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All Journal Folia Medica Indonesiana Indonesian Journal of Pharmaceutical Science and Technology Pharmascience Jurnal Ilmiah Manuntung SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Mandala Pharmacon Indonesia Jurnal Ilmu Kesehatan BERNAS: Jurnal Pengabdian Kepada Masyarakat Borneo Student Research (BSR) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Pharmaceutical Sciences and Research (PSR) FASKES : Jurnal Farmasi, Kesehatan, dan Sains Journal of Pharmaceutical (JOP) Media Farmasi Jurnal Pengabdian Masyarakat Panacea Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Ika Ayu Mentari
Universitas Muhammadiyah Kalimantan Timur
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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IDENTIFIKASI METABOLIT SEKUNDER DAN POTENSI ANTIDIARE EKSTRAK DAUN CINCAU (Stephania capitata (Blume) Spreng) Mentari, Ika Ayu; Hairunisa, Indah; Ibrahim, Arsyik; Fridayanti, Aditya
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (134.446 KB)

Abstract

Indonesia biodiversity has the second highest number of indigenous medical plants after the amazon rain forest, meanwhile Indonesian people usually used plants as a medicine source and some medicine plants have been developed as modern drugs. One of medicine plant in Indonesia that usually used as a refreshment was grass jelly (Stephania capitata (Blume) Spreng). This plant frequently found in Sumatra, Borneo and Java island and the leaf of grass jelly has been reported as a medicine against stomach complaint (diarrhea) and fevers. This research was designed to investigate the secondary metabolites and the efficacy of leaf extract of grass jelly as anti diarrhea. The leaves extraction was done by using maceration with ethanol solvent at room temperature. Meyer reagent, dagendroff reagent, methanol, magnesium band, hydrochloric acid, iron (III) chloride, anhydrous acetic acid, sulfuric acid, chloroform were used for identification of secondary metabolites from grass jelly leaves. For potency anti diarrhea, animals were divided into six group: diarrhea group, treatment group with loperamid HCl and treatment group of leaf extract of grass jelly. The results showed that the leaf extract of grass jelly contain saponin, phenol, sterol and triterpen and the treatment with leaf extract of grass jelly significantly decreasing time duration of diarrhea.
THE CARACTERIZATION THE CARACTERIZATION OF SIMPLISIA AND EXTRACT OF CLOVE LEAVES (Syzigium aromaticum Merr. Et Perry L) FOR HERBAL MOUTHWASH ACTIVE INGREDIENS Wirnawati Wirnawati; Ika Ayu Mentari; Nur Sholeh Aryodi Pernando
Jurnal Ilmu Kesehatan Vol 8 No 1 (2020): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30650/jik.v8i1.1377

Abstract

One of the oral and dental diseases that is often experienced by most people is dental caries. Clove leaves (Syzygium Aromaticum Merr. Et Perry L) have compounds that can prevent the activity of the bacterium Streptococcus mutans which is the cause of dental caries. This research is non experimental which focuses on the characterization of clove leaves. Characterization of simplisia and sample extracts include organoleptic observation, microscopy, phytochemical screening using Thin Layer Chromatography (TLC), determination of soluble substances in certain solvents (ethanol and water), total ash content, water soluble ash content, insoluble ash content in acid, then drying shrinkage test. The results of the organoleptic test for simplisia and extract of clove leaf showed that they have a dark brown color, specific aromatic odor, spicy and bitter taste. Clove leaf extract has a brownish black color, aromatic odor and has a bitter and pungent taste. Microscopic test of simplisia of clove leaves showed that there was a mesophyll includes palisade tissue, with calcium oxalate crystal, anomistic type stomata, identification fragments are fragments of the lower epidermis with stomata. The results of the percentage of soluble substances of simplisia and ethanol extract of clove leaf were 50% and 40%, the percentage of soluble substances of simplisia and ethanol extract of clove leaf were 1.73% and 4.33%. The percentage of total ash content of simplisia and ethanol extract of clove leaf 11.4% and 22%, the percentage of water soluble ash content of simplisia and extract was 16.9%, 17.5%. Percentage of insoluble ash content of simplisia acid and extract 9.5% and 10.5%. Shrinkage of simplisia and extracts were 7.6% and 11.46%.
Development Ischemic Stroke Model by Right Unilateral Common Carotid Artery Occlusion (RUCCAO) Method Ika Ayu Mentari; Rifda Naufalina; Mahardian Rahmadi; Junaidi Khotib
Folia Medica Indonesiana Vol. 54 No. 3 (2018): September
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (248.459 KB) | DOI: 10.20473/fmi.v54i3.10015

Abstract

This study was designed to examine motor and congnitive changes, infarct lesion and neurohistological changes, involving histologic staining and immunohistochemical expression of caspase-3 after induction by right unilateral common carotid artery occlusion (RUCCAO) for 90 minutes. The animals were divided into two groups: sham group and stroke model group. Cognitive impairment was evaluated by Y maze. Motor function was measured on days 0, 1, 3 and 7 using FUAT paradigm. Infarct area, histological and caspase-3 expressions were evaluated on day 14 after RUCCAO. The results showed that RUCCAO induced cognitive and motor impairment on day 3 and 7. Furthermore, stroke model group induced infarct lesion. Hispatology examination showed body damage of neuron cell in the ipsilateral hemisphere. Moreover, expression of caspase-3 on RUCCAO group was significantly higher than that in sham group. In conclusion, RUCCAO method caused significant cognitive and motor function impairment. Furthermore, RUCCAO also induced infarct lesions and cell death in the thalamus brain area. Thus, RUCCAO can be employed as a method for ischemic stroke model, especially in focal ischemia.
KARAKTERISASI SIMPLISIA DAN EKSTRAK DAUN BANDOTAN (Ageratum conyzoides L) SEBAGAI KANDIDAT OBAT KARIES GIGI Ika Ayu Mentari; Wirnawati Wirnawati; Maulina Rahmawati Putri
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 5 No 1 (2020): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (310.114 KB) | DOI: 10.36387/jiis.v5i1.346

Abstract

Bandotan leaves (Ageratum conyzoides L) has an activity to inhibit the growth of Streptococus mutans bacteria cause dental caries. This Research was designed to establish quality and safety standards for simplicia and Bandotan leaves extracts. This research is non-experimental, which includes sampling, determination, making simplicia, and extraction. Characterization tests including organoleptic, macroscopic, microscopic, phytochemicals screening using TLC, determination of soluble water content, soluble ethanol content, total ash content, water soluble in ash content, acid insoluble in ash content and decrease drying. Organoleptic characteristics of simplicia test showed dark green, has bitter taste and aromatic odor typical of bandotan. The extract showed blackish green, aromatic aroma typical of bandotan and has very bitter taste. Phytochemical screening showed that bandotan leaf extract contains alkaloids, steroids, flavonoids. Microscopic of Simplicia showed hair covering, upper and lower epidermis, corrugated walls with anomistic type stomata, mesophyll covering palisade tissue. The percentage simplicia and extract of soluble water are 2% and 2,4 %. Percentage soluble ethanol are 12,9% and 9,5%. Percentage of total ash content 25,5% and 51%. Percentage water soluble in ash content are 10% and 7,35%. Percentage acid insoluble in ash content are 9,7 % and 2,5%. Percentage decrease drying are 11% and 75%.
PENGARUH PEMBERIAN KONSELING MENGGUNAKAN BOOKLET TERHADAP PENGETAHUAN DIABETES MELLITUS MASYARAKAT DI KECAMATAN ANGGANA, KALIMANTAN TIMUR Deasy Nur Chairin Hanifa; Ika Ayu Mentari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 5 No 1 (2020): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.802 KB) | DOI: 10.36387/jiis.v5i1.367

Abstract

Diabetes mellitus is a metabolic disease characterized by an increase in blood sugar levels due to interference with insulin secretion, insulin action or both. The aim of this research is to look the effect of counseling on public knowledge about diabetes mellitus. This research was conducted in Sidomulyo Village, Anggana District. The target of the feasibility of this research is the people who are in rural areas who mostly do not know the information about the risk, prevention, and treatment of diabetes mellitus. The method was used a counseling with booklet and the discussions. The level of knowledge was assessed using the DKQ - 24. This research used a quasi-experimental method with one group pretest-posttest design. Measurement of knowledge used Wilcoxon statistical analysis. Research respondents were dominated by 68% women and 32% of men with an age range of fewer than 60 years by 77% and more than 60 years by 23%. The results of the pretest using the DKQ-24 questionnaire showed respondents with a low knowledge category of 27%, moderate knowledge of 65%, and high knowledge of 8%. Two weeks later a post-test was conducted using the DKQ-24 questionnaire, the results obtained by respondents with the category of low knowledge by 3%, moderate knowledge by 77%, and high knowledge by 20%. The average value about the prevention and treatment of diabetes mellitus, showed pretest 10.17 ± 4.891 and posttest 14.20 ± 3.119. The relationship between pre and post counseling was found with a value of p <0,000. These results indicate the effect of increasing knowledge about diabetes mellitus after counseling.
Pengaruh Pemberian Kombinasi Ekstrak Kayu Manis (Cinnamomum Burmannii) dan Daun Salam (Syzygium Polyanthum Wight) terhadap Penurunan Kadar Asam Urat pada Mencit Model Hiperurisemia Maulina Rahmawati Putri; Ika Ayu Mentari
Borneo Student Research (BSR) Vol 3 No 2 (2022): Borneo Student Research
Publisher : Borneo Student Research (BSR)

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Abstract

Tujuan studi: Hiperurisemia adalah peningkatan kadar asam urat darah di atas normal karena sintesa purin berlebihan dalam tubuh sehingga pengeluaran asam urat mengalami gangguan. Untuk mengatasi asam urat dalam tubuh banyak hal yang dapat dilakukan salah satu cara yang sudah dilakukan pemanfaatan tumbuhan obat tradisional. yaitu tumbuhan yang diketahui dapat menurunkan kadar asam urat tanaman daun salam (Syzygium polyanthum Wight.) dan kayu manis (Cinnamomum burmani).Penelitian ini bertujuan untuk mengetahui pengaruh pemberian kombinasi ekstrak etanol daun salam dan kayu manisterhadap penurunan kadar asam urat darah mencit yang diinduksi dengan Kalium oksonat dosis. Metodologi: Penelitian eksperimental Rancangan Acak Lengkap (RAL) menggunakan 30 ekor mencit (Mus musculus). Mencit dibagi menjadi 6 kelompok. K1 diberi Na-CMC 0,5 ml/30gBB secara oral, K2 diberi perlakuan Na-CMC 1 % dan Kalium oksonat dosis 250 mg/kgBB. K3 diberi perlakuan allopurinol 10 mg/kgBB dan diinduksi Kalium oksonat 250 mg/kgBB secara intraperitonial. K4 diberi ekstrak etanol daun salam dan kayu manis dengan dosis 125/25mg/kgBB dan diinduksi Kalium oksonat 250 mg/kgBB secara intraperitonial. K5 diberi ekstrak etanol daun salam dan kayu manis dengan dosis 125/75mg/kgBB dan diinduksi Kalium oksonat 250 mg/kgBB secara intraperitonial. K6 diberi ekstrak etanol daun salam dan kayu manis dengan dosis 375/25mg/kgBB dan diinduksi Kalium oksonat 250 mg/kgBB secara intraperitonial. Hasil: Kombinasi ekstrak etanol daun salam dan kayu manis menurunkan kadar asam urat darah mencit yang diinduksi Kalium oksonat dosis 250 mg/KgBB secara signifikan (P<0,05) Manfaat: Ekstrak etanol daun salam dan kayu manis menurunkan kadar asam urat darah mencit yang diinduksi Kalium oksonat.
Formulasi dan Uji Antioksidan Formula Granul Effervescent Ekstrak Kulit Buah Pulasan (Nephelium mutabile Blume) Tribudi Julianti; Ika Ayu Mentari; Erindyah Retno Wikantyasning; Salsabila Azzahra; Indah Hairunisa
Jurnal Pharmascience Vol 9, No 2 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i2.13717

Abstract

Pulasan (Nephelium mutabile Blume) merupakan tanaman yang banyak tumbuh di Kalimatan. Tanaman ini diketahui memiliki aktivitas antioksidan yang tinggi tertutama pada bagian kulitnya akan tetapi pemanfaatan aktivitas ini belum banyak dilakukan. Hal ini dibuktikan dengan kurangnya penelitian mengenai formulasi buah pulasan menjadi sediaan farmasi yang mudah dan menyenangkan untuk digunakan. Penelitian ini bertujuan untuk mendapatkan formula optimum effervescent ekstrak kulit buah pulasan yang dapat diterima dan mudah digunakan setelah itu dikaji aktivitas antioksidan dengan metode 2,2-diphenyl-1-picrylhydrazyl (DPPH) menggunakan spektrofotometer UV-Vis. Pembuatan serbuk effervescent ekstrak kulit buah pulasan dilakukan menggunakan empat formula dengan konsentrasi ekstrak yang berbeda, dilanjutkan dengan uji kestabilan fisik meliputi uji pH, organoleptis, moisture content, waktu alir dan sudut diam. Hasil penelitian menunjukkan tidak ada yang signifikan antara hasil uji organoleptis, pH dan waktu melarut pada ke empat formula yaitu masuk dalam kategori memenuhi syarat. Namun pada uji moisture content dan sudut diam ke empat formula masuk dalam kategori tidak memenuhi syarat. Hasil optimum pada pengujian  antioksidan formula effervescent ekstrak kulit buah pulasan ditunjukkan oleh formula IV ditentukan oleh nilai IC50 826,45 (μg/mL). Hasil penelitian ini menunjukkan ekstrak pulasan dapat diformulasikan dalam bentuk effervescent, tetapi pemilihan konsentrasi ekstrak kulit buah pulasan perlu ditinjau ulang agar didapatkan nilai IC50 yang optimum. Kata Kunci: Effervescent, Pulasan, Antioksidan, DPPH Pulasan (Nephelium mutabile Blume) is a plant that generally grows in Kalimantan. This plant is known to have high antioxidant activity, especially in its peels, but the utilization of this activity has not been widely used. This has been proven by the lack of research on the formulation of this fruit into pharmaceutical preparations that are easy and pleasant to use. The aim of this study was to obtain the optimum effervescent formula for the peel extract of pulasan that acceptable and easy to us and also the antioxidant activity of the formula was assessed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method using a UV-Vis spectrophotometer. The making of the effervescent powder of the fruit peel extract was carried out using four formulas with different extract concentrations, followed by physical stability tests including pH, organoleptic, moisture content, flow time and angle of repose tests. The results showed that there was no significant difference between the results of the organoleptic test, pH and dissolving time in the four formulas, which were included in the eligible category. However, in the test of moisture content and angle of repose the four formulas are in the category of not meeting the requirements. The optimum results in the antioxidant test of the effervescent formula of the outward skin extract were shown by formula IV determined by the IC50 value of 826.45 (μg/mL). The results of this study indicate that the pulasan peels extract can be formulated in the form of effervescent, but the selection of the concentration of the pulasan peels extract needs to be reviewed in order to obtain the optimum IC50 value.
Formulation and Physical Stability Test of Essence Sheet Mask Preparation from Kokang Leaf Extract (Lapisanthes amoena) Tsaniya Ukhti Nabilah; Ika Ayu Mentari
Jurnal Mandala Pharmacon Indonesia Vol. 9 No. 1 (2023): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v9i1.302

Abstract

Kokang leaf ethanol extract contains secondary metabolite compounds such as phenolics, flavonoids, tannins, steroids, and saponins that have antioxidant and antibacterial effects and play a role in wound healing. Seeing the potential in kokang leaves (Lepisanthes Amoena) until now the use of kokang leaves is still very lacking, therefore the need for innovation in the use of leaves, one of which is by developing a formulation of essence sheet mask preparations from kokang leaf extract (Lepisanthes Amoena). Formulations in the form of essence sheet masks are currently the latest developments in cosmetic preparations. The purpose of this study was to formulate and test the physical stability of the essence sheet mask preparation from the extract of kokang leaves. The preparation is made as many as 3 formulas, the leaf extract used is 0.1% (F1), 0.3% (F2), and 0.5% (F3). The evaluation carried out includes organoleptic tests (color, aroma, and texture), homogeneity tests, pH tests, room temperature stability tests, viscosity tests, and hedonic tests (favorability and irritation). The results showed that the preparation of the essence sheet mask was a thick solution with a characteristic green and homogeneous odor. The preparation of the essence sheet mask is stable at room temperature without any change. The pH value of the preparation essence sheet mask 5 – 6. Viscosity with a viscosity of 2,217 cP. A hedonic test of 12 panelists showed that the average favorability of all categories was superior to F2 (0.3%) and there was no irritation to the entire formula.
Formulation and Physical Stability Test Peel Off Mask from Kokang Leaf Extract ( Lepisanthes amoena (Haask) Leenh) as an Antioxidant Jati Pratiwi; Ika Ayu Mentari
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 1 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.47320

Abstract

Free radicals are substances that can damage skin cell membranes and damage skin cells resulting in melanogenesis which is the main defense of the skin. So that antioxidants are needed as an antidote to free radicals that can inhibit or neutralize the bad effects of free radicals and are formulated in the form of peel-off masks to remove dirt and dead skin cells. Kokang leaves (Lepisanthes amoena (Haask) Leenh) is a plant rich in antioxidants originating from East Kalimantan which contains alkaloids, flavonoids, saponins and tannins. This study aims to determine the characteristics and physical stability as well as determine the antioxidant activity of peel off mask preparations of kokang leaf extract (Lepisanthes amoena (Haask) Leenh), experimentally using the DPPH method with a UV-Vis spectrophotometer. The results and conclusions obtained were that kokang leaf extract (Lepisanthes amoena (Haask) Leenh) peel off mask preparations 1 (0%), 2 (1%), 3 (2.5) and 4 (5%) had physical characteristics and stability good tests (meet standard requirements) including organoleptic tests, pH, homogeneity, spreadability, adhesion, drying time and viscosity. Testing the antioxidant activity using a concentration of 5%. Kokang leaf extract contains strong antioxidant activity with a value of 59,707 ppm, while kokang leaf extract peel off mask contains medium category antioxidant activity with an IC50 value of 102,945 ppm. 
Pemanfaatan Kulit Ari Kedelai sebagai Bahan Pembuatan Nugget untuk Peningkatan Gizi Anak Stunting: Soybean Husk as the Nugget Basic Ingredient to Improve the Nutrition of Stunting Sinta Ratna Dewi; Rizki Nur Azmi; Ika Ayu Mentari; Vera Herliani Pratiwi; Erlinda Dwi Afriliani; Nabilah Husna Fitriyani
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 8 No. 5 (2023): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v8i5.4904

Abstract

Reducing the incidence of stunting in Indonesia is a top priority in overcoming health problems. Mesjid Ward, Samarinda City, is one of the areas that has a high prevalence of stunting, with as many as 34 children in 2020. Efforts to overcome this problem need to use unconventional food ingredients that contain adequate nutrition, are affordable, and are easy to obtain. Soybean husk, which has a high protein and fiber content, has the potential to be utilized in efforts to fulfill stunting children's nutrition. Community service activities aim to increase the utilization of soybean husk as processed healthy nuggets, increase public knowledge regarding stunting, and improve community skills in processing soybean husk-based nuggets—activities carried out by providing counseling and training. The results of this activity indicated that there was a significant change in the community's knowledge after giving the material (p-value <0.001). The knowledge about stunting and how to use soybean husk in processed food products has increased among the public.
Co-Authors Aat Arafat Aditya Fridayanti Aditya Fridayanti Andini Nur Amilia Annisa Nurul Safitri Arsyik Ibrahim Arsyik Ibrahim Astriani, Nur Atika Azmi, Rizky Nur Chanchao, Chanpen Deasy Nur Chairin Hanifa Erindyah Retno Wikantyasning Erlinda Dwi Afriliani Fenty Fauziah Hairunnisa, Indah Ichsan, Muhammad Nor Indah Hairunisa Indah Hairunisa Irfan Muris Setiawan Irsa Nur Hanifah Jati Pratiwi Junaidi Khotib Kafka Navisa Suwarno Kamilah, Lila Zulfa Kharisma, Putri Lisa Long, Yuliana Mahardian Rahmadi Maulina Rahmawati Putri Maulina Rahmawati Putri Muhammad Ali Syahbana Muhammad Nor Ichsan Nabilah Husna Fitriyani Nur Sholeh Aryodi Pernando Nur Supianti Paula Mariana Kustiawan Pratika, Rika Putri, Selmi Radityo, Muhammad Bayu Rahayu, Putri Dwi Rahmatang Raihana, Laila Ramadhan, Donny raudatul jannah Rifda Naufalina Rika Nur Junnah Rika Pratika Rizki Nur Azmi Rizky Putra Pratama, Rizky Putra Sabina Guseynova Salsabila Azzahra Shety, Shety Sinta Ratna Dewi Siti Aisyah Syahbana, Muhammad Ali Syaifie, Putri Hawa Tiara Tri Budi Julianti Tsaniya Ukhti Nabilah Vera Herliana Pratiwi Vera Herliana Pratiwi Vera Herliani Pratiwi Wirnawati Wirnawati Wirnawati Wirnawati Yoga Pratama, Virgiawan