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AKTIVITAS SEDIAAN SALEP EKSTRAK BATANG POHON PISANG AMBON (Musa paradisiaca var sapientum) DALAM PROSES PERSEMBUHAN LUKA PADA MENCIT (Mus musculus albinus) Febram, Bayu; Wientarsih, Ietje; Pontjo, Bambang
Majalah Obat Tradisional Vol 15, No 3 (2010)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (822.515 KB) | DOI: 10.14499/mot-TradMedJ15iss3pp121 – 137

Abstract

Tujuan dari penelitian ini adalah untuk mengetahui aktivitas pemberian ekstrak dari batang pohon pisang Ambon (Musa paradisiaca var sapientum) dalam bentuk sediaan salep terhadap proses persembuhan luka pada kulit mencit (mus musculus albinus) melalui pengamatan patologi anatomi dan histopatologi.  Hewan yang digunakan dalam penelitian ini adalah mencit dengan strain DDY umur 4-6 minggu sebanyak 45 ekor yang dibagi menjadi tiga kelompok, yaitu kelompok kontrol negatif (salep placebo), kontrol positif (salep komersil) dan salep ekstrak batang pohon pisang Ambon.  Semua mencit dilukai pada daerah punggung anterior sepanjang 1-1,5 cm menggunakan skalpel. Setiap hari luka diolesi dua kali dengan salep yang diuji ( salep placebo, salep komersil, dan salep ekstrak). Pengamatan patologi anatomi dilakukan setiap hari sementara pengamatan  histopatologi dilakukan pada hari ke 3, 5, 7, 14 dan 21 pasca perlukaan mencit yang dieuthanasia. Parameter pengamatan patologi anatomi adalah warna luka, pembekuan darah, terbentuknya keropeng dan ukuran luka. Parameter yang diamati pada sediaan  histopatologi adalah infiltrasi   sel-sel radang (neutrofil, limfosit, makrofag), neokapilerisasi, persentase re-epitelisasi dan ketebalan fibroblas.  Semua data kuantitatif diuji secara statistik menggunakan Analisa Sidik Ragam (ANOVA) dan dilanjutkan dengan uji wilayah berganda Duncan, sedangkan data kualitatif disajikan secara deskriptif.  Hasil penelitian menunjukkan bahwa pada pengamatan patologi anatomi kelompok salep ekstrak lebih cepat membentuk keropeng dan menutup luka tanpa bekas, jika dibandingkan dengan kontrol negatif. Hasil uji statistik pada parameter infiltrasi sel-sel radang pada kelompok salep ekstrak menunjukan hasil yang berbeda nyata (P<0.05) dengan kelompok kontrol negatif. Hasil pengamatan histopatologis menunjukkan bahwa ekstrak batang pohon pisang Ambon dalam sediaan salep mampu meningkatkan jumlah infiltrasi dari sel-sel radang, meningkatkan pembentukan neokapiler, meningkatkan persentase re-epitelisasi serta  mempercepat pembentukan fibroblas dibandingkan dengan kelompok kontrol negatif. Berdasarkan hasil diatas dapat disimpulkan bahwa pemberian salep ekstrak  batang pohon pisang ambon mempercepat proses persembuhan luka.
Antibacterial activity of temu kunci tuber (kaempheria pandurata) essential oil against Bacillus cereus Miksusanti, Miksusanti; J, Betty S.L.; Syarief, Rizal; Pontjo, Bambang; Mulyadi, Gatot T.
Medical Journal of Indonesia Vol 18, No 1 (2009): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (536.109 KB) | DOI: 10.13181/mji.v18i1.331

Abstract

Aim The mechanism of temu kunci tuber essential oil potential as antimicrobial agent has not been reported. To analyze the mechanism of antibacterial activity of temu kunci tuber essential oil from Yogyakarta on B.cereus. Antibacterial activity of essential oil were analyzed for its ability to disrupt bacterial cell membrane, that caused cell leakage and altered the morphology of the bacteria. Leakage was measured by analyzing the Ca+2, K+ ion outflow using an atomic adsorption spectrometry (AAS), and protein and nucleic acid using an ultraviolet spectrophotometer (UVS) on 280 nm and 260 nm respectively. Alterations in morphology were assessed using scanning electron microscopy (SEM).Results Minimum inhibitory concentration (MIC) of temu kunci essential oil on B.cereus was 0.12% (v/v). Treatment of B. cereus using 1MIC and 2MIC showed significant leakage compared to control (P<0.05). The K+ and Ca+2 ion leakage from the bacterial cells were between 10.32-35.57% and 15.05-41.54% respectively and showed significant difference compared to control (P<0.05). The absorbance observed by UVS for protein and nucleic acid leakage were 0.6330-0.8670 at 280 nm and 0.4320-0.8307 at 260 nm, respectively, and were significantly different compared to control (P<0.05). Exposure of 1 MIC temu kunci essential oil on B.cereus caused thickening as well as irregularities on the cell wall. At 2 MIC cells seemed transparent, empty looking and showed a ghost-like appearance.Conclusion Kaempheria pondurata essential oil could cause leakage and alter the morphology of the bacteria. (Med J Indones 2009; 18:10-7)Keywords: leakage, morphology
The influence of using platelet rich plasma for post-extraction wound healing process Oscar, Franky; Mangundjaja, Sunardhi; Yusuf, Makmuri; Pontjo, Bambang
Padjadjaran Journal of Dentistry Vol 22, No 1 (2010): March
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (683.555 KB) | DOI: 10.24198/pjd.vol22no1.14066

Abstract

Wound healing process characterized by specific processes of inflammation, proliferation, and maturation. It was coordinated by the regenerating and healing factors, including growth factor. Platelet-rich plasma was a blood component that separated from blood cell plasma, which contains a lot of growth factors for increased wound healing. The objective of this research was to observe the effect of the application of platelet-rich plasma for wound healing. The true experimental factorial design research was done to 24 rabbits (Oryctolagus cuniculus) which have been performed tooth extraction and application of platelet-rich plasma. These rabbits were terminated on 3rd, 7th, and 14th day, and the lower jaw region where the tooth had been extracted were cropped stained with hematoxylin-eosin for fibroblast and collagen histopathology examination. Based on ANOVA statistical analysis, the mean of fibroblast on the experimental group was 52.00+19.18 higher than the control group 24.83+10.46. Statistical tests showed a significant result of platelet-rich plasma application to fibroblast amount (p < 0.001). Collagen mean on the experimental group was 30.25+9.33 higher than the control group 13.75+6.96. It was significant statistically (p = 0.001). The conclusion of this research that wound healing process was influenced by the application of platelet-rich plasma.
Comparison of the effect of collagen (amino acid) and amnion (proteinase inhibitor) on the wound healing of soft tissues Adhiarto, Weko; Mangundjaja, Sunardhi; Yusuf, Makmuri; Pontjo, Bambang
Padjadjaran Journal of Dentistry Vol 22, No 1 (2010): March
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2000.307 KB) | DOI: 10.24198/pjd.vol22no1.14067

Abstract

The wound healing process of the soft tissue aims to accelerate the closing of the wound by recurring, restoring the function, and minimizing the scar tissue. This process has to occur in the surgery process to obtain better-wound healing. The aim of this study was to know the stimulation effect of the wound dressing to accelerate the wound healing process of the soft tissue using Collagen (amino acid) and Amnion (proteinase inhibitors). This true experimental study was done to 36 mice (Sprague Dawley) that were divided into three different groups, two groups were the treatment groups and one group was the control group. Each group was adapted in Pathology Laboratory of Faculty of Veterinary Medicine Bogor Agricultural University. All of the mice were injured on the skin by incising the right side of the back for 2 cm in length and 4 mm in depth and then cleaned with 0.9% NaCl solution. To the first group of treatment, the wound was applicated by Amnion, and the second group was applicated by Collagen. Each 4 mice of all group were a termination by ether and encryption on the wounded tissue was conducted on day 3rd, 7th, and 14th. Assessment for a number of fibroblast and collagen synthesis on the wound of back tissue was conducted with the histological examination by painted using hematoxylin-eosin. The results concluded that Collagen application was influencing the mean of fibroblast higher than Amnion, and the lowest was controlled with statistically significant. The mean of collagen used Collagen lower than Amnion, and the lowest was control with statistically significant. It could be concluded that collagen application was preeminent in increasing the productivity of the fibroblast, as well as in developing forms of the collagen synthesis compared with Amnion and control.
Potensi Beras Analog sebagai Alternatif Makanan Pokok untuk Mencegah Penyakit (Degeneratif Potency of Rice Analogue as Staple Food Alternative to Prevent Degenerative Diseases) Budijanto, Slamet; Sadek, Nur Fathonah; Dewi Yuliana, Nancy; Prangdimurt, Endang; Pontjo Priyosoeryanto, Bambang
JURNAL PANGAN Vol 25, No 1 (2016): PANGAN
Publisher : Perum BULOG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (223.678 KB) | DOI: 10.33964/jp.v25i1.307

Abstract

Perubahan gaya hidup telah menempatkan penyakit degeneratif sebagai penyebab kematian utama, baik di dunia maupun di Indonesia. Salah satu upaya pencegahan penyakit ini dapat dilakukan melalui pengaturan pola makan. Pembuatan beras analog selain bertujuan untuk mendukung program diversifikasi pangan, tetapi juga dapat dirancang dari bahan-bahan tertentu (seperti sorgum, bekatul, dan kedelai) agar memberikan manfaat fungsional khusus bagi kesehatan. Beras analog telah diteliti memiliki aktivitas hipokolesterolemik, nilai indeks glikemik yang rendah, serta menghambat proliferasi sel kanker kolon secara in vitro. Aktivitas tersebut selain berasal dari komponen fitokimia yang terdapat pada bahan-bahan tetapi juga dapat muncul akibat proses pengolahan, seperti terbentuknya pati resisten maupun terlepasnya komponen aktif dari matriks pangan. Hanya saja penambahan komponen fungsional terkadang memberikan dampak yang tidak diinginkan pada atribut sensori. Oleh karena itu, pengembangan beras analog fungsional dari segi sensori harus terus dilakukan supaya dapat diterima dengan baik oleh masyarakat.The changes of lifestyle nowadays bring degenerative diseases as the most leading cause of death, both in worldwide and Indonesia. It has been very well known that incident of the diseases could be prevented through food diet. Not only aimed to support the government’s diversification program, rice analogue development could be designed from certain materials (such as sorghum, rice bran, and soybean) to provide specific functional health benefit. Some reports showed that rice analogue has low glycemic index, as well as its activity in lowering cholesterol level and inhibiting the proliferation of in vitro colon cancer cell. The activity was expected to come from the phytochemical compounds naturally present in the ingredients and might also arise during the processing, such as the formation of resistant starches as well as the release of the active compounds from food matrix. However, the addition of functional ingredients sometime impacted on undesirable sensory attributes. Therefore, all sensory attributes of functional rice analogue should be improved to achieve the increment of public acceptance.
MEMBRAN GUIDED TISSUE REGENERATION UNTUK REGENERASI PERIODONTAL: GUIDED TISSUE REGENERATION MEMBRANE FOR PERIODONTAL REGENERATION Agus Susanto; Susi Susanah; Bambang Pontjo; Mieke Hemiawati Satari
Dentika: Dental Journal Vol. 18 No. 3 (2015): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (650.997 KB) | DOI: 10.32734/dentika.v18i3.1980

Abstract

Berbagai teknik bedah dan bahan terus dikembangkan untuk meningkatkan regenerasi periodontal. Salah satu metode bedahyang sering digunakan pada defek periodontal adalah menggunakan barriermembranguided tissue regeneration (GTR) atauguided bone regeneration (GBR). Prinsip GTR/GBR adalah menggunakan barriermembran untuk menutupi tulang danligamen periodontal, kemudian memisahkannya sementara dari epitel gusi. Fungsi membran ini meningkatkan dan menjagabekuan darah dan bertindak sebagai scaffold untuk perlekatan dan proliferasi sel. Terdapat dua jenis membran yaitumembran non resorbable dan resorbable. Membran non resorbable pada umumnya terbuat dari polytetrafluoroethylene,membran ini sifatnya stabil, nondegradable dan biokompatibel, tetapi penggunaannya memerlukan bedah kedua untukmengambil membran. Membran resorbable berasal dari bahan sintetis seperti polyglycolic, polylactic acid dan bahan alamiseperti kolagen dan laminar bone. Pembuatan membran yang ideal masih terus dikembangkan, membran kolagen saat inilebih sering digunakan karena mempunyai biocompatibility yang optimal walaupun tingkat resorpsi membran sulit untukdiprediksi.
Evaluasi Karakter Agro-Morfologi pada 20 Genotipe Hasil Seleksi Temu Hitam (Curcuma aeruginosa Roxb.) Nurcholis, Waras; Hartanti, Hartanti; Suryani, Suryani; Priosoeryanto, Bambang Pontjo
AGROSAINSTEK: Jurnal Ilmu dan Teknologi Pertanian Vol 3 No 2 (2019): AGROSAINSTEK: Jurnal Ilmu dan Teknologi Pertanian
Publisher : Universitas Bangka Belitung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (671.273 KB) | DOI: 10.33019/agrosainstek.v3i2.58

Abstract

The present study aimed to evaluate different agro-morphological traits among twenty genotypes of Curcuma aeruginosa Roxb. and three varieties of Curcuma zanthorrhiza Roxb. Agro-morphological data traits were investigated based on qualitative and quantitative parameters from PPVFRA descriptors with modification. All the recorded data was analyzed through SPSS 16.0 and R 3.4.2 for ANOVA and similarity analysis, respectively. Significant differences (P <0.05) were observed in the traits studied of the habit of the rhizome, the shape of the rhizome, length of primary rhizome, number of mother rhizome, plant height, pseudostem diameter, number of leaves, leaf length, leaf width, and number of shoots. Hierarchical cluster analysis (HCA) classified the genotypes into three groups. The principal component analysis (PCA) were showed consistent with results of the HCA. These genotypes could be used as novel genotype in agricultural biochemistry for breeding programs.
Potency of Bioactive Compound of Rice Bran for Colon Cancer Prevention Safrida, Safrida; Budijanto, Slamet; Nuraida, Lilis; Priosoeryanto, Bambang Pontjo
KEMAS: Jurnal Kesehatan Masyarakat Vol 16, No 2 (2020)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v16i2.21133

Abstract

Colon cancer is the second leading cause of death in the world. Bioactive compounds in rice bran have a very active role as antiproliferation of colon cancer cells such as ferulic acid, p-coumaric acid, caffeic acid, gallic acid, protocatechuic acid, sinapic acid, tricin, luteolin, apigenin, myrecitin, rutin, isorhamnetin, γ-oryzanol, γ-tocopherol, δ-tocopherol, γ-tocotrienol, β-sitosterol, phytic acid, and hemicellulose. Mechanism of the bioactive compounds in cells varied, including modulation of a cell cycle, activation of immune cells, damage of a lipid layer and mitochondrial membrane, activation of caspase proteins, inhibition of protein cell tumor invasion, metastasis, and angiogenesis, and also acts as an antioxidant. Therefore, the existence of the scientific studies results of this review with the potential availability of adequate rice bran in Indonesia is very potential to be developed.
Mode of Action Temu Kunci (Kaempferia pandurata) Essential Oil on E. coli K1.1 Cell Determined by Leakage of Material Cell and Salt Tolerance Assays MIKSUSANTI MIKSUSANTI; BETTY SRI LAKSMI JENIE; BAMBANG PONTJO PRIOSOERYANTO; RIZAL SYARIEF; GATOT TRIMULYADI REKSO
HAYATI Journal of Biosciences Vol. 15 No. 2 (2008): June 2008
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (44.681 KB) | DOI: 10.4308/hjb.15.2.56

Abstract

The essential oil of Kaempferia pandurata consist of terpen and oxygenated terpen that exhibits broad-spectrum antimicrobial activity. It’s mode of action against the gram-negative bacterium E. coli K1.1 has been investigated using a range of treatments. The mode action of the essential oil were analyzed by it’s ability to leakage E. coli K1.1 cell, to change permeability of the cell, and to alter salt tolerance of the cell. Ion leakage from the cell were analyzed by atomic absorption spectrophotometer. Salt tolerance assays was conducted by investigating the ability of E. coli K1.1 treated with temu kunci essential oil to grow on NA supplemented with NaCl. Protein and acid nucleic leakage were analyzed by UV spectrophotometer. There were inorganic compound leakage (potassium, calcium ion) and organic compound leakage (nucleic acid, protein) from cytoplasmic membrane, after exposing this organism to essential oil of Kaempferia pandurata. The more concentration of oil added, the more leakage was observed due to the loss of absorbing material such as nucleic acid (260 nm) and protein (280 nm), the loss of potassium and calcium ion, and loss of the salt tolerance of E. coli K1.1. Key words: essential oil, E. coli K1.1, leakage, salt tolerance assay
MINUMAN TINGGI AKTIVITAS ANTIOKSIDAN BERBAHAN DASAR ALAMI MINYAK BEKATUL PADI (Oryzae sativa) DAN EKSTRAK MENIRAN (Phyllanthus niruri) Purnawati Hustina Rachman; Priskila Priskila; Evy Damayanthi; Bambang Pontjo Priosoeryanto
Jurnal Gizi dan Pangan Vol. 7 No. 3 (2012)
Publisher : Food and Nutrition Society of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.495 KB) | DOI: 10.25182/jgp.2012.7.3.189-196

Abstract

This study aimed to assess the antioxidant potential of chocholate-rice bran oil-emulsion beverage and meniran extract beverage. RBO beverage was made using oil in water emulsion with sugar ester as the emulsifier.Four formulas was created with the RBO-chocolate concentrate : water ratio of 1:1, 1:3, 1:5, and 1:7. Meanwhile the meniran beverage was made by adding extract meniran in five different concentrations (30, 40, 50, 60, 70 ppm) along with flavor and sucralose. The selected emulsion beverage had the AEAC value of 30.75 mg Vit C/100 g, while the meniran extract beverage had the AEAC value of 9.12 mg Vit C/100 g with the total fenol of 92.75 mg/100 g. The results of TBA value, content of protein, fat, carbohydrate, ash, and water of the emulsion beverage were 0.12 mg malondialdehyde eq/kg, 0.24%, 0.52%,6.74%, 0.15% and 92.32%, respectively. Increasing concentrations of chocolate and RBO significantly affected the results of the chemical parameters (p<0.05). Overall, the chocolate emulsion beverage based on RBO and meniran extract beverage had high antioxidant activity that are potential to prevent non-communicable diseases.
Co-Authors . CHURIYAH . Darmawi Adhi Rahmat Hariyadi Aditya Primawidyawan Agus Susanto Ahmad Aulia Ahmad Aulia Andra Hendriarto Andri Hardianto Andri Lubis Andri Prasetiyo Anggraeny Putri Sekar Palupi Anggraini, Lutvi Anissa Canintika Anita Esfandiari Annisa Fitriyana Ardi Sandriya Ari Fahrial Syam Ari Fahrial Syam Aria Kekalih Asri, Lia Amelia Tresna Wulan Aulia Andi Mustika Azhari Azhari Bambang Sunendar Purwasasmita, Bambang Sunendar Bayu Febram Bayu Febram Bayu Febram Prasetyo Benny Syariefsjah Latief Bethy Suryawathy Hernowo Betty S.L. J Betty Sri Laksmi Jenie Budi Arifin Chudahman Manan Chudahman Manan Dahlia Sutanto Daldiyono Daldiyono Daldiyono Daldiyono Dara Juliana Deddy Muchtadi Dede Robiatul Adawiyah Deni Noviana Denny Widaya Lukman Dewi Fatma Suniarti Dewi Ratih Agungpriyono Djarot Sasongko Hami Seno Dwi Kesuma Sari Dyah Sulistyani Rahayu Edy Djauhari Purwakusumah Eka Nurul Qomaliyah Endang Prangdimurt Endang Prangdimurti Endang Sjamsudin Erniati, Erniati Esti Mumpuni Eva Harlina Evy Damayanthi Fachriyan Hasymi Pasaribu Fachrul Razi Fadila Raisyadikara Farra Sasmita Franky Oscar Franky Oscar, Franky Fransiska R. Zakaria Fransiska Rungkat Zakaria Fransiska Rungkat Zakaria Gatot T. Mulyadi Gatot Trimulyadi Rekso Gunanati Soedjono Gunanti Gunanti . GUSTAF ADOLF WATTIMENA Hamny Sofyan Hartanti Hartanti Hartanti Hartanti, Hartanti Hasim Hasim Hatibie, Mendy Juniaty Hatta, Isnur Herwin Pisestyani Hidayat Syarief Husnawati, . I Made Kardena I Nyoman Suarsana I Nyoman Suartha I Wayan Gorda I wayan Teguh Wibawan IETJE WIENTARSIH Irmanida Batubara Iwan Harjono Utama Jimmy Pangihutan Juliana, Dara Kazuyuki Uchida Koeswinarning Sigit Komariah Komariah Kreshanti, Prasetyanugraheni Kuroki, Yutaka KUSMARDI KUSMARDI Lanniari, Nafrina Latifah Darusman Lilis Nuraida Lina Noviyanti Sutardi Lisni Noraida Lucky Riawan Lusi Epsilawati Madyastuti, Rini Mahdi Abrar Makmuri Yusuf Makmuri Yusuf MARIA BINTANG Mawar Subangkit Maya Shofa Mieke Hemiawati Satari Mieke Hemiawati Satari Mieke Hermiawati Satari Miksusanti Miksusanti Min Rahminiwati Mirnawati Soedarwanto Mirnawati Soedarwanto Monica Septiani Muharty, Annisya Najmah Najmah Nancy Dewi Yuliana Naoaki Misawa NASRIANTI SYAM, NASRIANTI Nina Kusumawati Nur Fathonah Sadek Nurhidayat - Nurhidayat, Nurhidayat Okabayashi, Tamaki Prangdimurt, Endang Priskila Priskila Putu Angga Wiradana Putu Eka Sudaryatma Rachmi Ridho Rachmi Ridho Rahayu WoroWiranti Rahmadansah Rahmadansah Rahyussalim Ratna Puspita Rayendra, Raendi Retno Wulansari Rifki Septawendar Riki Siswandi Rimbawan , Rini, Dian Cipta Ripta Mustafa Nugraha Risa Tiuria Riski Rostantinata Riski Rostantinata Rizal Syarief Rizal Syarief Rizki Fitria Rizki Rostantinata Ros Sumarny Rostantinata, Riski Ryoji Yamaguchi Sabri Mustafa Sadek, Nur Fathonah Safrida Safrida Sajida Sajida Samuel Leonardo Silitonga SANTOSO CORNAIN Sarifah, Norlaila Sebayang, Shalina Septina Sabilla Lubis Shafiyyah Az Zahra SILMI MARIYA Slamet Budijanto Sri Anna Marliyati Sri Estuningsih Sri Kayati Widyastuti Subangkit, Mawar Sugeng Supriadi, Sugeng Sukasah, Chaula Luthfia Sunardhi Mangundjaja Sunardhi Mangundjaja, Sunardhi Surachmi Setiyaningsih Surachmi Setyaninigsih Surya Pangidoan Nasution Suryani Suryani Suryani Suryani Susi Susanah Susumu Tateyama Syamsudin Abdillah Takeshi Katayama Tangkonda, Elisabet Tena Djuartina, Tena Toshisada Suzuki Tri Isyana Tungga Dewi Tri Isyani Tungga Dewi Tungga Dewi, Tri Isyani Tutik Wresdiyati - Ummu Balqis Vetnizah Juniantito Wahyuni, Sri Waras Nurcholis Wasmen Manalu Wati, Vivi Septya Weko Adhiarto Weko Adhiarto, Weko Yonathan Arderian Mantik Ziad Alaztha