MX340696B - Anticuerpos anti-c5a y metodos para usar los anticuerpos. - Google Patents

Anticuerpos anti-c5a y metodos para usar los anticuerpos.

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Publication number
MX340696B
MX340696B MX2012012686A MX2012012686A MX340696B MX 340696 B MX340696 B MX 340696B MX 2012012686 A MX2012012686 A MX 2012012686A MX 2012012686 A MX2012012686 A MX 2012012686A MX 340696 B MX340696 B MX 340696B
Authority
MX
Mexico
Prior art keywords
antibodies
syndrome
methods
goodpasture
sepsis
Prior art date
Application number
MX2012012686A
Other languages
English (en)
Other versions
MX2012012686A (es
Inventor
P Rother Russell
P Tamburini Paul
L Sheridan Douglas
Zhang Yuchun
Original Assignee
Alexion Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexion Pharma Inc filed Critical Alexion Pharma Inc
Publication of MX2012012686A publication Critical patent/MX2012012686A/es
Publication of MX340696B publication Critical patent/MX340696B/es

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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
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    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/567—Framework region [FR]
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Abstract

La presente invención se refiere a anticuerpos, o fragmentos de unión a antígeno de los mismos, que se unen a C5a y al uso de los anticuerpos en métodos para tratar o evitar trastornos asociados con complemento tales como, pero no limitándose a, síndrome urémico hemolítico atípico, degeneración macular relacionada con la edad, artritis reumatoide, sepsis, quemaduras severas, síndrome antifosfolípidos, asma, nefritis lúpica, síndrome de Goodpasture, y enfermedad pulmonar obstructiva crónica.
MX2012012686A 2010-04-30 2011-04-29 Anticuerpos anti-c5a y metodos para usar los anticuerpos. MX340696B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33026010P 2010-04-30 2010-04-30
US201161471465P 2011-04-04 2011-04-04
PCT/US2011/034672 WO2011137395A1 (en) 2010-04-30 2011-04-29 Anti-c5a antibodies and methods for using the antibodies

Publications (2)

Publication Number Publication Date
MX2012012686A MX2012012686A (es) 2013-02-26
MX340696B true MX340696B (es) 2016-07-21

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MX2012012686A MX340696B (es) 2010-04-30 2011-04-29 Anticuerpos anti-c5a y metodos para usar los anticuerpos.

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US (10) US9011852B2 (es)
EP (2) EP2563813B1 (es)
JP (3) JP6022441B2 (es)
KR (1) KR101800913B1 (es)
CN (2) CN103201289B (es)
AU (1) AU2011245117B2 (es)
BR (1) BR112012027900A2 (es)
CA (1) CA2797856C (es)
CO (1) CO6660465A2 (es)
DK (1) DK2563813T3 (es)
EA (1) EA028899B1 (es)
ES (2) ES2552954T3 (es)
HR (1) HRP20151213T1 (es)
IL (2) IL222688A (es)
MX (1) MX340696B (es)
NZ (2) NZ629829A (es)
PL (1) PL2563813T3 (es)
PT (1) PT2563813E (es)
SG (1) SG185383A1 (es)
SI (1) SI2563813T1 (es)
WO (1) WO2011137395A1 (es)

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MX340696B (es) 2010-04-30 2016-07-21 Alexion Pharma Inc Anticuerpos anti-c5a y metodos para usar los anticuerpos.
EP2468295A1 (en) * 2010-12-21 2012-06-27 Affiris AG Vaccines based on peptides of the complement protein C5a
EP3604339B1 (en) 2011-01-14 2021-03-10 The Regents Of The University Of California Therapeutic antibodies against ror-1 protein and methods for use of same
HRP20170427T1 (hr) 2011-11-16 2017-06-16 Sphingotec Gmbh Testovi na adrenomedulin i postupci određivanja zrelog adrenomedulina
US11067586B2 (en) * 2011-11-16 2021-07-20 Sphingotec Gmbh Adrenomedullin assays and methods for determining mature adrenomedullin
EP3511339B1 (en) 2012-02-20 2025-04-09 IPC Research, LLC Polypeptides binding to human complement c5
EP3722320A3 (en) 2012-10-25 2020-12-30 Bioverativ USA Inc. Anti-complement c1s antibodies and uses thereof
DK2914291T3 (da) 2012-11-02 2022-05-16 Bioverativ Usa Inc Anti-komplement-c1s-antistoffer og anvendelser deraf
SG11201504728RA (en) 2012-12-18 2015-07-30 Icahn School Med Mount Sinai Influenza virus vaccines and uses thereof
US9908930B2 (en) 2013-03-14 2018-03-06 Icahn School Of Medicine At Mount Sinai Antibodies against influenza virus hemagglutinin and uses thereof
SI3011345T1 (sl) * 2013-08-07 2017-12-29 Alexion Pharmaceuticals, Inc. Biomarkerski proteini za atipični hemolitični uremični sindrom (ahus)
NZ631007A (en) * 2014-03-07 2015-10-30 Alexion Pharma Inc Anti-c5 antibodies having improved pharmacokinetics
CA2940319A1 (en) * 2014-03-20 2015-09-24 Inflarx Gmbh Inhibitors of c5a for the treatment of viral pneumonia
US20160168237A1 (en) * 2014-12-12 2016-06-16 Alexion Pharmaceuticals, Inc. Method for treating a complement mediated disorder caused by an infectious agent in a patient
US10736956B2 (en) 2015-01-23 2020-08-11 Icahn School Of Medicine At Mount Sinai Influenza virus vaccination regimens
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