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All Journal Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Yunitama, Alifa Agil Dhillu
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Computer Science & IT Engineering Medicine & Pharmacology Social Sciences Other

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Association of Cigarette Smoke Exposure with Tuberculosis in Children: A Literature Review Yunitama, Alifa Agil Dhillu; Asmara, Desilva Zahra; Balqis, Aida; Zahra, Adinda Aisyah; Shoom, Listyani Mubshiro Shom; Fauziyah, Nida Faradisa
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5485

Abstract

Purpose: This study purpose is to discuss cigarette smoke exposure as a risk factor for tuberculosis in children. Methodology: This study is a literature review, conducted through an extensive search of international literature using the BMC, Nature, PubMed, Scopus, and JEPH databases. The inclusion criteria: 1) Published in the last 5 years; 2) Sought for retrieval; 3) Abstract recording to the theme; 4) Free full text; 5) Content of the journal match the theme. Results: The filtering processes produced 15 articles that were relevant to this study. 13 studies stated that there was a remarkable relationship between smoking and TB in children. Cigarette smoke diminishes the effector cytokine response and hampers the ability of infected human macrophages to contain mycobacteria, increasing susceptibility to TB. Applications/Originality/Value: This study can be use for a reference regarding the influence of cigarette smoke exposure to tuberculosis in children.
Correlation of Eosinophil-basophil Count and Ratio with Length of Stay in Children Dengue Infection Yunitama, Alifa Agil Dhillu; Puspitasari, Metana; Jatmiko, Safari Wahyu; Fauziyah, Nida Faradisa
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5486

Abstract

Purpose: This study purpose is to determine the correlation between the number of absolute eosinophils, absolute basophils, and eosinophil-basophil ratio (EBR) with the length of stay of pediatric patients with dengue virus infection. Methodology: The study design used cross-sectional. The samples used in this study were taken from routine hematologic laboratory medical record data for the period January-October 2024, using consecutive non-probability sampling technique. Results: 49 samples were obtained and met the restriction criteria as subjects of this study. The results of the Spearman correlation bivariate test showed that the number of absolute eosinophil count, absolute basophil count, and EBR with length of stay had statistical data results respectively p = 0.139, p = 0.993, and p = 0.536. Applications/Originality/Value: This study provides a reference in laboratory results to determine the length of stay (LOS) in children with dengue virus infection.
Effectiveness of Ethanol Extract of Aegle Marmelos Fruit Flesh on Hela Cell Apoptosis Wulandari, Ervita Sri; Yunitama, Alifa Agil Dhillu; Futana, Ninda Pradani; Izzati, Shaula Nur; Wahyuni, Sri; Kurniawati, Yuwandira
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5509

Abstract

Background: Maja plant (Aegle marmelos) or plant commonly known as mojo, is one of the plants that contains many secondary metabolites, one of which is flavonoids. Flavonoids can be used to induce apoptosis mechanisms in cancer cells, so that specific apoptosis mechanisms in cancer cells become more effective and toxicity to normal cells is minimized. Aim: This study aims to evaluate the effectiveness of ethanol extract of maja fruit flesh (Aegle marmelos) in inducing apoptosis of HeLa cells in cervical cancer. Methodology: The method used includes ethanol extraction from maja fruit flesh and treatment of HeLa cells with various concentrations of the extract. Identification of compound content in Aegle marmelos was carried out by phytochemical tests. Apoptosis measurements were carried out using the MTT Assay method and flow cytometry analysis. Results: The results showed that 96% ethanol extract of Aegle marmelos contained secondary metabolites in the form of alkaloids, saponins, tannins, and flavonoids. The IC50 value of the MTT Assay results of maja fruit flesh extract was 7,573 µg/mL, with an apoptosis percentage of 17.6% and had an effect on inhibiting the growth of HeLa cells in the S phase as measured using the flow cytometry method. Value: The flavonoid content in 96% ethanol extract of maja fruit flesh (Aegle marmelos) has an apoptotic effect on HeLa cells. This is evidenced by the IC50 value index of 7,573 µg/mL, an apoptosis percentage of 17.6%, and the presence of inhibition in the S phase in the cell cycle.
Co-Authors Asmara, Desilva Zahra Balqis, Aida Futana, Ninda Pradani Izzati, Shaula Nur Kurniawati, Yuwandira Nida Faradisa Fauziyah Puspitasari, Metana Safari Wahyu Jatmiko Shoom, Listyani Mubshiro Shom Sri Wahyuni Wulandari, Ervita Sri Zahra, Adinda Aisyah