MX2021004348A - Procedimientos de diagnóstico y terapéuticos para el cáncer de riñón sarcomatoide. - Google Patents

Procedimientos de diagnóstico y terapéuticos para el cáncer de riñón sarcomatoide.

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Publication number
MX2021004348A
MX2021004348A MX2021004348A MX2021004348A MX2021004348A MX 2021004348 A MX2021004348 A MX 2021004348A MX 2021004348 A MX2021004348 A MX 2021004348A MX 2021004348 A MX2021004348 A MX 2021004348A MX 2021004348 A MX2021004348 A MX 2021004348A
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MX
Mexico
Prior art keywords
vegf
antibody
inhibitor
cancer
kidney cancer
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MX2021004348A
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English (en)
Inventor
Mahrukh Huseni
Christina Schiff
Marjorie Green
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Genentech Inc
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Publication date
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Publication of MX2021004348A publication Critical patent/MX2021004348A/es

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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57525—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the liver or pancreas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/507—Comprising a combination of two or more separate antibodies
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • A61K2039/868—Vaccine for a specifically defined cancer kidney
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

La presente invención proporciona procedimientos de diagnóstico, procedimientos terapéuticos y composiciones para el tratamiento del cáncer (por ejemplo, cáncer de riñón (por ejemplo, carcinoma de células renales (RCC)). Esta invención se basa, al menos en parte, en el descubrimiento de que los niveles de expresión de uno o más biomarcadores descritos en el presente documento en una muestra de un individuo que tiene cáncer se pueden usar en procedimientos para predecir la eficacia terapéutica del tratamiento con un antagonista de VEGF (por ejemplo, un anticuerpo anti-VEGF, (por ejemplo, bevacizumab) o un inhibidor de VEGFR (por ejemplo, un inhibidor de tirosina cinasa de múltiples dianas (por ejemplo, sunitinib, axitinib, pazopanib o cabozantinib))) y un antagonista de unión al eje de PDL1 (por ejemplo, un antagonista de unión a PD-L1 (por ejemplo, un anticuerpo anti-PD-L1, por ejemplo, atezolizumab (MPDL3280A)) o un antagonista de unión a PD-1 (por ejemplo, un anticuerpo anti-PD-1)) o con un inhibidor de la angiogénesis (por ejemplo, un antagonista de VEGF (por ejemplo, un inhibidor de VEGFR, (por ejemplo, un inhibidor de tirosina cinasa de múltiples dianas (por ejemplo, sunitinib, axitinib, pazopanib o cabozantinib)))).
MX2021004348A 2018-10-18 2019-10-17 Procedimientos de diagnóstico y terapéuticos para el cáncer de riñón sarcomatoide. MX2021004348A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862747559P 2018-10-18 2018-10-18
US201962855517P 2019-05-31 2019-05-31
PCT/US2019/056665 WO2020081767A1 (en) 2018-10-18 2019-10-17 Diagnostic and therapeutic methods for sarcomatoid kidney cancer

Publications (1)

Publication Number Publication Date
MX2021004348A true MX2021004348A (es) 2021-05-28

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MX2021004348A MX2021004348A (es) 2018-10-18 2019-10-17 Procedimientos de diagnóstico y terapéuticos para el cáncer de riñón sarcomatoide.

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Country Link
US (1) US20210253710A1 (es)
EP (1) EP3867646A1 (es)
JP (2) JP2022512744A (es)
KR (1) KR20210079311A (es)
CN (1) CN113196061A (es)
AU (1) AU2019361983A1 (es)
CA (1) CA3116324A1 (es)
IL (1) IL282232A (es)
MX (1) MX2021004348A (es)
TW (1) TW202027784A (es)
WO (1) WO2020081767A1 (es)

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Publication number Priority date Publication date Assignee Title
MX2019010295A (es) 2017-03-01 2019-11-21 Genentech Inc Métodos de diagnóstico y terapéuticos para el cáncer.
EP4127724A1 (en) * 2020-04-03 2023-02-08 Genentech, Inc. Therapeutic and diagnostic methods for cancer
CN115461079A (zh) * 2020-04-30 2022-12-09 正大天晴药业集团股份有限公司 用于治疗肾癌的联用药物
CN113109569B (zh) * 2021-03-05 2022-08-19 李朴 Gsdmd作为生物标志物在胸腔积液相关疾病鉴别诊断及疗效评估上的用途
WO2023080900A1 (en) * 2021-11-05 2023-05-11 Genentech, Inc. Methods and compositions for classifying and treating kidney cancer
CN114931634B (zh) * 2022-03-18 2023-03-17 广州达博生物制品有限公司 E10a与pd1单抗对肿瘤的联合治疗方法和制药用途
CN114661870B (zh) * 2022-04-12 2024-08-06 广州大学 一种基于miRNAs表达谱和自然语言模型的癌症分类方法
KR20250072709A (ko) * 2022-09-19 2025-05-26 에멘도바이오 인코포레이티드 Ctla4의 이중 대립유전자 녹아웃

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