Abstrak: Penyakit degenerative merupakan penyakit tidak menular karena faktor penurunan fungsi sel dan organ tubuh misal penyakit Diabetes mellitus (DM) yang disebabkan faktor genetik/pola hidup tidak sehat. Oleh karena itu, edukasi mengenai penyakit DM sangat penting. Kegiatan PKM dilaksanakan di OKU Timur Sumatera Selatan. Tim PKM terdiri atas 5 dosen dan 2 mahasiswa. Kegiatan terdiri atas penyuluhan pola hidup sehat dan pencegahan penyakit DM dilanjutkan pemeriksaan glukosa dan asam urat. PKM berupaya meningkatan pengetahuan tentang pola hidup yang mendukung upaya promotive dan preventif terhadap penyakit DM. Masyarakat diharapkan meningkatkan kemampuan softskill yakni kemampuan komunikasi dan edukasi terkait penyakit DM serta kemampuan hardskill yakni mendeteksi gejala penyakit dan memantau kadar glukosa secara mandiri. Hasil pemeriksaan glukosa menunjukkan 43% responden menunjukkan kadar glukosa tinggi, 57% menunjukkan kadar glukosa normal. Pada pemeriksaan asam urat, 55% responden menunjukkan hasil normal dan 45% menunjukkan hasil tidak normal. Evaluasi dilakukan dengan kuisioner, sebanyak 95% responden memahami langkah mendeteksi dan mencegah DM dengan pola hidup yang sehat dan rutin memantau kadar glukosa atau parameter lain yang berkontribusi seperti asam urat.Abstract: Degenerative diseases are non-communicable diseases caused by a decline in the function of cells and organs, for example, Diabetes mellitus (DM) caused by genetic factors/unhealthy lifestyles. Therefore, education about DM is very important. The Community Service Program (PKM) activity was carried out in East OKU, South Sumatra. The PKM team consisted of 5 lecturers and 2 students. The activities consisted of counseling on healthy lifestyles and prevention of DM, followed by glucose and uric acid examinations. PKM seeks to increase knowledge about lifestyles that support promotive and preventive efforts against DM. The community is expected to improve soft skills, namely communication and education skills related to DM, and hard skills, namely detecting disease symptoms and monitoring glucose levels independently. The results of the glucose examination showed that 43% of respondents showed high glucose levels, 57% showed normal glucose levels. In the uric acid examination, 55% of respondents showed normal results and 45% showed abnormal results. Evaluation is carried out using a questionnaire, as many as 95% of respondents understood the steps to detect and prevent DM through a healthy lifestyle and regularly monitoring glucose levels or other contributing parameters such as uric acid.