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Faktor Risiko Kanker Serviks Pada Pasien Rawat Jalan dan Rawat Inap Di Departemen Obstetri dan Ginekologi RSUP Dr. Mohammad Hoesin Palembang Monica Trifitriana; Rizal Sanif; Syarif Husin
Biomedical Journal of Indonesia Vol. 3 No. 1 (2017): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

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Kanker serviks adalah tumor ganas primer yang berasal dari sel epitel skuamosa merupakan salah satu penyakitkanker yang paling banyak terjadi bagi kaum wanita.. Penelitian ini menggunakan jenis penelitian deskriptif analitikdengan case-control. Sampel penelitian adalah 52 pasien yang terbagi menjadi 26 pasien kanker serviks dan 26pasien non-kanker serviks baik yang dirawat jalan maupun rawat inap di Departemen Obstetri dan Ginekologi RSUPDr. Mohammad Hoesin Palembang selama periode September-November 2016. Penelitian ini menggunakan dataprimer berupa wawancara. Data dianalisis secara univariat dan disajikan dalam bentuk tabel distribusi frekuensi.Selanjutnya, dianalisis secara bivariat untuk mengetahui hubungan dan nilai OR. Dari 8 faktor risiko yang diteliti,terdapat hubungan yang bermakna antara riwayat keputihan patologis (p= 0,0005 OR= âˆž), paritas (p= 0,0005 OR=22,7), usia (p= 0,0005 OR= 19,2), penggunaan kontrasepsi oral jangka panjang (p= 0,0005, OR= 12,4), usia pertamakali melakukan hubungan seksual (p= 0,006, OR= 6,1 ), dan pekerjaan suami (p= 0,05 OR= 3,6), dengan kejadiankanker serviks. Sedangkan Terdapat 2 faktor risiko yang tidak memiliki hubungan yang bermakna antara merokok(p= 1,0) dan berganti-ganti pasangan seksual (p= 1,0) dengan kejadian kanker serviks. Hasil penelitianmengidentifikasi faktor-faktor risiko dengan hubungan terhadap kejadian kanker serviks yang signifikan, yaitu usia,usia pertama kali melakukan hubungan seksual, paritas, penggunaan kontrasepsi oral jangka panjang, riwayatkeputihan, dan pekerjaan suami.

Ekspresi Epidermal Growth Factor Receptor dan Karakteristik Klinikohistopatologik pada Karsinoma Kolorektal . Reallyani; Mezfi Unita; Zulkarnain Musa; Syarif Husin
Majalah Patologi Indonesia Vol 23 No 1 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Background Colorectal carcinoma is one of the world's fourth most malignancies. Frequency of colorectal carcinoma malignancy most likely to occur in the gastrointestinal tract and causes the death of close to 15% of all cancers. Heterogeneous of the etiology is associated with many risk factors and molecular changes. Epidermal growth factor receptor is a 170 kDa transmembrane glycoprotein which contribute to carcinogenesis, prognostic impact and specific therapeutic targets. The aims this study to determine the relationship between EGFR expression and the clinicohistopathology characteristics in colorectal carcinoma. Methods This study is an observational study with cross sectional approach. The samples were specimens of the 57 samples that had been diagnosed as colorectal carcinoma from January 2010 to August 2012. Samples from histopathological preparations are reviewed and conducted outward EGFR immunohistochemistry with primary antibodies for the primary tumor. Results EGFR expression to histopathological characteristics are as follows pT3 of 45.6%, positive lymph node status was 52.6% and poorly differentiated histological degree of malignancy of 50.9%. Statistical calculations showed no significant correlation between EGFR expression and histopathologic characteristics of the pT in the TNM system (p=0.037), lymph node status (p=0.000), histological grading of malignancy (p=0.001), and high expression (61.4%). Conclusion EGFR expression affects the pT in TNM system, lymph node staging and histological grading of malignancy. Key words: characteristic clinicohistopathology, colorectal carcinoma, epidermal growth factor receptor.

Efek Pemberian Kombinasi Zinc dan Probiotik Terhadap Lama dan Frekuensi Diare Pada Penderita Diare Akut Rahmayani Rahmayani; Hasri Salwan; Achirul Bakri; Syarif Husin
Majalah Kedokteran Sriwijaya Vol 46, No 3 (2014): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v46i3.2702

Salah satu tatalaksana diare menurut WHO adalah pemberian zinc. Zinc berperan memelihara integritas mukosa usus dan memperbaiki sistem imunitas. Probiotik terbukti efektif dalam saluran cerna. Probiotik menginduksi kolonisasi dan pertumbuhan flora normal di usus, mencegah perlengketan bakteri patogen pada mukosa, dan mengaktivasi sistem imun. Tujuan dari penelitian ini adalah menilai efektifitas pemberian kombinasi zinc dan probiotik terhadap lama diare dan frekuensi BAB pada penderita diare akut selama perawatan di rumah sakit. Penelitian ini merupakan uji klinik acak tersamar ganda (double blind) terhadap anak usia 6-59 bulan yang dirawat di bangsal anak RSUP dr. Moh. Hoesin Palembang dari bulan Juni-November 2011. Penderita dibagi menjadi dua kelompok,Â kelompok yang mendapat zinc 20mg/hari dan probiotik (2x109 cfu/gr lactobacillus acidophilus dan bifidobacterium lactis) dan kelompok yang mendapat zinc 20 mg/hari dan plasebo. Terdapat 56 penderita yang memenuhi kriteria inklusi. Subjek penelitian terdiri dari laki-laki sebanyak 35 orang (62,5 %) dan 21 perempuan (37,5%). Umur rerata pada penelitian ini adalah 16,8 bulan dimana rerata pada kelompok zinc+plasebo adalah 15,6+7,4 bulan dan 18,14+12,3 bulan pada kelompok zinc+probiotik. Rerata lama diare pada kelompok zinc+probiotik 43,23+24,69 jam vs 47,12+32,27 jam pada kelompok zinc+plasebo (p=0,61). Rerata frekuensi BAB di RS pada kelompok zinc+probiotik 4,26+2,42 vs 4,19+2,97 kali/hari pada kelompok zinc+probiotik Â (p=0,61). Lama diare dan frekuensi BAB pada kelompok suplementasi zinc+probiotik tidak berbeda bermakna dibandingkan dengan kelompok zinc+plasebo.

Identification of Lactic Acid Bacteria Isolate From Fermentation Food Bekasam Ardesy Melizah; Syarif Husin; Syifa Alkaf
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 1 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i1.34

Bekasam is a local food from South Sumatera Indonesia, which is obtained through fermentation of fish. Previous study has shown that fermented food contained Lactic Acid Bacteria (LAB) bacteria, such as Lactobacillus plantarum, Lactobacillus sp, Pediococus sp and Weissella sp. The study was conducted to identify isolate LAB from bekasam. Bekasam contained fish, rice, and salt with a certain ratio. Further isolation of isolated LAB isolate, then performed PCR for bacterial analysis. Isolate 1 showed alleged bacteria Staphylococcus sp, non pathogen, while isolate 2 leads to Lactobacillus sp. The PCR results show the suitability of the bands formed between the Lactobacillus standard and the isolates. Keywords: bacteria, lactobacillus, acid

Identification of Lactic Acid Bacteria Isolate From Fermentation Food Bekasam Ardesy Melizah; Syarif Husin; Syifa Alkaf
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 1 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i1.34

Bekasam is a local food from South Sumatera Indonesia, which is obtained through fermentation of fish. Previous study has shown that fermented food contained Lactic Acid Bacteria (LAB) bacteria, such as Lactobacillus plantarum, Lactobacillus sp, Pediococus sp and Weissella sp. The study was conducted to identify isolate LAB from bekasam. Bekasam contained fish, rice, and salt with a certain ratio. Further isolation of isolated LAB isolate, then performed PCR for bacterial analysis. Isolate 1 showed alleged bacteria Staphylococcus sp, non pathogen, while isolate 2 leads to Lactobacillus sp. The PCR results show the suitability of the bands formed between the Lactobacillus standard and the isolates. Keywords: bacteria, lactobacillus, acid

THE FINAL YEAR OF MEDICAL SCHOOL TOGETHER WITH THE COVID-19 PANDEMIC WAS RELATED TO EMOTIONAL EATING BEHAVIOR Muhammad Ihsan Abdurrahman; Syarif Husin; Evi Lusiana; Ardesy Melizah Kurniati; Tri Suciati
Majalah Kedokteran Sriwijaya Vol 54, No 1 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i1.18182

Emotional eating, or overeating to ease unpleasant emotions, is one of the harmful impacts of stress. Students in their final year of college are more susceptible to emotional eating because their stress level is high. The main purpose of this study was to examine the association between stress and emotional eating behavior in final-year Medical Education Study Program students of Universitas Sriwijaya. Data was collected in January 2021, with as many as 121 students from the 2017 class participating. The Perceived Stress Scale (PSS) questionnaire was used in this study to assess students' stress levels, while the Dutch Eating Behaviour Questionnaire (DEBQ) was used to assess emotional eating behavior. The Chi-square test was used to examine the data. Overall, this study discovered that 19 students (15.7 percent) were classified as having low stress, 82 students (67.8 percent) as having moderate stress, and 20 students (16.5 percent) as having high stress. Emotional eating affects up to 74 (61.2%) of students, with female students experiencing more. The Chi-square test yielded p=0.018 (p 0.05) and OR 3.282 (1.186-9.081) indicating a significant link between stress and emotional eating behavior in final-year Medical Education Study Program students of Universitas Sriwijaya.

HUBUNGAN PEWARNA SINTETIS TERHADAP KEJADIAN DERMATITIS KONTAK OKUPASIONAL PADA PENGRAJIN KAIN JUMPUTAN PELANGI PALEMBANG Reza Mayasari; Soenarto Kartowigno; Nopriyati Nopriyati; Syarif Husin
Media Dermato-Venereologica Indonesiana Vol 49 No 3 (2022): Media Dermato-Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v49i3.305

Dermatitis kontak okupasional (DKO) adalah inflamasi kulit akibat paparan alergen atau iritan baik dalam proses maupun lingkungan pekerjaan. Paparan pewarna sintetis pada pengrajin kain jumputan pelangi diduga menyebabkan DKO yang mengganggu kesehatan dan produktivitas kerja. Saat ini belum tersedia data dasar prevalensi DKO, analisis faktor risiko dengan DKO, dan identifikasi dengan alergen dari bahan pewarnai kain penyebab DKO. Tujuan penelitian ini untuk mengetahui prevalensi, hubungan pewarna sintetis terhadap kejadian DKO, dan identifikasi bahan pewarna alergen dan iritan penyebab DKO. Metode penelitian observasional analitik dengan rancangan potong lintang pada 149 pengrajin kain jumputan pelangi di Kelurahan Tuan Kentang dan 35 Ilir Palembang selama empat bulan. Data dikumpulkan melalui pengisian kuesioner NOSQ 2002, pemeriksaan fisik, dan uji tempel, serta dianalisis menggunakan SPSS versi 22,0. Pada penelitian ini ditemukan prevalensi DKO sebesar 22,15%, yaitu 13,45% kasus DKIO dan 8,7% kasus DKAO. Terdapat hubungan bermakna antara jenis pewarna sintetis terhadap kejadian DKO pada pengrajin kain jumputan pelangi di Palembang (p=0,042). Alergen terkait pekerjaan yang terbanyak memberikan hasil positif pada uji tempel yaitu naftol AS dan naftol AS BO.

Analysis on Sentence Structure in Lewis Carrol’s Alice’s Adventures in Wonderland Lisa Ma'rufi; Sudarsono; Syarif Husin; Eusabinus Bunau; Ikhsanudin
Journal of Scientific Research, Education, and Technology (JSRET) Vol. 2 No. 1 (2023): Vol. 2 No. 1 2023
Publisher : Kirana Publisher (KNPub)

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The purpose of this research is to identify types of sentences and their frequency contained in the novel Alice’s Adventures in Wonderland in order to help high school students to improve their ability in understanding and practicing English sentence structure. This research was a descriptive study. The corpus of this research was the novel “Alice’s Adventures in Wonderland” which is written by Lewis Carroll. All of the declarative sentences of the conversation in all of the novel's chapters were analyzed in this research which include formal and informal sentences, direct sentences, and nominal and verbal sentences. This research used open coding and focused coding as the procedure of data analysis. The corpus was sorted for complete declarative sentences. After that, they were grouped and coded based on their types of sentences and subcategories. Then, each type of sentence’s frequency of occurrence was calculated. The finding found that there are four sentence types used by the novel, which are: simple sentences, compound sentences, complex sentences, complex sentences, and compound-complex sentences. The total declarative sentences found are 440 sentences. Simple sentence becomes the most frequent sentence type used by the novel and complex compound sentence becomes the least. This research covered the information for students about sentence types they need to master before reading the novel as one of their media to learn and practice sentence structure.

Improving Students’ Analytical Writing Skill by Writing Song Lyrics Analysis Khoirunnisak; Yanti Sri Rezeki; Syarif Husin
Ethical Lingua: Journal of Language Teaching and Literature Vol. 11 No. 2 (2024): Volume 11 No 2 October 2024
Publisher : Universitas Cokroaminoto Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30605/25409190.736

This study aimed to improve students’ analytical writing skill by writing song lyrics analysis. This study was conducted as classroom action research in two cycles. The subject of this study is the eleventh grade Social 3 students of Man Kota Singkawang in the academic year 2023/2024 which consists of thirty one students. The data obtained were quantitative and qualitative data. Quantitative data was obtained through the result of writing task and the qualitative data was obtained through field notes. The result from data analysis showed that the use of song could make students enjoy the learning activity. In addition, the use of song lyrics could make students remember the vocabulary easier and writing song lyrics analysis could improve students’ analytical essay writing skill. It also can be seen from the improvement of students writing tasks’ scores in cycle 1 and cycle 2. The mean score in cycle 1 was 59,19 and it was improved to be 76,45 in cycle 2. In conclusion, using song lyrics had successfully improved analytical essay writing skill of students’ in the eleventh grade Social 3 at Man Kota Singkawang.

Neutrophil-Lymphocyte Ratio as a Novel Biomarker for Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study Pradesta, Rahnowi; Novadian; Yulianto Kusnadi; Nova Kurniati; Syarif Husin
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 3 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i3.1235

Background: Early detection of diabetic nephropathy (DN) is crucial to prevent progression to end-stage renal disease. The gold standard for diagnosing DN involves urine microalbumin testing and renal biopsy. However, the availability of these diagnostic tools is limited in many healthcare facilities across Indonesia. Consequently, there is a pressing need for an alternative examination that is readily accessible and can effectively monitor the progression of DN. Methods: This cross-sectional study was conducted at Dr. Mohammad Hoesin General Hospital, Palembang, from February 2024 to May 2024. The study aimed to investigate the correlation between neutrophil-lymphocyte ratio (NLR) and urinary albumin levels in type 2 diabetes mellitus (DM) patients. NLR, calculated from complete blood counts, has emerged as a potential inflammatory marker for various conditions. A total of 65 participants diagnosed with type 2 DM were enrolled in the study. Data analysis involved Spearman's correlation test to assess the relationship between NLR and urinary albumin levels. Results: The majority of the 65 subjects were female (58.5%). The study found that 44 subjects had normoalbuminuria, 18 had microalbuminuria, and 3 had macroalbuminuria. A significant positive correlation was observed between NLR and albuminuria levels in type 2 DM patients (r = 0.795; p < 0.01). Conclusion: The study's findings suggest that NLR is a potential cost-effective biomarker for the early detection of DN in type 2 DM patients, especially in resource-limited settings. Further large-scale studies are recommended to validate these findings and establish specific NLR thresholds for predicting DN progression.

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