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All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) CHEESA: Chemical Engineering Research Articles JSFK (Jurnal Sains Farmasi & Klinis) Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmasi Sains dan Praktis Indonesian Journal of Pharmacology and Therapy
Arba Pramundita Ramadani
Jurusan Farmasi Universitas Islam Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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UJI IRITASI PRIMER LOTION EKSTRAK ETANOLIK DAUN KEMANGI (Ocimum basilicum Linn) PADA KELINCI JANTAN BERDASARKAN PARAMETER INDEKS IRITASI PRIMER Arba Pramundita Ramadani; Ari Marstiyani
Jurnal Ilmiah Farmasi Vol. 6 No. 1 (2009)
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACTKemangi (Ocimum basilicum L.) is Lamiaceae family, consists of volatile oil, saponin,flavonoid, tanin, and polifenole. One of its functions is as an antioxidant. The antioxidantmechanism is blocking free radical oxidative bound with LDL (Low Density Lipoprotein) (Udupa,2006). This study explores kemangi as a lotion formulation on its primary iritation effect using malerabbits. Kemangi leaves are extracted with soxhletation method and formulated on lotion. Primaryirritation test is conducted by using patch test on 12 male rabbits. Rabbits are divided into 2 groups,with incision and without incision. Each of it got same treatments normal control aquadest, lotionbase control, and 4 tapering dose of kemangi leaves extract. Each treatment is done 6 times ondifferent rabbits, with incision and without incision group. The treatment is applied on rabbits backafter 3 stage shaving. For incision group, after 3 stages shaving the skin is scratched with minorincision on cell surface. Toxic symptom is observed during 24 hours and 72 hours after lotionapplication. The study result is analyzed qualitatively and quantitatively. Qualitative analysisshowed that any erythema found as reddish spot on the rabbits back skin, but no edema found.Primary irritation index as quantitative analysis showed 0,083 for normal control aquadest; 0,207 forlotion base control; 0,292 for 0,25g/inci2kemangi leaves extract; 0,416 for 0,5g/inci2kemangileaves extract; 0,582 for 1 g/inci2kemangi leaves extract; 0,642 for 2 g/inci2kemangi leaves extract.It means kemangi leaves extract have no primary irritation effect.Keywords: Kemangi, patch test, anti oxidant
Preventive Activity of Muntingia calabura Fruits Extract in Aspirin-induced Gastric Ulcer Rat Cynthia Astiti Putri; Arba P. Ramadani; Maulidha Amanati
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 3 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i3.28935

Abstract

Gastric ulcer can be affected people at any age. One cause of this disease is NSAID usage. The aim of this study is to determine Muntingia calabura L. fruit activity for prevent ulcer using aspirin-induced gastric ulcer in rat model. Thirty male Wistar rats were divided become six groups: normal (CMC 0.5%), negative control (CMC 0.5%), positive control (omeprazole 20 mg/kg), treatment group (ethanol M. calabura L. fruit extract): I (100 mg/kg), II (200 mg/kg), and III (300 mg/kg) and given orally once a day for 9 days. On the 10th day, aspirin at a dose of 500 mg/kg was given to all groups except the normal group. Four hours after induction, all animals were sacrificed. Preventive effect against stomach ulcer were determined by calculating the index of ulcer and histopathological examination. Index ulcer of M. calabura fruit extract at all dose were different than negative group, although not significant (p<0.05). Histopathological examination of M. calabura extract at a dose of 300 mg/kg showed few inflammatory cells and congestion compared with the other treatment group. Therefore, ethanol M. calabura L. fruit extract at a dose 300mg/kg gave best activity in preventive of gastric ulcer.Keywords: aspirin, gastric ulcer, Muntingia calabura fruit
Efek Gastroprotektif Ekstrak Etanol Daun Pepaya (Carica papaya L.) pada Tikus Jantan yang Diinduksi Aspirin Cynthia Astiti Putri; Arba Pramudita Ramadani; Fanny Rahma Maulida
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 19, ISSUE 2, August 2019
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/eksakta.vol19.iss2.art1

Abstract

Obat antiinflamasi non steroid (AINS), terutama yang dapat diperoleh tanpa resep, telah banyak digunakan oleh masyarakat untuk meredakan rasa sakit dan gejala inflamasi pada penyakit yang diderita. Namun, efek samping berupa ulkus lambung yang banyak dialami oleh pengguna AINS.  Penelitian ini bertujuan untuk meneliti efek ekstrak etanol daun pepaya (Carica papaya L.) pada tikus Wistar jantan yang diinduksi ulkus lambung menggunakan aspirin. Hewan uji dibagi menjadi 6 kelompok; kontrol normal (CMC 0,5%), kontrol positif (omeprazol 20 mg/kg), kontrol negatif (CMC 0,5%), kelompok perlakuan (ekstrak etanol daun pepaya dosis 100, 200, dan 300 mg/kg). Perlakuan diberikan selama 9 hari. Pada hari ke-10, semua tikus diinduksi dengan aspirin dosis 500 mg/kg kecuali kelompok normal yang dipuasakan selama 24 jam terlebih dahulu. Pada akhir penelitian, semua hewan uji dikorbankan dan lambungnya diambil untuk diukur indeks ulkus dan dibuat preparat. Tikus yang diberikan etanol ekstrak pepaya tidak terbentuk ulkus, bahkan lebih baik, dibandingkan dengan kelompok kontrol positif (p<0,05). Selain itu, hasil pembacaan histopatologi lambung menunjukkan bahwa pemberian daun pepaya dapat menjaga lambung tetap normal. Pemberian ekstrak etanol daun pepaya 100 mg/kg dapat mencegah terjadinya ulkus lambung pada tikus yang diinduksi menggunakan aspirin. 0 mg/kg dapat mencegah ulkus lambung pada tikus yang diinduksi aspirin.Kata kunci: daun pepaya (Carica papaya L.), ulkus lambung, aspirin
Hepatoprotective Effect of Corn Silk Infusion in Male Wistar Rats Arba Pramundita Ramadani; Hady Anshory Tamhid; Tika Luthfi Sadrina; Jasno Jasno; Mabrurotul Mustafidah
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 1, ISSUE 1, February 2020
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol1.iss1.art8

Abstract

The use of medicinal plants in treating various disease has been reported since long time ago, including for hepatic disease. Corn silk contains phytochemicals of medical benefit such as flavonoids compounds which act as antioxidant agents and has been widely reported possess hepatoprotective effect. Using a model of carbon tetrachloride (CCl4)-induced hepatotoxicity in 36 male Wistar rats, this study investigated the effect of corn silk infusion and assessed using enzymes produced by the liver in plasma [alkaline phosphatase (ALP) and liver glutathione (GSH)]. The corn silk infusion (in 50, 100, and 200 mg/kg BW doses) were administered 24 hours after CCl4-induction liver damage with 3ml/kg BW CCl4 in olive oil (1:1, v/v), intraperitoneally for seven days. Along with corn silk groups, distilled water (0.2 mL/kg BW) and Curcumin (100 mg/kg BW) were given for induction and drug control, respectively. In the end of the study (8th day), the level of both ALP dan GSH were measured. The differences among groups for GSH and ALP level were statistically calculated using ANOVA method.  The result showed that the corn silk infusion is active at 200 mg/kg BW based on both ALP (18.74% decreased) and GSH (5-7% increased) level. Moreover, the flavonoid compound was detected on the infusion that may contribute on its hepatoprotective activity. In conclusion, corn silk infusion owned hepatoprotective effect in male Wistar rats.
Profil Ketoksikan Akut SNEDDS Propolis Arba Pramundita Ramadani; Yandi Syukri; Sherina Nabila Putri Hakim; Annisa Fitria
Jurnal Sains Farmasi & Klinis Vol 9, No 2 (2022): J Sains Farm Klin 9(2), Agustus 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (771.684 KB) | DOI: 10.25077/jsfk.9.2.105-110.2022

Abstract

Propolis memiliki efek imunostimulan yang tinggi namun tidak larut air dan memiliki bioavailabilitas yang rendah. Formulasi propolis dalam bentuk SNEDDS terbukti mampu meningkatkan aktivitas imunostimulannya, namun juga memberikan potensi ketoksikan dikarenakan kecilnya ukuran partikel nano dan akumulasi nya di dalam tubuh. Penelitian ini bertujuan untuk mengevaluasi efek ketoksikan akut SNEDDS propolis. Dengan metode standar OECD 425, tikus Wistar jantan digunakan sebagai hewan uji. Pengujian diawali dengan uji batas dosis 2000 mg/kgBB dan dilanjutkan uji utama yang diawali dengan dosis 175 mg/kgBB serta mengikuti faktor 1,3 untuk kenaikan maupun penurunan dosisnya. Pengamatan gejala klinis ketoksikan secara intensif dilakukan 4 jam pertama setelah pemejanan dan dilanjutkan secara periodik mulai 24 jam hingga 14 hari dengan pengukuran berat badan tiap minggunya. Pada akhir penelitian, tikus dikorbankan dan diisolasi hepar maupun ginjalnya untuk pembuatan preparat histopatologis. Hasil uji menunjukkan tidak adanya gejala ketoksikan, berat badan hewan uji meningkat dan nilai LD50 > 2000 mg/kgBB. Pengamatan histopatologis juga tidak menemukan adanya abnormalitas di hepar maupun ginjal. Sehingga dapat disimpulkan bahwa SNEDDS propolis tidak menimbulkan efek koetoksikan akut pada tikus jantan secara per oralPropolis memiliki efek imunostimulan yang tinggi namun tidak larut air dan memiliki bioavailabilitas yang rendah. Formulasi propolis dalam bentuk SNEDDS terbukti mampu meningkatkan aktivitas imunostimulannya, namun juga memberikan potensi ketoksikan dikarenakan kecilnya ukuran partikel nano dan akumulasi nya di dalam tubuh. Penelitian ini bertujuan untuk mengevaluasi efek ketoksikan akut SNEDDS propolis. Dengan metode standar OECD 425, tikus Wistar jantan digunakan sebagai hewan uji. Pengujian diawali dengan uji batas dosis 2000 mg/kgBB dan dilanjutkan uji utama yang diawali dengan dosis 175 mg/kgBB serta mengikuti faktor 1,3 untuk kenaikan maupun penurunan dosisnya. Pengamatan gejala klinis ketoksikan secara intensif dilakukan 4 jam pertama setelah pemejanan dan dilanjutkan secara periodik mulai 24 jam hingga 14 hari dengan pengukuran berat badan tiap minggunya. Pada akhir penelitian, tikus dikorbankan dan diisolasi hepar maupun ginjalnya untuk pembuatan preparat histopatologis. Hasil uji menunjukkan tidak adanya gejala ketoksikan, berat badan hewan uji meningkat dan nilai LD50 > 2000 mg/kgBB. Pengamatan histopatologis juga tidak menemukan adanya abnormalitas di hepar maupun ginjal. Sehingga dapat disimpulkan bahwa SNEDDS propolis tidak menimbulkan efek koetoksikan akut pada tikus jantan secara per oral
Aktivitas pegagan (Centella asiatica) pada dermatologi Larysa Fernenda; Arba Pramundita Ramadhani; Yandi Syukri
Jurnal Sains Farmasi & Klinis Vol 9, No 3 (2022): J Sains Farm Klin 9(3), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.3.237-244.2022

Abstract

Pegagan (Centella asiatica L.) is a herbal plant used in dermatology that has activity in treating skin diseases and skin lesions such as excoriations, burns, hypertrophic scars, antioxidants, anti-aging, skin whitening, and as a cosmetic ingredient. This review aims to collect data regarding the activity of Centella asiatica herb extracts in dermatology in both preclinical and clinical trial identification is done by searching literature through media Science Direct and Google Scholar using the keywords ''Centella asiatica'', ''Gotu kola'', ''dermatology'', ''cosmetics'', and ''whitening''. The search was based on the inclusion and exclusion criteria that had been set. The literature results show that the chemical constituents of Centella asiatica, such as asiaticoside, madecassoside, asiatic acid, and madecassic acid, are phytochemicals that play an essential role in the pharmacological activity of Centella asiatica in dermatology as a treatment and skin care. In both preclinical and clinical tests, it was shown that administration of Centella asiatica was capable of proliferating fibroblasts, activating the Smads pathway, increasing collagen synthesis, reducing metalloproteinase activity by increasing collagen deposition, and reducing melanin content in melanocytes so that it can modulate melanogenesis by inhibiting the expression of tyrosinase mRNA.
Nanoparticles and Nanoliposomes for Hair Growth Serum Arismunandar, Arif; Chabib, Lutfi; Ramadani, Arba Pramundita; Suryani, Arman; Kamarulzaman, Ezatul Ezleen
CHEESA: Chemical Engineering Research Articles Vol. 7 No. 1 (2024)
Publisher : Universitas PGRI Madiun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25273/cheesa.v7i1.19908.57-66

Abstract

Solubility in penetrating the follicles is the main obstacle in the formulation of hair growth serum preparation with chemicals derived from natural or synthetic materials. Therefore, a delivery system is needed to deliver more chemical compounds into the follicles. Nanoparticles and nanoliposomes are potential chemical compound delivery systems in hair growth serum. Specifically, nanoparticles with a particle size of less than 200 nm can increase the transport of serum chemical compounds into the scalp. The small particle size makes the interaction between atoms and molecules faster and prevents clumping with the repulsive force of dispersed particles. Meanwhile, nanoliposomes with lipids as encapsulation in the delivery of lipophilic or hydrophilic chemical compounds with nanosizes can significantly increase serum diffusion on the scalp.
KARAKTERISTIK GEL-NANOLIPOSOM MINYAK ROSEMARI (Rosmarinus officinalis) UNTUK FORMULASI SEDIAAN PENINGKATAN PERTUMBUHAN RAMBUT Baruna, Renno Ramadhani Ika; Ramadani, Arba Pramundita; Chabib, Lutfi
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 13 No 1 (2024): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v13i1.253

Abstract

Hair loss occurs in many people, both men and women. Rosemari (Rosemarinus officinalis) is one of the plants shown to significantly improve hair growth in alopecia patients. Nanoliposome gel can enhance the activity of bioactive agents by increasing solubility, bioavailability, stability and preventing unnecessary interactions with other molecules in cosmetic preparations. The purpose of this study was to determine the physical characteristics and stability of nanoliposome gel as a carrier of rosemary oil produced. The nanoliposome formulations were evaluated: organoleptical, particle size and zeta potential, and morphological tests. The results of the physical characteristics of nanoliposomes in the form of a slightly cloudy clear gel, semi-liquid texture and typical aromatic odor of rosemary, particle size of 210.5 nm, zeta potential of -23.2 nV, and spherical morphology. Rosemary oil nanoliposome gel preparation has good physical characteristics and stability, so it can be used as a preparation formulation for hair growth.
Narrative Review: Potential of Flavonoids from Moringa (Moringa oleifera Lam.) Leaves as Immunomodulators: Tinjauan Naratif: Potensi Flavonoid dari Daun Kelor (Moringa oleifera Lamk.) sebagai Imunomodulator Poluan, Jesica Carine; Zubair, Muhammad Sulaiman; Ramadani, Arba Pramundita; Hayati, Farida
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 9 No. 2 (2023): (October 2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2023.v9.i2.16265

Abstract

Background: Moringa leaves (Moringa oleifera Lamk.) are plants from the Moringaceae family that have many properties and are often used empirically as traditional medicine. One of the benefits of M. oleifera leaves is immunomodulator, which functions to modulate the human immune system in both immunostimulants and immunosuppressants. Objectives: To provide information on the potential of flavonoids in M. oleifera leaves as immunomudulators developed as alternative therapies. Methods: Review of articles using original articles from national and international journals with the keywords "immunomodulator," "immunostimulant," "immunosuppressant," "Flavonoids," and "Moringa oleifera leaf or leaves". Results: Based on a search of various literature studies, M. oleifera leaf extract is proven as an immunomodulator with the most compounds found, namely flavonoids such as quercetin and kaempferol. This content can affect the immune response to trigger or inhibit the proliferation and activation of immune cells in the process of increasing or decreasing the immune system in the body. Conclusions: Moringa leaves have activity as immunomodulators that can help maintain the immune system in the body.
Potential advancement utilizing nanotechnology-based delivery system to enhance the therapeutic properties of lavender essential oil: a review article Trianloka, A. M. Bagas; Chabib, Lutfi; Ramadani, Arba Pramundita
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art6

Abstract

Background: Essential oils (EO), such as lavender (Lavandula spp.), which are derived from its flower, have become a growing trend in recent years as an alternative medicine in therapy. However, the poor physicochemical properties of EOs have several disadvantages for their application. Integrating nanotechnology into the formulation of medicinal dosage forms may provide a viable way to mitigate these limitations and improve the effectiveness of EO utilization.Objective: This literature review aims to gather information on the medicinal benefits of lavender EO and the prospective applications of nanotechnology-based delivery systems for EOs.Method: Online databases such as PubMed, Science Direct, Research Gate, Google Scholar, and other reliable sources were used to find 65 publications between 1991 and 2021, which are assessed in this review.Results: It is revealed that the main constituents of lavender EO are linalool, linalyl acetate, and lavandulyl acetate. Its effectiveness as an antibacterial, antioxidant, anticancer, anti-anxiety, and having effects on the central nervous system, along with other qualities including pain relief, has been demonstrated via numerous studies. Additionally, it was demonstrated to have dermatological properties that helped treat dermatitis and encouraged both hair growth and wound healing. Furthermore, it was also found that the application of nanotechnology in EOs has improved the concentration of active compounds in the blood and produced a stable dosage form while also increasing its efficacy.Conclusion: It is feasible to create nanoparticle dosage forms from lavender EO that can improve the substance's solubility, stability, and pharmacological effects. More research is necessary to formulate lavender EO by applying nanotechnology.
Co-Authors Aisha Nanda Caela Amry Annisa Fitria Annisa Fitria Annisa Fitria Arde Toga Nugraha Ari Marstiyani Arismunandar, Arif Baruna, Renno Ramadhani Ika Cynthia Astiti Putri Diesty Anita Nugraheni Fanny Rahma Maulida Fitra, Romadhonsyah Fuadah, Shofiatul Hakim, Sherina Nabila Putri Hayati, Farida Jasno Jasno Kamarulzaman, Ezatul Ezleen Larysa Fernenda Lutfi Chabib, Lutfi Maria Hilaria Maulidha Amanati Muhammad Sulaiman Zubair Mustafidah, Mabrurotul Nangim Khasanah Poluan, Jesica Carine Priska Ernestina Tenda Rochmy Istikharah Romadhonsyah, Fitra Sherina Nabila Putri Hakim Suryani, Arman Syafira Tri Nurmala Sari Tamhid, Hady Anshory Tika Luthfi Sadrina Trianloka, A. M. Bagas Yandi Syukri