah Indartin Setyowati
Dental Journal (Majalah Kedokteran Gigi) Vol. 53 No. 4 (2020): December 2020
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v53.i4.p217-222

Background: The Pandalungan community is a unique community established through the assimilation of two dominant cultures: the Javanese and Madurese. Both of these communities created a community with a new culture called the Pandalungan community culture. The people of this community live in coastal, rural and urban areas. Generally, research on the uniqueness in the oral health behaviour of the Pandalungan community has not been conducted since the oral health practices of the Pandalungan community are considered to be the same as that of the Javanese community. Purpose: In order to develop programmes for oral health prevention, this research aims at comparing the oral health profiles of the elderly (classified as per age) living in the rural and urban areas in the Jember Regency. Methods: The research employs a cross-sectional approach. The subjects of the research were selected on the basis of the total number of elderly people who attended the monthly meetings of the Karang Werda (those not willing to participate in the study were excluded). The study was conducted by organising extensive interviews, performing observations and intraoral examinations. Each group was classified into three subgroups on the basis of age: pre-elderly, elderly and high-risk elderly. The intraoral examination conducted included the oral hygiene index-simplified (OHI-S), the number of teeth missing, the depth of the pocket and the number of all functional tooth units (all-FTU). Results: The oral health profile of people in the rural community was poor when compared to the oral health profile of people living in the urban community (by accounting for nearly all the variables in the examination). Conclusion: The oral health profile of the elderly people in the Pandalungan community was poor. Adequate prevention and care are essential to maintain the oral health of people in the Pandalungan community.

Potensi ekstrak daun singkong (Manihot esculenta Crantz) terhadap ekspresi MMP-8 fibroblas gingiva pada model tikus dengan disfungsi ovarium dan periodontitisPotential of cassava (Manihot esculenta Crantz) leaf extract on the MMP-8 expression of gingival fibroblast in rats model with ovarian dysfunction and periodontitis Zahara Meilawaty; Amandia Dewi Permana Shita; Paramudibta Lungit Kuncaraningtyas; Agustin Wulan Suci Dharmayanti; Zahreni Hamzah
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 32, No 2 (2020): Agustus 2020
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v32i2.27466

Pendahuluan: Disfungsi ovarium merupakan kondisi yang menimbulkan defisiensi hormon estrogen dan progesteron. Penurunan hormonal ini menyebabkan peningkatan produksi tumor necrosis factor (TNF) yang dapat memicu peningkatan produksi matriks metalloproteinase-8 (MMP-8). Periodontitis yang disebabkan oleh bakteri gram negatif akan memicu makrofag melepaskan TNF-α yang berkontribusi dalam pembentukan MMP-8. MMP-8 ini berperan dalam degradasi kolagen jaringan ikat gingiva. Meningkatnya MMP-8 dapat menyebabkan terjadinya periodontitis. Gejala periodontitis karena disfungsi ovarium dan induksi bakteri ini dapat diperlambat dengan bahan alam, yaitu daun singkong. Tujuan penelitian ini adalah untuk menganalisis potensi ekstrak daun singkong (Manihot esculenta Crantz) terhadap ekspresi MMP-8 fibroblas pada model tikus disfungsi ovarium dan periodontitis. Metode: Penelitian ini merupakan penelitian eksperimental laboratoris dengan post-test only control group design. Sampel yang digunakan adalah tikus Sprague-Dawley betina yang dibagi dalam 5 kelompok yaitu (1) kelompok kontrol (K), (2) Kelompok yang diinduksi bakteri Porphyromonas gingivalis dan diberi aquades, (3) Kelompok yang diinduksi bakteri Porphyromonas gingivalis dan diberi ekstrak daun singkong, (4) Kelompok yang diberi perlakuan ovariektomi dan diberi aquades, (5) Kelompok yang dilakukan ovariektomi dan diberi ekstrak daun singkong. Pengambilan jaringan gingiva setelah tahap euthanasia dilakukan untuk pembuatan preparat histopatologi dengan pewarnaan imunohistokimia. Pengamatan dan penghitungan ekspresi MMP-8 dilakukan dengan menggunakan software ImageJ dan Immunoratio. Hasil: Hasil analisis data one-way ANOVA, ekspresi MMP-8 fibroblas gingiva menunjukkan perbedaan yang signifikan (p=0,000). Hal ini menunjukkan bahwa ekstrak daun singkong dapat menurunkan ekspresi MMP-8 fibroblas gingiva tikus yang mengalami disfungsi ovarium dan periodontitis diinduksi P. gingivalis. Simpulan: Ekstrak daun singkong (Manihot esculenta Crantz) dapat menurunkan ekspresi MMP-8 sel fibroblas gingiva pada model tikus disfungsi ovarium dan periodontitis.Kata kunci: Disfungsi ovarium, periodontitis, ekspresi MMP-8, ekstrak daun singkong. ABSTRACTIntroduction: Ovarian dysfunction is a condition that causes estrogen and progesterone deficiency. This hormonal decrease causes an increase in the production of Tumour Necrosis Factor (TNF), which can trigger an increase in the production of matrix metalloproteinase-8 (MMP-8). Periodontitis caused by gram-negative bacteria will trigger macrophages to release TNF-α, which contributes to the formation of MMP-8. MMP-8 plays a role in collagen degradation of the gingival connective tissue. An increase in MMP-8 can cause periodontitis. Periodontitis symptoms due to ovarian dysfunction and bacterial induction can be slowed down by natural ingredients, such as cassava leaf. The purpose of this study was to analyse the potential of cassava leaf extract (Manihot esculenta Crantz) on MMP-8 expression of gingival fibroblast in rats model with ovarian dysfunction and periodontitis. Methods: This study was an experimental laboratory with post-test only control group design. The samples were female Sprague-Dawley rats divided into five groups: (1) control group (K); (2) Porphyromonas gingivalis induced group and given aquadest; (3) Porphyromonas gingivalis induced and given cassava leaf extract; (4) Group with ovariectomy treatment and given aquadest; (5) Group with ovariectomy treatment and given cassava leaf extract. Gingival tissue retrieval after the euthanasia was carried out for the histopathology preparations by immunohistochemical staining. Observation and calculation of MMP-8 expressions were performed using ImageJ and Immunoratio software. Results: The results of the one-way ANOVA analysis of MMP-8 expression of gingival fibroblasts showed a significant difference (p = 0.000); thus cassava leaf extract reduce the MMP-8 expression of gingival fibroblasts of rats with ovarian dysfunction and P. gingivalis induced periodontitis. Conclusion: Cassava (Manihot esculenta Crantz) leaf extract can reduce the MMP-8 expression of gingival fibroblast cells in rats’ model with ovarian dysfunction and periodontitis.Keywords: Ovarian dysfunction, periodontitis, MMP-8 expression, cassava leaf extract.

Co-Authors Adji , Novan Krisno Agustin Wulan Suci Dharmayanti Amandia Dewi Permana Shita Amandia Dewi Permana Shita Ari Tri Wanodyo Ari Tri Wanodyo Handayani Ari Tri Wanodyo Handayani Ari Tri Wanodyo Handayani Ary TW. Handayani Asyifa Af Ida Haffiz Banun Kusumawardani Berlian Prihatiningrum Debi Suntari Dessy Rachmawati Didin Erma Indahyani Dominica Diana Siswadi Dwi Prijatmoko Dwi Warna Aju Fatmawati Dwita Aryadina Rachmawati Dyah I. Setyowati Dyah Indartin Dyah Indartin Setyowati Dyah Indartin Setyowati Dyah Indartin Setyowati Elfrida M. Agustina Elyana Asnar STP Endang Joewarini Erfin Ramadana Pratama Erna Sulistyani Fitria Nurhabiba Agustine Hafizh, Cinantya Handayani, Ari T.W. Happy Harmono Heru Ernanda Hosea Ferdinan Ida Bagus Narmada Izzata Barid Jevina Sicilia Ahliawan kristianningrum dian Kristianningrum Dian Sofiana Kushariyadi Kushariyadi Kusumadewi, Jihan Tahira Lisa Wahyu Zelda Federika Lutfi Meiga Sari Mala Hayati Mei Syafriadi Nadia Kartikasari Ni Made Widia Sasmita Indraswari Niken Probosari Paramudibta Lungit Kuncaraningtyas Piramida, Delyta Prasetyo , Aris Pratama, Armando Hayden Maghriza Pudji Astuti Pujiana Endah Lestari Purwandhono , Azham Rizky Purboningtyas Rothschildi, Dhesyarmani Putri Sari Setyaningsih Suhartini Suhartini Suhartini Suhartini Suhartini Suhartono Taat Putra Swasthi Prasetyarini Tantin Ermawati Tantin Ermawati Tecky Indriana Yuliana Mahdiyah Daat Arina Zahara Meilawati Zahara Meilawaty Zainul Cholid

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