JPS60178807A - Dentifrice composition - Google Patents

Abstract

PURPOSE:A dentifrice composition for improving shelf stability and especially chopped skin of a dentifrice composition containing benzoic acid or a benzoate as an antiseptic, obtained by adding a specific amount of 2-3C alcohol to the composition. CONSTITUTION:A dentifrice composition is blended with (A) preferably 0.1- 1wt%, especially 0.2-0.8wt% benzoic acid or benzoate, and (B) 0.1-1wt%, preferably 0.2-0.7wt% based on the whole amount of the composition of one or more alcohols selected from ethyl alcohol, propyl alcohol, and isopropyl alcohol, to give a dentifrice composition having high antiseptic ability, improved shelf stability, and good feeling in use.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a toothpaste composition that has high anti-J14 power, good storage stability, and excellent usability.

BACKGROUND ART Conventionally, it has been known to incorporate benzoic acid or a salt thereof as a preservative into dentifrice compositions such as toothpaste. However, benzoic acids are insufficiently effective as preservatives when incorporated in small amounts, and when incorporated in amounts that exhibit sufficient preservative power, they reduce the storage stability of dentifrice compositions, especially in dentifrice compositions. There is a problem that has a sudden effect on rough skin.

The present inventors conducted intensive research on the storage stability of toothpaste compositions containing benzoic acid or its base, especially on improving skin roughness. It has been found that when used in combination with IVIi or two or more alcohols'f: 0.1 to 1 t (gravity-based, the same applies hereinafter), the roughness of the toothpaste composition can be surprisingly improved. Does a toothpaste composition containing acids or their bases have any effect on improving skin roughness even when polyhydric alcohols such as ethylene glycol, zoropylene glycol, and glycerin are used in combination?Ethyl alcohol, propyl alcohol,
When isopropyl alcohol is used in combination, as mentioned above, even if these alcohols are added in low amounts, the storage stability of toothpaste compositions containing benzoic acid or its salts is effectively prevented from decreasing and the occurrence of skin roughness is effectively prevented. Ru. In addition, due to the synergistic effect between benzoic acids and the lower alcohols, high preservative power can be obtained even with a small amount of lower alcohol.
Also, if ethyl alcohol, propyl alcohol, or isopropyl alcohol is added to a toothpaste composition containing benzoic acid or its salt in an amount exceeding 1%, the feeling of use will be significantly reduced. The inventors have discovered that, when the above-mentioned methods are used, a dentifrice composition having a good feeling in use without impairing the feeling in use of the dentifrice composition can be obtained, and the present invention has been completed based on this finding.

The present invention will be explained in detail below.

In the dentifrice composition C of the present invention, benzoic acid or a salt thereof is used as a preservative, and IWl or two or more alcohols selected from ethyl alcohol, propyl alcohol, and isopropyl alcohol are added to 0.0% of the total composition.
It is used in combination in an amount of 1 to 1, and is used as toothpaste, moisturized toothpaste, etc.

In this case, it is preferable that the amount of benzoic acid or its salt is 0.1 to 1%, particularly 0.2 to 0.8%, based on the total composition, and if it is less than 0.1%, sufficient preservative power is obtained. If the amount exceeds 1%, the feeling of use of the dentifrice composition may be impaired.

In addition, the amount of the alcohol added is 0.1 of the total composition.
~1% is necessary; if it is less than 0.1%, the toothpaste composition will not have the effect of improving skin roughness, and if it is more than 1%, the feeling of use will be impaired, both of which are the objectives of the present invention. cannot be achieved. The preferred amount of the above-mentioned alcohols is 0.2 to 0.7.

In addition, in the present invention, benzoic acid or its salt is blended as a preservative as described above, but other preservatives such as methyl paraoxybenzoate, ethyl paraoxybenzoate, paraoxybenzoate may also be added as necessary. Acid globil, butyl benzoate, sodium dehydroacetate, potassium sorbate, sodium propionate, etc. may be blended.

Other components of the dentifrice composition of the present invention are appropriately selected from commonly used components and blended.

For example, in the case of toothpaste, dibasic calcium phosphate,
Calcium carbonate, calcium birophosphate, insoluble sodium metaphosphate, amorphous silica, crystalline silica, aluminosilicate, aluminum oxide, aluminum hydroxide, abrasives such as resins, sodium carboxyl methyl cellulose, hydroxyethyl cellulose, alginate,
Binder such as caradanan, gum arabic, polyvinyl alcohol, thickening agent such as polyethylene glycol, sorbitol, glycerin, globylene glycol, sodium lauryl sulfate, sodium dodecylbenzene sulfonate, coconut fatty acid monoglyceride monosulfate added with ice cream, lauryl sulfonate. Foaming agents such as sodium acetate, sodium N-lauroyl sarcosinate, N-acylglutamate, lauric acid jetanolamide, sucrose fatty acid ester, essential oils such as peppermint and spearmint, t-menthol, carvone, eugenol, anethole, etc. A flavoring material such as saccharin sodium, stevioside, neohesberidyl dihydrochalcone, a sweetening agent such as glycyrrhizin, perillartine, p-methoxycinnamic aldehyde, and other ingredients are mixed with water and produced according to a conventional method.

In addition, in the present invention, mutanase, sorbic acid, alexidine, hinokitiol, cetyl viridinylamucoid, alkylglycine, alkyldiaminoethylglycine salt, allantoin, ε-aminocaproic acid, tranexamic acid, azulene, vitamin E, water bath It is also possible to combine all active ingredients such as primary or secondary phosphates, quaternary ammonium compounds, sodium chloride, crude drug extracts, etc.

Next, an experimental example will be shown and the effects of the present invention will be explained using nine shellfish.

[Experimental Example 1] The preservative power and storage stability (skin roughness) of a toothpaste composition containing sodium benzoate as a preservative was investigated.

Toothpastes with the following formulations were prepared using sodium benzoate at various concentrations shown in Table 1, and 10 6 to 10 7 aerobic bacteria isolated from the environment were added to the toothpaste. Next, after storing these toothpastes at 30° C. for two weeks, the number of viable bacteria was examined to evaluate the anti-U power of each toothpaste. The results are shown in Table 1. In addition, the preservative power 1ffiIIItl standard is as follows.

In addition, the above kneaded meat@f6: After being stored at -5℃ for 3 months,
A complete evaluation of rough skin caused by tooth brushing was performed. The results are also shown in Table 1.

In this case, the rough skin evaluation criteria are as shown below.

Toothpaste formulation Dicalcium phosphate 45.0% Sodium carboxymethyl cellulose 0.8 Carrageenan 0.2 Sorbit 15.0 Propylene glycol 3.0 Zanocalin sodium 0.1 Dullifying silica 3.0 Lauryl Sodium sulfate 1.5 Flavor 1.0 Sodium benzoate Required amount of water Remaining ○: Good preservative power (number of viable bacteria 102/y toothpaste) △: 〃
Fairly good (number of viable bacteria = 102-104102 104◎
: Smooth skin on the dental calendar.

○: Smooth.

△: There are some bumps and wrinkles.

×: There are noticeable lumps and wrinkles.

According to the results shown in Table 1, as the amount of sodium benzoate added to toothpaste increases, the preservative power improves, but on the other hand, it is found that the skin of the toothpaste becomes rough and spots and wrinkles appear.

[Experimental Example 2] The effect of improving skin roughness of the toothpaste composition when sodium benzoate and alcohol or polyhydric alcohol are used together was evaluated by horizontal 1.
"did.

Sodium benzoate is added to the toothpaste with the formula shown in the sample example.
5 1 was blended, and 1 liter of the alcohol or polyhydric alcohol shown in Table 2 was blended, and the storage stability (skin roughness) of the toothpaste was evaluated. The results are shown in Table 2. Note that the evaluation test method and evaluation criteria for rough skin are the same as in Experimental Example 1.

From the results in Table 2, it can be seen that when used in combination with ethyl alcohol, propyl alcohol, and isozolobyl alcohol sodium basozoate, the rough skin of the toothpaste can be effectively improved.

[Experiment Example 3] A tooth contact composition containing sodium benzoate was added with H↓
Contains ethyl alcohol to improve rough skin/ζ
.

0 sodium benzoate was added to the toothpaste with the formulation shown in Experimental Example 1.
．． The storage stability (rough skin) of the toothpaste was evaluated by adding 5% of ethyl alcohol as shown in Table 3. The results are shown in Table 3. Note that the evaluation test method and evaluation criteria for rough skin are the same as in Experimental Example 1.

Table 3 From the results shown in Table 3, it is found that when 0.1 to 2 g of ethyl alcohol is added, the rough skin of the toothpaste is improved.

[Experimental Example 4] The feeling of use (taste of toothpaste) of the toothpaste with the formulation shown in Experimental Example 3 was sensory evaluated by 10 expert Z-nels.

The results are shown in Table 4. The evaluation criteria are as follows.

Usability evaluation criteria ○: 10 people - 7 people or more, the taste is good.

△: 6-4 out of 10 people found the taste to be good.

×: 10 people - 7 people or more said the taste was poor.

Table 4 According to the results in Table 4, it is found that when more than 1% of ethanol is added to a toothpaste containing sodium benzoate, the feeling of use is reduced.

Therefore, from the results in Tables 1 to 4, by using sodium benzoate and alcohol at 0.1 to 1%,
It was found that it exhibited good preservative power and storage stability (7), and had a good usability (taste of toothpaste).

Examples are shown below.

[Example 1] Dibasic calcium phosphate 45 Tinolobilene glycol 3 Sorbit 15 Saccharin sodium 0.1 Sodium lauryl sulfate 15 Carrageenan 02 Sodium carboxymethyl cellulose 0.8 Tranexamic acid 0.1 Flavor 1.0 Butyl paraoxybenzoate 0.05 Sodium benzoate 0.5 Ethyl alcohol 0.3 Total 100.0% [Example 2] Aluminum hydroxide 50% Globylene glycol 2 Sorbit 20 Satucharin sodium 0.05 Dipotassium glycyrrhizinate 0.01 (C10-01
6) Sodium mixed alkyl sulfate 1.0 Lauric acid diethanolamide 1.0 Carrageenan 0.7 Thorium alginate 0.3 Dextranase (1 million u/'g) o.2 Flavor 1.0 Sodium dehydroacetate 0. 1 Ethyl panoxybenzoate 0.05 Sodium benzoate 0.2 Ethyl alcohol O, Eisoprobil alcohol 0.2 Refined ice Balance total 100.0 [Example 3] Calcium carbonate 40% Zoropylene glycol 3 Sorbit 15 Sodium quince 0.1 Sodium lauryl sulfate 1.5 I-lyoxyethylene hydrogenated castor oil 0.5 Sodium carboxymethyl cellulose 1. .

Allantoin chlorhydroxyaluminum 0.1 Epsilon aminocaproic acid 0.1 Fragrance i.

Butyl paraoxybenzoate 0.05 Sodium benzoate 0.9 Ethyl alcohol 0.6 Water Balance total 100.0% [Example 4] Silicic anhydride 20% Zoropylene glycol 4 Sorbit 2゜Glycerin 4゜Polyethylene glycol 400 1 Satucalin sodium 0.1 Sodium lauryl sulfate 1.5 Lactitol monolaurate 0.5 Carrageenan 0.5 Sodium carboxymethyl heptylulose 0.5 Chlorhexidine gluconate o, o i Vitamin E nicotinic acid ester 0.1 Flavor 1.0 Sodium benzoate 02 Potassium sorbate 0.1 Propyl alcohol 0.3 Purified water Total remaining 100.0 [Example 5] Dibasic calcium phosphate 50 Tertiary magnesium phosphate 2 Globylene glycol 2 Sorbit 1O Glycerin 5 Sodium saccharin o, i Sodium lauryl sulfate 1.0 Sucrose laurate monoester 0.25 Sucrose stearate monoester 0.25 Cal? Sodium oxymethylcellulose 10 Chlorhexidine salt 1Il12 salt 0.01 Flavoring 1.0 Haloxybenzoinated butyl 0.01 Sodium noropionate 0.1 Methyl paraoxybenzoate 0.1 Sodium benzoate 0.2 Ethyl alcohol 0.9 Total 100 .0% [Example 6] Calcium hyrophosphate 50% Propylene glycol 3 Sorbit 15 Satucharin sodium 0.1 (C1o to C16) mixed alkyl sodium sulfate 1.
ON-sodium lauroyl dercosinate 0.5'-
Carrageenan 0.3 Sodium Calgexymethyl Cellulose 0.7 Sodium Monofluorophosphate 0.76 Flavor 1.0 Glythyl Paraoxybenzoate 0.01 Benzoic Acid 0.2 Inglobil Alcohol 0.5 Kozue Ice Balance Total 100. 0% The dentifrice compositions of Examples 1 to 6 all have high storage stability and preservative power, and also have a good feel when used.

Applicant: Lion Corporation Representative Patent Attorney Suiji Kojima

Claims (1)

[Claims] J, benzoic acid or its salt and 0.1 to 0.1 of the total composition]
1. A toothpaste composition comprising gold and one or more alcohols selected from ethyl alcohol, noropylic alcohol and isopropyl alcohol in an amount of 41%. 2. The amount of benzoic acid or its salt is 0 in the entire composition.
．． The dentifrice composition according to claim 1, wherein the content is 1 to 1% by weight.