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All Journal JPM17: Jurnal Pengabdian Masyarakat JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Berkala Ilmiah Kimia Farmasi Pharmaceutical Sciences and Research (PSR)
Melanny Ika Sulistyowaty
Fakultas Farmasi, Universitas Airlangga, Surabaya
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Other

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Perbandingan Metode Sintesis Senyawa 1-benzil-3-(4-etil-benzoil)urea dan 1-benzil-3-(4-klorometil-benzoil)urea sebagai Calon Obat Antikanker Farida Suhud; Daryono Hadi Tjahjono; Tegar Achsendo Yuniarta; Galih Satrio Putra; Melanny Ika Sulistyowaty
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 8 No. 3 (2021): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v8i32021.277-283

Abstract

Pendahuluan: Pengembangkan obat antikanker yang selektif dari turunan hidroksiurea masih diteliti sampai saat ini. Tujuan: Penelitian ini bertujuan untuk membandingkan metode sintesis senyawa turunan hidroksiurea yaitu 1-benzil-3-(4-etil-benzoil)urea dan 1-benzil-3-(4-klorometil-benzoil)urea. Metode: Optimasi metode sintesis yang dilakukan dengan membandingkan produk hasil sintesis dengan pemanasan refluks dan tanpa pemasanan refluk. Produk yang didapat dilakukan analisis elusidatif meliputi FTIR, 1H-NMR dan 13C-NMR. Hasil: berdasarkan hasil perbandingan metode sintesis menggunakan refluks menyebabkan terbentuknya dua produk samping sehingga perlu dilakukan pemisahan dengan kromatograsi kolom antara produk utama dengan dua produk sampingnya. Metode tanpa pemasanan lebih dipilih karena tidak menghasilkan dua produk hasil samping walaupun rendemen masih dalam rentang 20-30%. Kesimpulan: Metode sintesis senyawa turunan 1-benzil-3-benzoilurea lebih direkomendasikan tanpa pemasanan daripada menggunakan pemanasan refluks, tetapi penelitian kedepannya harus didapatkan metode yang lebih baik untuk mendapatkan rendemen yang lebih besar.
IbM KELOMPOK USAHA BUDIDAYA JAMUR DI KABUPATEN KEDIRI PASCA ERUPSI GUNUNG KELUD Melanny Ika Sulistyowaty; Juni Ekowati; Achmad Toto Poernomo; M. Faris Adrianto
JPM17: Jurnal Pengabdian Masyarakat Vol 2 No 01 (2016)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30996/jpm17.v2i01.793

Abstract

The eruption of Mount Kelud, located in Kediri-East Java that occurred inearly of 2014 resulted damages of some public facilities and also agriculturalland. Most of the people who lived that area are working as farmers andranchers. Many of the villagers became unproductive and could not performactivities of farming and ranching. To solve such a problem, we would like toencourage them by training how to cultivate mushroom Pleurotus ostreatus orknown as “Tiram” mushroom. The expectation of this activity is they can beindependently economically by cultivating mushrooms in their area after theeruption of Mount Kelud.Keywords: Pleurotus spp, eruption, cultivate, Tiram mushroom, Kediri
Pemberdayaan Masyarakat melalui Edukasi Cara Pembuatan Pangan Olahan yang Baik, Bahan Tambahan Pangan, dan Kemasan Pangan untuk Penguatan Jaminan Keamanan pada Pelaku UMKM Bidang Makanan di Balikpapan Juni Ekowati; Rosita Handayani; Dewi Melani Hariyadi; Mohammad Rizki Fadhil Pratama; Putri Hamidah Khairunnisa; Melanny Ika Sulistyowaty; Rossa Auli Tasha; Imamatin Nufus Melania; Ersanda Nurma Praditapuspa; Muhamad Ilham Royyan Nafi’
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol 6 No 6 (2021): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v6i6.2676

Abstract

Food safety is a complex issue that involves stakeholders in its handling. The point of food safety is growing widely and is becoming a concern in the community because it is related to the quality of consumers' good health and well-being. The community service activities based on quality education focused on Good Processed Food Manufacturing Practices (CPPOB), safe use of Food Additives (BTP), and consideration of packaging selection that ensures food safety. Education is carried out to increase the understanding of SMEs actors regarding regulations of CPPOB, the use of BTP, and provisions on Food Packaging. The education process is carried out online using the Zoom Meeting platform. Learning activity is carried out in one direction through lectures and questions and answers sessions. The increase in participants' understanding was measured by comparing the distribution of average scores, pretest, and post-test statistical tests. The effectiveness and quality of the educational process were measured using an evaluation questionnaire with predetermined indicators. The education carried out related to CPPOB, the use of BTP, and the selection of food packaging performed by the community service team of the Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga to SMEs in Balikpapan has proven to increase the understanding of business actors. It can fulfill their needs and target activity evaluation indicators that have been determined.
Pemodelan Molekul Turunan p-Metoksi sinnamoil Hidrazida Sebagai Inhibitor Checkpoint Kinase 1 dan Inhibitor Aromatase secara In silico Putra, Galih Satrio; Sulistyowatya, Melanny Ika; Ekowati, Juni; Budiati, Tutuk
Pharmaceutical Sciences and Research Vol. 4, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The development of anticancer drugs from ethyl p-methoxycinnamate (EPMC) derivatives has been done to compounds high activity in inducing cancer cells apoptosis and minimal side effects. p-Methoxycinnamoyl hydrazide derivates, modified from EPMC structure, were docked into the ligand-binding pocket of Check point kinase 1 enzymes (2YWP) and the aromatase enzyme (3S7S) using software Molegro Virtual Docker (MVD) Ver.5.5. We compared the Rerank score of native ligand with p-Methoxycinnamoyl hydrazide derivates. Rerank scores of compounds 4b and 4c (-99.98 Kcal/mol and -99.80 Kcal/mol) were lower than the native ligand A42 in inhibiting the enzyme checkpoint kinase 1. Rerank values of p-Methoxycinnamoyl hydrazide derivate compounds were greater than the native ligand EXM in inhibiting the enzyme aromatase. p-Methoxycinnamoyl hydrazide derivate compounds, especially compounds 4b and 4c, had anticancer mechanism by inhibiting the checkpoint kinase 1 enzyme pathway and showed no activity in inhibiting the aromatase enzyme.
The comparison Study of Synthesis p-Methoxycinnamoylhydrazide by Conventional Thermal Heating and Microwave Irradiation Sulistyowaty, Melanny Ika; Nusandari, Ratna; Rudyanto, Marcellino; Ekowati, Juni
Berkala Ilmiah Kimia Farmasi Vol. 11 No. 1 (2024): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v11i1.56153

Abstract

Previous studies had shown that ethyl p-methoxycinnamate (EPMS) had various bioactivities, such as analgesic and anti-inflammatory through COX inhibition. Due to its unique structure, this compound was modified into a selective COX-2 inhibitor. In this research, EPMS was isolated from Kaempferia galanga L. and used as a starting material to be reacted with hydrazine hydrate to obtain 3-(4-methoxyfenil)propanehydrazide. This synthesis was carried out using conventional heating and microwave irradiation. The microwave irradiation was chosen because of its potential to reduce reaction time and increase yield. Next, the crude product was purified using column chromatography to produce a pure product, where characterization and structural analyses of the compound were carried out using the TLC test, melting point test, IR, 1H-NMR, and UV spectroscopy. The results showed that the product produced was 3-(4-methoxyphenyl)propanehydrazide with a yield of 0,76% by conventional thermal heating and 7,90% by microwave irradiation. Keywords:  EPMC, Hydrazine Hydrate, 3-(4-Metoxyphenyl)propanehydrazide, Conventional Heating, Microwave Irradiation
A Comparison Study between Green Synthesis of Microwave Irradiation and Solvent Evaporation Methods in The Formation of p-Methoxycinnamic Acid-Succinic Acid Cocrystals Sulistyowaty, Melanny Ika; Setyawan, Dwi; Prameswari, Putu Pradnya Mimba; Susilo, Raden Joko Kuncoroningrat; Amrillah, Tahta; Zaini, Erizal; Zidan, Sabry A. H.
Science and Technology Indonesia Vol. 9 No. 3 (2024): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.3.629-636

Abstract

Cocrystal of p-Methoxycinnamate acid-succinic acid has been produced by microwave irradiation and solvent evaporation methods. Cocrystals are formed using succinic acid as the coformer at a molar ratio of 1:1. The formation of cocrystal can be done by solvent evaporation method and microwave radiation method. Physicochemical properties have been studied by FT-IR, DSC, PXRD, and SEM analysis. The solubility test was carried out with pH 6.8 phosphate buffer at a temperature of 25±0.5°C for 5 hours and the dissolution test was carried out with 900 mL pH 6.8 phosphate buffer at a temperature of 37±0.5°C with the speed of 75 rpm using a paddle-type dissolution test apparatus. The solubility of PMCA has increased its solubility in cocrystals by the solvent evaporation method by 1.19 times and by the microwave radiation method by 1.16 times compared to PMCA. The dissolution rate of the cocrystals of the solvent evaporation method increased by 3.50 times and the cocrystals of the microwave radiation method increased by 2.29 times compared to PMCA.
Upaya Peningkatan Kualitas Produk UMKM Makanan Minuman di Surabaya Melalui Pelatihan Keamanan Aditif dan Kemasan Pangan serta Program Self Declare Halal Menggunakan Aplikasi SEHATI: Efforts to Improve the Quality of Food and Beverage MSME Products in Surabaya Through Additive and Food Packaging Safety Training as well as a Self-declare Halal Program Using the SEHATI Application Kholis Amalia Nofianti; Juni Ekowati; Bambang Tri Purwanto; Adistiar Prayoga; Mochammad Yuwono; Adistiar Prayoga; Muhammad Agus Syamsur Rijal; Suciati Suciati; Diajeng Putri Paramita; Melanny Ika Sulistyowaty; Luqmanul Hakim
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 8 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i8.7044

Abstract

MSMEs in the food sector are the dominant economic support in Indonesia. Surabaya has more than 60 thousand MSMEs. In food production at the MSME level, food additives and packaging is inevitable. Despite the current regulations, people still encounter dangerous food additives or packaging. This is caused by a lack of knowledge and awareness of food producers and consumers. On the other hand, since the implementation of the halal guarantee system, the use of halal labels on food and beverage products has become very important. For MSMEs, the government makes it easy to get a halal label through the self-declare halal program using the SEHATI. This activity aims to provide training on safe food additives and packaging, halal food, and the self-declare halal program using the SEHATI application in Surabaya. Carrying out activities using presentation and two-way interaction. Evaluate activities through pretest and posttest for each topic. The lowest values for food packaging, it is 52.92 and 79.58. The highest value was shown by the halal topic with an average of 69.58 and 97.92. The significance of the increase in value was demonstrated by the Wilcoxon test using SPSS 22 which showed the Asymp. Sig (2-tailed) value for the three topics less than 0.05. Thus, it can be concluded that this activity has proven to be able to improve participants' abilities regarding safe food additives and packaging, as well as halal food and the introduction of the self-declare halal program.
Peningkatan Pemberdayaan Masyarakat Tuban tentang Keamanan dan Kehalalan Pangan dalam Rangka Mempertahankan Kondisi Good Health and Well Being - SDG’s3: Enhancing Empowerment of Tuban Society Regarding Food Safety and Halalness in Order to Maintain Good Health and Well Being -SDG’s3 Juni Ekowati; Mochammad Yuwono; Adistiar Prayoga; Noorma Rosita; Bambang Tri Purwanto; Muhammad Faris Adrianto; Neny Purwitasari; Farida Ifadotunnikmah; Kholis Amalia Nofianti; Melanny Ika Sulistyowaty; Suzana Suzana; Angkasa Megistra Ulvan; Albertus Aditya Setiawan; Ryan Afandi; Etik Wahyuningsih; Dian Ratna Rianti; Winanda Rizki Febrianti
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 12 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i12.8410

Abstract

The food industry experiences various serious problems when several food MSMEs (micro/small/medium enterprises), especially micro-scale ones, practice improper food manufacturing methods, such as the use of formalin and borax which are prohibited for food preservation, and the marketing of expired food, even repackaged, and the writing of halal labels that are not followed by the fulfillment of requirements. Efforts to prevent things that are detrimental to the community, as well as food and beverage MSME actors, are not only the responsibility of government agencies but also the entire community, including universities for education and assistance in improving the quality and quantity of products produced, as well as the quality of human resources of business actors. The methods used include counseling and skills training, and the outcome is an increase in knowledge of 31%
Pemanfaatan Teh dan Rempah-rempah Khas Indonesia dalam Pemeliharaan Kesehatan Warga di Sumba Timur Menghadapi Pandemi Covid-19: Tea and Indonesian Spices for Improving Health for People in East Sumba for Facing Pandemic COVID-19 Sulistyowaty, Melanny Ika; Purwanto, Djoko Agus; Agil, Mangestuti; Ekowati, Juni; Isadiartuti, Dewi; Hendradi, Esti; Purwitasari, Neny; Yusniasari, Putri Antika
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 4 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i4.7043

Abstract

The coronavirus (SARS-CoV-2) has infected nearly 4 million people worldwide. This virus was first identified in Wuhan, China, in December 2019. Every day positive cases of Covid-19 are increasing in the world. Experts are still trying to find a vaccine to prevent this virus, one of which is by increasing the body's resistance (immunity). The use of family medicinal plants (TOGA) or tea, a drink that we usually drink every day is believed to increase one's body immunity. The content of natural chemicals in tea such as EGCG and curcumin found in the rhizomes have antioxidant activity and is clinically proven to increase a person's immunity.
Edukasi Pemanfaatan Obat Tradisional, Aromaterapi, dan Akupresur untuk Mengurangi Kelelahan pada Tenaga Kesehatan dan Pasien di Rumah Sakit Universitas Airlangga: Educational Intervention on the Use of Traditional Medicine, Aromatherapy, and Acupressure to Reduce Fatigue Among Healthcare Workers and Patients at Airlangga University Hospital Handayani, Rosita; Sukardiman, Sukardiman; Widyowati, Rr. Retno; Imandiri, Ario; Ekasari, Wiwied; Sudjarwo, Sudjarwo; Hafid, Achmad Fuad; Wahyuni, Tutik Sri; Lestari, Maria Lucia Ardhani Dwi; Sulistyowaty, Melanny Ika
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 8 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i8.10041

Abstract

Excessive fatigue and burnout are serious issues frequently experienced by healthcare workers and patients with chronic illnesses, particularly within high-pressure healthcare environments. These conditions not only impair the performance of medical personnel but also negatively affect the therapeutic outcomes of patients. To address this problem, a community service activity was conducted through educational outreach on fatigue and burnout management, utilizing acupressure, traditional remedies, and aromatherapy. The program involved 49 participants, including healthcare workers and Surabaya's chronic disease patients. Held on September 11, 2024, the activity employed lectures and two-way discussions as its primary methods. The material covered included traditional medicine, basic acupressure techniques, and training in roll-on and massage oil aromatherapy preparation. A structured module was developed to enhance learning effectiveness, and participants' comprehension was evaluated through pre- and post-tests. Statistical analysis using a paired t-test revealed a significant improvement in participants' understanding (p <0.01), with an average score increase of 19.8%. This initiative demonstrates that practical and interactive education can effectively improve participants' knowledge and skills in managing fatigue and burnout. Therefore, the outcomes of this activity are essential as a promotive and preventive effort to support the physical and mental well-being of vulnerable groups in healthcare settings.
Co-Authors Achmad Fuad Hafid Achmad Toto Poernomo Albertus Aditya Setiawan Angkasa Megistra Ulvan Ario Imandiri, Ario Bambang Tri Purwanto Daryono Hadi Tjahjono Dewi Isadiartuti Dewi Melani Hariyadi Dian Ratna Rianti Djoko Agus Purwanto Dwi Setyawan Erizal Zaini Esti Hendradi Etik Wahyuningsih Farida Ifadotunnikmah Farida Suhud Galih Satrio Putra Galih Satrio Putra Handayani, Rosita Imamatin Nufus Melania Juni Ekowati Kholis Amalia Nofianti Luqmanul Hakim M. Faris Adrianto Mangestuti Agil Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Mochammad Yuwono Mohammad Rizki Fadhil Pratama Muhamad Ilham Royyan Nafi’ Muhammad Agus Syamsur Rijal Muhammad Faris Adrianto Noorma Rosita Nusandari, Ratna Oktavia Eka Puspita, Oktavia Eka Paramita, Diajeng Putri Praditapuspa, Ersanda Nurma Prameswari, Putu Pradnya Mimba Prayoga, Adistiar Purwitasari, Neny Putri Hamidah Khairunnisa Raden Joko Kuncoroningrat Susilo Rossa Auli Tasha Rudy Salam, Rudy Ryan Afandi Suciati Suciati Sudjarwo Sudjarwo Sukardiman Suzana Tahta Amrillah Tegar Achsendo Yuniarta Tutik Sri Wahyuni Tutuk Budiati Widyowati, Rr. Retno Winanda Rizki Febrianti Wiwied Ekasari Yusniasari, Putri Antika Zidan, Sabry A. H.