SI2933252T1 - Apoptosis signal-regulating kinase inhibitors - Google Patents

Apoptosis signal-regulating kinase inhibitors Download PDF

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SI2933252T1
SI2933252T1 SI201031622T SI201031622T SI2933252T1 SI 2933252 T1 SI2933252 T1 SI 2933252T1 SI 201031622 T SI201031622 T SI 201031622T SI 201031622 T SI201031622 T SI 201031622T SI 2933252 T1 SI2933252 T1 SI 2933252T1
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cyclopropyl
triazol
phenyl
carboxamide
bipyridine
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SI201031622T
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Slovenian (sl)
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Britton Corkey
Michael Graupe
Keith Koch
Lawrence S. Melvin
Gregory Notte
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Gilead Sciences, Inc.
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Abstract

The present invention relates to compounds of Formula (I): wherein X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are as defined above. The compounds have apoptosis signal-regulating kinase ("ASK1") inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).

Description

Original document published without description

Claims (15)

KINAZNI INHIBITORJI KOT REGULATORJI APOPTOZNEGA SIGNALA EP 2 933 252 B1 PATENTNI ZAHTEVKIKINDER INHIBITORS AS APPOTSION SIGNAL REGULATORS EP 2 933 252 B1 PATENT REQUIREMENTS 1. Spojina s formulo I za uporabo pri zdravljenju akutne kardiovaskularne bolezni, kjer se spojina s formulo 1 daje istočasno s terapevtskim sredstvom in formula I je:A compound of formula I for use in the treatment of an acute cardiovascular disease wherein the compound of formula I is administered simultaneously with the therapeutic agent and formula I is: pri čemer: R1 je alkil z 1-10 atomi ogljika, cikloalkil s 3-8 atomi ogljika, alkenil z 2-10 atomi ogljika, alkinil z 2-10 atomi ogljika, aril, heteroaril ali heterociklil, od katerih so vsi po izbiri substituirani z 1, 2 ali 3 substituenti, izbranimi izmed haloa, oksa, alkila z 1-6 atomi ogljika, cikloalkila s 3-8 atomi ogljika, heterociklila, fenila, fenoksija, haloa, -CN, -O-R6, -C(0)-R6, -0C(0)-R6-C (O)-O-R6, -N(R6)-C(0)-0-R7 ,-N(R6)-C(0)-R7, -N(R6)-C(0)-N(R6)(R7) in -C (0)-N(R6)(R7), kjer so alkil, cikloalkil, heterociklil, fenil in fenoksi po izbiri substituirani z 1, 2 ali 3 substituenti, izbranimi izmed alkila z 1-6 atomi ogljika, cikloalkila s 3-8 atomi ogljika, alkoksija z 1-6 atomi ogljika, hidroksila in haloa; pod pogojem, da R1 ni metil, kadar je R3 morfolinil ali furil; kjer sta R6 in R7 neodvisno izbrana iz skupine, ki jo sestavljajo vodik, alkil z 1-6 atomi ogljika, ali cikloalkil s 3-8 atomi ogljika; ali R6 in R7, kadar sta vzeta skupaj z dušikom, na katerega sta vezana, tvorita heterocikel; R2 je vodik, halo, ciano, alkoksi ali alkil, po izbiri substituiran s halo; R3 je aril, heteroaril ali heterociklil, od katerih so vsi po izbiri substituirani z 1, 2 ali 3 substituenti izbranimi izmed alkila z 1-6 atomi ogljika, alkoksija z 1-6 atomi ogljika, cikloalkila s 3-8 atomi ogljika, cikloalkilalkila, arila, arilalkil, heteroarila, heteroarilalkila, heterociklila, heterociklilalkila, haloa, haloalkoksija, oksa, -CN, -O-R6, - 0-C(0)-R6, -0-C(0)-N(R6)(R7), -S-R6, -N(R6)(R7), -S(=0)-R6, -S(=0)2R6, -S(=0)2-N(R6)(R7), -S(=0)2-0-R6, -N(R6)-C(0)-R7, -N(R6)-C(0)-0-R7, -N(R6)-C(0)-N(R6)(R7), -C(0)-R6, -C(0)-0-R6, -C(0)-N(R6)(R7), in -N(R6)-S(=0)2-R7, kjer so alkil, alkoksi, cikloalkil, aril, heteroaril ali heterociklil nadalje po izbiri substituirani z enim ali večimi substituenti, izbranimi izmed haloa, hidroksila, oksa, -CN in -O-R6; s pridržkom, da heteroarilni ali heterociklilni delec vključuje vsaj en obročni atom dušika; X1, X2, X3, X4, X5, X6, X7 in X8 so neodvisno C(R4) ali N, kjer je vsak R4 neodvisno vodik, hidroksil, halo, alkil z 1-6 atomi ogljika, alkoksi z 1-6 atomi ogljika ali cikloalkil s 3-8 atomi ogljika, pri čemer sta alkil ali cikloalkil nadalje po izbiri substituirana z enim ali več substituenti, izbranimi izmed haloa, hidroksila, oksa, -CF3, -O-CFs, -N(R6)(R7), -C(0)-R6, -C(0)-0-R7, -C (0)-N(R6)(R7), -CN, -O-R6; ali X5 in X6 ali X6 in X7 sta združena, da zagotovita zlit cikloalkil, zlit aril ali zlit heteroaril, ki so vsi po izbiri substituirani z alkilom z 1-6 atomi ogljika, hidroksilom ali halojem; in pod pogojem, da vsaj eden izmed X2, X3 in X4 je C(R4); vsaj dva od X5, X6, X7 in X8 sta C(R4); in vsaj eden izmed X2, X3, X4, X5, X6, X7 in X8 je N.wherein: R 1 is alkyl of 1-10 carbon atoms, cycloalkyl of 3-8 carbon atoms, alkenyl of 2-10 carbon atoms, alkynyl of 2-10 carbon atoms, aryl, heteroaryl or heterocyclyl, all of which are optionally substituted with 1, 2 or 3 substituents selected from halo, oxa, alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, heterocyclyl, phenyl, phenoxy, halo, -CN, -O-R 6, -C (O ) -R6, -O-C (O) -R6-C (O) -O-R6, -N (R6) -C (O) -O-R7, -N (R6) -C (O) -R7, - N (R6) -C (O) -N (R6) (R7) and -C (O) -N (R6) (R7) wherein alkyl, cycloalkyl, heterocyclyl, phenyl and phenoxy are optionally substituted with 1, 2 or 3 substituents selected from alkyl having 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, alkoxy having 1-6 carbon atoms, hydroxyl and halo; with the proviso that R 1 is not methyl when R 3 is morpholinyl or furyl; wherein R 6 and R 7 are independently selected from the group consisting of hydrogen, alkyl of 1-6 carbon atoms, or cycloalkyl of 3-8 carbon atoms; or R 6 and R 7 when taken together with the nitrogen to which they are attached form a heterocycle; R2 is hydrogen, halo, cyano, alkoxy or alkyl optionally substituted with halo; R3 is aryl, heteroaryl or heterocyclyl, all of which are optionally substituted with 1, 2 or 3 substituents selected from alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, haloalkoxy, oxa, -CN, -O-R 6, -O-C (O) -R 6, -O-C (O) -N (R 6) ) -S (= O) 2-N (R6) (R7), -S (= O) -R6, -S S (= O) 2-O-R6, -N (R6) -C (O) -R7, -N (R6) -C (O) -O-R7, -N (R6) -C (O) - N (R6) (R7), -C (O) -R6, -C (O) -O-R6, -C (O) -N (R6) (R7), and -N (R6) O) 2-R 7 wherein alkyl, alkoxy, cycloalkyl, aryl, heteroaryl or heterocyclyl are further optionally substituted with one or more substituents selected from halo, hydroxyl, oxa, -CN and -O-R 6; with the proviso that the heteroaryl or heterocyclyl moiety includes at least one ring nitrogen atom; X1, X2, X3, X4, X5, X6, X7 and X8 are independently C (R4) or N, wherein each R4 is independently hydrogen, hydroxyl, halo, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms or cycloalkyl of 3-8 carbon atoms, wherein the alkyl or cycloalkyl is further optionally substituted with one or more substituents selected from halo, hydroxyl, oxa, -CF 3, -O-CF 3, -N (R 6) (R 7), -C (O) -R6, -C (O) -O-R7, -C (O) -N (R6) (R7), -CN, -O-R6; or X5 and X6 or X6 and X7 are joined to provide fused cycloalkyl, fused aryl or fused heteroaryl, all of which are optionally substituted with alkyl of 1-6 carbon atoms, hydroxyl or halo; and provided that at least one of X 2, X 3 and X 4 is C (R 4); at least two of X5, X6, X7 and X8 are C (R4); and at least one of X 2, X 3, X 4, X 5, X 6, X 7 and X 8 is N. 2. Spojina za uporabo po zahtevku 1, kjer je terapevtsko sredstvo uporabljeno pri zdravljenju bolezni ali stanj, ki so kardiovaskularni po naravi, pljučne motnje, presnovne motnje ali motnje v prebavilih; ali stanja, ki imajo koristi od dajanja terapevtskih sredstev, izbranih iz skupine, ki jo sestavljajo antibiotiki, analgetiki, antidepresivi in sredstva proti anksioznosti.A compound for use according to claim 1, wherein the therapeutic agent is used in the treatment of diseases or conditions that are cardiovascular in nature, pulmonary disorders, metabolic disorders or gastrointestinal disorders; or conditions that benefit from administering therapeutic agents selected from the group consisting of antibiotics, analgesics, antidepressants and anti-anxiety agents. 3. Spojina za uporabo po zahtevku 1, kjer je terapevtsko sredstvo uporabljeno pri zdravljenju kardiovaskularnih bolezni, po izbiri, kjer je bolezen izbrana iz skupine, ki jo sestavljajo angina, aritmija, intermitentna klavdikacija, miokardni infarkt, srčno popuščanje in ponavljajoča se ishemija.The compound for use according to claim 1, wherein the therapeutic agent is used in the treatment of cardiovascular diseases, optionally wherein the disease is selected from the group consisting of angina, arrhythmia, intermittent claudication, myocardial infarction, heart failure, and recurrent ischemia. 4. Spojina za uporabo po zahtevku 1 ali zahtevku 3, kjer je terapevtsko sredstvo izbrano iz skupine, ki jo sestavljajo anti-anginali, sredstva za srčno popuščanje, antitromboti, antiaritmiki, antihipertenzivi in sredstva za zniževanje lipidov.The compound for use according to claim 1 or claim 3, wherein the therapeutic agent is selected from the group consisting of anti-anginals, heart failure agents, antithrombotic agents, antiarrhythmic agents, antihypertensives and lipid lowering agents. 5. Spojina za uporabo po zahtevku 1, kjer je terapevtsko sredstvo uporabljeno pri zdravljenju pljučnih motenj, po izbiri, kjer je motnja izbrana iz skupine, ki jo sestavljajo astma, kronična obstruktivna pljučna bolezen (KOPB), bronhitis in emfizem.The compound for use according to claim 1, wherein the therapeutic agent is used in the treatment of pulmonary disorders, optionally wherein the disorder is selected from the group consisting of asthma, chronic obstructive pulmonary disease (COPD), bronchitis and emphysema. 6. Spojina za uporabo po zahtevku 1 ali zahtevku 5, kjer je terapevtsko sredstvo bronhodilatator, kortikosteroid ali elektrolitski dodatki.The compound for use according to claim 1 or claim 5, wherein the therapeutic agent is bronchodilator, corticosteroid, or electrolytic supplements. 7. Spojina za uporabo po zahtevku 1, kjer je terapevtsko sredstvo uporabljeno pri zdravljenju metabolnih motenj, po izbiri je metabolna motnja izbrana iz skupine, ki jo sestavljajo diabetes, metabolični sindrom, dislipidemija, debelost, intoleranca na glukozo, hipertenzija, zvišani serumski holesterol in povišani trigliceridi.The compound for use according to claim 1, wherein the therapeutic agent is used to treat metabolic disorders, optionally the metabolic disorder is selected from the group consisting of diabetes, metabolic syndrome, dyslipidemia, obesity, glucose intolerance, hypertension, elevated serum cholesterol, and elevated triglycerides. 8. Spojina za uporabo po zahtevku 1 ali zahtevku 7, kjer je terapevtsko sredstvo izbrano iz skupine, ki jo sestavljajo antihipertenzivna sredstva, sredstva za zniževanje lipidov, inzulin, sulfonilsečnine, bigvanidi, zaviralce alfa-glukozidaze in incretin mimetiki.The compound for use according to claim 1 or claim 7, wherein the therapeutic agent is selected from the group consisting of antihypertensive agents, lipid lowering agents, insulin, sulphonylureas, biguanides, alpha-glucosidase inhibitors, and incretin mimetics. 9. Spojina za uporabo po zahtevku 1, kjer je terapevtsko sredstvo uporabljeno pri zdravljenju gastrointestinalnih motenj, po izbiri je gastrointestinalna motnja izbrana iz skupine, ki jo sestavljajo gastroezofagealna refluksna bolezen (GERD), vnetna črevesna bolezen (IBD), gastroenteritis, gastritis in peptične ulkusne bolezni in pankreatitis.The compound for use according to claim 1, wherein the therapeutic agent is used in the treatment of gastrointestinal disorders, optionally the gastrointestinal disorder is selected from the group consisting of gastroesophageal reflux disease (GERD), inflammatory bowel disease (IBD), gastroenteritis, gastritis and peptic ulcer disease and pancreatitis. 10. Spojina za uporabo po zahtevku 1 ali zahtevku 9, kjer je terapevtsko sredstvo izbrano iz skupine, ki jo sestavljajo zaviralci protonske črpalke, zaviralci H2, prostaglandini, sukralfat in antacidi.The compound for use according to claim 1 or claim 9, wherein the therapeutic agent is selected from the group consisting of proton pump inhibitors, H2 blockers, prostaglandins, sucralfate, and antacids. 11. Spojina za uporabo po zahtevku 1, kjer je terapevtsko sredstvo antibiotično sredstvo, izbrano iz skupine, ki jo sestavljajo β-Lactam antibiotiki, tetraciklini, makrolidni antibiotiki, aminoglikozidi, kinoloni, ciklični peptidi, lincozamidi in sulfa antibiotiki.The compound for use according to claim 1, wherein the therapeutic agent is an antibiotic selected from the group consisting of β-Lactam antibiotics, tetracyclines, macrolide antibiotics, aminoglycosides, quinolones, cyclic peptides, lincosamides and sulfa antibiotics. 12. Spojina za uporabo po zahtevku 1, kjer je terapevtsko sredstvo analgetik, izbran iz skupine, ki jo sestavljajo opiati, morfinomimetiki, nesteroidna protivnetna zdravila in zaviralci COX-2.The compound for use according to claim 1, wherein the therapeutic agent is an analgesic selected from the group consisting of opiates, morphinomimetics, non-steroidal anti-inflammatory drugs and COX-2 inhibitors. 13. Spojina za uporabo po zahtevku 1, kjer je terapevtsko sredstvo antidepresivno sredstvo in anti-anksiozno sredstvo izbrano iz skupine, ki jo sestavljajo benzodiazepini, enzodiazepini, barbiturati, glutetimii, kloralni hidrat, meprobamat, sertralin, escitalopram, fluoksetin, venlafaksin, citalopram, paroksetin, trazodon, amitriptilin in bupropion.The compound for use according to claim 1, wherein the therapeutic agent is an antidepressant and an anti-anxiotic agent selected from the group consisting of benzodiazepines, enzodiasepins, barbiturates, glutethymii, chloral hydrate, meprobamate, sertraline, escitalopram, fluoxetine, venlafaxine, citalopram, paroxetine, trazodone, amitriptyline and bupropion. 14. Farmacevtski sestavek, ki obsega spojino s formulo 1, kot je definirana v zahtevku 1, in terapevtsko sredstvo, kot je definirano v kateremkoli od zahtevkov 4, 6, 8 in 10 do 13.A pharmaceutical composition comprising a compound of formula I as defined in claim 1 and a therapeutic agent as defined in any one of claims 4, 6, 8 and 10 to 13. 15. Spojina za uporabo po katerem koli od zahtevkov 1 do 13 ali farmacevtski sestavek po zahtevku 14, kjer je spojina s formulo I izbrana iz skupine, ki jo sestavljajo: 6-ciklopropil-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’- karboksamid; 4-(4-ciklopropil-1 H-imidazol-1 -il)-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(2-ciklopropilpirimidin-5- il)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-(2,2,2-trifluoroetil)-3,4’-bipiridin- 2’-karboksamid; 4-(imidazo[1,2-a]piridin-3-il)-N-(3-(4-metil-4H-1,2,4-triazol-3-il)fenil)- pikolinamid; 4-(2-aminopirimidin-5-il)-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3- il)fenil)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-fenilpicolinamid; N-(3-(4-(tetrahidro-2H-piran-4-il)-4H-1,2I4-triazol-3-il)fenil)-3,4,-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’-karboksamid; N-(3-(4-ciklopropil-4H-1 ,2,4-t riazol-3-i I )fe n i 1)-4-( 1 H-imidazol-1 -il)pikolinamid; N-(3-(4-metil-4H-1,2,4-triazol-3-il)fenil)-4-fenilpicolinamid; N-(3-(4-(3-amino-3-oksopropil)-4H-1I2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(1 H-1,2,4-triazol-1-il)pikolinamid; N-(3-(4-metil-4H-1I2,4-triazol-3-il)fenil)-6-feniipicolinamid; N-(3-(4-(2-acetamidoetill)-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’-karboksamid; N-(3-(4-metil-4H-1,2,4-triazol-3-il)fenil)-4-(4-metilpiperazin-1-il)pikolinamid; N-(3-(4-metil-4H-1,2,4-triazol-3-il)fenil)-2,3’-bipiridin-6-karboksamid; N-(3-(4-metil-4H-1,2,4-triazol-3-il)fenil)-4-morfolinopicolinamid; N-(3-(4-metil-4H-1,2,4-triazol-3-il)fenil)-6-(kuinolin-6-il)pikolinamid; (R) -N-(3-(4-(1-hidroksipΓopan-2-il)-4H-1)2,4-triazolo-3-il)fenil)-3>4,-bipiridin-2,-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-hidroksi-3,4’-bipiridin-2’- karboksamid; (S) -N-(3-(4-(1-hidroksipropan-2-il)-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’-karboksamid; N-(3-(4-metil-4H-1,2,4-triazol-3-il)fenil)-4-(3-oksopiperazin-1-il)pikolinamid; N-(3-(4-metil-4H-1,2I4-triazol-3-il)fenil)-3,4’-bipiridin-2’-karboksamid; N-(3-(4-ciklopropil-4H-1,2)4-triazol-3-il)fenil)-6-metoksi-3)4’-bipiridin-2’- karboksamid; 4- (3-aminopirolidin-1-il)-N-(3-(4-metil-4H-1,2,4-triazol-3-il)fenil)pikolinamid; 6-amino-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’-karboksamid; (R) -N-(3-(4-(2-hidroksipropil)-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’-karboksamid; 5- metoksi-N-(3-(4-metil-4H-1,2)4-triazol-3-il)fenil)-3,4,-bipiridin-2’-karboksamid; metil 2’-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenilkarbamoil)-3,4’-bipiridin-6-ilkarbamat; (S) -N-(3-(4-(2-hidroksipropil)-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’-karboksamid; 4-(1-metil-1H-imidazol-5-il)-N-(3-(4-metil-4H-1 ,2,4-triazol-3-il)fenil)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(1 -metil-1 H-imidazol-5-il)pikolinamid; 4-(1 H-benzo[d]imidazol-1 -il)-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil) pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(2,4-dimetoksipirimidin-5- il)pikolinamid; N-(3-(4-((1-hidroksiciklopropil)metil)-4H-1,2,4-triazol-3-il)fenil)-3I4’-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(4-fenil-1H-imidazol-1-il) pikolinamid; N-(3-(4-ciklobutil-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’-karboksamid; N2’-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’,6-dikarboksamid; (S)-N-(3-(4-(1,1,1-trifluoropropan-2-il)-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’ -karboksamid; N-(3-(4-ciklopentil-4H-1>2,4-triazol-3-il)fenil)-3>4’-bipiridin-2’-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-(trifluorometil)-3,4’-bipiridin-2’- karboksamid; N2’-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’,5-dikarboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(2-metil-1 H-imidazol-1 -il) pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-metil-3,4’-bipiridin-2’- karboksamid; 5-ciano-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(4-metil-1 H-imidazol-1 -il) pikolinamid; 2-amino-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(4,5-dimetil-1 H-imidazol-1-il) pikolinamid; N-(3-(4-((1S,2S)-2-metilciklopropil)-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-2-metoksi-3,4’-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(4-(trifluorometil)-1 H-imidazol-1 -il)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-(2,2,2-trifluoroetoksi)-3,4’- bipiridin-2’-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(1 -metil-1 H-pirazol-4-il) pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(2-metoksipirimidin-5-il) pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-metil-3,4’-bipiridin-2’-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(imidazo[1,2-a]piridin-3- il)pikolinamid; 6’-metil-N-(3-(4-metil-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’-karboksamid; N-(3-(4-(2,2l2-trifluoroetil)-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’- karboksamid; 6-kloro-[3,2’,5’,4"]terpiridin-2"-karboksilična kislina [3-(4-ciklopropil-4H-[1,2,4]triazol-3-il)-fenil]amid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-(pirolidin-1-il)-3,4’-bipiridin-2’-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-5-(trifluorometil)-3,4’-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(1,2-dimetil-1 H-imidazol-5-il) pikolinamid; 4-(1 H-benzo[d][1,2,3]triazol-1-il)-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil) pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(4-sulfamoilfenil)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-5-metoksi-3,4’-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-fluoro-5-metil-3,4’-bipiridin-2’-karboksamid; N-(3-(4-ciklopropil-4H-1l2l4-triazol-3-il)fenil)-5-fluoro-3,4’-bipiridin-2’- karboksamid; Ν-(3-(4-οΐΜορΓθρΝ4Η4,24-ΙΠ3ζοΙ-3Ηΐ)ίΘηΐΙ)-2-ΓηθύΙ-3,4’-^ρΐΓκ1ΐη-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(4,5,6,7-tetrahidro-1H-benzo[d] imidazol-1 -il)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(4-(N-metilsulfamoil)fenil) pikolinamid; N5-tert-butil-N2’-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’,5- dikarboksamid; N-(3-(4-ciklopropil-4H-1,2)4-triazol-3-il)fenil)-4-(pirazin-2-il)pikormamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(4-(N-izopropilsulfamoil) fenil)pikolinamid; 5- kloro-N-iS-^^iklopropiMH^^^riazol-S-iOfeniO-S^-bipiridin^’-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(3-(metilsulfonil)fenil) pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(izokuinolin-4-il)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(2-(metilsulfonil)fenil) pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(1,5-dimetiM H-pirazol-4-il) pikolinamid; 6- ciklobutil-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-izopropil-3,4’-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(4-(metilsulfonil)fenil) pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-(dimetilamino)-3,4’-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(1 H-pirolo[2,3-b]piridin-5-il) pikolinamid; 6-ciklopropoksi-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(1 H-imidazo[4,5-b]piridin-1 -il) pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-fluoiO-3,4’-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(4-(2-oksoimidazolidin-1-il)fenil) pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(3H-imidazo[4,5-b]piridin-3-il) pikolinamid; N-(3-(4-ciklopropil-4H-1l2,4-triazol-3-il)fenil)-6-izopropoksi-3,4’-bipiridίn-2,- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(1H-imidazo[4,5-c]piridin-1-il) pikolinamid; 6-ciklobutoksi-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(kuinolin-3-il)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(4-(N-ciklopropilsulfamoil)fenil) pikolinamid; 6-ciklopentil-N-(3-(4-ciklopropil-4H-1 ^^-triazol-S-iOfeniO-S^^bipiridin^’-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(imidazo[2,1-b][1,3,4]thiadiazol- 5- il)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(5-ciklopropilpirazin-2-il) pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-(1-metil-2-oksopirolidin-3-il)-3,4’- bipiridin-2’-karboksamid; 4-(4-kloro-1H-imidazol-1-il)-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil) pikolinamid; 6- ciklopropil-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-5-fluoro-3,4’-bipiridin-2’-karboksamid; (S)-4-(4-ciklopropil-1 H-imidazol-1 -il)-N-(3-(4-(3-metilbutan-2-il)-4H-1,2,4-triazol-3-il)fenil)pikolinamid; 6’-ciklopropil-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-2,3’-bipiridin-6- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(5-metil-4-(trifluorometil)-4,5,6,7-tetrahidro-1 H-imidazo[4,5-c]piridin-1 -il)pikolinamid; 4-(5-ciklopropil-4-metil-4H-1,2,4-triazol-3-il)-N-(3-(4-ciklopropil-4H-1,2,4-triazol- 3- il)fenil)pikolinamid; 4- (3-ciklopropil-1,2,4-oksadiazol-5-il)-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il) fenil)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(3-metil-1,2,4-oksadiazol-5-il) pikolinamid; 6-ciklopropil-N-(3-(4-(3-hidroksibutan-2-il)-4H-1,2,4-triazol-3-il)fenil)-3,4’- bipiridin-2’-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(5-(1-hidroksietil)-1,3,4- oksadiazol-2-il)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(6-metoksikuinolin-3-il) pikolinamid; 6-αΗορΓορΐΙ-Ν-(3-(4-αΜορΓορϊΙ-4Η-1,2,4-ίπ3ζοΙ-3-ϊΙ)ίΘηϊΙ)-5’^βΙίΙ-3,4’^ΐρϊ^ΐη- 2’-karboksamid; 6-ciklopropil-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6’-metil-3,4’-bipiridin- 2’-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(1-(2,2,2-trifluoroetil)-1H- pirolo[3,2-b]piridin-6-il)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(1 -izopropil-1 H-pirolo[3,2-b] piridin-6-il)pikolinamid; (S)-6-ciklopropil-N-(3-(4-(3,3-dimetilbutan-2-il)-4H-1,2,4-triazol-3-il)fenil)-3,4’- bipiridin-2’-karboksamid; N-(3-(4-sec-butil-4H-1,2,4-triazol-3-il)fenil)-6-ciklopropil-3,4’-bipiridin-2’- karboksamid; (S)-6-ciklopropil-N-(3-(4-(1-ciklopropiletil)-4H-1,2,4-triazol-3-il)fenil)-3,4’- bipiridin-2’-karboksamid; 6-ciklopropil-N-(3-(4-(pentan-3-il)-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’- karboksamid; (S)-6-ciklopropil-N-(3-(4-(1-metoksipropan-2-il)-4H-1,2,4-triazol-3-il)fenil)-3,4’- bipiridin-2’-karboksamid; (S)-N-(3-(4-sec-butil-4H-1,2,4-triazol-3-il)fenil)-6-ciklopropil-3,4’-bipiridin-2’- karboksamid; (S)-6-ciklopropil-N-(3-(4-(3-metilbutan-2-il)-4H-1,2,4-triazol-3-il)fenil)-3,4’- bipiridin-2’-karboksamid; (R) -6-ciklopropil-N-(3-(4-(1-(2,6-dimetilfenoksi)propan-2-il)-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’-karboksamid; (S) -6-ciklopropil-N-(3-(4-(1,1,1-trifluoropropan-2-il)-4H-1,2,4-triazol-3-il)fenil)-S^-bipiridin^-karboksamid; N-(3-(4-ciklobutil-4H-1,2,4-triazol-3-il)fenil)-6-ciklopropil-3,4’-bipiridin-2’- karboksamid; (S)-6-ciklopropil-N-(3-(4-(1-feniletil)-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’- karboksamid; 6-ciklopropil-N-(3-(4-izopropil-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’- karboksamid; N-(3-(4-(ciklopropilmetil)-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’- karboksamid; 4-(4-ciklopropil-2-metil-1 H-imidazol-1 -il)-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il) fenil)pikolinamid; 4-(4-ciklopropil-1 H-imidazol-1 -il)-N-(3-(4-izopropil-4H-1 ^^-triazol-S-iOfenil) pikolinamid; 4-(4-ciklopropil-1 H-imidazol-1-il)-N-(3-(4-(ciklopropilmetil)-4H-1,2I4-triazol-3-il) fenil)pikolinamid; 4-(4-ciklopropil-1 H-imidazol-1-il)-N-(3-(4-(1-feniletil)-4H-1 H-1,2,4-triazol-3-il) fenil)pikolinamid; (R)-4-(4-ciklopropil-1 H-imidazol-1-il)-N-(3-(4-(1,1,1-trifluoropropan-2-il)-4H- 1,2,4-triazol-3-il)fenil)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(1,5-nafthiridin-3-il)pikolinamid; N-(3-(4-ciklopropil-4H-112,4-triazol-3-il)fenil)-4-(4-(trifluoromethyl)-4,5,6,7-tetrahidro-1 H-imidazo[4,5-c]piridin-1 -il)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(4-(perfluoroetil)-1 H-imidazol-1 -il)pikolinamid; 4-(3-ciklopropil-1 H-1,2,4-triazol-1-il)-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il) fenil)pikolinamid; 4- (5-ciklopropil-1 H-1,2,4-triazol-1-il)-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il) fenil)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(4-(2,2,2-trifluoro-1-hidroksietil)-1 H-imidazol-1-il)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(2-etilpirimidin-5-il)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-5-etil-3,4’-bipiridin-2’-karboksamid; 6-ciklopropil-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)-4-fluorofenil)-3,4’-bipiridin- 2’-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)-4-fluorofenil)-6-etil-3,4’-bipiridin-2’- karboksamid; 6-tert-butil-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(5,6,7,8-tetrahidro-1,6- nafthiridin-3-il)pikolinamid; 6-ciklopropil-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)-2-fluorofenil)-3,4’-bipiridin- 2’-karboksamid; 5- ciklopropil-N-(3-(4-ciklopropil-4H-1 ^^-triazol-S-iOfeniO-S^^bipiridin^’-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)-2-fluorofenil)-3,4’-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(4-etil-1H-imidazol-1-il) pikolinamid; N-iS-^-ciklopropiMH-l^^-triazol-S-iOfenilH-ie-^^.ž-trifluoroetiO-S.e.T.e- tetrahidro-1,6-nafthiridin-3-il)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(4-izopropil-1 H-imidazol-1 -il)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-(2-hidroksipropan-2-il)-3,4’- bipiridin-2’-karboksamid; 6-ciklopropil-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)-5-fluorofenil)-3,4’-bipiridin- 2’-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)-5-fluorofenil)-3,4’-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(6-izopropil-5,6,7,8-tetrahidro- 1,6-nafthiridin-3-il)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(6-metil-5,6,7,8-tetrahidro-1,6- nafthiridin-3-il)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(3-hidroksipiperidin-1-il) pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(4-etil-3-oksopiperazin-1-il) pikolinamid; N-(3-(4-izopropil-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-propil-3,4’-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-neopentil-3,4’-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(1-metil-2-fenil-1H-imidazol-5-il) pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(4-(etilsulfonil)fenil)-pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(4-(izopropilsulfonil) fenil) pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-(etilamino)-3,4’-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-(ciklopropilamino)-3,4’-bipiridin- 2’-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6’-(trifluorometil)-3,4’-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(kuinolin-3-il)-6-(trifluorometil) pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-tnazol-3-il)fenil)-4-(1H-pirolo[3,2-b]piridin-6-il) pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(4-ciklopropilfenil)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-(metiltio)-3,4’-bipiridin-2’-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-(izobutiltio)-3,4’-bipiridin-2’-karboksamid; 5-kloro-6-ciklopropil-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin- 2’-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-(2-metoksietilamin)-3,4’- bipiridin-2’-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(4-(metilsulfonil)piperazin-1-il) pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-etil-5-fluoro-3,4’-bipiridin-2’- karboksamid; 5- kloro-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-etil-3,4’-bipiridin-2’-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-5,6-dietil-3,4’-bipiridin-2’- karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(furo[3,2-b]piridin-6- il)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(3-metil-3H-imidazo[4,5- b]piridin-6-il)pikolinamid; 6- ciklopropil-N-(3-(4-(2-fenilciklopropil)-4H-1,2,4-triazol-3-il)fenil)-3>4’-bipiridin-2’-karboksamid; (S)-4-(4-ciklopropil-1 H-imidazol-1 -il)-N-(3-(4-(1,1,1 -trifluoropropan-2-il)-4H- 1.2.4- triazol-3-il)fenil)pikolinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-(ciklopropilmetil)-3,4’-bipiridin-2’- karboksamid; 4-(5-ciklopropil-1,3,4-thiadiazol-2-il)-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il) fenil)pikolinamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-3-(kuinolin-3-il)benzamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-5-(6-ciklopropilpiridin-3-il)- 2.4- difluorobenzamid; 4-kloro-N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-5-(6- ciklopropilpiridin-3-il)-2-fluorobenzamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-3-(4-(2,2,2-trifluoro-1-metoksietil)-1 H-imidazol-1 -il)benzamid; 3- (4-ciklopropil-1 H-imidazol-1 -il)-N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin- 2- il)-4-metoksibenzamid; 4- kloro-3-(4-ciklopropil-1 H-imidazol-1 -il)-N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)benzamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-5-(6-ciklopropilpiridin-3-il)-2- fluorobenzamid; 3- (4-ciklopropil-1 H-imidazol-1 -il)-N-(6-(4-izopropil-4H-1,2,4-triazol-3-il)piridin-2-il)benzamid; (S)-3-(4-ciklopropil-1 H-imidazol-1 -il)-N-(6-(4-(1-feniletil)-4H-1H-1,2,4-triazol-3-il)piridin-2-il)benzamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-3-(1,5-nafthiridin-3-il) benzamid; 3-(4-ciklopropil-1 H-imidazol-1 -il)-N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin- 2- il)benzamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-3-(4-izopropil-1 H-imidazol-1-il)benzamid; 3- (4-ciklopropil-1 H-imidazol-1 -il)-N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-2-metilbenzamid; 5- (4-ciklopropil-1 H-imidazol-1-il)-N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin- 2- il)-2-metilbenzamid; 3- (4-ciklopropil-1 H-imidazol-1-il)-N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin- 2- il)-4-metilbenzamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-3-(6-(2-hidroksipropan-2- il)piridin-3-il)benzamid; 3- (4-ciklopropil-1 H-imidazol-1 -il)-N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-5-fluorobenzamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-3-(4-(2,2,2-trifluoro-1 -hidroksietil)-1 H-imidazol-1 -il)benzamid; 3- (4-ciklopropil-1 H-imidazol-1 -il)-N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin- 2- il)-5-metilbenzamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-3-(4,5-dimetil-1 H-imidazol-1 -il)benzamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-3-(4,5,6,7-tetrahidro-1H- benzo[d]imidazol-1-il)benzamid; 1 -(3-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-ilkarbamoil)fenil)-5-metil-1 H-imidazole-4-karboksilična kislina; (S)-3-(4-ciklopropil-1 H-imidazol-1 -il)-N-(6-(4-(1 -feniletil)-4H-1 H-1,2,4-triazol-3-il)piridin-2-il)benzamid; (S)-3-(4,5-dimetil-1 H-imidazol-1-il)-N-(6-(4-(1,1,1-trifluoropropan-2-il)-4H-1,2,4-triazol-3-il)piridin-2-il)benzamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-3-(6-ciklopropilpiridin-3-il)benzamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-3-(piridin-3-il)benzamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-5-(6-ciklopropilpiridin-3-il)- 2,4-difluorobenzamid; 4- kloro-N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-5-(6-ciklopropilpiridin -3-il)-2-fluorobenzamid; 3- (4-ciklopropil-1 H-1,2,3-triazol-1 -il)-N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)benzamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(6-ciklopropilpiridin-3-il)-7,8- dimetilkuinolin-2-karboksamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-4-(piridin-3-il)kuinolin-2- karboksamid; N-(3-(4-metil-4H-1,2,4-triazol-3-il)fenil)-3,3’-bipiridin-5-karboksamid; N-(3-(4-metil-4H-1,2,4-triazol-3-il)fenil)-5-fenilnikotinamid; N-(3-(4-metil-4H-1,2,4-triazol-3-il)fenil)-2-fenilizonikotinamid; e^ciklopropil-N-iS-^-ciklopropiMH-l^^-triazol-S-iOfenil^.S-bipiridin-e- karboksamid; 6’-ciklopropil-N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-2,3’-bipiridin-4- karboksamid; 5- (2,5-difluorofenil)-N-(3-(4-metil-4H-1,2,4-triazol-3-il)fenil)nikotinamid; N-(3-(4-ciklopropil-4H-1,2,4-triazol-3-il)fenil)-6-(6-ciklopropilpiridin-3-il)pirimidin- 4-karboksamid; 6’-ciklopropil-N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-2,3’-bipiridin-4- karboksamid; 2-hidroksi-N-(3-(4-metil-4H-1,2,4-triazol-3-il)fenil)-6-fenilpirimidin-4- karboksamid; N-(6-(1-ciklopropil-1H-imidazol-5-il)piridin-2-il)-4-(4,5-dimetil-1H-imidazol-1- il)pikolinamid; N-(6-(1-ciklopropil-1H-imidazol-5-il)piridin-2-il)-6-(2-hidroksipropan-2-il)-3,4’- bipiridin-2’-karboksamid; N-(6-(1-ciklopropil-1H-imidazol-5-il)piridin-2-il)-4-(kuinolin-3-il)pikolinamid; 6- ciklopropil-N-(6-(1-ciklopropil-1H-imidazol-5-il)piridin-2-il)-3,4’-bipiridin-2’-karboksamid; 6-ciklopropil-N-(3-(1-ciklopropil-1H-imidazol-5-il)fenil)-3,4’-bipiridin-2’- karboksamid; N-(3-(1-ciklopropil-1H-imidazol-5-il)fenil)-3,4’-bipiridin-2’-karboksamid; 4-(1 H-benzo[d]imidazol-1 -il)-N-(3-(1 -ciklopropil-1 H-imidazol-5-il)fenil) pikolinamid; N-(3-(1-ciklopropil-1H-imidazol-5-il)fenil)-4-(kuinolin-3-il)pikolinamid; 6-ciklopropil-N-(6-(4-ciklopropil-4H-1I2,4-triazol-3-il)piridin-2-il)-3,4’-bipiridin-2’- karboksamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-4-(4,5-dimetil-1 H-imidazol-1-il)pikolinamid; N-(6-(4-ciklopropil-4H-1,2l4-triazol-3-il)piridin-2-il)-6-(2-hidroksipropan-2-il)- 3,4’-bipiridin-2’-karboksamid. 6’-ciklopropil-N-(6-(4-ciklopropil-4H-1)2,4-triazol-3-il)piridin-2-il)-2,3’-bipiridin-6- karboksamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-4-(5-metil-4-(trifluorometil)- 4,5,6,7-tetrahidro-1H-imidazo[4I5-c]piridin-1-il)pikolinamid; 6-ciklopropil-N-(6-(4-((2R)-3-hidroksibutan-2-il)-4H-1,2,4-triazol-3-il)piridin-2-il)- 3,4’-bipiridin-2’-karboksamid; 6-ciklopropil-N-(6-(4-((2S,3R)-3-hidroksibutan-2-il)-4H-1,2)4-triazol-3-il)piridin- 2-il)-3,4’-bipiridin-2’-karboksamid; 6-ciklopropil-N-(6-(4-((2S,3S)-3-hidroksibutan-2-il)-4H-1,2I4-triazol-3-il)piridin- 2-il)-3,4’-bipiridin-2’-karboksamid; 6-ciklopropil-N-(6-(4-(1-(pirolidin-1-il)propan-2-il)-4H-1,2,4-triazol-3-il)piridin-2- il)-3,4’-bipiridin-2’-karboksannid; N-(6-(4-ciklopropil-4H-1 ^^-triazol-S-iOpiridin^-iO^-ie-ciklopropilpiridin-S-il)-7,8-dimetilkuinolin-2-karboksamid; 4-(4-ciklopropil-1H-imidazol-1-il)-N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin- 2-il)kuinolin-2-karboksamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-4-(6-ciklopropilpiridin-3- il)kuinolin-2-karboksamid; 4-(4-ciklopropil-2-metil-1 H-imidazol-1-il)-N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)pikolinamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-4-(4,5>6,7-tetrahidro-1H- benzo[d]imidazol-1-il)pikolinamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-4-(4-(trifluorometil)-1H- imidazol-1-il)pikolinamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-4-(4-(trifluorometil)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]piridin-1-il)pikolinamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-4-(4-(perfluoroetil)-1H-imidazol-1 -il)pikolinamid; 4-(3-ciklopropil-1 H-1,2(4-triazol-1-il)-N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)pikolinamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-4-(4-(2,2,2-trifluoro-1-hidroksietil)-1 H-imidazol-1 -il)pikolinamid; 6-ciklopropil-N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-5’-metil-3,4’- bipiridin-2’-karboksamid; 6-ciklopropil-N-(2-(4-ciklopropil-4H-1l2,4-triazol-3-il)piridin-4-il)-3,4’-bipiridin-2’- karboksamid; N-(2-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-4-il)-4-(kuinolin-3-il)pikolinamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-4-(4-metil-1 H-imidazol-1 -il)pikolinamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-4-(4-izopropyl-1H-imidazol- 1-il)pikolinamid; 4-(4-ciklopropil-1 H-imidazol-1 -il)-N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)pikolinamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-4-(3-hidroksipiperidin-1- il)pikolinamid; 6-ciklopropil-N-(6-(4-izopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-3,4’-bipiridin-2’- karboksamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-4-(4-etil-3-oksopiperazin-1- il)pikolinamid; (R)-6-ciklopropil-N-(6-(4-(1,1,1-trifluoropropan-2-il)-4H-1,2,4-triazol-3-il)piridin-2-il)-3,4’-bipiridin-2’-karboksamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-4-(4-(N-metilsulfamoil) fenil)pikolinamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-4-(kuinolin-3-il)pikolinamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-4-(4-fenil-1 H-imidazol-1 -il)pikolinamid; N-(6-(4-ciklopropil-4H-1,2,4-triazol-3-il)piridin-2-il)-4-(4-(metilsulfonil)fenil) pikolinamid; N-ie^-ciklopropiMH-l^^-triazol-S-iOpiridin^-iO-S^-bipiridin^-karboksamid; 6-ciklopropil-N-(3-(4-fenil-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’- karboksamid; 6-ciklopropil-N-(3-(4-(piridin-2-il)-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’- karboksamid; 6-ciklopropil-N-(3-(4-(piridin-3-il)-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’- karboksamid; 6-ciklopropil-N-(3-(4-(piridin-4-il)-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’- karboksamid; 6-ciklopropil-N-(3-(4-(pirimidin-5-il)-4H-1,2,4-triazol-3-il)fenil)-3,4’-bipiridin-2’- karboksamid; N-(3-(4-(but-2-inil)-4H-1,2,4-triazol-3-il)fenil)-6-ciklopropil-3,4’-bipiridin-2’- karboksamid; 6-ciklopropil-N-(3-(4-(1-(piridin-3-iloksi)propan-2-il)-4H-1,2,4-triazol-3-il)fenil)- 3,4’-bipiridin-2’-karboksamid; 6-ciklopropil-N-(3-(4-(1-(2,2,2-trifluoroetoksi)propan-2-il)-4H-1,2,4-triazol-3- il)fenil)-3,4’-bipiridin-2’-karboksamid; 4-(4-ciklopropil-1 H-imidazol-1 -il)-N-(3-(4-fenil-4H-1,2,4-triazol-3-il)fenil) pikolinamid; 4-(4-ciklopropil-1H-imidazol-1-il)-N-(3-(4-(piridin-2-il)-4H-1,2,4-triazol-3-il)fenil) pikolinamid; 4-(4-ciklopropil-1 H-imidazol-1-il)-N-(3-(4-(piridin-3-il)-4H-1,2,4-triazol-3-il)fenil) pikolinamid; 4-(4-ciklopropil-1H-imidazol-1-il)-N-(3-(4-(piridin-4-il)-4H-1,2,4-triazol-3-il)fenil) pikolinamid; 4-(4-ciklopropil-1 H-imidazol-1 -il)-N-(3-(4-(pirimidin-5-il)-4H-1,2,4-triazol-3-il) fenil)pikolinamid; N-(3-(4-(but-2-inil)-4H-1,2,4-triazol-3-il)fenil)-4-(4-ciklopropil-1 H-imidazol-1 - il) pikolinamid; 4-(4-ciklopropil-1 H-imidazol-1 -il)-N-(3-(4-(1 -(piridin-3-iloksi)propan-2-il)-4H- 1,2,4-triazol-3-il)fenil)pikolinamid; in 4-(4-ciklopropil-1 H-imidazol-1-il)-N-(3-(4-(1-(2,2,2-trifluoroetoksi)propan-2-il)-4H-1,2,4-triazol-3-il)fenil) pikolinamid.A compound for use according to any one of claims 1 to 13, or a pharmaceutical composition according to claim 14 wherein the compound of formula I is selected from the group consisting of: 6-cyclopropyl-N- (3- (4-cyclopropyl-4H- 1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; 4- (4-cyclopropyl-1H-imidazol-1-yl) -N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (2-cyclopropylpyrimidin-5-yl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6- (2,2,2-trifluoroethyl) -3,4'-bipyridine-2'-carboxamide ; 4- (imidazo [1,2-a] pyridin-3-yl) -N- (3- (4-methyl-4H-1,2,4-triazol-3-yl) phenyl) -pycolinamide; 4- (2-Aminopyrimidin-5-yl) -N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -pycolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4-phenylpicolinamide; N- (3- (4- (tetrahydro-2H-pyran-4-yl) -4H-1,2,4-triazol-3-yl) phenyl) -3,4-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (1H-imidazol-1-yl) picolineamide; N- (3- (4-methyl-4H-1,2,4-triazol-3-yl) phenyl) -4-phenylpicolinamide; N- (3- (4- (3-amino-3-oxopropyl) -4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (1H-1,2,4-triazol-1-yl) picolinamide; N- (3- (4-methyl-4H-1,2,4-triazol-3-yl) phenyl) -6-phenylpicolinamide; N- (3- (4- (2-acetamidoethyl) -4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-methyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (4-methylpiperazin-1-yl) picolinamide; N- (3- (4-methyl-4H-1,2,4-triazol-3-yl) phenyl) -2,3'-bipyridine-6-carboxamide; N- (3- (4-methyl-4H-1,2,4-triazol-3-yl) phenyl) -4-morpholinopicolinamide; N- (3- (4-methyl-4H-1,2,4-triazol-3-yl) phenyl) -6- (quinolin-6-yl) picolinamide; (R) -N- (3- (4- (1-hydroxypiperan-2-yl) -4H-1) 2,4-triazolo-3-yl) phenyl) -3, 4-bipyridine-2-carboxamide ; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6-hydroxy-3,4'-bipyridine-2'-carboxamide; (S) -N- (3- (4- (1-hydroxypropan-2-yl) -4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide ; N- (3- (4-methyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (3-oxopiperazin-1-yl) picolinamide; N- (3- (4-methyl-4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2) 4-triazol-3-yl) phenyl) -6-methoxy-3H-bipyridine-2'-carboxamide; 4- (3-aminopyrrolidin-1-yl) -N- (3- (4-methyl-4H-1,2,4-triazol-3-yl) phenyl) picolinamide; 6-Amino-N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; (R) -N- (3- (4- (2-hydroxypropyl) -4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; 5-methoxy-N- (3- (4-methyl-4H-1,2,4-triazol-3-yl) phenyl) -3,4-bipyridine-2'-carboxamide; methyl 2 '- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenylcarbamoyl) -3,4'-bipyridin-6-ylcarbamate; (S) -N- (3- (4- (2-hydroxypropyl) -4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; 4- (1-methyl-1H-imidazol-5-yl) -N- (3- (4-methyl-4H-1,2,4-triazol-3-yl) phenyl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (1-methyl-1H-imidazol-5-yl) picolinamide; 4- (1H-benzo [d] imidazol-1-yl) -N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (2,4-dimethoxypyrimidin-5-yl) picolinamide; N- (3- (4 - ((1-hydroxycyclopropyl) methyl) -4H-1,2,4-triazol-3-yl) phenyl) -3H-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (4-phenyl-1H-imidazol-1-yl) picolinamide; N- (3- (4-cyclobutyl-4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; N 2 '- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2', 6-dicarboxamide; (S) -N- (3- (4- (1,1,1-trifluoropropan-2-yl) -4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridin- 2'-carboxamide; N- (3- (4-cyclopentyl-4H-1,2,4-triazol-3-yl) phenyl) -3'-4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6- (trifluoromethyl) -3,4'-bipyridine-2'-carboxamide; N 2 '- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2', 5-dicarboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (2-methyl-1H-imidazol-1-yl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6-methyl-3,4'-bipyridine-2'-carboxamide; 5-Cyano-N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (4-methyl-1H-imidazol-1-yl) picolinamide; 2-Amino-N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (4,5-dimethyl-1H-imidazol-1-yl) picolinamide; N- (3- (4 - ((1S, 2S) -2-methylcyclopropyl) -4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -2-methoxy-3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (4- (trifluoromethyl) -1H-imidazol-1-yl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6- (2,2,2-trifluoroethoxy) -3,4'-bipyridine-2'-carboxamide ; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (1-methyl-1H-pyrazol-4-yl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (2-methoxypyrimidin-5-yl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4-methyl-3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (imidazo [1,2-a] pyridin-3-yl) picolinamide; 6'-methyl-N- (3- (4-methyl-4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4- (2,2,2-trifluoroethyl) -4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; 6-chloro- [3,2 ', 5', 4 "] tertriridine-2" -carboxylic acid [3- (4-cyclopropyl-4H- [1,2,4] triazol-3-yl) -phenyl] amide ; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6- (pyrrolidin-1-yl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -5- (trifluoromethyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (1,2-dimethyl-1H-imidazol-5-yl) picolinamide; 4- (1 H -benzo [d] [1,2,3] triazol-1-yl) -N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3- yl) phenyl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (4-sulfamoylphenyl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -5-methoxy-3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6-fluoro-5-methyl-3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,12,4-triazol-3-yl) phenyl) -5-fluoro-3,4'-bipyridine-2'-carboxamide; N- (3- (4-chloro-4H-pyrenyl) -4,24-trifluoro-3H) -phenyl) -2-pyridine-3,4 '- [[2H-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (4,5,6,7-tetrahydro- 1 H- benzo [d] imidazol- 1- yl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (4- (N-methylsulfamoyl) phenyl) picolinamide; N5-tert-butyl-N2 '- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2', 5-dicarboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (pyrazin-2-yl) picormamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (4- (N-isopropylsulfamoyl) phenyl) picolinamide; 5-chloro-N-yl-ethyl-cyclopropyl-1H-imidazol-5-ylphenyl) -5-piperidinecarboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (3- (methylsulfonyl) phenyl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (isoquinolin-4-yl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (2- (methylsulfonyl) phenyl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (1,5-dimethyl-1H-pyrazol-4-yl) picolinamide; 6-cyclobutyl-N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6-isopropyl-3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (4- (methylsulfonyl) phenyl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6- (dimethylamino) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (1H-pyrrolo [2,3-b] pyridin-5-yl) picolinamide; 6-cyclopropoxy-N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (1H-imidazo [4,5-b] pyridin-1-yl) picolineamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6-fluoro-3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (4- (2-oxoimidazolidin-1-yl) phenyl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (3H-imidazo [4,5-b] pyridin-3-yl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6-isopropoxy-3,4'-bipyridine-2, carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (1H-imidazo [4,5-c] pyridin-1-yl) picolinamide; 6-cyclobutoxy-N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (quinolin-3-yl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (4- (N-cyclopropylsulfamoyl) phenyl) picolinamide; 6-cyclopentyl-N- (3- (4-cyclopropyl-4H-1-yl) -triazol-5-ylphenyl) -Sy-bipyridinylcarboxamide; N- (3- (4-cyclopropyl-4H-1,2 , 4- triazol-3-yl) phenyl) -4- (imidazo [2,1-b] [1,3,4] thiadiazol-5-yl) picolinamide; N- (3- (4-cyclopropyl-4H- 1,2,4-triazol-3-yl) phenyl) -4- (5-cyclopropylpyrazin-2-yl) picolinamide N- (3- (4-cyclopropyl-4 H -1,2,4-triazol-3- yl) phenyl) -6- (1-methyl-2-oxopyrrolidin-3-yl) -3,4'-bipyridine-2'-carboxamide; 4- (4-chloro-1H- imidazol-1-yl) -N - (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) picolinamide; 6-cyclopropyl-N- (3- (4-cyclopropyl-4H-1,2,4-triazole -3-yl) phenyl) -5-fluoro-3,4'-bipyridine-2'-carboxamide; (S) -4- (4-cyclopropyl-1H-imidazol-1-yl) -N- (3- (4- (3-methylbutan-2-yl) -4H-1,2,4-triazol-3-yl) phenyl) picolineamide; 6'- cyclopropyl-N- (3- (4- cyclopropyl-4H- 2,4-triazol-3-yl) phenyl) -2,3'-bipyridine-6-carboxamide N- (3- (4-cyclopropyl-4 H -1,2,4-triazol-3- yl) phenyl) -4- (5-methyl-4- (trifluoromethyl) -4,5,6,7-tetrahydro-1H-imidazo [4,5-c] pyridin-1-yl) picolinamide; 4- (5-cyclopropyl- 4-methyl-4H-1,2,4-triazol-3-yl 1) -N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) picolinamide; 4- (3-cyclopropyl-1,2,4-oxadiazol-5-yl) -N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (3-methyl-1,2,4-oxadiazol-5-yl) picolinamide; 6-cyclopropyl-N- (3- (4- (3-hydroxybutan-2-yl) -4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide ; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (5- (1-hydroxyethyl) -1,3,4-oxadiazol-2- picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (6-methoxyquinolin-3-yl) picolinamide; 6-αH-pyrrolidine-N- (3- (4-α-pyrrolidin-4H-1,2,4-triazol-3-yl) ethyl) -5H-pyridine-3,4'H-pyridine-2'-carboxamide; 6-cyclopropyl-N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6'-methyl-3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (1- (2,2,2- trifluoroethyl) -1H-pyrrolo [3,2- b] pyridin-6-yl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (1-isopropyl-1H-pyrrolo [3,2- b] pyridin-6-yl ) picolinamide; (S) -6-cyclopropyl-N- (3- (4- (3,3-dimethylbutan-2-yl) -4H-1,2,4-triazol-3-yl) phenyl) bipyridine-2'-carboxamide; N- (3- (4-sec-butyl-4H-1,2,4-triazol-3-yl) phenyl) -6-cyclopropyl-3,4'-bipyridine-2'-carboxamide; (S) -6-cyclopropyl-N- (3- (4- (1-cyclopropylethyl) -4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide ; 6-cyclopropyl-N- (3- (4- (pentan-3-yl) -4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; (S) -6-cyclopropyl-N- (3- (4- (1-methoxypropan-2-yl) -4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridin- 2'-carboxamide; (S) -N- (3- (4-sec-butyl-4H-1,2,4-triazol-3-yl) phenyl) -6-cyclopropyl-3,4'-bipyridine-2'-carboxamide; (S) -6-cyclopropyl-N- (3- (4- (3-methylbutan-2-yl) -4H-1,2,4-triazol-3- yl) phenyl) -3,4'- bipyridin- 2'-carboxamide; (R) -6-cyclopropyl-N- (3- (4- (1- (2,6-dimethylphenoxy) propan-2-yl) -4H-1,2,4-triazol-3- yl) phenyl) 3,4'-bipyridine-2'-carboxamide; (S) -6-cyclopropyl-N- (3- (4- (1,1,1-trifluoropropan-2-yl) -4H-1,2,4-triazol-3-yl) phenyl) bipyridine-carboxamide; N- (3- (4-cyclobutyl-4H-1,2,4-triazol-3-yl) phenyl) -6-cyclopropyl-3,4'-bipyridine-2'-carboxamide; (S) -6-cyclopropyl-N- (3- (4- (1-phenylethyl) -4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide ; 6-cyclopropyl-N- (3- (4-isopropyl-4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4- (cyclopropylmethyl) -4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; 4- (4-cyclopropyl-2-methyl-1H-imidazol-1-yl) -N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) picolinamide; 4- (4-cyclopropyl-1H-imidazol-1-yl) -N- (3- (4-isopropyl-4H-1-yl) -triazole-5-ylphenyl) picolinamide 4- (4-cyclopropyl- (4-cyclopropyl-1 H-imidazol-1-yl) yl) -N- (3- (4- (1-phenylethyl) -4H-1 H -1,2,4-triazol-3-yl) phenyl) picolinamide; (R) -4- (4-cyclopropyl- H-imidazol-1-yl) -N- (3- (4- (1,1,1-trifluoropropan-2-yl) -4H-1,2,4-triazol-3-yl) phenyl) picolinamide; - (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (1,5- naphthyridin-3-yl) picolinamide; N- (3- (4-cyclopropyl -4H-112,4-triazol-3-yl) phenyl) -4- (4- (trifluoromethyl) -4,5,6,7-tetrahydro-1H-imidazo [4,5- c] pyridin- yl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (4- (perfluoroethyl) -1H-imidazol-1-yl) picolinamide 4- (3-cyclopropyl-1H-1,2,4-triazol-1-yl) -N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3- yl) phenyl) 4- (5-cyclopropyl-1H-1,2,4-triazol-1-yl) -N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl ) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl l) -4- (4- (2,2,2-trifluoro-1-hydroxyethyl) -1H-imidazol-1-yl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (2-ethylpyrimidin-5-yl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -5-ethyl-3,4'-bipyridine-2'-carboxamide; 6-cyclopropyl-N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) -4-fluorophenyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) -4-fluorophenyl) -6-ethyl-3,4'-bipyridine-2'-carboxamide; 6-tert-butyl-N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (5,6,7,8-tetrahydro-1,6- naphthyridin-3- picolinamide; 6-cyclopropyl-N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) -2-fluorophenyl) -3,4'-bipyridine-2'-carboxamide; 5-cyclopropyl-N- (3- (4-cyclopropyl-4H-1-yl-triazol-5-ylphenyl) -sulfanyl] -carboxamide; N- (3- (4-cyclopropyl-4H-1,2 , 4- triazol-3-yl) -2-fluorophenyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3- ) phenyl) -4- (4-ethyl-1H-imidazol-1-yl) picolinamide; N- (S) -cyclopropylmethyl-1 H-triazol-5-ylphenylH-isoquinolin- tetrahydro-1,6-naphthyridin-3-yl) picolinamide N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (4-isopropyl-1H N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6- (2-hydroxypropan-2-yl) -3, 4'-bipyridine-2'-carboxamide; 6-cyclopropyl-N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3- yl) -5- fluorophenyl) -3,4'-bipyridine - 2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) -5-fluorophenyl) -3,4'-bipyridine-2'- carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (6-isopropyl-5,6,7,8-tetrahydro-1,6- naphthyridin- yl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (6-methyl-5,6,7,8-tetrahydro -1,6-naphthyridin-3-yl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (3-hydroxypiperidin-1-yl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (4-ethyl-3-oxopiperazin-1-yl) picolinamide; N- (3- (4-isopropyl-4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6-propyl-3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6-neopentyl-3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (1-methyl-2-phenyl-1H-imidazol-5-yl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (4- (ethylsulfonyl) phenyl) -pycolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (4- (isopropylsulfonyl) phenyl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6- (ethylamino) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6- (cyclopropylamino) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6 '- (trifluoromethyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (quinolin-3-yl) -6- (trifluoromethyl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (1H-pyrrolo [3,2-b] pyridin-6-yl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (4-cyclopropylphenyl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6- (methylthio) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6- (isobutylthio) -3,4'-bipyridine-2'-carboxamide; 5-chloro-6-cyclopropyl-N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6- (2-methoxyethylamine) -3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (4- (methylsulfonyl) piperazin-1-yl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6-ethyl-5-fluoro-3,4'-bipyridine-2'-carboxamide; 5-Chloro-N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6-ethyl-3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -5,6-diethyl-3,4'-bipyridine-2'-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (furo [3,2-b] pyridin-6-yl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (3-methyl-3H- imidazo [4,5- b] pyridin-6-yl) picolinamide; 6-cyclopropyl-N- (3- (4- (2-phenylcyclopropyl) -4H-1,2,4-triazol-3-yl) phenyl) -3'-4'-bipyridine-2'-carboxamide; (S) -4- (4-cyclopropyl-1H-imidazol-1-yl) -N- (3- (4- (1,1,1-trifluoropropan-2-yl) -4H- 1,2,4-triazole -3-yl) phenyl) picolinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6- (cyclopropylmethyl) -3,4'-bipyridine-2'-carboxamide; 4- (5-cyclopropyl-1,3,4-thiadiazol-2-yl) -N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) picolinamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -3- (quinolin-3-yl) benzamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -5- (6-cyclopropylpyridin-3-yl) -2,4-difluorobenzamide; 4-Chloro-N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -5- (6- cyclopropylpyridin-3-yl) -2-fluorobenzamide ; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -3- (4- (2,2,2-trifluoro- 1 -methoxyethyl) 1 H-imidazol-1-yl) benzamide; 3- (4-cyclopropyl-1H-imidazol-1-yl) -N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -4- methoxybenzamide; 4-Chloro-3- (4-cyclopropyl-1H-imidazol-1-yl) -N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3- yl) pyridin-2- ) benzamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -5- (6-cyclopropylpyridin-3-yl) -2-fluorobenzamide; 3- (4-cyclopropyl-1H-imidazol-1-yl) -N- (6- (4-isopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) benzamide; (S) -3- (4-cyclopropyl-1H-imidazol-1-yl) -N- (6- (4- (1-phenylethyl) -4H-1H-1,2,4-triazol-3- ) pyridin-2-yl) benzamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -3- (1,5-naphthyridin-3-yl) benzamide; 3- (4-cyclopropyl-1H-imidazol-1-yl) -N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) benzamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -3- (4-isopropyl-1H-imidazol-1-yl) benzamide; 3- (4-cyclopropyl-1H-imidazol-1-yl) -N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2- methylbenzamide; 5- (4-cyclopropyl-1H-imidazol-1-yl) -N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -2- methylbenzamide; 3- (4-cyclopropyl-1H-imidazol-1-yl) -N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) methylbenzamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -3- (6- (2-hydroxypropan-2-yl) pyridin-3- ) benzamide; 3- (4-cyclopropyl-1H-imidazol-1-yl) -N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2- fluorobenzamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -3- (4- (2,2,2- trifluoro-1-hydroxyethyl) 1 H-imidazol-1-yl) benzamide; 3- (4-cyclopropyl-1H-imidazol-1-yl) -N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2- methylbenzamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -3- (4,5-dimethyl-1H-imidazol-1-yl) benzamide ; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -3- (4,5,6,7-tetrahydro- 1 H- benzo [d] imidazol-1-yl) benzamide; 1- (3- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-ylcarbamoyl) phenyl) -5-methyl-1H-imidazole-4-carboxylic acid; (S) -3- (4-cyclopropyl-1H-imidazol-1-yl) -N- (6- (4- (1-phenylethyl) -4H-1 H -1,2,4-triazol-3- yl) pyridin-2-yl) benzamide; (S) -3- (4,5-dimethyl-1H-imidazol-1-yl) -N- (6- (4- (1,1,1-trifluoropropan-2-yl) -4H-1,2 , 4-triazol-3-yl) pyridin-2-yl) benzamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -3- (6-cyclopropylpyridin-3-yl) benzamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -3- (pyridin-3-yl) benzamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -5- (6-cyclopropylpyridin-3-yl) -2,4-difluorobenzamide; 4-Chloro-N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -5- (6-cyclopropylpyridin-3-yl) -2-fluorobenzamide ; 3- (4-cyclopropyl-1H-1,2,3-triazol-1-yl) -N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2 -yl) benzamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (6-cyclopropylpyridin-3-yl) -7,8-dimethylquinoline-2-carboxamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -4- (pyridin-3-yl) quinoline-2-carboxamide; N- (3- (4-methyl-4H-1,2,4-triazol-3-yl) phenyl) -3,3'-bipyridine-5-carboxamide; N- (3- (4-methyl-4H-1,2,4-triazol-3-yl) phenyl) -5-phenylnicotinamide; N- (3- (4-methyl-4H-1,2,4-triazol-3-yl) phenyl) -2-phenylisonocotinamide; e-cyclopropyl-N-yl-cyclopropyl-1H-1 H-triazol-5-ylphenyl] S-bipyridine-e-carboxamide; 6'-cyclopropyl-N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -2,3'-bipyridine-4-carboxamide; 5- (2,5-Difluorophenyl) -N- (3- (4-methyl-4H-1,2,4-triazol-3-yl) phenyl) nicotinamide; N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) -6- (6-cyclopropylpyridin-3-yl) pyrimidine-4-carboxamide; 6'-cyclopropyl-N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -2,3'-bipyridine-4-carboxamide; 2-Hydroxy-N- (3- (4-methyl-4H-1,2,4-triazol-3-yl) phenyl) -6-phenylpyrimidine-4-carboxamide; N- (6- (1-cyclopropyl-1H-imidazol-5-yl) pyridin-2-yl) -4- (4,5-dimethyl-1H-imidazol-1-yl) picolinamide; N- (6- (1-cyclopropyl-1H-imidazol-5-yl) pyridin-2-yl) -6- (2-hydroxypropan-2-yl) -3,4'-bipyridine-2'-carboxamide; N- (6- (1-cyclopropyl-1H-imidazol-5-yl) pyridin-2-yl) -4- (quinolin-3-yl) picolinamide; 6-cyclopropyl-N- (6- (1-cyclopropyl-1H-imidazol-5-yl) pyridin-2-yl) -3,4'-bipyridine-2'-carboxamide; 6-cyclopropyl-N- (3- (1-cyclopropyl-1H-imidazol-5-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (1-cyclopropyl-1H-imidazol-5-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; 4- (1H-benzo [d] imidazol-1-yl) -N- (3- (1-cyclopropyl-1H-imidazol-5-yl) phenyl) picolinamide; N- (3- (1-cyclopropyl-1H-imidazol-5-yl) phenyl) -4- (quinolin-3-yl) picolinamide; 6-cyclopropyl-N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -3,4'-bipyridine-2'-carboxamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -4- (4,5-dimethyl-1H-imidazol-1- yl) picolinamide ; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -6- (2-hydroxypropan-2-yl) -3'-bipyridin- -carboxamide. 6'-cyclopropyl-N- (6- (4-cyclopropyl-4H-1) 2,4-triazol-3-yl) pyridin-2-yl) -2,3'-bipyridine-6-carboxamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -4- (5-methyl- 4- (trifluoromethyl) 7-tetrahydro-1H-imidazo [4I5-c] pyridin-1-yl) picolinamide; 6-cyclopropyl-N- (6- (4 - ((2R) -3-hydroxybutan-2-yl) -4H-1,2,4-triazol-3-yl) pyridin-2- yl) -bipyridine-2'-carboxamide; 6-cyclopropyl-N- (6- (4 - ((2S, 3R) -3-hydroxybutan-2-yl) -4H-1,2,4-triazol-3-yl) pyridin-2-yl) -3 , 4'-bipyridine-2'-carboxamide; 6-cyclopropyl-N- (6- (4 - ((2S, 3S) -3-hydroxybutan-2-yl) -4H-1,2,4-triazol-3-yl) pyridin-2-yl) -bipyridine-2'-carboxamide; 6-cyclopropyl-N- (6- (4- (1- (pyrrolidin-1-yl) propan-2-yl) -4H-1,2,4-triazol-3-yl) pyridin-2- yl) 3,4'-bipyridine-2'-carboxanide; N- (6- (4-cyclopropyl-4H-1R) -triazol-5-yl) pyridin-1-yl] -cyclopropylpyridin-S-yl) -7,8- dimethylquinoline 2- cyclopropyl-1H-imidazol-1-yl) -N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) quinoline-2-carboxamide; N- ( 6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -4- (6-cyclopropylpyridin-3-yl) quinoline-2-carboxamide; 4- (4- cyclopropyl-2-methyl-1H-imidazol-1-yl) -N- (6- (4-cyclopropyl-4 H -1,2,4-triazol-3- yl) pyridin-2- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -4- (4,5,6,7-tetrahydro- 1 H- benzo [d] imidazol- 1-yl) picolinamide N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -4- (4- (trifluoromethyl) -1H- imidazol- 1-yl) picolinamide N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -4- (4- (trifluoromethyl) N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-6,7-tetrahydro- 1 H- imidazo [4,5- c] pyridin- 2-yl) -4- (4- (perfluoroethyl) -1H-imidazol-1-yl) picolinamide; 4- (3-cyclopropyl-1H-1,2- (4-triazol-1-yl) 6- (4-cyclopropyl-4H-1,2,4-triene azol-3-yl) pyridin-2-yl) picolinamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -4- (4- (2,2,2-trifluoro-1-hydroxyethyl) 1 H-imidazol-1-yl) picolinamide; 6-cyclopropyl-N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -5'- methyl-3,4'- bipyridin-2'- carboxamide; 6-cyclopropyl-N- (2- (4-cyclopropyl-4H-1,12,4-triazol-3-yl) pyridin-4-yl) -3,4'-bipyridine-2'-carboxamide; N- (2- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-4-yl) -4- (quinolin-3-yl) picolinamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -4- (4-methyl-1H-imidazol-1-yl) picolinamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -4- (4-isopropyl-1H-imidazol-1-yl) picolinamide; 4- (4-cyclopropyl-1H-imidazol-1-yl) -N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) picolinamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -4- (3-hydroxypiperidin-1-yl) picolinamide; 6-cyclopropyl-N- (6- (4-isopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -3,4'-bipyridine-2'-carboxamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -4- (4-ethyl-3-oxopiperazin-1-yl) picolinamide; (R) -6-cyclopropyl-N- (6- (4- (1,1,1-trifluoropropan-2-yl) -4H-1,2,4-triazol-3-yl) pyridin-2- -3,4'-bipyridine-2'-carboxamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -4- (4- (N-methylsulfamoyl) phenyl) picolinamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -4- (quinolin-3-yl) picolinamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -4- (4-phenyl-1H-imidazol-1-yl) picolineamide; N- (6- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) pyridin-2-yl) -4- (4- (methylsulfonyl) phenyl) picolinamide; N-yl-cyclopropylmethyl-1 H-triazol-5-yl) pyridin-1-yl] -bipyridine-2-carboxamide; 6-cyclopropyl-N- (3- (4-phenyl-4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; 6-cyclopropyl-N- (3- (4- (pyridin-2-yl) -4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; 6-cyclopropyl-N- (3- (4- (pyridin-3-yl) -4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; 6-cyclopropyl-N- (3- (4- (pyridin-4-yl) -4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; 6-cyclopropyl-N- (3- (4- (pyrimidin-5-yl) -4H-1,2,4-triazol-3-yl) phenyl) -3,4'-bipyridine-2'-carboxamide; N- (3- (4- (but-2-ynyl) -4H-1,2,4-triazol-3-yl) phenyl) -6-cyclopropyl-3,4'-bipyridine-2'-carboxamide; 6-cyclopropyl-N- (3- (4- (1- (pyridin-3-yloxy) propan-2-yl) -4H-1,2,4-triazol-3-yl) phenyl) -bipyridine-2'-carboxamide; 6-cyclopropyl-N- (3- (4- (1- (2,2,2-trifluoroethoxy) propane-2-yl) -4H-1,2,4-triazol-3- yl) phenyl) 4'-bipyridine-2'-carboxamide; 4- (4-cyclopropyl-1H-imidazol-1-yl) -N- (3- (4-phenyl-4H-1,2,4-triazol-3-yl) phenyl) picolinamide; 4- (4-cyclopropyl-1H-imidazol-1-yl) -N- (3- (4- (pyridin-2-yl) -4H-1,2,4-triazol-3-yl) phenyl) picolinamide; 4- (4-cyclopropyl-1H-imidazol-1-yl) -N- (3- (4- (pyridin-3-yl) -4H-1,2,4-triazol-3- yl) phenyl) picolinamide ; 4- (4-cyclopropyl-1H-imidazol-1-yl) -N- (3- (4- (pyridin-4-yl) -4H-1,2,4-triazol-3-yl) phenyl) picolinamide; 4- (4-cyclopropyl-1H-imidazol-1-yl) -N- (3- (4- (pyrimidin-5-yl) -4H-1,2,4-triazol-3- yl) phenyl) picolinamide ; N- (3- (4- (but-2-ynyl) -4H-1,2,4-triazol-3-yl) phenyl) -4- (4-cyclopropyl-1H-imidazol-1- yl) picolinamide ; 4- (4-cyclopropyl-1H-imidazol-1-yl) -N- (3- (4- (1- (pyridin-3-yloxy) propan-2- yl) -4H- 1,2,4- triazol-3-yl) phenyl) picolinamide; and 4- (4-cyclopropyl-1H-imidazol-1-yl) -N- (3- (4- (1- (2,2,2-trifluoroethoxy) propane-2-yl) -4H-1,2 , 4-triazol-3-yl) phenyl) picolinamide.
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