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Pratidina, Rr. Wening Gelar
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Medicine & Pharmacology

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Gambaran Histopatologi Jaringan Paru Tikus (Rattus norvegicus) Pada Beberapa Keadaan Tenggelam di Air Tawar Savitri, Annisa; Syamsu Hidayat, Muhammad Zaenuri; Rahmawati, Indah; Pratidina, Rr. Wening Gelar
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.14846

Abstract

Background: Drowning remains a significant cause of mortality, with complex pathophysiological mechanisms that are often challenging to diagnose. Histopathological examination of the lung is one of the tests that supports the diagnosis of the cause of death and manner of death in drowning cases. Objective: This study aims to analyze the histopathological features of rat lungs drowned in freshwater under conscious, unconscious, and post-mortem conditions. Methods: A descriptive experimental study by dividing the rats into three conditions; conscious, unconscious and post-mortem drowning. The lung tissues collected from the drowned rats, processed, stained with hematoxylin eosin and observed under the microscope. The results stated in descriptive form and scores. Results: In Group 1, alveolar edema (score 2), hemorrhage (score 4), inflammatory cell infiltration (score 2.2), and alveolar thickening (score 2.4) were observed. Group 2 exhibited a similar histopathological pattern to Group 1. Group 3 showed mild alveolar edema (score 1), massive hemorrhage (score 4), extensive inflammatory cell infiltration (score 4), and severe alveolar thickening (score 3). Conclusion: Histopathology of lung tissue of rats that drowned alive showed moderate alveolar edema, massive hemorrhage, moderate inflammatory cell infiltration and moderate alveolar thickening. Rats that drowned unconsciously showed moderate alveolar edema, massive hemorrhage, moderate inflammatory cell infiltration and moderate alveolar thickening. Rats that drowned after death showed minimal alveolar edema, massive hemorrhage, massive inflammatory cell infiltration and severe alveolar thickening.
Association Between Prematurity and Neonatal Sepsis: A Case–Control Study at a Tertiary Referral Hospital in Indonesia Hapsari, Ariadne Tiara; Krisniawati, Nia; Syiraz, Thauriq Azfa; Pratidina, Rr. Wening Gelar
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17292

Abstract

Background: Neonatal sepsis remains a leading cause of morbidity and mortality in newborns, particularly among preterm infants whose immature organ systems and immune defenses increase their vulnerability to infection. Evidence on the association between prematurity and neonatal sepsis remains variable across settings, highlighting the need for context-specific research. Objective: To examine the association between prematurity and the occurrence of neonatal sepsis at a tertiary referral hospital in Indonesia. Methods: A hospital-based analytic observational study with an unmatched case–control design was conducted at Margono Soekarjo Regional Hospital, Central Java, Indonesia, from June to November 2024. Medical records of neonates admitted in 2023 were reviewed. Cases were neonates diagnosed with sepsis, while controls had no sepsis diagnosis. A total of 136 neonates were selected using simple random sampling, with 68 cases and 68 controls. Data were analyzed using Chi-square tests and odds ratios (OR) with 95% confidence intervals (CI). Results: Preterm birth was more frequent among cases (64.7%) compared to controls (32.4%). The majority of sepsis cases were moderate-to-late preterm (41.2%) and predominantly late-onset (86.8%). Bivariable analysis demonstrated a significant association between prematurity and neonatal sepsis (χ² = 14.248, p < 0.001), with an OR of 3.833 (95% CI: 1.883–7.805), indicating that preterm neonates had nearly four times higher risk of developing sepsis than term neonates. Conclusion: Prematurity is a significant risk factor for neonatal sepsis, particularly late-onset cases, in this tertiary care setting. These findings highlight the urgent need for targeted infection prevention strategies and enhanced clinical monitoring for preterm infants in neonatal intensive care units.
Co-Authors Annisa Savitri, Annisa Ariadne Tiara Hapsari Indah Rahmawati Krisniawati, Nia Syamsu Hidayat, Muhammad Zaenuri Syiraz, Thauriq Azfa