Article Per Year (5 Year)
p-Index From 2020 - 2025
0.23
P-Index
This Author published in this journals
All Journal Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology
Maknun, Fazidatul Lu’luil
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Immunology & microbiology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Tyrosinase Inhibitory Activity of Methanolic Extract and Fractions from Green Seaweed Ulva lactuca Gazali, Mohamad; Maknun, Fazidatul Lu’luil; Husni, Amir; Nurjanah, Nurjanah; Nursid, Muhammad; Hasanah, Uswatun; Zuriat, Zuriat; Syafitri, Rina
Squalen, Buletin Pascapanen dan Bioteknologi Kelautan dan Perikanan Vol 20, No 1 (2025): May 2025
Publisher : :Agency for Marine and Fisheries Research and Human Resources, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15578/squalen.915

Abstract

Ulva lactuca, a widely available green seaweed, has demonstrated promising bioactivity as a tyrosinase inhibitor. This study aimed to evaluate the tyrosinase inhibitory activity of U. lactuca extracts and identify the active compounds responsible. The seaweed was extracted using methanol via maceration, followed by partitioning with hexane, chloroform, and water. Total phenolic and flavonoid contents were determined using UV-VIS spectrophotometry, and tyrosinase inhibition was assessed in vitro. Among the tested fractions, the hexane fraction exhibited the highest tyrosinase inhibitory activity with an IC50 value of 584.34 ± 35.07 µg/mL, classifying it as an active inhibitor. Although this activity was weaker than kojic acid (IC50 = 11.07 ± 0.86 µg/mL), the hexane fraction showed relatively high phenolic (11.66 ± 0.53 mg GAE/g) and flavonoid (9.75 ± 0.30 mg QE/g) contents. Gas Chromatography-Mass Spectrometry (GC-MS) analysis identified several bioactive compounds, notably 2,4-dimethoxycinnamic acid, chalcone, and derivatives such as 2,6-dihydroxybenzoic acid and phloretin. These findings highlight the potential of U. lactuca, particularly its hexane fraction, as a source of natural tyrosinase inhibitors. This opens avenues for its application in the pharmaceutical and cosmetic industries, especially in formulations targeting hyperpigmentation and skin brightening.
Co-Authors Amir Husni Mohamad Gazali Muhammad Nursid N. Nurjanah Rina Syafitri, Rina Uswatun Hasanah Zuriat, Zuriat