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All Journal Jurnal Biologi Tropis Window of Health : Jurnal Kesehatan Jurnal Pengabdian Magister Pendidikan IPA Jurnal Dunia Farmasi Journal of Pharmaceutical and Health Research International Journal Of Science, Technology & Management (IJSTM) FORTE JOURNAL Sciences of Pharmacy Jurnal Bakti Nusantara Jurnal Sains dan Kesehatan
Ziza Putri Aisyia Fauzi
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Toxic Effect Of The Compound {1,3 Bis (P-Hydroxyphenyl) Urea} On Triiodothyronine (T3) Hormone Levels In Pregnant White Rats (Rattus Norvegicus L.) Ziza Putri Aisyia Fauzi; Urip Harahap; Yuandani Yuandani; Syukur Berkat Waruwu; Hari Purnomo; Denny Satria
International Journal of Science, Technology & Management Vol. 4 No. 1 (2023): January 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i1.719

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed drugs for pregnant women to treat fever, pain and inflammation. Specific NSAIDs can displace thyroid hormone from its protein binding sites, causing thyroid hormone measurement problems. {1,3 bis (p-Hydroxyphenyl)urea} is a modified p-aminophenol compound with potent analgesic and anti-inflammatory activity and less toxicity. This study is a follow-up to previous research to observe the toxic effect on triiodothyronine hormone levels after administration of {1,3 bis(p-Hydroxyphenyl)urea} compound in pregnant white rats. The toxic effect test was carried out by giving the test preparation to pregnant rats, which had been divided into five groups, namely the normal control group (CMC-Na 0.5%), the positive control (Gabapentin 50 mg/kg BW), Compound {1.3 bis (p- Hydroxyphenyl)urea} at a dose of 50 mg/kg BW, 500 mg/kg BW and 1000 mg/kg BW. Mice were given the test preparation every day from the 6th to the 15th day of pregnancy. Blood was taken on the 16th day, and T3 hormone levels were measured using the ELISA method. The results showed that the T3 hormone levels in the {1,3 bis(p-Hydroxyphenyl)urea group had no significant difference from the normal control group, so it was concluded that {1,3 bis(p-Hydroxyphenyl)urea) did not have a significant effect on the hormone T3.
Analisis Tingkat Kepuasan Pasien terhadap Kualitas Pelayanan Resep di Instalasi Farmasi Rumah Sakit Tentara Binjai Ginting, Ovalina Sylvia Br.; Lestari, Amanda Putri; Rambe, Robiatun; Rani, Zulmai; Fauzi, Ziza Putri Aisyia; Dalimunthe, Gabena Indrayani; Harahap, Aswan Pangondian; Chandra, Putra
Jurnal Dunia Farmasi Vol 8, No 3 (2024): Edisi Agustus
Publisher : LPPM Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/jdf.v8i3.6152

Abstract

Pendahuluan: Pelayanan kefarmasian rumah sakit merupakan bagian yang tidak terpisahkan dari sistem pelayanan kesehatan yang ada dirumah sakit yang berorientasi kepada pelayanan pasien, penyediaan obat, maupun pelayanan farmasi klinik. Tujuan: Tujuan penelitian ini adalah untuk mengetahui tingkat kepuasan pasien terhadap pelayanan kefarmasian di Rumah Sakit Tentara Binjai. Metode: Penelitian ini menggunakan metode survei deskriptif melalui penyebaran kuesioner. Populasi pada penelitian ini adalah seluruh pasien rawat jalan BPJS yang berobat di Rumah Sakit Tentara Binjai. Teknik pengambilan sampel pada penelitian ini adalah Random Sampling. Besar sampel dalam penelitian ini sebanyak 100 orang. Hasil: Hasil penelitian ini menunjukkan bahwa kategori tingkat kepuasan terbesar yaitu pada dimensi ketanggapan dan jaminan memiliki skor yang sama yaitu sebanyak 83,60% dengan kategori  puas, dimensi empati 83,52%dengan kategori puas, dimensi kehandalan 80,68% dengan kategori puas, dan  dimensi bukti fisik 76,60%dengan kategori puas. Kesimpulan: Kesimpulan dari penelitian ini yang berdasarkan 5 dimensi kualitas pelayanan adalah puas dengan persentase sebanyak 81,60% dengan kategori puas.
Potensi Buah Rimbang (Solanum torvum Sw.) sebagai Analgetik dengan Metode Induksi Asam Asetat dan plantar test Utami, Dinda Sari; Nasution, Melvi Ariati; Fauzi, Ziza Putri Aisyia; Sari, Syilvi Rinda; Hartini, Putri Tri; Rawitri, Kiki
Journal of Pharmaceutical and Health Research Vol 5 No 2 (2024): June 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i2.5057

Abstract

Abstract is Solanum torvum is a traditional medicine plant ingredient for treating stomach disease, relieving pain (analgesic), initiating blood circulation, removing cough (anti-tussing) and anti-inflammatory. At this examination, a phytochemical screening of powder and fruit extracts has been carried out. Simplicity characteristic tests and analgesic effect tests with acetate acid induction method and plantar tests with suspensions of ethanol extract are given in doses of 500, 1000 and 2000 mg/kgBB, metampiron suspense 2% positive ontrol, CMC suspense 0.5% as negative control as well as gland data are analyzed with ANOVA method. Results of screening of phytomia powder and ethanole extract contains secondary metabolite compounds of the classes of alkaloids, tannins, saponins, flavonoids, steoids and glycosides. Characteristic results of simplisia powder are 8% water content, 5.3% total ash content, 29.6% water-soluble sulphur content, 18.9% ethanol-solubility, 0.48% acid-insoluble ash content. Ethanol extract with 2000 mg/kgBB acetate acid induction method has the highest analgesic strength and effectiveness percentage of 55.9% and 86.04% for plantar test methods with hight analgetic values with 29,3±1,7 second.
Uji Sitotoksisitas Ekstrak Etanol Daun Bayam Duri (Amaranthus spinosus L.) dengan Metode Brine Shrimp Lethality Test (BSLT) Fauzi, Ziza Putri Aisyia; Ridwanto, Ridwanto; Rani, Zulmai; Arifin, Khairil Fikri
Journal of Pharmaceutical and Health Research Vol 5 No 2 (2024): June 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i2.5398

Abstract

Free radicals can cause chronic disease, it takes years for the disease to become real or accumulative. One possibility that can occur as a result of the work of free radicals such as cancer. Cancer is one of the non-communicable diseases that is a public health problem, both in the world and in Indonesia. One of the plants that has the potential as an anticancer is Amaranthus spinosus L. The results showed that thorn spinach leaves contain strong antioxidants. This study aims to determine the class of secondary metabolites contained in the ethanolic extract of thorn spinach leaves and the cytotoxicity of the ethanolic extract of A.spinosus by looking at the LC50 value which was tested using the Brine Shrimp Lethality Test (BSLT) method. This research includes phytochemical screening of A.spinosus extract and Brine Shrimp Lethality Test (BSLT) method by looking at the number of larvae mortality of Artemia salina leach (LC50). The results of the phytochemical screening test showed that A.spinosus were positive for flavonoids, alkaloids, saponins, tannins, steroids and glycosides. The results of the cytotoxicity test using probit analysis showed an LC50 value of 269.15 g/mL, so it can be concluded that the ethanolic extract of A.spinosus is toxic and has potential as an anticancer.
Formulation of Tembelekan Leaf Hand Sanitizer (Lantana camara L.) and Antibacterial Activity Test Against Escherichia coli and Staphylococcus aureus Ziza Putri Aisyia Fauzi; Cut Intan Annisa Putri; Nawalul Aska; Dinda Sari Utami
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7595

Abstract

Disease-causing microorganisms stick to hands every day through physical contact with the environment. One of the easiest and most appropriate ways to clean them is to wash hands with soap and clean water. This study aims to determine the formulation of tembelekan leaf hand sanitizer (Lantana camara L.) and test its antibacterial activity against Escherichia coli and Staphylococcus aureus. Assessment of the arrangements acquired incorporates organoleptic tests with libertine tests, homogeneity, pH, spreadability, dependability, bothering to chip in skin, and antibacterial movement against Staphylococcus aureus and Escherichia coli by agar dispersion utilizing poke holes. The outcomes showed that the hand sanitizer readiness containing 10% tembelekan leaf remove was the best planning since it was liked by specialists, stable when put away at room temperature for a very long time, didn't cause bothering, and had solid antibacterial movement so that the tembelekan leaf gel planning utilized as a characteristic natural substance can be utilized to clean hands from microscopic organisms that is simple, reasonable and protected to use without utilizing water.
The Analgesic Activity Study of Ethanol Extract of Plantago Major L. in Mice (Mus Musculus L.) using Writhing Test Method Cut Intan Annisa Puteri; Sadjnah Simahate; Anggitha Ningtias; Ziza Putri Aisyia Fauzi; Sry Ulina Karo-Karo; Muhammad Andry
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7650

Abstract

Plantago major L. are known as weeds on plantations. Plantago major L. is effective to overcome pain because they contain secondary flavonoid metabolites that have the potential as pain relievers. The purpose of the experiment was to determine the analgesic effect of ethanol extract on Plantago major L. plant on male white mice. The experiment, phytochemical screening of ethanol and powder extracts from Plantago major L. plant, powder of simplicia characterization examination and analgesic effect using writhing test were carried out. As a pain inducer, 0.5% acetic acid is used intraperitoneally injected the lower abdomen of the mice and the amount of stretching is calculated with an interval of 5 minutes for 1 hour. The suspension of ethanol extract of Plantago major L. was given at a dose of 500, 1000 and 2000 mg / kg BW, 2% methampyron suspension as a positive control and 0.5% CMC suspension as a negative control. Pharmacological test results based on ANOVA test found that the amount of stretching between treatment groups was significantly different (p <0.05). The results of the analgesic effectiveness percentage obtained that the EEPM (Ethanol Extract of Plantago Major L.) suspension dose 500, 1000 and 2000 mg / kg BW had the highest analgesic power at a dose of 2000 mg / kg BW of 85.84%, EEPM suspension group 1000 mg / kg BW of 74.96 % and in the EETDS suspension group 500 mg / kg BW 62.37%.
Uji Efektivitas Ekstrak Jamur Susu Harimau (Lignosus rhinocerus) Sebagai Antioksidan dengan Metode DPPH: Test of the Effectiveness of Tiger Milk Fungus (Lignosus rhinocerus) Extract as an Antioxidant by DPPH Method Robiatun Rambe; Zulmai Rani; Ovalina Sylvia Br Ginting; Ziza Putri Aisyia Fauzi
Jurnal Sains dan Kesehatan Vol. 6 No. 3 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i3.2117

Abstract

Chemicals including alkaloids, flavonoids, tannins, saponins, and steroids are present in tigers milk mushrooms (Lignosus rhinocerus). This work compares the IC50 value of tiger milk mushrooms and assesses the antioxidant activity of ethanol extract. This study employed maceration as the extraction technique, utilizing a 1:10 ratio of 96% ethanol solvent. The antioxidant activity was assessed using the DPPH free radical reduction technique. Based on antioxidant activity studies, the tiger milk mushroom ethanol extract's IC50 value was 149.26 ppm, while vitamin C's was 3,238 ppm. Antioxidant activity was detected in the ethanol extract of tiger milk mushrooms, with an IC50 value of 19,206 ppm and an IC50 value of 3,238 ppm, suggesting that the antioxidant activity was in the middle range. But compared to the ethanol extract of tiger milk mushrooms, the vitamin C IC50 value was greater. Keywords:          Lignosus rhinocerus, Antioxidant activity, DPPH method   Abstrak Jamur susu harimau (Lignosus rhinocerus) memiliki kandungan kimia seperti alkaloid, flavonid, tanin, saponin dan steroid. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan ekstrak etanol serta perbandingan nilai IC50 dari jamur susu harimau. Metode Ekstraksi yang digunakan dalam penelitian ini adalah maserasi menggunakan pelarut etanol 96% dengan perbandingan 1:10. Pengujian aktivitas antioksidan menggunakan metode peredaman radikal bebas DPPH. Dari hasil pengukuran aktivitas antioksidan diperoleh nilai IC50 ekstrak etanol jamur susu harimau sebesar 149,26 ppm dan vitamin C sebesar 3,238 ppm. Aktivitas antioksidan dari ekstrak etanol jamur susu harimau diperoleh dengan nilai IC50 ekstrak etanol jamur susu harimau sebesar 19,206 ppm dan vitamin C sebesar 3,238 ppm dimana aktivitas antioksidan tergolong kategori sedang, tetapi nilai IC50 vitamin C lebih baik dibandingkan ekstrak etanol jamur susu harimau. Kata Kunci:         Lignosus rhinocerus, Aktivitas antioksidan, Metode DPPH
Antimicrobial Activity Test of Ethanol Extract of Senggani Leaves (Melastoma malabraticum L) Against Propionibacterium Acnes and Staphylococcus Epidermidis Haris Munandar Nasution; Zulmai Rani; Ziza Putri Aisyia Fauzi; Ahmad Rasyid Ridho
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.2208

Abstract

Senggani leaves are a plant that can be found in Indonesia, including hilly locations. The people of Marendal, Patumbak subdistrict, believe that senggani leaves may heal minor skin wounds. The goal of this study was to identify the class of secondary metabolite chemical compounds and their antibacterial efficacy against the microorganisms Propionibacterium acnes and Staphylococcus epidermidis at 5, 10, and 20% concentrations. The ethanol extract of senggani leaves contains secondary metabolite compounds with antibacterial activity. According to the antibacterial test results, a 20% ethanol extract of senggani leaves is effective against Propionibacterium with a diameter of 10.7 mm, a 10% in the medium category with a diameter of 9.27 mm, and a 5% in the medium category with a diameter of 8.8 mm. Meanwhile, the diameter of Staphylococcus epidermidis at a 20% was 8.77 mm in the medium category, 8.37 mm at 10%, and 8.6 mm at a 5% concentration.   Keywords:          Propionibacterium acnes, Senggani leaves, Staphylococcus epidermidis
Edukasi Penggunaan Antibiotik yang Benar dalam Mencegah Resistensi Antibiotik Rinda Sari, Sylvi; Yunus, Muhammad; Fauzi, Ziza Putri Aisyia; Rani, Zulmai; Nasution, Muhammad Amin; Pertiwi, Nia Novranda; Syahputri, Hindri
Jurnal Bakti Nusantara Vol. 2 No. 1 (2024): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/jbn.v2i1.55

Abstract

Penggunaan antibiotik yang tidak benar memunculkan problematika kesehatan dalam masyarakat.  Alih-alih menjadi obat dalam mengatasi infeksi oleh bakteri, penggunaan antibiotik yang salah dapat menyebabkan resistensi dimana antibiotik tidak dapat membunuh bakteri di dalam tubuh dan akan kebal terhadap infeksi bakteri yang sama. Pengabdian kepada masyarakat ini bertujuan memberikan edukasi penggunaan antibiotik yang benar kepada masyarakat sekitar Apotek Farmasi Universitas Muslim Nusantara Al Washliyah Medan, untuk menghindari resistensi antibiotik. Kegiatan edukasi dilakukan dengan metode ceramah, diskusi dan tanya jawab. Penilaian terhadap keberhasilan kegiatan dilakukan dengan menggunakan kuesioner. Hasil kuisioner menunjukkan ketertarikan peserta akan kegiatan sebesar 95,25%, memahami informasi obat sebesar 87,52%, dan pengetahuan peserta terhadap penggunaan antibiotik yang benar sebesar 90,74%. Edukasi ini terbukti dapat meningkatkan pemahaman masyarakat mitra tentang penggunaan antibiotik yang benar dalam mencegah resistensi antibiotik.
PROFIL PENGGUNAAN OBAT TUBERCULOSIS MULTI DRUG RESISTANT (MDR) DI RSUD DR. MOEWARDI SURAKARTA, JAWA TENGAH Aulia Fitri; Zulmai Rani; Robiatun Rambe; Ziza Putri Aisyia Fauzi
FORTE JOURNAL Vol 4 No 1 (2024): Edisi Januari 2024
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v4i1.777

Abstract

Tuberkulosis Multi Drug Resistant (TB MDR) adalah TB yang disebabkan oleh resistensi kuman tuberkulosis terhadap dua jenis obat anti tuberkulosis (OAT) lini pertama, isoniazid dan rifampisin, baik bersamaan dengan atau tanpa OAT tambahan. Secara global insiden kasus TB MDR pada tahun 2016 berkisar 153.000 pasien dan diantaranya ada 130.000 pasien baru yang memulai pengobatan TB MDR di tahun tersebut, sedangkan keberhasilan terapi TB MDR terhadap pasien yang memulai pengobatan sejak 2014 sebanyak 54%. Total kasus TB MDR pada tahun tersebut juga diketahui pasien meninggal sebanyak 16% dan 8% lainnya gagal dalam pengobatan. Riset ini menggunakan metode deskriptif non-eksperimenal dengan desain penelitian potong lintang yang dilakukan setiap bulan. Data dikumpulkan di Poliklinik TB MDR RSUD dr. Moewardi dari Mei hingga Agustus 2019 melalui penelusuran rekam medis pasien. Hasil penelitian menunjukkan bahwa jenis kelamin laki-laki, sebanyak 67 orang (57,26 persen), orang di bawah 60 tahun, sebanyak 103 orang (88,03 persen), dan orang dengan berat badan tertinggi 33 hingga 50 kg, sebanyak 61 orang (52,10 persen). Jenis obat yang paling banyak dikonsumsi yaitu <10 adalah 63 orang (53,80%), tanpa komorbiditas sebanyak 76 orang (64,96%), riwayat tuberculosis yang kambuh sebanyak 39 orang (33,33%), riwayat sosial yang merokok sebanyak 32 orang (27,35%). Hasil penelitian menunjukkan bahwa yang paling umum adalah pria dan orang di bawah 60 tahun. Pola peresepan obat TB MDR berdasarkan jenis obat yang paling umum digunakan adalah kurang dari 10.
Co-Authors Ahmad Rasyid Ridho Anita Naibaho, Tri Arifin, Khairil Fikri Aulia Fitri Candrika Candrika Chandra, Putra Cut Intan Annisa Putri Denny Satria Dewi, Sri Harti Dinda Sari Utami Gabena Indrayani Dalimunthe Ginting, Ovalina Sylvia Br. Harahap, Aswan Pangondian Hari Purnomo Haris Munandar Nasution Hartini, Putri Tri Hindri Syahputri Karo-Karo, Sry Ulina Lestari, Amanda Putri Lubis, Minda Sari Muhammad Amin Nasution Muhammad Andry Muhammad Yunus Nasution, Melvi Ariati Nawalul Aska Nia Novranda Pertiwi Nindya Indah Damayanti Ningtias, Anggitha Ovalina Sylvia Br Ginting Puteri, Cut Intan Annisa Rafita Yuniarti Rambe, Robiatun Rawitri, Kiki Ridwanto Ridwanto Rinanda Silitonga, Desni Rinda Sari, Sylvi Robiatun Rambe Robiatun Rambe Rukmana, Siti Sadjnah Simahate Samran, Samran Sari, Syilvi Rinda Siti Anisa Sry Ulina Karo-Karo Syukur Berkat Waruwu Urip Harahap Yuandani Yuniarti, Rafita Zulmai Rani