ATE416755T1 - Verfahren und zusammensetzung für die pulmonale darreichung von insulin - Google Patents
Verfahren und zusammensetzung für die pulmonale darreichung von insulinInfo
- Publication number
- ATE416755T1 ATE416755T1 AT04076082T AT04076082T ATE416755T1 AT E416755 T1 ATE416755 T1 AT E416755T1 AT 04076082 T AT04076082 T AT 04076082T AT 04076082 T AT04076082 T AT 04076082T AT E416755 T1 ATE416755 T1 AT E416755T1
- Authority
- AT
- Austria
- Prior art keywords
- insulin
- composition
- pulmonary administration
- pulmonary
- provides
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
- 102000004877 Insulin Human genes 0.000 title abstract 2
- 108090001061 Insulin Proteins 0.000 title abstract 2
- 229940125396 insulin Drugs 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000002685 pulmonary effect Effects 0.000 title abstract 2
- 239000000843 powder Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20747294A | 1994-03-07 | 1994-03-07 | |
| US38347595A | 1995-02-01 | 1995-02-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE416755T1 true ATE416755T1 (de) | 2008-12-15 |
Family
ID=26902263
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04076082T ATE416755T1 (de) | 1994-03-07 | 1995-02-07 | Verfahren und zusammensetzung für die pulmonale darreichung von insulin |
| AT95909506T ATE264096T1 (de) | 1994-03-07 | 1995-02-07 | Verfahren und mittel zur verabreichung von insulin über die lunge |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95909506T ATE264096T1 (de) | 1994-03-07 | 1995-02-07 | Verfahren und mittel zur verabreichung von insulin über die lunge |
Country Status (23)
| Country | Link |
|---|---|
| US (6) | US6685967B1 (de) |
| EP (3) | EP2036541A1 (de) |
| JP (2) | JPH10501519A (de) |
| KR (1) | KR100419037B1 (de) |
| CN (1) | CN1098679C (de) |
| AT (2) | ATE416755T1 (de) |
| AU (1) | AU689217B2 (de) |
| BR (1) | BR9507023A (de) |
| CA (1) | CA2183577C (de) |
| CZ (1) | CZ295827B6 (de) |
| DE (2) | DE69532884T2 (de) |
| DK (1) | DK0748213T3 (de) |
| ES (2) | ES2316917T3 (de) |
| FI (1) | FI116195B (de) |
| HU (1) | HUT75676A (de) |
| IL (1) | IL112618A (de) |
| MX (1) | MX9603936A (de) |
| MY (1) | MY124282A (de) |
| NO (1) | NO316661B1 (de) |
| NZ (1) | NZ281112A (de) |
| PL (1) | PL179443B1 (de) |
| PT (1) | PT748213E (de) |
| WO (1) | WO1995024183A1 (de) |
Families Citing this family (317)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6673335B1 (en) * | 1992-07-08 | 2004-01-06 | Nektar Therapeutics | Compositions and methods for the pulmonary delivery of aerosolized medicaments |
| US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| EP0679088B1 (de) * | 1992-09-29 | 2002-07-10 | Inhale Therapeutic Systems | Pulmonale abgabe von aktiven fragmenten des parathormons |
| US6024090A (en) * | 1993-01-29 | 2000-02-15 | Aradigm Corporation | Method of treating a diabetic patient by aerosolized administration of insulin lispro |
| US7448375B2 (en) | 1993-01-29 | 2008-11-11 | Aradigm Corporation | Method of treating diabetes mellitus in a patient |
| US5830853A (en) | 1994-06-23 | 1998-11-03 | Astra Aktiebolag | Systemic administration of a therapeutic preparation |
| US6794357B1 (en) | 1993-06-24 | 2004-09-21 | Astrazeneca Ab | Compositions for inhalation |
| TW402506B (en) * | 1993-06-24 | 2000-08-21 | Astra Ab | Therapeutic preparation for inhalation |
| US20010003739A1 (en) * | 1993-06-24 | 2001-06-14 | Astrazeneca Ab | Systemic administration of a therapeutic preparation |
| US6632456B1 (en) | 1993-06-24 | 2003-10-14 | Astrazeneca Ab | Compositions for inhalation |
| US20030113273A1 (en) * | 1996-06-17 | 2003-06-19 | Patton John S. | Methods and compositions for pulmonary delivery of insulin |
| ATE416755T1 (de) | 1994-03-07 | 2008-12-15 | Nektar Therapeutics | Verfahren und zusammensetzung für die pulmonale darreichung von insulin |
| US6051256A (en) | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| MX9605717A (es) * | 1994-05-18 | 1998-05-31 | Inhale Therapeutic Syst | Metodos y composiciones para la formulacion de polvo seco de interferones. |
| US6165976A (en) * | 1994-06-23 | 2000-12-26 | Astra Aktiebolag | Therapeutic preparation for inhalation |
| US6586006B2 (en) | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
| US6290991B1 (en) * | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| US5863563A (en) * | 1994-10-20 | 1999-01-26 | Alphagene Inc. | Treatment of pulmonary conditions associated with insufficient secretion of surfactant |
| US6524557B1 (en) | 1994-12-22 | 2003-02-25 | Astrazeneca Ab | Aerosol formulations of peptides and proteins |
| EE9700138A (et) | 1994-12-22 | 1997-12-15 | Astra Aktiebolag | Aerosoolravimvormid |
| EP1283035A3 (de) * | 1994-12-22 | 2003-03-19 | AstraZeneca AB | Parathyroidhormon enthaltende therapeutische Zubereitung zur Inhalation |
| US6258341B1 (en) * | 1995-04-14 | 2001-07-10 | Inhale Therapeutic Systems, Inc. | Stable glassy state powder formulations |
| US6309671B1 (en) * | 1995-04-14 | 2001-10-30 | Inhale Therapeutic Systems | Stable glassy state powder formulations |
| US6428771B1 (en) | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
| GB9515182D0 (en) † | 1995-07-24 | 1995-09-20 | Co Ordinated Drug Dev | Improvements in and relating to powders for use in dry powder inhalers |
| DE19539574A1 (de) * | 1995-10-25 | 1997-04-30 | Boehringer Mannheim Gmbh | Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren |
| PT877602E (pt) | 1996-01-24 | 2002-07-31 | Byk Gulden Lomberg Chem Fab | Processo para o fabrico de composicoes de surfactantes pulmonares em po |
| EP0879048B2 (de) † | 1996-02-09 | 2009-07-29 | Quadrant Drug Delivery Limited | Verfahren zur Herstellung von Tabletten mit Hilfe von Trehalose |
| US6254854B1 (en) | 1996-05-24 | 2001-07-03 | The Penn Research Foundation | Porous particles for deep lung delivery |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| USRE37053E1 (en) | 1996-05-24 | 2001-02-13 | Massachusetts Institute Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US20020052310A1 (en) | 1997-09-15 | 2002-05-02 | Massachusetts Institute Of Technology The Penn State Research Foundation | Particles for inhalation having sustained release properties |
| US5985309A (en) * | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US5855913A (en) * | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US6503480B1 (en) | 1997-05-23 | 2003-01-07 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| AUPO269996A0 (en) * | 1996-10-01 | 1996-10-24 | Walter And Eliza Hall Institute Of Medical Research, The | A method of prophylaxis and treatment |
| AU5719798A (en) | 1996-12-31 | 1998-07-31 | Inhale Therapeutic Systems, Inc. | Processes for spray drying aqueous suspensions of hydrophobic drugs with hydrophilic excipients and compositions prepared by such processes |
| US20030203036A1 (en) | 2000-03-17 | 2003-10-30 | Gordon Marc S. | Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients |
| US5898028A (en) * | 1997-03-20 | 1999-04-27 | Novo Nordisk A/S | Method for producing powder formulation comprising an insulin |
| EP1005490B1 (de) * | 1997-03-20 | 2006-03-29 | Novo Nordisk A/S | Zinkfreie insulinkristalle für die verwendung in medikamenten, die über die lunge verabreicht werden. |
| US6310038B1 (en) * | 1997-03-20 | 2001-10-30 | Novo Nordisk A/S | Pulmonary insulin crystals |
| US20030035778A1 (en) * | 1997-07-14 | 2003-02-20 | Robert Platz | Methods and compositions for the dry powder formulation of interferon |
| ES2287971T3 (es) | 1997-08-11 | 2007-12-16 | Pfizer Products Inc. | Dispersiones farmaceuticas solidas con biodisponibilidad incrementada. |
| US7052678B2 (en) | 1997-09-15 | 2006-05-30 | Massachusetts Institute Of Technology | Particles for inhalation having sustained release properties |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| US20060165606A1 (en) * | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| ZA989744B (en) * | 1997-10-31 | 2000-04-26 | Lilly Co Eli | Method for administering acylated insulin. |
| WO1999055310A1 (en) | 1998-04-27 | 1999-11-04 | Altus Biologics Inc. | Stabilized protein crystals, formulations containing them and methods of making them |
| US6451349B1 (en) * | 1998-08-19 | 2002-09-17 | Quadrant Healthcare (Uk) Limited | Spray-drying process for the preparation of microparticles |
| GB9814172D0 (en) * | 1998-06-30 | 1998-08-26 | Andaris Ltd | Formulation for inhalation |
| US6956021B1 (en) | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
| UA73924C2 (en) | 1998-10-09 | 2005-10-17 | Nektar Therapeutics | Device for delivering active agent formulation to lungs of human patient |
| US20060171899A1 (en) * | 1998-12-10 | 2006-08-03 | Akwete Adjei | Water-stabilized aerosol formulation system and method of making |
| US7087215B2 (en) * | 1998-12-21 | 2006-08-08 | Generex Pharmaceuticals Incorporated | Methods of administering and enhancing absorption of pharmaceutical agents |
| WO2000047203A1 (en) * | 1999-02-12 | 2000-08-17 | Mqs, Inc. | Formulation and system for intra-oral delivery of pharmaceutical agents |
| DE60026982T2 (de) * | 1999-04-05 | 2006-11-16 | Mannkind Corp., Danbury | Verfahren zur bildung von feinem pulver |
| US7001892B1 (en) | 1999-06-11 | 2006-02-21 | Purdue Research Foundation | Pharmaceutical materials and methods for their preparation and use |
| US6858199B1 (en) * | 2000-06-09 | 2005-02-22 | Advanced Inhalation Research, Inc. | High efficient delivery of a large therapeutic mass aerosol |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| DK1808438T3 (da) | 1999-06-29 | 2014-10-27 | Mannkind Corp | Rensning og stabilisering af peptid og proteiner i lægemidler |
| GB9916316D0 (en) * | 1999-07-12 | 1999-09-15 | Quadrant Holdings Cambridge | Dry powder compositions |
| JP2003510024A (ja) * | 1999-08-09 | 2003-03-18 | インサイト・ゲノミックス・インコーポレイテッド | プロテアーゼ及びプロテアーゼインヒビター |
| US7252840B1 (en) | 1999-08-25 | 2007-08-07 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles |
| US6586008B1 (en) * | 1999-08-25 | 2003-07-01 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles during spray drying |
| US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
| US6749835B1 (en) * | 1999-08-25 | 2004-06-15 | Advanced Inhalation Research, Inc. | Formulation for spray-drying large porous particles |
| AU7353500A (en) * | 1999-09-10 | 2001-04-10 | Incyte Genomics, Inc. | Apoptosis proteins |
| US6761909B1 (en) * | 1999-12-21 | 2004-07-13 | Rxkinetix, Inc. | Particulate insulin-containing products and method of manufacture |
| AU2729101A (en) * | 1999-12-21 | 2001-07-03 | Rxkinetix, Inc. | Particulate drug-containing products and method of manufacture |
| SK11142002A3 (sk) * | 1999-12-30 | 2004-09-08 | Chiron Corporation | Liečivo na podávanie interleukínu-2 a stabilizovaný lyofilizovaný alebo sprejovo sušený farmaceutický prostriedok s obsahom interleukínu-2 |
| FI20002217A7 (fi) * | 1999-12-30 | 2001-07-01 | Orion Yhtymae Oyj | Inhalaatiopartikkelit |
| KR100773323B1 (ko) | 2000-01-10 | 2007-11-05 | 맥시겐 홀딩스 리미티드 | 지-씨에스에프 접합체 |
| US6596261B1 (en) * | 2000-01-25 | 2003-07-22 | Aeropharm Technology Incorporated | Method of administering a medicinal aerosol formulation |
| US6540983B1 (en) * | 2000-01-25 | 2003-04-01 | Aeropharm Technology Incorporated | Medical aerosol formulation |
| US6585957B1 (en) | 2000-01-25 | 2003-07-01 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
| CN1440298A (zh) * | 2000-01-25 | 2003-09-03 | 气体药品技术公司 | 药用气雾剂 |
| US6540982B1 (en) * | 2000-01-25 | 2003-04-01 | Aeropharm Technology Incorporated | Medical aerosol formulation |
| JP2004507212A (ja) * | 2000-03-03 | 2004-03-11 | インサイト・ゲノミックス・インコーポレイテッド | Ｇタンパク質共役受容体 |
| JP4711520B2 (ja) * | 2000-03-21 | 2011-06-29 | 日本ケミカルリサーチ株式会社 | 生理活性ペプチド含有粉末 |
| US6447750B1 (en) * | 2000-05-01 | 2002-09-10 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
| GB0010709D0 (en) * | 2000-05-03 | 2000-06-28 | Vectura Ltd | Powders for use a in dry powder inhaler |
| US8404217B2 (en) * | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| PT1280520E (pt) | 2000-05-10 | 2014-12-16 | Novartis Ag | Pós à base de fosfolípidos para administração de fármacos |
| GB0011807D0 (en) * | 2000-05-16 | 2000-07-05 | Quadrant Holdings Cambridge | Formulation for inhalation |
| EP2093293A3 (de) | 2000-06-16 | 2010-07-07 | Incyte Corporation | G-Protein-gekoppelte Rezeptoren |
| US7575761B2 (en) | 2000-06-30 | 2009-08-18 | Novartis Pharma Ag | Spray drying process control of drying kinetics |
| AU2001280934A1 (en) * | 2000-07-28 | 2002-02-13 | Alliance Pharmaceutical Corp. | Methods and compositions to upregulate, redirect or limit immune responses to bioactive compounds |
| WO2002009669A2 (en) * | 2000-08-01 | 2002-02-07 | Inhale Therapeutic Systems, Inc. | Apparatus and process to produce particles having a narrow size distribution and particles made thereby |
| US6613308B2 (en) | 2000-09-19 | 2003-09-02 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| US7608704B2 (en) * | 2000-11-08 | 2009-10-27 | Incyte Corporation | Secreted proteins |
| ATE420630T1 (de) * | 2000-11-29 | 2009-01-15 | Itoham Foods Inc | Pulverzubereitungen und verfahren zu ihrer herstellung |
| ES2474199T3 (es) * | 2000-11-30 | 2014-07-08 | Vectura Limited | Composiciones farmacéuticas para inhalaci�n |
| DE60140268D1 (de) * | 2000-11-30 | 2009-12-03 | Vectura Ltd | Partikel zur verwendung in einer pharmazeutischen zusammensetzung |
| US20020106331A1 (en) * | 2000-12-08 | 2002-08-08 | Joan Rosell | Use of electrolytes (ions in solution) to suppress charging of inhalation aerosols |
| EP1797902A3 (de) * | 2000-12-29 | 2007-10-03 | Advanced Inhalation Research, Inc. | Inhalationspartikel mit verzögerter Freigabe |
| US20020141946A1 (en) * | 2000-12-29 | 2002-10-03 | Advanced Inhalation Research, Inc. | Particles for inhalation having rapid release properties |
| JP2005504715A (ja) * | 2000-12-29 | 2005-02-17 | アドバンスト インハレーション リサーチ，インコーポレイテッド | 持続放出特性を有する吸入用粒子 |
| US7060675B2 (en) | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
| US6867183B2 (en) | 2001-02-15 | 2005-03-15 | Nobex Corporation | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
| WO2002074806A2 (en) | 2001-02-27 | 2002-09-26 | Maxygen Aps | New interferon beta-like molecules |
| US7905230B2 (en) | 2001-05-09 | 2011-03-15 | Novartis Ag | Metered dose inhaler with lockout |
| US9994853B2 (en) | 2001-05-18 | 2018-06-12 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
| US6828297B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| JP2004531333A (ja) | 2001-06-20 | 2004-10-14 | ネクター セラピューティクス | 粉末エアロゾル化装置及び方法 |
| NZ519403A (en) * | 2001-06-21 | 2005-03-24 | Pfizer Prod Inc | Use of insulin in a medicament to reduce weight gain in a diabetic patient who is using exogenous insulin to control blood sugar levels |
| GB0208742D0 (en) | 2002-04-17 | 2002-05-29 | Bradford Particle Design Ltd | Particulate materials |
| US7196059B2 (en) | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
| US20030095928A1 (en) * | 2001-09-19 | 2003-05-22 | Elan Pharma International Limited | Nanoparticulate insulin |
| WO2003026559A2 (en) | 2001-09-28 | 2003-04-03 | Kurve Technology, Inc | Nasal nebulizer |
| KR100951750B1 (ko) * | 2001-11-01 | 2010-04-09 | 노바르티스 아게 | 분무 건조 방법 및 그 조성물 |
| AU2002346424A1 (en) | 2001-11-19 | 2003-06-10 | Becton, Dickinson And Company | Pharmaceutical compositions in particulate form |
| AU2002352836B2 (en) | 2001-11-20 | 2005-09-29 | Alkermes, Inc. | Improved particulate compositions for pulmonary delivery |
| CA2466525C (en) | 2001-12-07 | 2011-05-17 | Eiffel Technologies Limited | Synthesis of small particles |
| PT1458360E (pt) | 2001-12-19 | 2011-07-13 | Novartis Ag | Derivados de indole como agonistas do recetor s1p1 |
| US8777011B2 (en) | 2001-12-21 | 2014-07-15 | Novartis Ag | Capsule package with moisture barrier |
| US9181551B2 (en) | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| US7378492B2 (en) * | 2002-02-20 | 2008-05-27 | Incyte Corporation | CD40-related receptor that binds CD40L |
| WO2003080149A2 (en) | 2002-03-20 | 2003-10-02 | Mannkind Corporation | Inhalation apparatus |
| AU2003218307B8 (en) | 2002-03-20 | 2006-08-31 | Alkermes, Inc. | Pulmonary delivery for levodopa |
| WO2003079991A2 (en) * | 2002-03-20 | 2003-10-02 | Advanced Inhalation Research, Inc. | Method for administration of growth hormone via pulmonary delivery |
| WO2003079885A2 (en) | 2002-03-20 | 2003-10-02 | Advanced Inhalation Research, Inc. | Inhalable sustained therapeutic formulations |
| US20050163725A1 (en) * | 2002-03-20 | 2005-07-28 | Blizzard Charles D. | Method for administration of growth hormone via pulmonary delivery |
| US7754242B2 (en) * | 2002-03-20 | 2010-07-13 | Alkermes, Inc. | Inhalable sustained therapeutic formulations |
| US7008644B2 (en) * | 2002-03-20 | 2006-03-07 | Advanced Inhalation Research, Inc. | Method and apparatus for producing dry particles |
| US7582284B2 (en) | 2002-04-17 | 2009-09-01 | Nektar Therapeutics | Particulate materials |
| AU2003226603A1 (en) | 2002-04-19 | 2003-11-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Beta-agonist compounds comprising nitric oxide donor groups and reactive oxygen species scavenger groups and their use in the treatment of respiratory disorders |
| AU2003263024A1 (en) * | 2002-04-23 | 2003-11-10 | Christopher Mcconville | Process of forming and modifying particles and compositions produced thereby |
| GB0216562D0 (en) | 2002-04-25 | 2002-08-28 | Bradford Particle Design Ltd | Particulate materials |
| US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
| AU2003249623A1 (en) | 2002-05-09 | 2003-12-12 | Kurve Technology, Inc. | Particle dispersion chamber for nasal nebulizer |
| AU2003236521A1 (en) | 2002-06-13 | 2003-12-31 | Nobex Corporation | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus |
| US7185651B2 (en) | 2002-06-18 | 2007-03-06 | Nektar Therapeutics | Flow regulator for aerosol drug delivery and methods |
| US6941980B2 (en) | 2002-06-27 | 2005-09-13 | Nektar Therapeutics | Apparatus and method for filling a receptacle with powder |
| SI1531794T1 (sl) | 2002-06-28 | 2017-12-29 | Civitas Therapeteutics, Inc. | Epinefrin za vdihavanje |
| US20070276126A1 (en) * | 2002-08-13 | 2007-11-29 | Incyte Corporation | Cell adhesion and extracellular matrix proteins |
| US20070219353A1 (en) * | 2002-09-03 | 2007-09-20 | Incyte Corporation | Immune Response Associated Proteins |
| AU2003279829A1 (en) * | 2002-10-04 | 2004-05-04 | Incyte Corp | Protein modification and maintenance molecules |
| US20050164275A1 (en) * | 2002-10-18 | 2005-07-28 | Incyte Corporation | Phosphodiesterases |
| AU2003300785A1 (en) * | 2002-11-12 | 2004-06-03 | Incyte Corporation | Carbohydrate-associated proteins |
| AU2003295462A1 (en) * | 2002-11-13 | 2004-06-03 | Incyte Corporation | Lipid-associated proteins |
| AU2003302234A1 (en) * | 2002-11-26 | 2004-06-18 | Incyte Corporation | Immune response associated proteins |
| US20040105818A1 (en) | 2002-11-26 | 2004-06-03 | Alexza Molecular Delivery Corporation | Diuretic aerosols and methods of making and using them |
| US7516741B2 (en) | 2002-12-06 | 2009-04-14 | Novartis Ag | Aerosolization apparatus with feedback mechanism |
| WO2004054606A1 (en) * | 2002-12-13 | 2004-07-01 | Pfizer Products Inc. | Method of decreasing hepatic glucose output in diabetic patients |
| WO2004058218A2 (en) | 2002-12-30 | 2004-07-15 | Nektar Therapeutics | Prefilming atomizer |
| US20050236296A1 (en) * | 2002-12-30 | 2005-10-27 | Nektar Therapeutics (Formerly Inhale Therapeutic Systems, Inc.) | Carry case for aerosolization apparatus |
| US7669596B2 (en) | 2002-12-31 | 2010-03-02 | Novartis Pharma Ag | Aerosolization apparatus with rotating capsule |
| JP4943838B2 (ja) | 2003-04-09 | 2012-05-30 | ネクター セラピューティクス | 空気入口シールドを備えたエアゾール化装置 |
| MXPA05010835A (es) | 2003-04-09 | 2006-03-30 | Nektar Therapeutics | Aparato para aerosolizacion con guia de alineamiento con perforacion capsular. |
| US8869794B1 (en) | 2003-04-09 | 2014-10-28 | Novartis Pharma Ag | Aerosolization apparatus with capsule puncturing member |
| US7829682B1 (en) | 2003-04-30 | 2010-11-09 | Incyte Corporation | Human β-adrenergic receptor kinase nucleic acid molecule |
| US7683029B2 (en) * | 2003-05-07 | 2010-03-23 | Philip Morris Usa Inc. | Liquid aerosol formulations containing insulin and aerosol generating devices and methods for generating aerosolized insulin |
| CA2526222A1 (en) * | 2003-05-16 | 2004-12-02 | Arriva Pharmaceuticals, Inc. | Treatment of respiratory disease associated with matrix metalloprotease inhibitors |
| US7338171B2 (en) * | 2003-10-27 | 2008-03-04 | Jen-Chuen Hsieh | Method and apparatus for visual drive control |
| NZ548980A (en) * | 2004-01-12 | 2009-10-30 | Mannkind Corp | Reducing serum proinsulin levels in type 2 diabetics |
| EP1718277A1 (de) * | 2004-02-10 | 2006-11-08 | Advanced Inhalation Research, Inc. | Partikel zur inhalation mit schnellen freisetzungseigenschaften |
| US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
| US7279457B2 (en) * | 2004-03-12 | 2007-10-09 | Biodel, Inc. | Rapid acting drug delivery compositions |
| EP1734938B1 (de) | 2004-03-26 | 2012-06-20 | Universita' Degli Studi Di Parma | Stark einatembare insulin-mikroteilchen |
| US20060039985A1 (en) * | 2004-04-27 | 2006-02-23 | Bennett David B | Methotrexate compositions |
| AU2005244128B2 (en) * | 2004-05-07 | 2009-06-25 | President And Fellows Of Harvard College | Pulmonary malarial vaccine |
| US10508277B2 (en) | 2004-05-24 | 2019-12-17 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
| US7481219B2 (en) * | 2004-06-18 | 2009-01-27 | Mergenet Medical, Inc. | Medicine delivery interface system |
| JP2008503586A (ja) | 2004-06-21 | 2008-02-07 | ネクター セラピューティクス | アンフォテリシンｂを含む組成物、方法、およびシステム |
| US8513204B2 (en) | 2004-06-21 | 2013-08-20 | Novartis Ag | Compositions comprising amphotericin B, mehods and systems |
| RU2527893C2 (ru) * | 2004-07-19 | 2014-09-10 | Биокон Лимитед | Инсулин-олигомерные конъюгаты, их препараты и применения |
| PL1786784T3 (pl) | 2004-08-20 | 2011-04-29 | Mannkind Corp | Kataliza syntezy diketopiperazyn |
| KR101644250B1 (ko) | 2004-08-23 | 2016-07-29 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
| US7115561B2 (en) * | 2004-09-22 | 2006-10-03 | Patterson James A | Medicament composition and method of administration |
| SE0402345L (sv) * | 2004-09-24 | 2006-03-25 | Mederio Ag | Uppmätt läkemedelsdos |
| WO2007011396A2 (en) | 2004-10-29 | 2007-01-25 | President And Fellows Of Harvard College | Particles for treatment of pulmonary infection |
| US20060115468A1 (en) * | 2004-11-26 | 2006-06-01 | Kara Morrison | Dietary supplement for treating and preventing gastrointestinal disorders |
| WO2006071102A1 (en) | 2004-12-30 | 2006-07-06 | Dobeel Co., Ltd. | Spray-dried composition containing collectin family proteins or variants therof and process for preparing the same |
| US20080206342A1 (en) * | 2005-01-10 | 2008-08-28 | Rosemary Kovelesky | Compositions and Methods For Increasing the Bioavailability of Pulmonarily Administered Insulin |
| CN100431634C (zh) * | 2005-04-04 | 2008-11-12 | 陈庆堂 | 干粉气溶胶化吸入器 |
| UA95446C2 (ru) | 2005-05-04 | 2011-08-10 | Іллюміджен Байосайєнсіз, Інк. | Мутаци в генах oas1 |
| EP1893273B1 (de) | 2005-05-18 | 2014-06-25 | Nektar Therapeutics | Adapter zur anwendung mit einer aerosolisierungsvorrichtung für endobronchiale therapie |
| US20070031342A1 (en) * | 2005-06-22 | 2007-02-08 | Nektar Therapeutics | Sustained release microparticles for pulmonary delivery |
| CA2614409C (en) * | 2005-07-07 | 2014-05-20 | Nanotherapeutics, Inc | Process for milling and preparing powders and compositions produced thereby |
| CN104324362B (zh) | 2005-09-14 | 2018-04-24 | 曼金德公司 | 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法 |
| US8084420B2 (en) | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
| US7713929B2 (en) | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
| WO2007041481A1 (en) * | 2005-09-29 | 2007-04-12 | Biodel, Inc. | Rapid acting and prolonged acting insulin preparations |
| US20070123449A1 (en) * | 2005-11-01 | 2007-05-31 | Advanced Inhalation Research, Inc. | High load particles for inhalation having rapid release properties |
| GB0524194D0 (en) * | 2005-11-28 | 2006-01-04 | Univ Aston | Respirable powders |
| TWI299993B (en) * | 2005-12-15 | 2008-08-21 | Dev Center Biotechnology | Aqueous inhalation pharmaceutical composition |
| WO2007102946A2 (en) | 2006-01-23 | 2007-09-13 | Amgen Inc. | Crystalline polypeptides |
| IN2015DN00888A (de) | 2006-02-22 | 2015-07-10 | Mannkind Corp | |
| ES2622493T3 (es) | 2006-02-24 | 2017-07-06 | Rigel Pharmaceuticals, Inc. | Composiciones y métodos para la inhibición de la ruta de JAK |
| EP2012817A2 (de) | 2006-04-12 | 2009-01-14 | Biodel, Inc. | Insulinkombinationsformulierungen mit schneller wirkung und langzeitwirkung |
| WO2008085549A2 (en) * | 2006-07-28 | 2008-07-17 | Board Of Regents Of The University Of Texas System | Compositions and methods for stimulation of lung innate immunity |
| CN101573133B (zh) | 2006-07-31 | 2014-08-27 | 诺沃-诺迪斯克有限公司 | Peg化延长的胰岛素 |
| GB0616299D0 (en) * | 2006-08-16 | 2006-09-27 | Cambridge Consultants | Drug Capsules for dry power inhalers |
| US20080063722A1 (en) * | 2006-09-08 | 2008-03-13 | Advanced Inhalation Research, Inc. | Composition of a Spray-Dried Powder for Pulmonary Delivery of a Long Acting Neuraminidase Inhibitor (LANI) |
| RU2524150C2 (ru) | 2006-09-22 | 2014-07-27 | Ново Нордиск А/С | Аналоги инсулина, устойчивые к протеазам |
| WO2008097664A1 (en) | 2007-02-11 | 2008-08-14 | Map Pharmaceuticals, Inc. | Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile |
| WO2008124522A2 (en) * | 2007-04-04 | 2008-10-16 | Biodel, Inc. | Amylin formulations |
| JP5496082B2 (ja) | 2007-04-30 | 2014-05-21 | ノボ・ノルデイスク・エー／エス | タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物 |
| WO2008137747A1 (en) | 2007-05-02 | 2008-11-13 | The Regents Of The University Of Michigan | Nanoemulsion therapeutic compositions and methods of using the same |
| RU2453332C2 (ru) * | 2007-10-16 | 2012-06-20 | Байокон Лимитид | Твердая фармацевтическая композиция (варианты) и способ контроля концентрации глюкозы с ее помощью, способ получения твердой фармацевтической композиции (варианты), таблетка (варианты) и способ получения амфорных частиц |
| US8785396B2 (en) | 2007-10-24 | 2014-07-22 | Mannkind Corporation | Method and composition for treating migraines |
| AU2008317307A1 (en) * | 2007-10-25 | 2009-04-30 | Novartis Ag | Powder conditioning of unit dose drug packages |
| EP2060268A1 (de) * | 2007-11-15 | 2009-05-20 | Novo Nordisk A/S | Pharmazeutische Zusammensetzungen für die Zufuhr von Peptiden über die Lunge oder Nase |
| EP2234644B1 (de) * | 2008-01-04 | 2013-07-31 | Biodel, Inc. | Insulinformulierungen zur insulinfreisetzung als funktion des gewebeglukosespiegels |
| WO2009112583A2 (en) | 2008-03-14 | 2009-09-17 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
| HUE032284T2 (en) | 2008-03-18 | 2017-09-28 | Novo Nordisk As | Protease-stabilized, acylated insulin analogues |
| USD605283S1 (en) | 2008-04-04 | 2009-12-01 | Novartis Pharma Ag | Aerosolization device |
| ES2929343T3 (es) | 2008-06-13 | 2022-11-28 | Mannkind Corp | Inhalador de polvo seco accionado por aspiración para la administración de fármacos |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| KR101628410B1 (ko) | 2008-06-20 | 2016-06-08 | 맨카인드 코포레이션 | 흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법 |
| TWI614024B (zh) | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| WO2010030790A2 (en) * | 2008-09-10 | 2010-03-18 | The Texas A&M University System | Methods and compositions for stimulation of mammalian innate immune resistance to pathogens |
| WO2010033240A2 (en) | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Carbohydrate-based drug delivery polymers and conjugates thereof |
| CN102223876A (zh) * | 2008-09-26 | 2011-10-19 | 纳米生物公司 | 纳米乳剂治疗性组合物及其使用方法 |
| RS59913B1 (sr) | 2008-10-17 | 2020-03-31 | Sanofi Aventis Deutschland | Kombinacija insulina i glp-1-agonista |
| CA2742802C (en) | 2008-11-10 | 2019-11-26 | Alexion Pharmaceuticals, Inc. | Methods and compositions for treating complement-associated disorders |
| CA2743904A1 (en) | 2008-11-17 | 2010-05-20 | The Regents Of The University Of Michigan | Cancer vaccine compositions and methods of using the same |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| JP5341532B2 (ja) | 2009-01-19 | 2013-11-13 | 第一電子工業株式会社 | １対の誤嵌合防止キー及び該キーを用いた電気コネクタ |
| JP5498960B2 (ja) | 2009-01-19 | 2014-05-21 | 三菱瓦斯化学株式会社 | エレクトロスプレーにより薬剤を生体内へ注入する方法及び装置 |
| BRPI1006942A2 (pt) | 2009-01-23 | 2016-04-12 | Rigel Pharmaceuticals Inc | composto, composição farmacêutica, kit, métodos para inibir uma atividade de uma jak quinase, para tratar uma doença, para tratar a rejeição de transplante de aloenxerto em um receptor de transplante, para tratar uma reação de hipersensibilidade, e para inibir uma cascata de transdução de sinal, e, uso do composto |
| CA2750711C (en) | 2009-01-26 | 2015-07-07 | Teva Pharmaceutical Industries Ltd. | Processes for coating a carrier with microparticles |
| US9060927B2 (en) | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
| MX2011009251A (es) | 2009-03-04 | 2011-11-18 | Mannkind Corp | Sistema mejorado de suministro de farmaco en polvo seco. |
| US8685458B2 (en) | 2009-03-05 | 2014-04-01 | Bend Research, Inc. | Pharmaceutical compositions of dextran polymer derivatives |
| DK2405963T3 (da) | 2009-03-11 | 2013-12-16 | Mannkind Corp | Apparat, system og fremgangsmåde til at måle modstand i en inhalator |
| EP3552602B1 (de) | 2009-03-18 | 2025-03-05 | Incarda Therapeutics, Inc. | Einheitsdosen, aerosole, kits und verfahren zur behandlung von herzleiden mittels pulmonaler verabreichung |
| CN103800906B (zh) | 2009-03-25 | 2017-09-22 | 德克萨斯大学系统董事会 | 用于刺激哺乳动物对病原体的先天免疫抵抗力的组合物 |
| EP2411137B1 (de) | 2009-03-27 | 2016-09-07 | Bend Research, Inc. | Sprühtrocknungsverfahren |
| WO2010135459A2 (en) * | 2009-05-19 | 2010-11-25 | Mount Sinai School Of Medicine Of New York University | Brain delivery of insulin to treat systemic inflammation |
| EP2440251A4 (de) | 2009-06-09 | 2013-01-16 | Defyrus Inc | Verabreichung von interferon zur prophylaxe gegen oder zur behandlung von krankheitserregenden infektionen |
| CN104721825B (zh) | 2009-06-12 | 2019-04-12 | 曼金德公司 | 具有确定比表面积的二酮哌嗪颗粒 |
| CA2766565A1 (en) | 2009-06-23 | 2010-12-29 | Alexion Pharmaceuticals, Inc. | Bispecific antibodies that bind to complement proteins |
| CN102596175A (zh) | 2009-07-06 | 2012-07-18 | 赛诺菲-安万特德国有限公司 | 含有甲硫氨酸的水性胰岛素制备物 |
| GB0918450D0 (en) | 2009-10-21 | 2009-12-09 | Innovata Ltd | Composition |
| WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
| PT3345593T (pt) | 2009-11-13 | 2023-11-27 | Sanofi Aventis Deutschland | Composição farmacêutica compreendendo despro36exendina- 4(1-39)-lys6-nh2 e metionina |
| MY180661A (en) | 2009-11-13 | 2020-12-04 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine |
| US10842951B2 (en) | 2010-01-12 | 2020-11-24 | Aerami Therapeutics, Inc. | Liquid insulin formulations and methods relating thereto |
| US9180261B2 (en) | 2010-01-12 | 2015-11-10 | Dance Biopharm Inc. | Preservative free insulin formulations and systems and methods for aerosolizing |
| US20130102591A1 (en) | 2010-01-26 | 2013-04-25 | Andrew Lurie Salzman | Compositions and methods for prevention and treatment of pulmonary hypertension |
| MX340696B (es) | 2010-04-30 | 2016-07-21 | Alexion Pharma Inc | Anticuerpos anti-c5a y metodos para usar los anticuerpos. |
| AU2011202239C1 (en) | 2010-05-19 | 2017-03-16 | Sanofi | Long-acting formulations of insulins |
| US20130059916A1 (en) | 2010-05-26 | 2013-03-07 | Stephane Rocchi | Biguanide compounds and its use for treating cancer |
| IL223742A (en) | 2010-06-21 | 2016-06-30 | Mannkind Corp | A dry powder inhaler and preparation for it |
| PL2611458T3 (pl) | 2010-08-30 | 2017-02-28 | Sanofi-Aventis Deutschland Gmbh | Zastosowanie AVE0010 do produkcji leku do leczenia cukrzycy typu 2 |
| WO2012031133A2 (en) | 2010-09-03 | 2012-03-08 | Bench Research, Inc. | Spray-drying apparatus and methods of using the same |
| US8815294B2 (en) | 2010-09-03 | 2014-08-26 | Bend Research, Inc. | Pharmaceutical compositions of dextran polymer derivatives and a carrier material |
| EP2611529B1 (de) | 2010-09-03 | 2019-01-23 | Bend Research, Inc. | Sprühtrocknungsverfahren |
| WO2012040502A1 (en) | 2010-09-24 | 2012-03-29 | Bend Research, Inc. | High-temperature spray drying process and apparatus |
| WO2012058210A1 (en) | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA) |
| AU2012236150B2 (en) | 2011-04-01 | 2016-03-31 | Mannkind Corporation | Blister package for pharmaceutical cartridges |
| US9060938B2 (en) | 2011-05-10 | 2015-06-23 | Bend Research, Inc. | Pharmaceutical compositions of active agents and cationic dextran polymer derivatives |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| CA2754237A1 (en) | 2011-05-27 | 2012-11-27 | The Regents Of The University Of California | Cyanoquinoline compounds having activity in correcting mutant-cftr processing and increasing ion transport and uses thereof |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| AR087693A1 (es) | 2011-08-29 | 2014-04-09 | Sanofi Aventis Deutschland | Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2 |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| BR112014009686A2 (pt) | 2011-10-24 | 2018-08-07 | Mannkind Corp | composição analgésica inalável, pó seco e método para tratar dor |
| RU2615076C2 (ru) | 2011-12-16 | 2017-04-03 | Новартис Аг | Устройство аэрозолизации для независимой от профиля вдоха доставки лекарственного средства |
| KR20140108516A (ko) | 2011-12-30 | 2014-09-11 | 그리폴스, 에스.에이. | 폐 악화의 발현 또는 진행을 지연시키기 위한 알파1-프로테이나제 억제제 |
| US9770192B2 (en) | 2012-03-19 | 2017-09-26 | Richard C. Fuisz | Method and system to amplify and measure breath analytes |
| CA2865504A1 (en) | 2012-03-23 | 2013-09-26 | Oxigene, Inc. | Compositions and methods for inhibition of cathepsins |
| CN104364260B (zh) | 2012-04-11 | 2017-02-22 | 诺和诺德股份有限公司 | 胰岛素制剂 |
| CN104619369B (zh) | 2012-07-12 | 2018-01-30 | 曼金德公司 | 干粉药物输送系统和方法 |
| US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
| US20140179597A1 (en) * | 2012-11-16 | 2014-06-26 | Steven Lehrer | Method for the treatment and prevention of Alzheimer's disease and central nervous system dysfunction |
| AU2014228415B2 (en) | 2013-03-15 | 2018-08-09 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
| UA117480C2 (uk) | 2013-04-03 | 2018-08-10 | Санофі | Лікування цукрового діабету за допомогою складу інсуліну тривалої дії |
| MX375448B (es) * | 2013-07-18 | 2025-03-06 | Mannkind Corp | Composiciones farmacéuticas en polvo seco estables al calor y métodos. |
| US10850289B2 (en) * | 2013-07-22 | 2020-12-01 | Inhalation Sciences Sweden Ab | Apparatus and method for generating an aerosol |
| US11446127B2 (en) | 2013-08-05 | 2022-09-20 | Mannkind Corporation | Insufflation apparatus and methods |
| JP6499184B2 (ja) | 2013-10-07 | 2019-04-10 | ノヴォ ノルディスク アー／エス | インスリン類似体の新規な誘導体 |
| NZ631007A (en) | 2014-03-07 | 2015-10-30 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| CN106794156B (zh) * | 2014-07-08 | 2021-03-09 | 美药星制药股份有限公司 | 微粒化胰岛素、微粒化胰岛素类似物及其制备方法 |
| WO2016044839A2 (en) | 2014-09-19 | 2016-03-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| EP4112076A1 (de) | 2014-10-10 | 2023-01-04 | The Regents of The University of Michigan | Nanoemulsionszusammensetzungen zur prävention, unterdrückung oder eliminierung von allergischen und entzündlichen erkrankungen |
| WO2016067132A1 (en) | 2014-10-31 | 2016-05-06 | Bend Research Inc. | Process for forming active domains dispersed in a matrix |
| EP3229828B1 (de) | 2014-12-12 | 2023-04-05 | Sanofi-Aventis Deutschland GmbH | Insulin-glargin/lixisenatid-fixierte verhältnisformulierung |
| BR112017018060A2 (pt) | 2015-02-25 | 2018-04-10 | Dance Biopharm Inc | formulação de insulina, dose de unidade, e, método de tratar um indivíduo com diabetes melito. |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| US10322168B2 (en) | 2016-01-07 | 2019-06-18 | Amphastar Pharmaceuticals, Inc. | High-purity inhalable particles of insulin and insulin analogues, and high-efficiency methods of manufacturing the same |
| CN109069495A (zh) | 2016-02-01 | 2018-12-21 | 英凯达治疗公司 | 电子监测联合吸入药理学疗法管理包括心房颤动在内的心律失常 |
| CA3024618A1 (en) | 2016-05-27 | 2017-11-30 | Alexion Pharmaceuticals, Inc. | Methods for treatment of refractory generalized myasthenia gravis |
| US11826422B2 (en) | 2016-11-09 | 2023-11-28 | Board Of Regents, The University Of Texas System | Methods and compositions for adaptive immune modulation |
| CA3047098A1 (en) | 2016-12-16 | 2018-06-21 | Jia Zhou | Inhibitors of bromodomain-containing protein 4 (brd4) |
| PE20210857A1 (es) | 2016-12-16 | 2021-05-18 | Novo Nordisk As | Composiciones farmaceuticas que contienen insulina |
| AU2018266199A1 (en) | 2017-05-10 | 2019-11-07 | Incarda Therapeutics, Inc. | Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration |
| EP3638312B1 (de) * | 2017-06-12 | 2024-02-21 | Elgan Pharma Ltd. | Insulinhaltiges multipartikelgranulat |
| DK3658184T5 (da) | 2017-07-27 | 2024-08-26 | Alexion Pharma Inc | Højkoncentrerede anti-c5-antistofformuleringer |
| CN118512588A (zh) | 2017-10-26 | 2024-08-20 | 亚力兄制药公司 | 用于治疗阵发性夜间性血红蛋白尿(pnh)和非典型溶血性尿毒症综合征(ahus)的抗c5抗体的剂量和施用 |
| WO2019126536A1 (en) | 2017-12-20 | 2019-06-27 | Alexion Pharmaceuticals Inc. | Humanized anti-cd200 antibodies and uses thereof |
| US10744087B2 (en) | 2018-03-22 | 2020-08-18 | Incarda Therapeutics, Inc. | Method to slow ventricular rate |
| EP3802593B1 (de) | 2018-05-31 | 2024-09-11 | Alexion Pharmaceuticals, Inc. | Dosierung und verabreichung von anti-c5 antikörpern zur behandlung von paroxysalen nocturalen hämoglobin-uria (pnh) in pädiatrischen patienten |
| EP3802603A1 (de) | 2018-06-04 | 2021-04-14 | Alexion Pharmaceuticals, Inc. | Dosierung und verabreichung von anti-c5-antikörpern zur behandlung des atypischen hämolytisch-urämischen syndroms (ahus) bei kindern |
| US11389433B2 (en) | 2018-06-18 | 2022-07-19 | Board Of Regents, The University Of Texas System | BRD4 inhibitor treatment of IgE-mediated diseases |
| US12312394B2 (en) | 2018-06-28 | 2025-05-27 | Alexion Pharmaceuticals, Inc. | Methods of producing anti-C5 antibodies |
| EP3873602B1 (de) | 2018-10-30 | 2023-12-06 | Alexion Pharmaceuticals, Inc. | Subcutane dosierung und ztudienung von anti-c5-antikörpern zur behandlung der paroxysmalen nicht-turnalen hämoglobinurie (pnh) |
| WO2020092845A1 (en) | 2018-11-01 | 2020-05-07 | Rigel Pharmaceuticals, Inc. | Method and composition embodiments for treating acute myeloid leukemia |
| WO2020123336A1 (en) | 2018-12-13 | 2020-06-18 | Qrumpharma Inc. | Compositions of bedaquiline, combinations comprising them, processes for their preparation, uses and methods of treatment comprising them |
| WO2020239696A1 (en) | 2019-05-24 | 2020-12-03 | Stichting Katholieke Universiteit | Improved administration of glycylcyclines by inhalation |
| WO2020243612A1 (en) | 2019-05-29 | 2020-12-03 | Rigel Pharmaceuticals, Inc. | Method of preventing and treating thrombosis |
| AU2020323594B2 (en) | 2019-08-01 | 2022-02-03 | Incarda Therapeutics, Inc. | Antiarrhythmic formulation |
| US11007185B2 (en) | 2019-08-01 | 2021-05-18 | Incarda Therapeutics, Inc. | Antiarrhythmic formulation |
| MX2022001596A (es) | 2019-08-08 | 2022-03-11 | Rigel Pharmaceuticals Inc | Compuestos y metodos para tratar sindrome de liberacion de citocinas. |
| EP4013420B1 (de) | 2019-08-14 | 2023-11-01 | Rigel Pharmaceuticals, Inc. | Verfahren zur blockierung oder linderung des zytokinfreisetzungssyndroms |
| TW202228792A (zh) | 2020-10-09 | 2022-08-01 | 殷漢生技股份有限公司 | 吸入用奈米載體製劑 |
| CN114712336B (zh) * | 2020-12-22 | 2023-11-07 | 黄嘉若 | 一种用于肺部给药的水性气溶胶、制备方法和用途 |
| US20240299353A1 (en) | 2021-03-12 | 2024-09-12 | Alvarius Pharmaceuticals Ltd. | Compositions and methods for treating addictions comprising 5-meo-dmt |
| WO2022219625A1 (en) * | 2021-04-11 | 2022-10-20 | Elgan Pharma Ltd | Insulin formulations and methods of using same in preterm infants |
| IL315677A (en) | 2022-03-23 | 2024-11-01 | Rigel Pharmaceuticals Inc | Pyrimid-2-yl-pyrazole compounds as irak inhibitors |
Family Cites Families (403)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US558085A (en) * | 1896-04-14 | And william c | ||
| US979993A (en) | 1910-03-24 | 1910-12-27 | Joseph Francis O'byrne | Projectile. |
| US1855591A (en) | 1926-02-03 | 1932-04-26 | Wallerstein Co Inc | Invertase preparation and method of making the same |
| US2598525A (en) | 1950-04-08 | 1952-05-27 | E & J Mfg Co | Automatic positive pressure breathing machine |
| DE1080265B (de) | 1958-09-30 | 1960-04-21 | Bayer Ag | Verfahren zur Herstellung von oral anzuwendenden Arzneimittel-zubereitungen mit protrahierter Wirkung aus Wirkstoffen und Schutzstoffen |
| DE1812574U (de) | 1960-04-05 | 1960-06-02 | Felix Duerst | Betonmischer. |
| NL113394C (de) | 1960-04-07 | |||
| US3300474A (en) | 1964-02-12 | 1967-01-24 | Pharmacia Ab | Sucrose ether copolymerizates |
| US3362405A (en) | 1964-04-06 | 1968-01-09 | Hamilton O. Hazel | Method and apparatus for admixing gas with solid particles |
| BR6570825D0 (pt) | 1964-07-04 | 1973-08-16 | Shiryo Kogyo Co Inc Nippon | Processo para produzir granulos cristalizados a partir de solucoes de acucares e outros cristaloides |
| GB1122284A (en) | 1965-03-19 | 1968-08-07 | Fisons Pharmaceuticals Ltd | Inhalation device |
| US3314803A (en) | 1966-01-26 | 1967-04-18 | Gen Foods Corp | Mannitol fixed flavor and method of making same |
| US3674901A (en) | 1966-07-26 | 1972-07-04 | Nat Patent Dev Corp | Surgical sutures |
| US3425600A (en) | 1966-08-11 | 1969-02-04 | Abplanalp Robert H | Pressurized powder dispensing device |
| GB1182779A (en) | 1966-09-17 | 1970-03-04 | Fisons Pharmaceuticals Ltd | Inhalation Device |
| US3554768A (en) | 1967-08-01 | 1971-01-12 | Gen Foods Corp | Carbohydrate fixed acetaldehyde |
| US3620776A (en) | 1968-06-28 | 1971-11-16 | Nestle Sa | Spray drying process |
| US3619294A (en) | 1968-07-15 | 1971-11-09 | Penick & Ford Ltd | Method of combining crystalline sugar with impregnating agents and products produced thereby |
| US3555717A (en) | 1968-10-24 | 1971-01-19 | Victor Comptometer Corp | Artificial fishing lure |
| DE1812574A1 (de) | 1968-12-04 | 1970-06-11 | Riedel De Haen Ag | Verfahren zur Herstellung biozider Granulate |
| US3632357A (en) | 1969-07-29 | 1972-01-04 | Standard Brands Inc | Method of producing hard candy |
| US3655442A (en) | 1969-08-27 | 1972-04-11 | California & Hawaiian Sugar | Method of making sugar and sugar products |
| US3666496A (en) | 1969-09-03 | 1972-05-30 | Firmenich Inc | Water soluble,powdered,terpene-containing flavors |
| US3937668A (en) * | 1970-07-15 | 1976-02-10 | Ilse Zolle | Method for incorporating substances into protein microspheres |
| US3764716A (en) | 1970-11-16 | 1973-10-09 | American Potato Co | Preparation of dehydrated mashed potatoes |
| US3745682A (en) | 1971-09-28 | 1973-07-17 | Pneu Dart Inc | Gun for propelling a drug or medicine projectile |
| DE2246013A1 (de) | 1972-09-20 | 1974-03-28 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von poroesen tabletten |
| US4069819A (en) | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
| US3971852A (en) | 1973-06-12 | 1976-07-27 | Polak's Frutal Works, Inc. | Process of encapsulating an oil and product produced thereby |
| GB1479283A (en) | 1973-07-23 | 1977-07-13 | Bespak Industries Ltd | Inhaler for powdered medicament |
| FR2238476A1 (en) | 1973-07-23 | 1975-02-21 | Aries Robert | Double esters of zeranol and natural hormones - and their implants for livestock, have protein anabolism props |
| FR2257351A1 (en) | 1974-01-11 | 1975-08-08 | Obert Jean Claude | Aerosol device for solid vaccines - feed and breaker screws deliver material sideways into blower chamber |
| IT1016489B (it) | 1974-03-18 | 1977-05-30 | Isf Spa | Inalatore |
| DE2415159A1 (de) | 1974-03-29 | 1975-10-09 | Hoechst Ag | Alkalialkansulfonathaltige spruehprodukte und verfahren zu ihrer herstellung |
| US3948263A (en) | 1974-08-14 | 1976-04-06 | Minnesota Mining And Manufacturing Company | Ballistic animal implant |
| JPS5134879A (en) | 1974-09-19 | 1976-03-24 | Eisai Co Ltd | Bishochukuryushinoseizoho |
| US3964483A (en) | 1975-01-13 | 1976-06-22 | Syntex Puerto Rico, Inc. | Inhalation device |
| US4005711A (en) | 1975-01-13 | 1977-02-01 | Syntex Puerto Rico, Inc. | Inhalation device |
| FR2299011A1 (fr) | 1975-01-29 | 1976-08-27 | Obert Jean Claude | Generateur d'aerosols de part |
| US4102999A (en) | 1975-02-10 | 1978-07-25 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Process for producing stable macromomycin powder |
| US3991304A (en) | 1975-05-19 | 1976-11-09 | Hillsman Dean | Respiratory biofeedback and performance evaluation system |
| US4153689A (en) | 1975-06-13 | 1979-05-08 | Takeda Chemical Industries, Ltd. | Stable insulin preparation for nasal administration |
| GB1527605A (en) | 1975-08-20 | 1978-10-04 | Takeda Chemical Industries Ltd | Insulin preparation for intranasal administration |
| US3994421A (en) | 1975-09-29 | 1976-11-30 | American Cyanamid Company | Unitary therapeutic aerosol dispenser |
| US4109019A (en) | 1975-11-18 | 1978-08-22 | William Percy Moore | Process for improved ruminant feed supplements |
| JPS5733509Y2 (de) | 1976-04-19 | 1982-07-23 | ||
| GB1533012A (en) | 1976-12-20 | 1978-11-22 | Lloyd C | Confectionery machines |
| NL7704348A (nl) | 1977-04-21 | 1978-10-24 | Philips Nv | Werkwijze voor het bereiden van een geattenueer- de transmissible gastroenteritis(tge)-virusstam voor toepassing in levende vaccins. |
| US4180593A (en) | 1977-04-29 | 1979-12-25 | Cohan Allan N | Process for producing round spherical free flowing blown bead food products of controlled bulk density |
| US4127502A (en) | 1977-06-10 | 1978-11-28 | Eastman Kodak Company | Stabilizers for reconstituted, lyophilized samples |
| US4211769A (en) * | 1977-08-24 | 1980-07-08 | Takeda Chemical Industries, Ltd. | Preparations for vaginal administration |
| DE2748132A1 (de) | 1977-10-27 | 1979-05-03 | Behringwerke Ag | Stabilisator fuer polysaccharid |
| NL7712041A (en) | 1977-11-01 | 1979-05-03 | Handelmaatschappij Voorheen Be | Suction equipment for powdery material - incorporates ejector type suction pump and cyclone type separator |
| US4244949A (en) | 1978-04-06 | 1981-01-13 | The Population Council, Inc. | Manufacture of long term contraceptive implant |
| EP0005585B1 (de) | 1978-05-03 | 1981-08-12 | FISONS plc | Inhalationsvorrichtung |
| US4158544A (en) | 1978-07-17 | 1979-06-19 | Beckman Instruments, Inc. | Process for preparing a biological composition for use as a reference control in diagnostic analysis |
| US4253468A (en) | 1978-08-14 | 1981-03-03 | Steven Lehmbeck | Nebulizer attachment |
| US4588744A (en) | 1978-09-19 | 1986-05-13 | Mchugh John E | Method of forming an aqueous solution of 3-3-Bis(p-hydroxyphenyl)-phthalide |
| US4503035B1 (en) | 1978-11-24 | 1996-03-19 | Hoffmann La Roche | Protein purification process and product |
| GB2037735B (en) | 1978-12-21 | 1983-11-09 | Standard Telephones Cables Ltd | Glass composition |
| SU1003926A1 (ru) | 1979-01-24 | 1983-03-15 | Всесоюзный Научно-Исследовательский И Конструкторский Институт Автогенного Машиностроения | Порошковый питатель |
| DE3061384D1 (en) | 1979-02-21 | 1983-01-27 | Ici Plc | A process for the extraction of poly-3-hydroxy-butyric acid from microbial cells |
| IT1116047B (it) | 1979-04-27 | 1986-02-10 | Sigma Tau Ind Farmaceuti | Dispositivo per la rapida inalazione di farmaci in polvere da parte di persone sofferenti di asma |
| JPS6034925B2 (ja) | 1979-07-31 | 1985-08-12 | 帝人株式会社 | 持続性鼻腔用製剤およびその製造法 |
| JPS57500862A (de) | 1979-10-30 | 1982-05-20 | ||
| US4294624A (en) | 1980-03-14 | 1981-10-13 | Veltman Preston Leonard | Drying co-mingled carbohydrate solution and recycled product by dielectric heating |
| JPS56138111U (de) | 1980-03-21 | 1981-10-19 | ||
| US4452239A (en) | 1980-03-25 | 1984-06-05 | Hilal Malem | Medical nebulizing apparatus |
| JPS56138110A (en) * | 1980-03-28 | 1981-10-28 | Teijin Ltd | Suppository containing citric acid or salt thereof |
| EP0111216A3 (de) | 1980-03-31 | 1985-01-16 | Takeda Chemical Industries, Ltd. | Enzymimmunologisches Testverfahren, Peptid-Enzym-Konjugat, dessen Lyophilisat, Antikörper und Reagenzsatz dafür |
| US4423079A (en) | 1980-07-14 | 1983-12-27 | Leo Kline | Growth promoting compositions for Lactobacillus sanfrancisco and method of preparation |
| US4326524A (en) | 1980-09-30 | 1982-04-27 | Minnesota Mining And Manufacturing Company | Solid dose ballistic projectile |
| US4327076A (en) | 1980-11-17 | 1982-04-27 | Life Savers, Inc. | Compressed chewable antacid tablet and method for forming same |
| US4371557A (en) | 1981-01-21 | 1983-02-01 | General Foods Corporation | Maintenance of protein quality in foods containing reducing sugars |
| US5366734A (en) | 1981-02-16 | 1994-11-22 | Zeneca Limited | Continuous release pharmaceutical compositions |
| US4327077A (en) | 1981-05-29 | 1982-04-27 | Life Savers, Inc. | Compressed chewable antacid tablet and method for forming same |
| US4484577A (en) | 1981-07-23 | 1984-11-27 | Key Pharmaceuticals, Inc. | Drug delivery method and inhalation device therefor |
| GB2105189B (en) | 1981-07-24 | 1985-03-20 | Fisons Plc | Inhalation drugs |
| EP0072046B1 (de) | 1981-07-24 | 1986-01-15 | FISONS plc | Inhalierbare Arzneimittel, Verfahren zu deren Herstellung und pharmazeutische Formulierungen diese enthaltend |
| US5260306A (en) | 1981-07-24 | 1993-11-09 | Fisons Plc | Inhalation pharmaceuticals |
| KR890000664B1 (ko) | 1981-10-19 | 1989-03-22 | 바리 안소니 뉴우샘 | 미분된 베클로메타손 디프로피오네이트 일수화물의 제조방법 |
| DE3141498A1 (de) | 1981-10-20 | 1983-04-28 | Bayer Ag, 5090 Leverkusen | Arzneimittel enthaltend kallikrein und verfahren zu seiner herstellung |
| NL193099C (nl) | 1981-10-30 | 1998-11-03 | Novo Industri As | Gestabiliseerde insuline-oplossing. |
| SE8204244L (sv) * | 1982-07-09 | 1984-01-10 | Ulf Schroder | Kristalliserad kolhydratsmatris for biologiskt aktiva substanser |
| US4713249A (en) | 1981-11-12 | 1987-12-15 | Schroeder Ulf | Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use thereof |
| JPS58154548A (ja) | 1982-03-09 | 1983-09-14 | Nippon Shinyaku Co Ltd | アズレン誘導体の安定化方法 |
| JPS58164683A (ja) | 1982-03-25 | 1983-09-29 | Takeda Chem Ind Ltd | 安定化された固体組成物 |
| US4659696A (en) * | 1982-04-30 | 1987-04-21 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition and its nasal or vaginal use |
| US4823784A (en) | 1982-04-30 | 1989-04-25 | Cadema Medical Products, Inc. | Aerosol inhalation apparatus |
| US4599311A (en) | 1982-08-13 | 1986-07-08 | Kawasaki Glenn H | Glycolytic promotersfor regulated protein expression: protease inhibitor |
| US4457916A (en) | 1982-08-31 | 1984-07-03 | Asahi Kasei Kogyo Kabushiki Kaisha | Method for stabilizing Tumor Necrosis Factor and a stable aqueous solution or powder containing the same |
| US4591552A (en) | 1982-09-29 | 1986-05-27 | New York Blood Center, Inc. | Detection of hepatitis B surface antigen (or antibody to same) with labeled synthetic peptide |
| US4778054A (en) | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
| GB2129691B (en) | 1982-10-08 | 1987-08-05 | Glaxo Group Ltd | Devices for administering medicaments to patients |
| US4559298A (en) | 1982-11-23 | 1985-12-17 | American National Red Cross | Cryopreservation of biological materials in a non-frozen or vitreous state |
| JPS5995885U (ja) | 1982-12-17 | 1984-06-29 | 日本擬餌鈎工業株式会社 | うき |
| ES8403520A1 (es) | 1983-02-08 | 1984-03-16 | Gandariasbeitia Aguirreche Man | Procedimiento continuo para la produccion de enzimas proteoliticas y aminoliticas a partir de microorganismos vegetales. |
| JPS59163313A (ja) | 1983-03-09 | 1984-09-14 | Teijin Ltd | 経鼻投与用ペプチドホルモン類組成物 |
| US4883762A (en) | 1983-06-06 | 1989-11-28 | Ciba Corning Diagnostics Corp. | Stabilized isoenzyme control products |
| JPS6035263A (ja) | 1983-08-05 | 1985-02-23 | Wako Pure Chem Ind Ltd | 不溶性担体に固定化された免疫活性物質の安定化法及び該物質を構成単位として含む生理活性物質測定用試薬 |
| US4865871A (en) | 1983-08-23 | 1989-09-12 | Board Of Regents The University Of Texas System | Method for cryopreparing biological tissue |
| GB8323094D0 (en) | 1983-08-26 | 1983-09-28 | Franks F | Preservation of cells |
| US4649911A (en) | 1983-09-08 | 1987-03-17 | Baylor College Of Medicine | Small particle aerosol generator for treatment of respiratory disease including the lungs |
| EP0139286B1 (de) | 1983-10-14 | 1991-08-21 | Sumitomo Pharmaceuticals Company, Limited | Verlängerte Präparate mit verzögerter Abgabe |
| DE3345722A1 (de) | 1983-12-17 | 1985-06-27 | Boehringer Ingelheim KG, 6507 Ingelheim | Inhalator |
| US4534343A (en) | 1984-01-27 | 1985-08-13 | Trutek Research, Inc. | Metered dose inhaler |
| GB2187191B (en) | 1984-01-30 | 1989-11-01 | Quadrant Bioresources Ltd | Protection of proteins and the like |
| US4820534A (en) | 1984-03-19 | 1989-04-11 | General Foods Corporation | Fixation of volatiles in extruded glass substrates |
| US4758583A (en) | 1984-03-19 | 1988-07-19 | The Rockefeller University | Method and agents for inhibiting protein aging |
| US4927763A (en) | 1984-03-21 | 1990-05-22 | Chr. Hansen's Laboratory, Inc. | Stabilization of dried bacteria extended in particulate carriers |
| DD238305A3 (de) | 1984-04-23 | 1986-08-20 | Maisan Werke Barby Veb | Verfahren zur herstellung von d-glucose und staerkehydrolysaten |
| US4617272A (en) | 1984-04-25 | 1986-10-14 | Economics Laboratory, Inc. | Enzyme drying process |
| JPS60244288A (ja) | 1984-05-18 | 1985-12-04 | Ookura Seiyaku Kk | 安定なセラペプタ−ゼ粉末の製造方法 |
| US4956295A (en) | 1984-05-21 | 1990-09-11 | Chr. Hansen's Laboratory, Inc. | Stabilization of dried bacteria extended in particulate carriers |
| US4620847A (en) | 1984-06-01 | 1986-11-04 | Vsesojuzny Nauchno-Issledovatelsky Institut Meditsinskikh Polimerov | Device for administering powdered substances |
| JPS60258195A (ja) | 1984-06-05 | 1985-12-20 | Ss Pharmaceut Co Ltd | α．α―トレハロース脂肪酸ジエステル誘導体 |
| JPS60258125A (ja) | 1984-06-06 | 1985-12-20 | Hayashibara Biochem Lab Inc | 蛋白性生理活性物質を含有する水溶性乾燥物 |
| US4721709A (en) | 1984-07-26 | 1988-01-26 | Pyare Seth | Novel pharmaceutical compositions containing hydrophobic practically water-insoluble drugs adsorbed on pharmaceutical excipients as carrier; process for their preparation and the use of said compositions |
| US4624251A (en) | 1984-09-13 | 1986-11-25 | Riker Laboratories, Inc. | Apparatus for administering a nebulized substance |
| NZ209900A (en) | 1984-10-16 | 1989-08-29 | Univ Auckland | Automatic inhaler |
| IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| DE3445010A1 (de) | 1984-12-10 | 1986-06-19 | Boehringer Mannheim Gmbh | Kontroll- bzw. eichserum fuer die lipid-diagnostik |
| FR2575678B1 (fr) | 1985-01-04 | 1988-06-03 | Saint Gobain Vitrage | Ejecteur pneumatique de poudre |
| GB8500698D0 (en) | 1985-01-11 | 1985-02-13 | Unilever Plc | Preparation of reagents |
| US4857319A (en) | 1985-01-11 | 1989-08-15 | The Regents Of The University Of California | Method for preserving liposomes |
| FR2575923B1 (fr) | 1985-01-15 | 1988-02-05 | Jouveinal Sa | Composition laxative a base de lactulose, et son procede de fabrication |
| US4830858A (en) | 1985-02-11 | 1989-05-16 | E. R. Squibb & Sons, Inc. | Spray-drying method for preparing liposomes and products produced thereby |
| US4942544A (en) | 1985-02-19 | 1990-07-17 | Kenneth B. McIntosh | Medication clock |
| JPS61194034A (ja) | 1985-02-25 | 1986-08-28 | Teijin Ltd | 経鼻投与用粉末状組成物 |
| US4946828A (en) * | 1985-03-12 | 1990-08-07 | Novo Nordisk A/S | Novel insulin peptides |
| GB8508173D0 (en) | 1985-03-28 | 1985-05-01 | Standard Telephones Cables Ltd | Controlled delivery device |
| FR2580087B1 (de) | 1985-04-03 | 1988-12-02 | Hispano Suiza Sa | |
| IL78342A (en) | 1985-04-04 | 1991-06-10 | Gen Hospital Corp | Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof |
| JPS63500175A (ja) | 1985-05-22 | 1988-01-21 | リポソ−ム テクノロジ−，インコ−ポレイテツド | リポソ−ム吸入法および吸入システム |
| JPS61293201A (ja) | 1985-06-22 | 1986-12-24 | Yokohama Rubber Co Ltd:The | 天然ゴムラテツクス漿液から得られる粉末状非ゴム成分 |
| JPH0779694B2 (ja) | 1985-07-09 | 1995-08-30 | カドラント バイオリソ−シズ リミテツド | 蛋白質および同類品の保護 |
| US4847079A (en) | 1985-07-29 | 1989-07-11 | Schering Corporation | Biologically stable interferon compositions comprising thimerosal |
| AU591152B2 (en) | 1985-07-30 | 1989-11-30 | Glaxo Group Limited | Devices for administering medicaments to patients |
| NZ217645A (en) | 1985-09-25 | 1991-11-26 | Oncogen | Recombinant viruses expressing lav/htlv-iii related epitopes and vaccine formulations |
| US4719762A (en) | 1985-11-21 | 1988-01-19 | Toshiba Heating Appliances Co., Ltd. | Stored ice detecting device in ice making apparatus |
| US4680027A (en) | 1985-12-12 | 1987-07-14 | Injet Medical Products, Inc. | Needleless hypodermic injection device |
| JPS62174094A (ja) | 1985-12-16 | 1987-07-30 | Ss Pharmaceut Co Ltd | α．α―トレハロース誘導体 |
| JPH0710344B2 (ja) | 1985-12-26 | 1995-02-08 | 株式会社林原生物化学研究所 | 無水グリコシルフルクト−スによる含水物の脱水方法 |
| GB8604983D0 (en) | 1986-02-28 | 1986-04-09 | Biocompatibles Ltd | Protein preservation |
| SE453566B (sv) | 1986-03-07 | 1988-02-15 | Draco Ab | Anordning vid pulverinhalatorer |
| US4897353A (en) | 1986-03-13 | 1990-01-30 | University Of Southwestern Louisiana | Cryogenic protection of phosphofructokinase using amino acids and zinc ions |
| US4806343A (en) * | 1986-03-13 | 1989-02-21 | University Of Southwestern Louisiana | Cryogenic protectant for proteins |
| JPS62228272A (ja) | 1986-03-27 | 1987-10-07 | Amano Pharmaceut Co Ltd | 安定なペルオキシダ−ゼ製剤 |
| US5017372A (en) * | 1986-04-14 | 1991-05-21 | Medicis Corporation | Method of producing antibody-fortified dry whey |
| IL82245A (en) | 1986-04-25 | 1990-07-26 | Basf Ag | Preparation of spray-dried granules of active ingredients |
| JPH0655678B2 (ja) | 1986-04-26 | 1994-07-27 | 不二製油株式会社 | オリゴペプチド輸液 |
| US4739754A (en) | 1986-05-06 | 1988-04-26 | Shaner William T | Suction resistant inhalator |
| JPS62267238A (ja) | 1986-05-15 | 1987-11-19 | R P Shiila- Kk | インシユリン坐剤の製法 |
| US5160745A (en) | 1986-05-16 | 1992-11-03 | The University Of Kentucky Research Foundation | Biodegradable microspheres as a carrier for macromolecules |
| US4762857A (en) | 1986-05-30 | 1988-08-09 | E. I. Du Pont De Nemours And Company | Trehalose as stabilizer and tableting excipient |
| US4790305A (en) | 1986-06-23 | 1988-12-13 | The Johns Hopkins University | Medication delivery system |
| US4926852B1 (en) | 1986-06-23 | 1995-05-23 | Univ Johns Hopkins | Medication delivery system phase one |
| US4832686A (en) | 1986-06-24 | 1989-05-23 | Anderson Mark E | Method for administering interleukin-2 |
| US5042975A (en) * | 1986-07-25 | 1991-08-27 | Rutgers, The State University Of New Jersey | Iontotherapeutic device and process and iontotherapeutic unit dose |
| NZ221411A (en) | 1986-08-11 | 1989-10-27 | Innovata Biomed Ltd | Pharmaceutical compositions containing microcapsules and a surfactant |
| ATE76311T1 (de) * | 1986-08-19 | 1992-06-15 | Genentech Inc | Einrichtung und dispersion zum intrapulmonalen eingeben von polypeptidwuchsstoffen und zytokinen. |
| US4729754A (en) * | 1986-10-15 | 1988-03-08 | Rexnord Inc. | Sealed bushing joint for chain |
| DE3636669C2 (de) | 1986-10-28 | 2001-08-16 | Siemens Ag | Anordnung zur Zufuhr von Aerosol zu den Luftwegen und/oder Lungen eines Patienten |
| US5049388A (en) | 1986-11-06 | 1991-09-17 | Research Development Foundation | Small particle aerosol liposome and liposome-drug combinations for medical use |
| US4833125A (en) | 1986-12-05 | 1989-05-23 | The General Hospital Corporation | Method of increasing bone mass |
| NZ222907A (en) | 1986-12-16 | 1990-08-28 | Novo Industri As | Preparation for intranasal administration containing a phospholipid absorption enhancing system |
| US4906463A (en) | 1986-12-22 | 1990-03-06 | Cygnus Research Corporation | Transdermal drug-delivery composition |
| US5093316A (en) | 1986-12-24 | 1992-03-03 | John Lezdey | Treatment of inflammation |
| JPS63186799A (ja) | 1987-01-29 | 1988-08-02 | 不二製油株式会社 | 油脂粉末の製造方法 |
| US5089181A (en) | 1987-02-24 | 1992-02-18 | Vestar, Inc. | Method of dehydrating vesicle preparations for long term storage |
| FR2611501B1 (fr) | 1987-03-04 | 1991-12-06 | Corbiere Jerome | Nouvelles compositions pharmaceutiques pour la voie buccale a base d'acetylsalielylate de lysine et leur procede d'obtention |
| CA1337268C (en) | 1987-03-09 | 1995-10-10 | Edmund P. Bass | Canine distemper virus vaccine |
| US4855326A (en) | 1987-04-20 | 1989-08-08 | Fuisz Pharmaceutical Ltd. | Rapidly dissoluble medicinal dosage unit and method of manufacture |
| US5387431A (en) | 1991-10-25 | 1995-02-07 | Fuisz Technologies Ltd. | Saccharide-based matrix |
| JP2656944B2 (ja) | 1987-04-30 | 1997-09-24 | クーパー ラボラトリーズ | タンパク質性治療剤のエアロゾール化 |
| US4861627A (en) | 1987-05-01 | 1989-08-29 | Massachusetts Institute Of Technology | Preparation of multiwall polymeric microcapsules |
| GB8712176D0 (en) | 1987-05-22 | 1987-06-24 | Cosmas Damian Ltd | Drug delivery system |
| US4876241A (en) | 1987-05-22 | 1989-10-24 | Armour Pharmaceutical Company | Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US5571499A (en) | 1987-06-24 | 1996-11-05 | Autoimmune, Inc. | Treatment of autoimmune diseases by aerosol administration of autoantigens |
| GB8715238D0 (en) | 1987-06-29 | 1987-08-05 | Quadrant Bioresources Ltd | Food process |
| US5240712A (en) | 1987-07-17 | 1993-08-31 | The Boots Company Plc | Therapeutic agents |
| US5059587A (en) * | 1987-08-03 | 1991-10-22 | Toyo Jozo Company, Ltd. | Physiologically active peptide composition for nasal administration |
| US5139016A (en) | 1987-08-07 | 1992-08-18 | Sorin Biomedica S.P.A. | Process and device for aerosol generation for pulmonary ventilation scintigraphy |
| IT1222509B (it) | 1987-08-17 | 1990-09-05 | Miat Spa | Insufflatore per la somministrazione di farmaci sotto forma di polvere predosata in opercoli |
| CA1327161C (en) | 1987-09-01 | 1994-02-22 | Mitsugu Kobayashi | Lyophilized pharmaceutical composition of neocarzinostatin derivative |
| GB8723846D0 (en) * | 1987-10-10 | 1987-11-11 | Danbiosyst Ltd | Bioadhesive microsphere drug delivery system |
| DE3738228A1 (de) | 1987-11-11 | 1989-05-24 | Hoechst Ag | Verfahren zur herstellung von bioabbaubaren mikrokapseln wasserloeslicher peptide und proteine sowie nach diesem verfahren erhaltene mikrokapseln |
| US5081228A (en) | 1988-02-25 | 1992-01-14 | Immunex Corporation | Interleukin-1 receptors |
| US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| WO1989004838A1 (en) | 1987-11-25 | 1989-06-01 | Immunex Corporation | Interleukin-1 receptors |
| EP0325936A3 (de) | 1988-01-16 | 1990-01-17 | Ono Pharmaceutical Co., Ltd. | Aminoguanidin-Derivate und für die Maillardreaktion inhibitorische Substanzen, die sie als aktive Inhaltsstoffe enthalten |
| GB8801338D0 (en) | 1988-01-21 | 1988-02-17 | Quadrant Bioresources Ltd | Preservation of viruses |
| GB8802174D0 (en) | 1988-02-01 | 1988-03-02 | Quadrant Bioresources Ltd | Method of drying macromolecules |
| US5096885A (en) | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
| DE3815221C2 (de) | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
| US5045446A (en) | 1988-08-26 | 1991-09-03 | Cryopharm Corporation | Lyophilization of cells |
| IT1217890B (it) | 1988-06-22 | 1990-03-30 | Chiesi Farma Spa | Dispositivo per l'inalazione di aerosol dosati |
| US4919962A (en) | 1988-08-12 | 1990-04-24 | General Foods Corporation | Coffee flakes and process |
| US5049664A (en) | 1988-08-26 | 1991-09-17 | Sawai Pharmaceutical Co., Ltd. | Trehalose derivatives |
| US5342625A (en) | 1988-09-16 | 1994-08-30 | Sandoz Ltd. | Pharmaceutical compositions comprising cyclosporins |
| EP0360340A1 (de) | 1988-09-19 | 1990-03-28 | Akzo N.V. | Peptidenthaltende Zubereitung zur intranasalen Verabreichung |
| EP0363060B1 (de) | 1988-10-04 | 1994-04-27 | The Johns Hopkins University | Inhalationsgerät für Aerosolen |
| US4984158A (en) | 1988-10-14 | 1991-01-08 | Hillsman Dean | Metered dose inhaler biofeedback training and evaluation system |
| JPH02104531A (ja) | 1988-10-14 | 1990-04-17 | Toyo Jozo Co Ltd | 経鼻投与用生理活性ペプチド組成物 |
| GB8824897D0 (en) | 1988-10-24 | 1988-11-30 | Ici Plc | Biocatalysts |
| SE8803935L (sv) | 1988-10-31 | 1990-05-01 | Kabivitrum Ab | Laekemedelskomposition |
| GB8826429D0 (en) | 1988-11-11 | 1988-12-14 | Univ Leeds Ind Service Ltd | Enzyme stabilisation systems |
| US4931361A (en) | 1988-11-18 | 1990-06-05 | California Institute Of Technology | Cryoprotective reagents in freeze-drying membranes |
| US5225183A (en) * | 1988-12-06 | 1993-07-06 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
| US5043165A (en) | 1988-12-14 | 1991-08-27 | Liposome Technology, Inc. | Novel liposome composition for sustained release of steroidal drugs |
| US4906476A (en) | 1988-12-14 | 1990-03-06 | Liposome Technology, Inc. | Novel liposome composition for sustained release of steroidal drugs in lungs |
| JPH0284401U (de) | 1988-12-15 | 1990-06-29 | ||
| US5006343A (en) * | 1988-12-29 | 1991-04-09 | Benson Bradley J | Pulmonary administration of pharmaceutically active substances |
| DK479189D0 (da) | 1989-01-06 | 1989-09-28 | Hans Gernot Schenk | Inhalator |
| US5011678A (en) | 1989-02-01 | 1991-04-30 | California Biotechnology Inc. | Composition and method for administration of pharmaceutically active substances |
| GB8903593D0 (en) | 1989-02-16 | 1989-04-05 | Pafra Ltd | Storage of materials |
| IT1228459B (it) | 1989-02-23 | 1991-06-19 | Phidea S R L | Inalatore con svuotamento regolare e completo della capsula. |
| GB8904370D0 (en) | 1989-02-25 | 1989-04-12 | Cosmas Damian Ltd | Liquid delivery compositions |
| SE466684B (sv) | 1989-03-07 | 1992-03-23 | Draco Ab | Anordning vid en inhalator samt foerfarande foer att med anordningen registrera medicinering med inhalator |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| AU5414990A (en) | 1989-04-12 | 1990-11-05 | Aberdeen University | Slow release vitreous systems |
| US5270048A (en) | 1989-04-21 | 1993-12-14 | Borden (Uk) Limited | Controlled delivery devices |
| CA2058764A1 (en) | 1989-04-28 | 1990-10-29 | Peter D. Hodson | Dry powder inhalation device |
| GB8909891D0 (en) | 1989-04-28 | 1989-06-14 | Riker Laboratories Inc | Device |
| ES2062530T3 (es) | 1989-05-01 | 1994-12-16 | Alkermes Inc | Procedimiento para producir particulas pequeñas de moleculas biologicamente activas. |
| ATE111364T1 (de) | 1989-05-31 | 1994-09-15 | Fisons Plc | Medikament und inhalationsvorrichtung dafür. |
| FI84698C (fi) | 1989-06-16 | 1992-01-10 | Huhtamaeki Oy | Anordning foer finfoerdelning av agglomerat av en enkeldos av ett laekemedelpreparat i pulverform. |
| IT1230313B (it) | 1989-07-07 | 1991-10-18 | Somova Spa | Inalatore per medicamenti in capsule. |
| GB8917470D0 (en) | 1989-07-31 | 1989-09-13 | Quadrant Bioresources Ltd | Composition and method |
| DE3927170A1 (de) | 1989-08-17 | 1991-02-21 | Boehringer Ingelheim Kg | Inhalator |
| GB8918879D0 (en) | 1989-08-18 | 1989-09-27 | Danbiosyst Uk | Pharmaceutical compositions |
| US5238920A (en) | 1989-08-22 | 1993-08-24 | Abbott Laboratories | Pulmonary surfactant protein fragments |
| US5240846A (en) | 1989-08-22 | 1993-08-31 | The Regents Of The University Of Michigan | Gene therapy vector for cystic fibrosis |
| US5562608A (en) | 1989-08-28 | 1996-10-08 | Biopulmonics, Inc. | Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation |
| US5013557A (en) | 1989-10-03 | 1991-05-07 | Warner-Lambert Company | Taste masking compositions comprising spray dried microcapsules containing sucralfate and methods for preparing same |
| IT1237118B (it) | 1989-10-27 | 1993-05-18 | Miat Spa | Inalatore multidose per farmaci in polvere. |
| GB2237510B (en) * | 1989-11-04 | 1993-09-15 | Danbiosyst Uk | Small particle drug compositions for nasal administration |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| JPH03161441A (ja) | 1989-11-20 | 1991-07-11 | Senjiyu Seiyaku Kk | メイラード反応阻害剤 |
| JP2854631B2 (ja) | 1989-11-21 | 1999-02-03 | 千寿製薬株式会社 | 糖尿病合併症および老化によって引き起こされる疾患の予防・治療剤 |
| PL166267B1 (pl) | 1989-11-28 | 1995-04-28 | Syntex Inc | Sposób wytwarzania nowych zwiazków trójpierscieniowych PL PL PL PL |
| US5376386A (en) | 1990-01-24 | 1994-12-27 | British Technology Group Limited | Aerosol carriers |
| GB9001635D0 (en) | 1990-01-24 | 1990-03-21 | Ganderton David | Aerosol carriers |
| US5113855A (en) | 1990-02-14 | 1992-05-19 | Newhouse Michael T | Powder inhaler |
| DE4004904A1 (de) | 1990-02-16 | 1990-09-13 | Gerhard Brendel | Trommel-applikator |
| CA2049940C (en) | 1990-02-19 | 1996-03-05 | Jun Inoue | Maillard's reaction inhibitor compositions |
| JP2859919B2 (ja) | 1990-03-15 | 1999-02-24 | 旭化成工業株式会社 | 難溶性薬物の溶出性改善方法 |
| US5312909A (en) | 1990-03-28 | 1994-05-17 | Gist Brocades, N.V. | Recombinant DNA encoding neutral trehalase |
| JPH05963A (ja) | 1990-04-13 | 1993-01-08 | Toray Ind Inc | ポリペプチド類組成物 |
| US5112596A (en) | 1990-04-23 | 1992-05-12 | Alkermes, Inc. | Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability |
| CA2081474A1 (en) | 1990-05-08 | 1991-11-09 | Manzer Durrani | Direct spray-dried drug/lipid powder composition |
| US5621094A (en) | 1990-05-14 | 1997-04-15 | Quadrant Holdings Cambridge Limited | Method of preserving agarose gel structure during dehydration by adding a non-reducing glycoside of a straight-chain sugar alcohol |
| GB9010742D0 (en) | 1990-05-14 | 1990-07-04 | Quadrant Bioresources Ltd | Stabilization of biological macromolecular substances |
| GB9012663D0 (en) | 1990-06-07 | 1990-08-01 | Erba Carlo Spa | Galenic formulations containing cyclodextrins |
| IT1246350B (it) | 1990-07-11 | 1994-11-17 | Eurand Int | Metodo per ottenere una rapida sospensione in acqua di farmaci insolubili |
| IT1243344B (it) | 1990-07-16 | 1994-06-10 | Promo Pack Sa | Inalatore plurimonodose per medicamenti in polvere |
| US5037912A (en) | 1990-07-26 | 1991-08-06 | The Goodyear Tire & Rubber Company | Polymerization of 1,3-butadiene to trans-1,4-polybutadiene with organolithium and alkali metal alkoxide |
| WO1992002133A1 (en) | 1990-08-10 | 1992-02-20 | Analytical Control Systems, Inc. | Improved diagnostic and therapeutic compositions |
| US5230884A (en) | 1990-09-11 | 1993-07-27 | University Of Wales College Of Cardiff | Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations |
| CA2051092C (en) | 1990-09-12 | 2002-07-23 | Stephen A. Livesey | Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions |
| UA26915C2 (uk) * | 1990-09-12 | 1999-12-29 | Ханс БІСГОРД | Іhгаляторhий пристрій для вдихаhhя активhої порошкоподібhої або рідкої речовиhи |
| US5200399A (en) | 1990-09-14 | 1993-04-06 | Boyce Thompson Institute For Plant Research, Inc. | Method of protecting biological materials from destructive reactions in the dry state |
| US5173298A (en) | 1990-09-27 | 1992-12-22 | Allergan, Inc. | Nonaqueous fluorinated drug delivery vehicle suspensions |
| FR2667509B1 (fr) | 1990-10-04 | 1995-08-25 | Valois | Inhalateur a poudre, dispositif de conditionnement de microdoses de poudre sous forme de bandes adaptees a etre utilisees dans un inhalateur a poudre, et procede de fabrication de ces bandes. |
| US5149543A (en) | 1990-10-05 | 1992-09-22 | Massachusetts Institute Of Technology | Ionically cross-linked polymeric microcapsules |
| US5217004A (en) | 1990-12-13 | 1993-06-08 | Tenax Corporation | Inhalation actuated dispensing apparatus |
| GB9027234D0 (en) | 1990-12-15 | 1991-02-06 | Harris Pharma Ltd | An inhalation device |
| WO1992014697A1 (en) | 1991-02-08 | 1992-09-03 | Cambridge Neuroscience, Inc. | Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers |
| US5182097A (en) | 1991-02-14 | 1993-01-26 | Virginia Commonwealth University | Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content |
| US5099833A (en) | 1991-02-19 | 1992-03-31 | Baxter International Inc. | High efficiency nebulizer having a flexible reservoir |
| WO1992014449A1 (en) * | 1991-02-20 | 1992-09-03 | Nova Pharmaceutical Corporation | Controlled release microparticulate delivery system for proteins |
| US5404871A (en) | 1991-03-05 | 1995-04-11 | Aradigm | Delivery of aerosol medications for inspiration |
| US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| US5186164A (en) | 1991-03-15 | 1993-02-16 | Puthalath Raghuprasad | Mist inhaler |
| JP3507486B2 (ja) | 1991-03-15 | 2004-03-15 | アムジエン・インコーポレーテツド | 顆粒球コロニー刺激因子の肺内投与 |
| DE59107894D1 (de) | 1991-03-21 | 1996-07-11 | Ritzau Pari Werk Gmbh Paul | Vernebler insbesondere zur Anwendung in Geräten für die Inhalationstherapie |
| GB9106648D0 (en) | 1991-03-28 | 1991-05-15 | Rhone Poulenc Rorer Ltd | New inhaler |
| GB9107628D0 (en) | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
| US5993805A (en) | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
| HK1006813A1 (en) | 1991-04-15 | 1999-03-19 | Leiras Oy | Device intended for measuring a dose of powdered medicament for inhalation |
| US5206200A (en) | 1991-04-22 | 1993-04-27 | W. R. Grace & Co.-Conn. | Tin catalysts for hydrolysis of latent amine curing agents |
| ES2128343T3 (es) | 1991-05-07 | 1999-05-16 | Liposome Co Inc | Formulaciones de prostaglandina liposomica. |
| US6060069A (en) | 1991-05-20 | 2000-05-09 | Dura Pharmaceuticals, Inc. | Pulmonary delivery of pharmaceuticals |
| AU659645B2 (en) | 1991-06-26 | 1995-05-25 | Inhale Therapeutic Systems | Storage of materials |
| US6681767B1 (en) | 1991-07-02 | 2004-01-27 | Nektar Therapeutics | Method and device for delivering aerosolized medicaments |
| DE69230613T2 (de) | 1991-07-02 | 2000-12-28 | Inhale Inc | Verfahren und vorrichtung zum abgeben von medikamenten in aerosolform |
| ES2078052T3 (es) | 1991-07-31 | 1995-12-01 | Blatter Farros Ag | Aparato rectificador para el rectificado de la superficie cilindrica o esferica de un rodillo en especial de un rodillo de una maquina de manipulacion del papel. |
| GB9116610D0 (en) | 1991-08-01 | 1991-09-18 | Danbiosyst Uk | Preparation of microparticles |
| US5161524A (en) | 1991-08-02 | 1992-11-10 | Glaxo Inc. | Dosage inhalator with air flow velocity regulating means |
| TW221689B (de) | 1991-08-27 | 1994-03-11 | Otsuka Pharma Co Ltd | |
| US5253468A (en) | 1991-09-03 | 1993-10-19 | Robert Raymond | Crop chopping machine |
| US6123924A (en) | 1991-09-25 | 2000-09-26 | Fisons Plc | Pressurized aerosol inhalation compositions |
| US6013638A (en) | 1991-10-02 | 2000-01-11 | The United States Of America As Represented By The Department Of Health And Human Services | Adenovirus comprising deletions on the E1A, E1B and E3 regions for transfer of genes to the lung |
| GB9123953D0 (en) | 1991-11-12 | 1992-01-02 | Minnesota Mining & Mfg | Inhalation device |
| US5124162A (en) | 1991-11-26 | 1992-06-23 | Kraft General Foods, Inc. | Spray-dried fixed flavorants in a carbohydrate substrate and process |
| DK0615438T3 (da) | 1991-12-05 | 1996-11-11 | Mallinckrodt Veterinary Inc | En carbohydratglasmatrix til langvarig frigivelse af et terapeutisk middel |
| DE4140689B4 (de) | 1991-12-10 | 2007-11-22 | Boehringer Ingelheim Kg | Inhalationspulver und Verfahren zu ihrer Herstellung |
| CA2455115C (en) | 1991-12-12 | 2008-05-27 | Glaxo Group Limited | Pharmaceutical aerosol formulation |
| US6001644A (en) | 1991-12-17 | 1999-12-14 | The Regents Of The University Of California | Mammalian transformation complex comprising a lipid carrier and DNA encoding CFTR |
| US5849700A (en) | 1991-12-20 | 1998-12-15 | Novo Nordisk A/S | Pharmaceutical formulation |
| US5320094A (en) | 1992-01-10 | 1994-06-14 | The Johns Hopkins University | Method of administering insulin |
| ATE146359T1 (de) | 1992-01-21 | 1997-01-15 | Stanford Res Inst Int | Verbessertes verfahren zur herstellung von mikronisierter polypeptidarzneimitteln |
| ES2099428T3 (es) | 1992-03-10 | 1997-05-16 | Fisons Plc | Composiciones farmaceuticas para inhalacion. |
| CA2075521C (en) | 1992-05-05 | 1995-11-28 | Kuniaki Koyama | Stabilized live vaccine |
| IT1254359B (it) | 1992-05-11 | 1995-09-14 | Serono Cesare Ist Ricerca | Composizioni farmaceutiche contenenti il-6 |
| NL9200844A (nl) | 1992-05-13 | 1993-12-01 | De Wijdeven Gijsbertus G P Van | Inrichting en werkwijze voor het injecteren met een vaste stof. |
| US5215079A (en) | 1992-05-19 | 1993-06-01 | Armstrong Pharmaceuticals, Inc. | Single dose metered dose inhaler for delivery of vaccines and other drugs |
| KR100208979B1 (ko) * | 1992-06-12 | 1999-07-15 | 야스이 쇼사꾸 | 기도내 투여용 제제 |
| CA2115065C (en) * | 1992-06-12 | 2000-10-03 | Kiyoyuki Sakon | Ultrafine particle powder for inhalation and method for production thereof |
| GB9213874D0 (en) | 1992-06-30 | 1992-08-12 | Fisons Plc | Process to novel medicament form |
| US5376359A (en) | 1992-07-07 | 1994-12-27 | Glaxo, Inc. | Method of stabilizing aerosol formulations |
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| US6673335B1 (en) | 1992-07-08 | 2004-01-06 | Nektar Therapeutics | Compositions and methods for the pulmonary delivery of aerosolized medicaments |
| US6509006B1 (en) | 1992-07-08 | 2003-01-21 | Inhale Therapeutic Systems, Inc. | Devices compositions and methods for the pulmonary delivery of aerosolized medicaments |
| ES2110573T3 (es) | 1992-08-07 | 1998-02-16 | Takeda Chemical Industries Ltd | Produccion de microcapsulas de farmacos solubles en agua. |
| US5239993A (en) | 1992-08-26 | 1993-08-31 | Glaxo Inc. | Dosage inhalator providing optimized compound inhalation trajectory |
| EP0679088B1 (de) | 1992-09-29 | 2002-07-10 | Inhale Therapeutic Systems | Pulmonale abgabe von aktiven fragmenten des parathormons |
| SK51695A3 (en) | 1992-10-19 | 1995-11-08 | Dura Pharma Inc | Dry powder medicament inhaler |
| US5380473A (en) | 1992-10-23 | 1995-01-10 | Fuisz Technologies Ltd. | Process for making shearform matrix |
| US5422384A (en) | 1992-11-25 | 1995-06-06 | Battelle Memorial Institute | Glass/polymer composites and methods of making |
| JP3168550B2 (ja) | 1992-12-02 | 2001-05-21 | 株式会社林原生物化学研究所 | 脱水剤およびそれを用いる含水物の脱水方法並びにその方法で得られる脱水物品 |
| SE9203743D0 (sv) | 1992-12-11 | 1992-12-11 | Astra Ab | Efficient use |
| US5453514A (en) | 1992-12-25 | 1995-09-26 | Yamanouchi Pharmaceutical Co., Ltd. | Pyrazole derivatives and compositions and methods of use as maillard reaction inhibitors |
| US5672581A (en) | 1993-01-29 | 1997-09-30 | Aradigm Corporation | Method of administration of insulin |
| EP0681491B1 (de) | 1993-01-29 | 2000-12-13 | Aradigm Corporation | Intrapulmonares hormonabgabesystem |
| US5558085A (en) | 1993-01-29 | 1996-09-24 | Aradigm Corporation | Intrapulmonary delivery of peptide drugs |
| US5364838A (en) | 1993-01-29 | 1994-11-15 | Miris Medical Corporation | Method of administration of insulin |
| US5354934A (en) | 1993-02-04 | 1994-10-11 | Amgen Inc. | Pulmonary administration of erythropoietin |
| AU685784B2 (en) | 1993-02-23 | 1998-01-29 | Genentech Inc. | Excipient stabilization of polypeptides treated with organic solvents |
| US5994314A (en) | 1993-04-07 | 1999-11-30 | Inhale Therapeutic Systems, Inc. | Compositions and methods for nucleic acid delivery to the lung |
| US20020132787A1 (en) | 1993-04-07 | 2002-09-19 | Mohammed Eljamal | Compositions and methods for nucleic acid delivery to the lung |
| DK42093D0 (da) | 1993-04-07 | 1993-04-07 | Bukh Meditec | Administrationsmetode |
| TW360548B (en) | 1993-04-08 | 1999-06-11 | Powderject Res Ltd | Products for therapeutic use |
| TW402506B (en) * | 1993-06-24 | 2000-08-21 | Astra Ab | Therapeutic preparation for inhalation |
| IS1796B (is) | 1993-06-24 | 2001-12-31 | Ab Astra | Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband |
| US5506203C1 (en) | 1993-06-24 | 2001-02-06 | Astra Ab | Systemic administration of a therapeutic preparation |
| GB9313642D0 (en) | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
| GB9313650D0 (en) | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
| GB9314886D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Production of a biological control agent |
| AU4953393A (en) | 1993-08-24 | 1995-03-21 | Mogen International N.V. | Production of trehalose in plants |
| GB9322014D0 (en) | 1993-10-26 | 1993-12-15 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| EP0655237A1 (de) * | 1993-11-27 | 1995-05-31 | Hoechst Aktiengesellschaft | Medizinische Aerosolformulierung |
| AU692237B2 (en) | 1994-02-03 | 1998-06-04 | Picower Institute For Medical Research, The | Compositions and methods for advanced glycosylation endproduct-mediated modulation of amyloidosis |
| ATE268605T1 (de) | 1994-03-04 | 2004-06-15 | Genentech Inc | Pharmazeutische akzeptabel dnase zusammensetzung |
| US6051256A (en) | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| ATE416755T1 (de) | 1994-03-07 | 2008-12-15 | Nektar Therapeutics | Verfahren und zusammensetzung für die pulmonale darreichung von insulin |
| US20030113273A1 (en) | 1996-06-17 | 2003-06-19 | Patton John S. | Methods and compositions for pulmonary delivery of insulin |
| US5955448A (en) | 1994-08-19 | 1999-09-21 | Quadrant Holdings Cambridge Limited | Method for stabilization of biological substances during drying and subsequent storage and compositions thereof |
| GB2288732B (en) | 1994-04-13 | 1998-04-29 | Quadrant Holdings Cambridge | Pharmaceutical compositions |
| PT759780E (pt) | 1994-05-10 | 2001-01-31 | American Home Prod | Vacina melhorada de vsrb vivo modificado |
| MX9605717A (es) | 1994-05-18 | 1998-05-31 | Inhale Therapeutic Syst | Metodos y composiciones para la formulacion de polvo seco de interferones. |
| DE69530196T2 (de) | 1994-06-02 | 2003-11-20 | Elan Drug Delivery Ltd | Methode zum verhindern der aggregation von proteinen/peptiden bei rehydratation oder auftauen |
| US5567439A (en) | 1994-06-14 | 1996-10-22 | Fuisz Technologies Ltd. | Delivery of controlled-release systems(s) |
| US6142216A (en) | 1994-07-27 | 2000-11-07 | Bradford White Corporation | Indirect water heater |
| US5591453A (en) | 1994-07-27 | 1997-01-07 | The Trustees Of The University Of Pennsylvania | Incorporation of biologically active molecules into bioactive glasses |
| ATE252373T1 (de) | 1994-08-04 | 2003-11-15 | Elan Drug Delivery Ltd | Feste verabreichungssysteme zur gesteuerten freisetzung von darin eingebauten molekülen sowie verfahren zu deren herstellung |
| US6586006B2 (en) | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
| US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| NZ293163A (en) | 1994-09-21 | 1998-09-24 | Inhale Therapeutic Syst | Inhalation medicament disperser, aerosol from high pressure gas entrainment of fluidised powder drawn from receptacle feed tube |
| NZ292980A (en) | 1994-09-29 | 1999-02-25 | Andaris Ltd | Smooth, spherical water-soluble microparticles as therapeutic or diagnostic vehicles |
| US5547696A (en) | 1994-10-13 | 1996-08-20 | Novo Nordisk A/S | Pharmaceutical formulation |
| US5654278A (en) | 1994-10-13 | 1997-08-05 | Novo Nordisk A/S | Composition and method comprising growth hormone and leucine |
| US5512547A (en) | 1994-10-13 | 1996-04-30 | Wisconsin Alumni Research Foundation | Pharmaceutical composition of botulinum neurotoxin and method of preparation |
| US5631225A (en) | 1994-10-13 | 1997-05-20 | Novo Nordisk A/S | Pharmaceutical formulation |
| JPH08157491A (ja) | 1994-11-30 | 1996-06-18 | Hayashibara Biochem Lab Inc | トレハロース誘導体の製造方法 |
| US5681746A (en) | 1994-12-30 | 1997-10-28 | Chiron Viagene, Inc. | Retroviral delivery of full length factor VIII |
| US5705482A (en) | 1995-01-13 | 1998-01-06 | Novo Nordisk A/S | Pharmaceutical formulation |
| WO1996027393A1 (en) | 1995-03-07 | 1996-09-12 | University Of Pittsburgh | A dry powder formulation for gene therapy |
| US6309671B1 (en) | 1995-04-14 | 2001-10-30 | Inhale Therapeutic Systems | Stable glassy state powder formulations |
| US6165463A (en) | 1997-10-16 | 2000-12-26 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| US6019968A (en) | 1995-04-14 | 2000-02-01 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| ATE287703T1 (de) | 1995-04-14 | 2005-02-15 | Nektar Therapeutics | Pulverförmige pharmazeutische formulierungen mit verbesserter dispergierbarkeit |
| US6258341B1 (en) | 1995-04-14 | 2001-07-10 | Inhale Therapeutic Systems, Inc. | Stable glassy state powder formulations |
| US5780014A (en) | 1995-04-14 | 1998-07-14 | Inhale Therapeutic Systems | Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin |
| US6190859B1 (en) | 1995-04-17 | 2001-02-20 | The United States Of America As Represented By The Secretary Of The Army | Method and kit for detection of dengue virus |
| GB9508691D0 (en) | 1995-04-28 | 1995-06-14 | Pafra Ltd | Stable compositions |
| DE69628007T2 (de) | 1995-06-07 | 2003-11-27 | Elan Drug Delivery Ltd., Ruddington | Verfahren zur stabilen einarbeitung von substanzen in trockene geschäumte glasmatrizen und auf diese weise hergestellte zusammensetzungen |
| US5904935A (en) | 1995-06-07 | 1999-05-18 | Alza Corporation | Peptide/protein suspending formulations |
| GB9515182D0 (en) | 1995-07-24 | 1995-09-20 | Co Ordinated Drug Dev | Improvements in and relating to powders for use in dry powder inhalers |
| US5611344A (en) | 1996-03-05 | 1997-03-18 | Acusphere, Inc. | Microencapsulated fluorinated gases for use as imaging agents |
| NZ331865A (en) | 1996-03-18 | 1999-04-29 | Univ Wales Bangor Change Of Na | Apparatus with electrode arrays for carrying out chemical, physical or physico-chemical reactions |
| US5766520A (en) | 1996-07-15 | 1998-06-16 | Universal Preservation Technologies, Inc. | Preservation by foam formation |
| US5792366A (en) | 1996-10-03 | 1998-08-11 | Cytec Technology Corp. | Aqueous dispersions |
| US6468782B1 (en) | 1996-12-05 | 2002-10-22 | Quadrant Healthcare (Uk) Limited | Methods of preserving prokaryotic cells and compositions obtained thereby |
| AU5719798A (en) | 1996-12-31 | 1998-07-31 | Inhale Therapeutic Systems, Inc. | Processes for spray drying aqueous suspensions of hydrophobic drugs with hydrophilic excipients and compositions prepared by such processes |
| US20030203036A1 (en) | 2000-03-17 | 2003-10-30 | Gordon Marc S. | Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients |
| US20020045049A1 (en) | 1997-06-20 | 2002-04-18 | Madsen Niels Joergen | Hydrophilic coating and a method for the preparation thereof |
| US20030035778A1 (en) | 1997-07-14 | 2003-02-20 | Robert Platz | Methods and compositions for the dry powder formulation of interferon |
| US6423334B1 (en) | 1997-10-01 | 2002-07-23 | Elan Corporation, Plc | Composition and method for enhancing transport across gastrointestinal tract cell layers |
| OA11529A (en) | 1998-03-16 | 2004-05-07 | Inhale Therapeutic Syst | Aerosolized active agent delivery. |
| US6334182B2 (en) | 1998-08-18 | 2001-12-25 | Intel Corp | Scheduling operations using a dependency matrix |
| US6265384B1 (en) | 1999-01-26 | 2001-07-24 | Dale L. Pearlman | Methods and kits for removing, treating, or preventing lice with driable pediculostatic agents |
| US6630169B1 (en) | 1999-03-31 | 2003-10-07 | Nektar Therapeutics | Particulate delivery systems and methods of use |
| US6737066B1 (en) | 1999-05-06 | 2004-05-18 | The Immune Response Corporation | HIV immunogenic compositions and methods |
| NZ518401A (en) | 1999-10-29 | 2004-01-30 | Nektar Therapeutics | Dry powder compositions having improved dispersivity |
| GB0011807D0 (en) | 2000-05-16 | 2000-07-05 | Quadrant Holdings Cambridge | Formulation for inhalation |
| CA2418960A1 (en) | 2000-08-07 | 2002-02-14 | Inhale Therapeutic Systems, Inc. | Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation |
| JP3620479B2 (ja) | 2001-07-31 | 2005-02-16 | 株式会社島津製作所 | イオン蓄積装置におけるイオン選別の方法 |
| US6752893B2 (en) | 2001-09-28 | 2004-06-22 | Gentex Corporation | Rimless spectacles and method for making the same |
| AU2003225777B2 (en) | 2002-03-12 | 2008-04-10 | Microdose Therapeutx, Inc. | Site specific delivery of co-administered drugs via inhalation |
| US7192919B2 (en) | 2004-01-07 | 2007-03-20 | Stelios Tzannis | Sustained release compositions for delivery of pharmaceutical proteins |
| US8278929B2 (en) | 2006-05-19 | 2012-10-02 | Exxonmobil Upstream Research Company | Determining orientation for seafloor electromagnetic receivers |
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