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All Journal JBIO: jurnal biosains (the journal of biosciences) Best Journal (Biology Education, Sains and Technology)
Putri, Syarifah Riska Mela
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Public Health

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UJI EFEK NEFROPROTEKTIF EKSTRAK ETANOL DAUN BIWA (Eriobotrya japonica Lindl) TERHADAP KADAR KREATININ TIKUS MODEL KANKER PAYUDARA YANG DIINDUKSI Benzo(a)Pyrene Syahfitri, Widya; Elizabeth, Fitri; Putri, Syarifah Riska Mela; Maelani, Imelda; Hutahaean, Salomo; Ilyas, Syarifuddin
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 1 (2025): Juni 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i1.11120

Abstract

Benzo(a)pyrene (BaP) merupakan senyawa toksik dan karsinogenik yang dapat menyebabkan stres oksidatif, peradangan, dan gangguan fungsi organ, termasuk ginjal. Penelitian ini bertujuan untuk menguji efek nefroprotektif ekstrak metanol daun biwa (Eriobotrya japonica) terhadap kadar kreatinin tikus model kanker payudara yang diinduksi BaP. Penelitian ini menggunakan rancangan acak lengkap dengan lima kelompok perlakuan, yaitu kontrol negatif (tanpa perlakuan), kontrol positif (BaP 50 mg/kg BB), serta tiga kelompok perlakuan dengan pemberian ekstrak daun biwa dosis 200, 300, dan 400 mg/kg BB selama 30 hari. Kadar kreatinin diukur menggunakan metode modifikasi Jaffe. Data hasil penelitian dianalisis menggunakan uji ANOVA dan dilanjutkan dengan uji Duncan. Hasil penelitian menunjukkan bahwa kadar kreatinin serum darah tikus pada semua kelompok masih berada dalam rentang normal, dengan nilai antara 0,66 hingga 0,73 mg/dl, dan tidak terdapat perbedaan yang signifikan (p0,05) antara kelompok perlakuan dan kontrol. Hal ini mengindikasikan bahwa paparan BaP tidak secara langsung mengganggu fungsi ginjal tikus model kanker payudara, serta pemberian ekstrak daun biwa tidak menunjukkan efek protektif yang signifikan terhadap kadar kreatinin. Namun, kandungan antioksidan dalam daun biwa, seperti flavonoid dan triterpenoid, tetap berpotensi dalam menjaga stabilitas fungsi ginjal melalui mekanisme antioksidatif dan antiinflamasi
PHYSICOCHEMICAL CHARACTERISTICS OF ECO-ENZYME DERIVED FROM DURIAN ALBEDO AS A SOLUTION FOR WASTE MANAGEMENT Harahap, Doli Fadly; Ayu, Gabriella Marry; Putri, Syarifah Riska Mela
JURNAL BIOSAINS Vol. 10 No. 3 (2024): JBIO : JURNAL BIOSAINS (THE JOURNAL OF BIOSCIENCES)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v10i3.63717

Abstract

North Sumatra is the largest durian-producing province in Indonesia. As a result, durian skin waste has increased, reaching 332,712 tons annually. Durian skin is divided into the outer layer, known as the flavedo and the inner layer called the albedo. Durian skin contains chemical compounds such as lignin and tannins, which hinder its efficient decomposition. Therefore, environmentally friendly solutions for processing durian skin waste are needed. One such solution is the production of eco-enzyme. Eco-enzyme is a complex solution produced by fermenting organic waste with molasses and water, using selective microorganisms. It has various applications, such as household cleaners, organic fertilizers, and pest control. The purpose of this study was to identify the physicochemical characteristics and quality of the eco-enzyme produced, as well as its potential to reduce environmental pollution. The research employed a descriptive qualitative method with an experimental approach. The process involved coarsely chopping durian albedo and mixing it with molasses and water in a 1:3:10 ratio (sugar, albedo, and water). The mixture was fermented for three months, sealed tightly in a container, and periodically opened. The resulting liquid was the eco-enzyme. Physicochemical tests were conducted to evaluate pH, aroma, color, total dissolved solids (TDS) and other properties, including Wagner's Reagent test, Alkaline Reagent test, Foam test, and Quinone test. The results showed that durian albedo is highly suitable for producing eco-enzyme, yielding a product with a pH of 2.4, a TDS value of 855, a blackish-brown color, a fruity fermentation aroma, and containing phytochemical compounds such as alkaloids, flavonoids, saponins, and quinones.
Co-Authors Ayu, Gabriella Marry Elizabeth, Fitri Harahap, Doli Fadly Ilyas, Syarifuddin Maelani, Imelda Salomo Hutahaean Syahfitri, Widya