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All Journal ACTA VETERINARIA INDONESIANA ARSHI Veterinary Letters Biopendix: Jurnal Biologi, Pendidikan dan Terapan The International Journal of Tropical Veterinary and Biomedical Research Jurnal Medika Veterinaria
Nabila Latifa Hafizsha
Universitas Syiah Kuala
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Konsentrasi IL-6 Serum terhadap Penyembuhan Luka Pasca Pemasangan Implan Paduan Logam pada Babi (Sus scrofa) Nabila Latifa Hafizsha; Gunanti Gunanti; Deni Noviana; Sus Derthi Widhyari
Acta VETERINARIA Indonesiana Vol. 9 No. 1 (2021): Maret 2021
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.9.1.21-29

Abstract

Penelitian ini bertujuan untuk mengetahui gambaran konsentrasi IL-6 serum pada fase akut dan kronis selama proses penyembuhan luka pasca pemasangan implan paduan logam pada vesika urinaria babi. Penelitian ini menggunakan 6 ekor babi jantan dan betina, usia 2-3 bulan, dengan bobot badan berkisar 25-30 kg yang dibagi ke dalam dua kelompok implan dan tiga waktu pengamatan. Implan logam yang digunakan adalah Zn-0.5Al sebagai kelompok I dan ZnMg(4x) sebagai kelompok II, sedangkan waktu pengamatan dilakukan pada hari ke-0, 14, dan 28. Pemasangan implan dilakukan pada vesika urinaria (VU) menggunakan teknik cystotomi. Pengukuran konsentrasi IL-6 serum menggunakan metode enzyme-linked immunosorbent assay (ELISA). Data dianalasis menggunakan analysis of variance (ANOVA). Hasil penelitian menunjukkan pada hari ke-0, implan Zn-0.5Al dan ZnMg(4x) berturut-turut adalah 1.38±2.40 pg/mL dan 0.10±0.17 pg/mL. Konsentrasi IL-6 hari ke-14 pada setiap implan terlihat mengalami penurunan dibandingkan pada hari ke-0, yaitu 0.74±1.29 pg/mL dan 0 pg/mL. Selanjutnya hari ke-28 konsentrasi IL-6 kembali mengalami penurunan, yaitu 0.32±0.35 pg/mL dan 0 pg/mL. Penurunan konsentrasi IL-6 dari fase akut ke fase kronis proses penyembuhan luka pada setiap kelompok implan tidak berbeda signifikan (P>0,05). Pemeriksaan serum pada babi (Sus scrofa) terhadap konsentrasi IL-6 kelompok perlakuan implan Zn-0,5Al dan ZnMg(4x) tidak menunjukkan perbedaan nyata (P>0,05) pada hari ke-0, 14, dan 28.
20. The Histological Structure of Tegal Duck (Anas javanicus) Spleen at Different Age Nabila Latifa Hafizsha; Hamdani Budiman; Hamny Hamny; Dian Masyitha; Cut Dahlia Iskandar; Ummu Balqis; Muhammad Jalaluddin
Jurnal Medika Veterinaria Vol 11, No 2 (2017): J. Med. Vet.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v11i2.3522

Abstract

The aim of the  study was to determine the histological structure of tegal duck (Anas javanicus) spleen according to ages variation. One month, 2 month and 3 months of tegal duck were used as the sample of this study. The spleen of each duck was analyzed by Hematoxylin-Eosin (HE) method, then observed under light microscope. The result of this study performed there were the differences of histological structure of the ducks spleen. The capsule thickness had increased along with increasing age, which was 16.0 ± 1.0 µm; 25.3 ± 2.5 µm; and 29.0 ± 1.0 µm. The boundary between the two pulp in the tegal duck 3 months  old more obvious than 1 month or 2 months old. The diameter of white pulp had increased in the oldest duck. It can be concluded that the development of spleen histological structure was more perfect with the  increasing age of tegal duck.
Case report: clinical presentation and diagnostic findings in a cat with diabetes mellitus and hepatic-biliary disorders Hafizsha, Nabila Latifa; Agung, Nabilah Putroe; Nurfadhilah, Elvina; Fitriana, Rizky
The International Journal of Tropical Veterinary and Biomedical Research Vol 9, No 2 (2024): Vol. 9 (2) November 2024
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v9i2.43956

Abstract

Diabetes mellitus (DM) is a metabolic disorder and endocrinopathy characterized by hyperglycemia or a persistent increase in blood glucose levels. This case describes a male domestic cat exhibiting symptoms of vomiting, loss of appetite, and yellowish discoloration of the ears and oral mucosa, which was diagnosed with DM and hepatic-biliary disorders based on serum biochemistry and ultrasonographic examinations. The treatment included insulin injections, antibiotics, antiemetics, a liver supplement, and a specialized diabetic diet. After 14 days of insulin injection and a diabetic diet, the cats blood glucose levels returned to normal. A diabetic diet will be provided for the cat throughout its lifetime.
The effect of katuk leaf (Sauropus androgynous L. merr) extract administration on reducing blood triglyceride levels in male local rabbits induced with hypercholesterolemia Khalid, Idham; Ferasyi, Teuku Reza; Sugito, Sugito; Hafizsha, Nabila Latifa; Ulfa, Rasyida; Fitriana, Rizky; Makmur, Ali
The International Journal of Tropical Veterinary and Biomedical Research Vol 9, No 2 (2024): Vol. 9 (2) November 2024
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v9i2.44322

Abstract

This research aimed to study the effectiveness of katuk leaf extract in lowering blood triglyceride levels in male local rabbits treated with hypercholesterolemia. The research was done at the Laboratory of Veterinary Public Health and the Animal Experimental Unit of the Faculty of Veterinary Medicine, Universitas Syiah Kual. This experiment used the Split Plot design, comprising two factors. The first factor was treatment (P1, P2, and P3) that gives katuk leaf extract 2.5 cc, 5 cc, and 10 cc, whereas the second factor was the sampling time (I, II, III, IV, and V). The results of this research showed that the treatment did not significantly (P0.05) on levels of triglycerides in the blood of local rabbits. Still, different sampling times were very significant (P 0.01) on levels of triglycerides in the blood of local rabbits. After doing Duncan tests, the results test showed that the sampling time between a decrease of local rabbit blood triglyceride levels was not significant (P0.05) by giving katuk leaf extract. The treatment of katuk leaf extracts of 2.5 cc, 5cc, and 10cc has not been able to reduce levels of triglycerides in the blood of male local rabbits treated with hypercholesterolemia.
Bahasa IngDiagnosis and treatment of suspected symmetrical peripheral gangrene in a Persian cat with feline infectious peritonitisgris Hafizsha , Nabila Latifa; Nurfadhilah , Elvina
ARSHI Veterinary Letters Vol. 9 No. 2 (2025): ARSHI Veterinary Letters - May 2025
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.9.2.47-48

Abstract

Gangren Perifer Simetris (SPG) adalah kondisi klinis langka yang ditandai dengan kerusakan iskemik pada area ekstremitas simetris di dua tempat atau lebih tanpa adanya obstruksi pembuluh darah yang lebih besar atau vaskulitis. Laporan kasus ini menjelaskan seekor kucing Persia jantan yang didiagnosis dengan Peritonitis Infeksi Kucing (FIP) berdasarkan biokimia serum, yang pada hari keempat pengobatan FIP, menunjukkan gejala edema metatarsal kiri, dingin, dan perubahan warna kulit kekuningan pucat. Berdasarkan gejala klinis, kucing tersebut didiagnosis dengan dugaan SPG. Pengobatan untuk lesi tersebut meliputi debridemen, antibiotik, obat antiinflamasi, diuretik, perawatan luka dengan semprotan nano-perak, dan vitamin suportif. Setelah pengobatan, lesi menunjukkan perbaikan yang signifikan pada hari ke-14 dengan pengeringan yang terlihat, meskipun penutupan lengkap belum terjadi.
Serum IL-6 AS A marker of immuno-inflammatory response to Zn-Mg alloy implants in porcine (Sus scrofa) Hafizsha, Nabila Latifa; Safitri, Jessica Anggun; Ulfa, Rasyida; Khalid, Idham; Agung, Nabilah Putroe; Makmur, Ali; Fitriana, Rizky
The International Journal of Tropical Veterinary and Biomedical Research Vol 10, No 1 (2025): Vol 10 (1) May 2025
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v10i1.45637

Abstract

Background and Aim: The present study aimed to evaluate the immune-inflammatory response induced by ZnMg(3x) and ZnMg(4x) alloy implants in the porcine urinary bladder by measuring serum interleukin-6 (IL-6) levels.Materials and Methods: Nine porcines, aged 2-3 months old with 25-30 kg body weight, were divided into three groups: ZnMg(3x), ZnMg(4x), and control, while the observation time was performed on days 0, 14, and 28. Implantation was performed on the urinary bladder using cystotomy techniques. Measurement of IL-6 levels is done using enzyme-linked immunosorbent assay (ELISA). Data were analyzed statistically using analysis of variance (ANOVA).Results : The results showed that at day 0 for the ZnMg(3x) and ZnMg(4x) implants were 0.53 0.92 pg/mL and 0.10 0.17 pg/mL, respectively. On day 14, IL-6 levels in both implants decreased, although not significantly. On day 28, a slight increase was observed in ZnMg(3x) compared to ZnMg(4x), but this was also not significant (P0.05).Conclusion: Based on the results, Zn-Mg materials are suitable to be used as urinary stent base materials.
Phytoestrogenic Activity of Fresh Bitter Melon (Momordica charantia L.) Fruit Extract on Ovarian Folliculogenesis in Female Mice Ulfa, Rasyida; Agung, Nabilah Putroe; Fitriana, Rizky; Makmur, Ali; Hafizsha, Nabila Latifa
BIOPENDIX: Jurnal Biologi, Pendidikan dan Terapan Vol 12 No 2 (2025): Biopendix: Jurnal Biologi, Pendidikan & Terapan
Publisher : Program Studi Pendidikan Biologi FKIP Unpatti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biopendixvol12issue2page102-109

Abstract

Momordica charantia L., commonly known as bitter melon, is a medicinal plant that contains various bioactive compounds such as flavonoids, saponins, tannins, triterpenoids, and alkaloids. These compounds have potential antifertility properties. This study aimed to evaluate the potential of bitter melon extract as an antifertility agent in female animals. A total of 18 female mice (Mus musculus L.) were divided into three groups: a control group (K0), treatment group 1 (P1) received 5% bitter melon extract, and treatment group 2 (P2) received 10% extract. The mice (Mus musculus L.) were orally administered the extract for 16 consecutive days using the gavage method. On the final day of treatment, the mice were dissected to isolate the ovaries. The ovaries were weighed and processed for histological examination using the paraffin method and Hematoxylin-Eosin staining. The observed parameters included the number of primary, secondary, tertiary, and Graafian follicles. Data were analyzed using one-way analysis of variance (ANOVA) followed by Duncan’s post hoc test to determine statistical differences among groups. The results showed that administration of 5% bitter melon extract significantly increased the number of primary and secondary follicles. However, at the 10% concentration, a reduction was observed in the number of all follicle types, including Graafian follicles. These findings indicate that low-dose bitter melon extract may promote ovarian follicle development, whereas high-dose administration exhibits antifertility potential through a phytoestrogen mechanism that inhibits follicular maturation.
Co-Authors Agung, Nabilah Putroe Cut Dahlia Iskandar Deni Noviana Dian Masyitha Fitriana, Rizky Gunanti . Hamdani Budiman Hamny Sofyan Idham Khalid Jessica Anggun Safitri Makmur, Ali Muhammad Jalaluddin Nurfadhilah , Elvina Nurfadhilah, Elvina Rasyida Ulfa Sembiring, Rinawati Sugito - Sus Derthi Widhyari Teuku Reza Ferasyi Ummu Balqis