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All Journal Journal of Electronics, Electromedical Engineering, and Medical Informatics
Adawiyah, Laila
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Computer Science & IT Control & Systems Engineering Electrical & Electronics Engineering Engineering

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1D and 2D Feature Extraction Based on AAC and DC Protein Descriptors for Classification of Acetylation in Lysine Proteins using Convolutional Neural Network Faisal, Mohammad Reza; Adawiyah, Laila; Saragih, Triando Hamonangan; kartini, Dwi; Herteno, Rudy; Lumbanraja, Favorisen Rosyking; Handayani, Lilies; Solechah, Siti Aisyah
Journal of Electronics, Electromedical Engineering, and Medical Informatics Vol 6 No 4 (2024): October
Publisher : Department of Electromedical Engineering, POLTEKKES KEMENKES SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/jeeemi.v6i4.458

Abstract

Post-Translational Modification (PTM) denotes a biochemical alteration observed in an amino acid, playing crucial roles in protein activity, functionality, and the regulation of protein structure. The recognition of associated PTMs serves as a fundamental basis for understanding biological processes, therapeutic interventions for diseases, and the development of pharmaceutical agents. Using computational approaches (in silico) offers an efficient and cost-effective means to identify PTM sites swiftly. The exploration of protein classification commences with extracting protein sequence features that are subsequently transformed into numerical features for utilization in classification algorithms. Feature extraction methodologies involve using protein descriptors like Amino Acid Composition (AAC) and Dipeptide Composition (DC). Yet, these approaches exhibit a limitation by neglecting crucial amino acid sequence details. Moreover, both descriptor techniques generate a limited number of 1-dimensional (1D) features, which may not be ideal for processing through the Convolutional Neural Network (CNN) classification method. This investigation presents a novel approach to enhance feature diversity through protein sequence segmentation techniques, employing adjacent and overlapping segment strategies. Furthermore, the study illustrates the organization of features into 1D and 2D formats to facilitate processing through 1D CNN and 2D CNN classification methodologies. The findings of this research endeavour highlight the potential for enhancing the accuracy of acetylation classification in lysine proteins through the multiplication of protein sequence segments in a 2D configuration. The highest accuracy achieved for AAC and DC-based feature extraction methods is 77.39% and 76.75%, respectively.
Co-Authors Dwi Kartini, Dwi Favorisen R. Lumbanraja Herteno, Rudy Lilies Handayani Muhammad Reza Faisal, Muhammad Reza Saragih, Triando Hamonangan Siti Aisyah Solechah