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All Journal Tropical Medicine Journal JURNAL INFO KESEHATAN Jurnal Kesehatan Prima Jurnal Farmasi Sains dan Praktis Jurnal Katalisator Journal of World Future Medicine, Health and Nursing Indonesian Journal of Pharmacology and Therapy Jurnal Info Kesehatan
Priska Ernestina Tenda
Poltekkes Kemenkes Kupang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

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Hubungan Antara Pencatatan Pelaporan Laporan Pemakaian-Lembar Permintaan Obat (LP-LPO) Dengan Perencanaan Obat Di Gudang Farmasi Dinas Kesehatan Kabupaten Manggarai Nara, Theodorik Erik; ELISMA, ELISMA; TENDA, PRISKA ERNESTINA
JURNAL INFO KESEHATAN Vol 15 No 1 (2017): JURNAL INFO KESEHATAN
Publisher : Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1025.802 KB) | DOI: 10.31965/infokes.v15i1.128

Abstract

Pencatatan pelaporan data obat di Instasi Farmasi Kabupaten/Kota merupakan rangkaian kegiatan dalam rangka pengelolaan obat secara tertib baik obat yang diterima, disimpan, didistribusikan maupun yang digunakan di unit pelayanan kesehatan seperti Puskesmas. Penelitian ini bertujuan untuk menghitung jumlah pemakaian 10 obat tertinggi di Gudang Farmasi Dinas Kesehatan Kabupaten Manggarai berdasarkan pelaporan LP-LPO tahun 2012 dan tahun 2013, mengetahui perencanaan obat tahun 2013 dan 2014 dan menganalisa hubungan antara pencatatan pelaporan LP-LPO tahun 2012 dan tahun 2013 dengan perencanaan obat tahun 2013 dan 2014. Jenis penelitian ini adalah penelitian deskriptif. Hasil penelitian menunjukkan bahwa obat dengan pemakaian terbanyak pada tahun 2012 dan 2013 adalah Besi II sulfat tablet kombinasi 13,92% dan Asam askorbat 500 mg tablet 21,69%. Obat dengan peringkat kesepuluh terbanyak pada tahun 2012 dan 2013 adalah Antalgin 500 mg tablet 4,72% dan Deksametason 0,5 mg tablet 3,40%. Obat dengan perencanaan terbesar pada tahun 2012 dan 2013 adalah Antasida DOEN tablet kombinasi (655.000 tablet) dan Amoksisilin 500 mg (1.148.000 tablet). Obat peringkat kesepuluh dengan perencanaan terkecil tahun 2012 dan 2013 adalah Besi II sulfat tablet salut kombinasi (60.000 tablet pada tahun 2012 dan 40.000 tablet pada tahun 2013. Pencatatan pelaporan LP-LPO tahun 2012 dengan perencanaan obat 2013 dan pencatatan pelaporan LP-LPO tahun 2013 dengan perencanaan obat tahun 2014 memiliki hubungan yang cukup erat.
Uji Aktivitas Antibakteri Ekstrak Etanol Kulit Pohon Faloak (Sterculia sp.) Terhadap Bakteri Staphylococcus Aureus Tenda, Priska Ernestina; Lenggu, Maria Yangsye; Ngale, Marini Sriyuni
JURNAL INFO KESEHATAN Vol 15 No 1 (2017): JURNAL INFO KESEHATAN
Publisher : Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (880.401 KB) | DOI: 10.31965/infokes.v15i1.143

Abstract

Faloak merupakan tumbuhan obat yang tumbuh pada kondisi ekstrim di wilayah Nusa Tenggara Timur (NTT). Faloak mempunyai manfaat untuk pengobatan herbal dimana pada kandungan senyawa saponin, steroid dan triterpenoid, flavonoid dan alkaloida yang terdapat pada kulit pohon faloak berfungsi untuk pengobatan berbagai penyakit yang disebabkan oleh bakteri. Tujuan penelitian untuk mengetahui adanya aktivitas antibakteri ekstrak etanol kulit pohon faloak (Sterculia sp.) terhadap pertumbuhan bakteri Staphylococcus aureus. Penentuan aktivitas antibaketri dengan metode difusi menggunakan silinder, dan melihat adanya zona bening disekitar silinder. Hasil analisis menunjukkan bahwa konsentrasi 22,5% b/v; 45% b/v; 75% b/v dan 100% b/v mampu menghambat pertumbuhan bakteri Staphylococcus aureus dengan diameter rata- rata zona hambat berturut- turut sebesar 1,33 cm, 1,66 cm, 1,90 cm, 2,13 cm, semakin tinggi konsentrasi maka zona hambat makin besar sehingga konsentrasi efektif mengambat pertumbuhan bakteri Staphylococcus aureus adalah 100% b/v.
In Vitro Antiplasmodial Activity of Brucein A Semisynthetic Compounds Priska Ernestina Tenda; Eti Nurwening Solikhah; Mahardika Agus Wijayanti
Tropical Medicine Journal Vol 2, No 1 (2012): Tropical Medicine Journal
Publisher : Pusat Kedokteran Tropis

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (471.321 KB) | DOI: 10.22146/tmj.4305

Abstract

Introduction: Brucein A has been known to have antiplasmodial activity. Some new compounds were synthesized to increase their antiplasmodial activity, i.e 3-benzoylbruceinA, 3-dimethyl sulphate bruceine A, 3-choro benzoyl brucein A, and 3-chloro acetyl bruceine A.However, their antiplasmodial activity have not studied yet.Objectives: To know the in vitro antiplasmodial activity of 3-benzoyl brucein A, 3-dimethyl sulphate bruceine A, 3-choro benzoyl brucein A, and 3-chloro acetyl bruceine A.Methods: Antiplasmodial activity was conducted by incubating FCR-3 strain of P. falciparum with 3- benzoyl brucein A, 3-dimethyl sulphate bruceine A, 3-choro benzoyl brucein A, and 3-chloro acetyl bruceine A in various concentrations for 72 hours. Parasitemia after incubation period of each compound was calculated by making a thin smear stained with 5% Giemsa.Results: Semisynthetic compounds of bruceine A have antiplasmodial activity in vitro with IC50 value were 2.648 ± 1.30 ng/mL for 3-benzoyl bruceine A, 1.098 ± 0.510 ng/mL for 3-dimethyl sulphate bruceine A, 50.246 ± 0.207 ng/mL for 3-chloro benzoyl bruceine A and 67.951 ± 11.517 ng/mL for 3- chloro acetyl brucein A. The IC50 value of Bruceine A as the lead compound was 3.87 ± 2.530 ng/mLConclusion: The 3-dimethyl sulphate bruceine A showed the highest antiplasmodial activity among 4 semisynthetic compounds of Bruceine A.Keywords:bruceineA, semisynthetic compound, Plasmodiumfalciparum, invitroantiplasmodial activity.
Assessment of Job Risks in the Chemical Laboratory of the Pharmacy Study Program with Job Safety Analysis (JSA) Techniques Priska Ernestina Tenda; Faizal Reza Soeharto
Jurnal Kesehatan Prima Vol 15, No 2 (2021): AUGUST
Publisher : poltekkes kemenkes mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jkp.v15i2.689

Abstract

Chemistry laboratory organizes practicum, one of them quantitative pharmaceutical chemistry which uses a variety of chemicals and tools where if not careful, not following instructions or procedures even underestimate will cause work accidents and/ or occupational illness. Is observational descriptive research on the job risk assessments in chemical laboratories prodi pharmacy  with JSA techniques aimed at finding out the risk of work performed. Population is type practicum work in chemistry laboratory and the sample is quantitative pharmaceutical chemistry practicum. Data collection techniques i.e. the work that has been selected is further determined with the working procedure and the working steps and then determines the findings of errors from each step of the work then further identify the potential hazards of each step of the work. Data analysis techniques is data from each finding of errors determined potential injury / danger / loss and its impact is then calculated risk value (risk matrix) i.e. the value of consequences multiplied by opportunity value where the results are could grouped into risk extreme, high, medium or low that continued with to determine safeguards measures that can be done to control the such danger. The results showed that performs the titration step has high very risk level value compared to another work step other of pharmaceutical chemical practicum quantitative. Titration activities carry an extreme or significant risk of harm when performed incompatible with working measures and unsafe with potential danger (disadvantage) is liquid evaporates (inhaled), disturbances The End Point of the Titration: change in color and determination of concentration, and perform movements manual repetitive continuously namely mixing the liquid or rotating the container (erlenmeyer) contains a chemical liquid by hand continuously. Chemistry laboratory organizes practicum, one of them quantitative pharmaceutical chemistry which uses a variety of chemicals and tools where if not careful, not following instructions or procedures even underestimate will cause work accidents and/ or occupational illness. Is observational descriptive research on the job risk assessments in chemical laboratories prodi pharmacy  with JSA techniques aimed at finding out the risk of work performed. Population is type practicum work in chemistry laboratory and the sample is quantitative pharmaceutical chemistry practicum. Data collection techniques i.e. the work that has been selected is further determined with the working procedure and the working steps and then determines the findings of errors from each step of the work then further identify the potential hazards of each step of the work. Data analysis techniques is data from each finding of errors determined potential injury / danger / loss and its impact is then calculated risk value (risk matrix) i.e. the value of consequences multiplied by opportunity value where the results are could grouped into risk extreme, high, medium or low that continued with to determine safeguards measures that can be done to control the such danger. The results showed that performs the titration step has high very risk level value compared to another work step other of pharmaceutical chemical practicum quantitative. Titration activities carry an extreme or significant risk of harm when performed incompatible with working measures and unsafe with potential danger (disadvantage) is liquid evaporates (inhaled), disturbances The End Point of the Titration: change in color and determination of concentration, and perform movements manual repetitive continuously namely mixing the liquid or rotating the container (erlenmeyer) contains a chemical liquid by hand continuously. 
Hubungan Antara Pencatatan Pelaporan Laporan Pemakaian-Lembar Permintaan Obat (LP-LPO) Dengan Perencanaan Obat Di Gudang Farmasi Dinas Kesehatan Kabupaten Manggarai Theodorik Erik Nara; ELISMA ELISMA; PRISKA ERNESTINA TENDA
JURNAL INFO KESEHATAN Vol 15 No 1 (2017): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1025.802 KB)

Abstract

The recording of drug data reporting at Regency/City Pharmacy is a series of activities in order to manage medicine in an orderly manner either medicine received, stored, distributed or used in health care unit such as Puskesmas. This study aims to calculate the highest number of drug use in Pharmaceutical Warehouse of Manggarai District Health Office based on LP-LPO reporting in 2012 and 2013, to know drug planning in 2013 and 2014 and to analyze the relationship between LP-LPO reporting in 2012 and 2013 with drug planning in 2013 and 2014. This type of research is descriptive research. The results showed that the most used drugs in 2012 and 2013 were Iron II sulfate tablet combination 13.92% and Ascorbic acid 500 mg tablet 21.69%. The drugs with the highest ranking in 2012 and 2013 are Antalgin 500 mg tablet 4.72% and Dexamethasone 0.5 mg tablet 3.40%. Drugs with the largest planning in 2012 and 2013 are Antacids DOEN combination tablets (655,000 tablets) and Amoxicillin 500 mg (1,148,000 tablets). The tenth-grade drug with the smallest planning of 2012 and 2013 is Iron II sulfate combination coated tablet (60,000 tablets in 2012 and 40,000 tablets in 2013. Record of LP-LPO reporting in 2012 with 2013 drug planning and LP-LPO reporting record in 2013 with Drug planning in 2014 has a fairly close relationship.
Uji Aktivitas Antibakteri Ekstrak Etanol Kulit Pohon Faloak (Sterculia sp.) Terhadap Bakteri Staphylococcus Aureus Priska Ernestina Tenda; Maria Yangsye Lenggu; Marini Sriyuni Ngale
JURNAL INFO KESEHATAN Vol 15 No 1 (2017): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (880.401 KB)

Abstract

Faloak is a medicinal plant that grows in extreme conditions in the East Nusa Tenggara region. Faloak has benefits for herbal treatment wherein the content of saponin compounds, steroids and triterpenoids, flavonoids, and alkaloids found in the bark of the faloak tree serves for the treatment of various diseases caused by bacteria. The purpose of this research is to know the antibacterial activity of ethanol extract of faloak bark (Sterculia sp.) On the growth of Staphylococcus aureus bacteria. Determination of antibacterial activity by a diffusion method using a cylinder, and see the existence of a clear zone around a cylinder. The results showed that the concentration of 22.5% w / v; 45% w / v; 75% w / v and 100% w / v were able to inhibit the growth of Staphylococcus aureus bacteria with mean inhibitory zone diameter of 1.33 cm, 1.66 cm, 1.90 cm, 2.13 cm, the concentration of the inhibitory zone is greater so that the effective concentration inhibiting the growth of Staphylococcus aureus bacteria is 100% w / v.
Anti-Cholesterolemic Activity of Mulberry (Morus australis Poir) Ethanol Extract in Increasing HDL Levels and Inhibiting Formation of Foam Cells on Rat Priska Ernestina Tenda; Eleonora Maryeta Toyo
JURNAL INFO KESEHATAN Vol 19 No 1 (2021): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (308.957 KB) | DOI: 10.31965/infokes.Vol19.Iss1.497

Abstract

Mulberry leaves are one of the medicinal plants empirically used by people to reduce cholesterol levels. Previous study found that mulberry leaves contain flavonoids, act as cholesterol-lowering and tannins function to inhibit the absorption of food, including fat in the GI tract. The objective of this study is to determine the effect of mulberry leaf ethanol extract on increased HDL levels and to determine the inhibition of the formation of foam cells in male Wistar strain rats given the atherogenic diet. Thirty male Wistar rats were divided into six groups, which were normal group, negative control, positive control, and three groups of mulberry leaf extract at a dose of 25, 50, and 100 mg/200g BW rats, respectively. The HDL levels were measured pre- and post- treatment on days 0, 28, 35 and 42. The results showed that the most effective dose augmenting the HDL as well as inhibited the formation of aortic wall foam cell was the ethanol extract at a dose of 100 mg/200 g BW. In conclusion, mulberry leaves ethanolic extract have the potency to be developed as a natural cholesterol-lowering agent.
Immunostimulant Activity of Moringa Leaves (Moringa Oleifera Lam.) Combined with Lime Peel (Citrus Aurantifolia) in Vitro Tenda, Priska Ernestina; Ramadhani, Arba Pramundita
Journal of World Future Medicine, Health and Nursing Vol. 2 No. 1 (2024)
Publisher : Yayasan Pendidikan Islam Daarut Thufulah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/health.v2i1.724

Abstract

Moringa leaves (Moringa Oleifera Lam.) are known to have many chemical contents such as vitamin A, vitamin C, flavonoids, phenolic compounds, carotenoids, tannins and triterpenoids with high uses, one of which is as an immunostimulant. Previous researchers reported that moringa leaves have been developed in various preparations but have not been able to cover the problem of the smell and taste of moringa leaves that are less accepted by consumers. In this study, moringa leaves were combined with lime peel ginger (Citus aurantifolia) to cover the taste and smell of moringa leaves. This study aims to determine the immunostimulant activity of moringa and lime peel in three formulas.  Formula F1= moringa:lime peel (1:1); F2= moringa:lime peel (2:1) F3= moringa:lime peel (3:1); F4= moringa extract. The research conducted was experimental research with the research design used was a completely randomised design and three different treatments with three repetitions. Each treatment was repeated 3 times so that 12 experimental units were obtained. Statistical analysis using the probit test. The results of plant identification showed true moringa leaves and lime peel with chemical content of flavonoids, tannins, terpenoids, alkaloids, saponins based on the results of colour recreation. The IC50 value of immunostimulant activity test of the best formula of tea as immunostimulant is F4, F3, F2 and F1 respectively: 701.83 ± 113.36; 701.83 ± 113.36; 488.08 ± 139.60; 488.08 ± 139.60 µg/mL. Overall, the formulas have the potential to be developed as immunostimulants.
PENILAIAN RISIKO PERALATAN DI LABORATORIUM FARMASETIKA PROGRAM STUDI FARMASI Faizal Soeharto; Priska Ernestina Tenda; Maria Imakulata Masiya Indrawati; Ratih Variani
JURNAL KATALISATOR Vol. 8 No. 2 (2023): Jurnal Katalisator Volume 8 No. 2, Oktober 2023
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v8i2.2614

Abstract

Pengerjaan penelitian Kimia di Laboratorium yang menggunakan alat-alat kimia semetinya selalu diperhatikan resikonya. Belum banyak yang mempelajari mengenai kesehatan dan keselamatan kerja di Laboratorium kimia saat berlansungnya aktivitas penelitian maupun praktikum. Tetapi hal ini sangat diperlukan karena kalau tidak, akan memahayakan. sehingga penelitian ini bertujuan mempelajari penilaian risiko peralatan di laboratorium Farmasetika. Metodenya adalah deskriptif observasional dimana populasi adalah peralatan standar di laboratorium Farmasetika dan sampelnya peralatan yang menimbulkan risiko tinggi. Teknik pengambilan sampel purposif. Instrumen penelitian adalah mengamati dan mengidentifikasi potensi bahaya peralatan dengan lembar What-If. Teknik pengumpulan data adalah menentukan pertanyaan bahaya “Bagaimana Jika” dari kondisi peralatan, deskripsi konsekuensi, nilai konsekuensi, nilai peluang bahaya untuk mendapat nilai risiko dan peringkat risiko. Data dianalisis setelah menentukan nilai risiko dan peringkat risiko, maka ditentukan pengamanan bahaya, rekomendasi pengendalian, tanggung jawab pengendalian. Hasil penelitian menunjukkan kegiatan yang menimbulkan risiko tinggi di laboratorium Farmasetika terkait praktikum Farmasetika dasar adalah meleburkan atau memanaskan dan menimbang karena menggunakan lampu spritus, waterbath digital, neraca elektronik digital portable yang menggunakan api dan listrik dalam proses kerjanya. Ada nilai tingkat risiko tertinggi 16 (peringkat risiko ekstrim) akibat penggunaan peralatan tidak standar dan penggunaan keliru yaitu wadah botol bahan obat dan neraca (elektronik digital dan sama lengan).
Antiplasmodial activity of faloak bark (Sterculia quadrifida, R.Br.) extract from East Nusa Tenggara, Indonesia Priska Ernestina Tenda; Maria Hilaria; Arba Pramundita Ramadani
Indonesian Journal of Pharmacology and Therapy Vol 2 No 2 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.1975

Abstract

The current development of antimalarial drug resistance encourages researchers to discover and develop novel antimalarials. One of its alternatives for antimalarial discovery is using medicinal plants remembering the success of artemisinin. Sterculia quardrifida R. Br. bark, locally name as faloak, is an endemic medicinal plant from East Nusa Tenggara that has been used traditionally to treat malaria. However, its antimalarial activity has not been investigated, yet. This study was aimed to evaluate the antiplasmodial activity of ethanolic extract of faloak bark against Plasmodium falciparum in vitro. Using FCR-3 P. falciparum strain, the ethanolic extract was evaluated on various concentration (1, 10, 50, and 100 μg/mL, respectively). The IC50 value was determined by the relationship between concentration and percentage of growth inhibition. The result showed that the percentage of inhibition of P. falciparum was concentration dependent, higher concentration resulting on higher percentage of inhibition with the IC50 42.399 ± 9.517 μg/mL. It can be concluded that the ethanolic extract of faloak bark have moderate antiplasmodial activity against P. falciparum in vitro.
Co-Authors Arba Pramundita Ramadani Eleonora Maryeta Toyo Elisma Elisma Eti Nurwening Sholikhah Faizal Reza Soeharto Faizal Soeharto Fatmawati Blegur Fuadah, Shofiatul Jamhari Jamhari Lely Adel Violin Kapitan Mahardika Agus Wijayanti Maria Hilaria Maria Imakulata Masiya Indrawati MARIA YANGSYE LENGGU Marini Sriyuni Ngale Najib, Mohd Nadzri Bin Mohd Nara, Theodorik Erik Ngale, Marini Sriyuni Ramadhani, Arba Pramundita Ratih Variani Rochmy Istikharah Soeharto, Faizal R. Theodorik Erik Nara