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All Journal Majalah Obstetri dan Ginekologi Majalah Kesehatan FKUB Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Journal of Issues in Midwifery Jurnal Info Kesehatan
Subandi Subandi
Fakultas Kedokteran Universitas Brawijaya
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Pengaruh Pemberian Aromaterapi Lavender secara Inhalasi terhadap Penurunan Intensitas Nyeri Persalinan Fisiologis pada Primipara Inpartu Kala Satu Fase Aktif di BPM “Fetty Fathiyah” Kota Mataram Karlina, Sisca Dewi; Reksohusodo, Subandi; Widayati, Aris
Majalah Kesehatan FKUB Vol 2, No 2 (2015)
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.01 KB)

Abstract

Nyeri merupakan perasaan sensorik dan emosional yang tidak menyenangkan. Pada persalinan nyeri  disebabkan kontraksi miometrium, regangan segmen bawah rahim dan serviks, serta iskemia otot rahim sebagai proses fisiologis yang menimbulkan rasa takut dan khawatir yang dapat berdampak pada ibu dan janin. Aromaterapi adalah salah satu metode nonfarmakologis untuk menangani nyeri dengan memproduksi   enkefalin. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pemberian aromaterapi lavender secara inhalasi terhadap penurunan intesitas nyeri persalinan fisiologis pada primipara inpartu kala I fase aktif. Desain penelitian ini adalah experimental dengan rancangan one group pretest-posttes without control. Jumlah sampel 20 orang yang ditentukan dengan metode purposive sampling. Variabel bebas adalah pemberian aromaterapi dan variabel terikatnya adalah nyeri persalinan. Uji statistik menggunakan paired t-test diperoleh nilaii p value = 0,000 (p value < 0,05) artinya pemberian aromaterapi lavender terbukti signifikan dapat menurunkan intensitas nyeri persalinan fisiologis kala satu fase aktif. Dapat disimpulkan bahwa terdapat pemberian aromaterapi lavender secara inhalasi mampu menurunkan intensitas nyeri persalinan fisiologis pada primipara inpartu kala satu fase aktif. Kata kunci: Aromaterapi Lavender, Nyeri persalinan, Primipara.
Factors Related to the Need of Sexuality Education in Primary School in Gondanglegi Sub-District, Malang Regency Wati, Linda Ratna; Putri, Rismaina; Ariani, Dewi; Hidayah, Nurul; Reksohusodo, Subandi; Silvani, Yulia
Journal of Issues in Midwifery Vol 1, No 1 (2017)
Publisher : Journal of Issues in Midwifery

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (269.831 KB) | DOI: 10.21776/ub.JOIM.2017.001.01.1

Abstract

Semakin tingginya kekerasan dan pelecehan seksual pada anak di wilayah Kabupaten Malang serta adanya proses tumbuh kembang anak, dimana pada usia 9-12 tahun anak mulai memasuki masa pubertas, maka anak sekolah dasar perlu mendapatkan pendidikan seksualitas. Dan pendidikan seksualitas akan lebih baik jika diberikan sesuai kebutuhan anak. Tujuan dari penelitian ini adalah menganalisis kebutuhan pendidikan seksualitas pada anak sekolah dasar di Kecamatan Gondanglegi Kabupaten Malang. Metode penelitian yang digunakan adalah metode kuantitatif dengan rancangan explanatory research dengan pendekatan cross sectional. Pengumpulan data menggunakan kuesioner pada 317 sampel pada 24 sekolah dasar. Analisa data secara univariat, bivariat dengan chi-square dan multivariate dengan regresi logistik. Hasil penelitian menunjukkan bahwa sebagian besar responden (70.03%) membutuhkan pendidikan seksualitas dengan variabel yang berpengaruh pada kebutuhan pendidikan seksualitas adalah informasi (OR= 4.870), pengetahuan (OR=3.028), dan sikap terhadap pendidikan seksualitas (OR= 4.271).
Laporan Kasus : Pubertas Dini Akibat Kanker Ovarium Tipe Embrional Reksohusodo, Subandi
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Publisher : Journal of Issues in Midwifery

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.JOIM.2021.005.01.5

Abstract

Embryonic carcinoma (EC) cells were the first pluripotent cells identified. These cells were derived from malignant germ cell tumors called teratocarcinomas. Embryonal carcinoma also affects young patients but is far less common than yolk sac tumor in the ovary and, when encountered, is always a component of a mixed germ cell tumor.1 Malignant germ cell tumors are subdivided into dysgerminoma and nondygerminomatous tumors. The most common types of nondysgerminomatous tumors are yolk sac and immature teratoma. Mixed germ cell tumors with embryonal carcinoma, nongestational choriocarcinoma, and polyembryoma are less common. Embryonal carcinomas, though rare, are one of the most malignant cancers arising in the ovary.2In this case report, a 4,5-year-old girl was diagnosed with suspected embryonal ovarian carcinoma after complaints having menstruation for three months, develop pubic hair and breast. This patients later had laparotomy surgical staging and undergoing chemotherapy. 
PENGARUH PEMBERIAN SARI TOMAT (Solanum lycopersicum L) DAN INSULIN TERHADAP KADAR GLUKOSA, KADAR LDL, KADAR KOLESTEROL DAN BERAT BADAN LAHIR TIKUS PUTIH STRAIN WISTAR (Rattus Norvegicus) BUNTING DENGAN MODEL DIABETES MELLITUS TIPE 2 Savitri, Faradea Ubaidurrohmah; Safitri, Risma Andani Ayu; Maharani, Wening Pangesthi; Andriani, Lela Dwi; Kalsum, Umi; Proborini, Astri; Reksohusodo, Subandi; Dian Hanifarizani, Rahma
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Publisher : Journal of Issues in Midwifery

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.JOIM.2021.005.01.2

Abstract

Diabetes Mellitus is a chronic disease caused by abnormal working insulin, insulin secretion or both so that the body tends to have high glucose levels. Type 2 diabetes mellitus can cause elevated levels of LDL and cholesterol. Risks obtained by fetuses with type 2 diabetes can be in the form of macrosomia due to hyperglycemia and hyperinsulin in the body of the fetus. Insulin is the first choice pharmacological therapy for type 2 DM that can be given during pregnancy. Non-pharmacological therapy as recommended by the World Health Organization (WHO) on a healthy diet by increasing consumption of fruits and vegetables. Good fruit consumed for pregnant women with diabetes mellitus (DM) type 2 is tomatoes (Solanum lycopersicum L). The purpose of this study was to determine the administration of tomato extract (Solanum lycopersicum L) and insulin can affect glucose levels, LDL levels, cholesterol levels and birth weight of white wistar strain (Rattus norvegicus) pregnant women with type 2 diabetes mellitus models. experimental design using the pre post test only control group design and post test only control group design. Termination was done on the 17th day of pregnancy and then followed by measurements of LDL levels, cholesterol and birth weight. Data analysis using the One Way Anova test and Kruskal Wallis then continued with the Post Hoc test using. The results showed that there were significant differences between glucose levels, LDL levels, cholesterol levels and BW born in the insulin treatment group and the tomato juice treatment (p value = 0.00 <α = 0.05). The conclusion of giving insulin and tomato juice affects a decrease in glucose levels, LDL levels, cholesterol levels and birth weight.
PRODUKSI TOTAL REACTIVE OXYGEN SPECIES PADA KULTUR JARINGAN MOLA HYDATIDOSA KOMPLIT DENGAN PEMAPARAN 17-BETA ESTRADIOL Reksohusodo, Subandi; Nurseta, Tatit
Majalah Kesehatan FKUB Vol 8, No 2 (2021): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.majalahkesehatan.2021.008.02.1

Abstract

Frekuensi kejadian mola hydatidosa yang berpotensi menjadi penyakit trofoblast ganas terus meningkat. Mekanisme patologis yang mendasari penyakit tersebut belum dapat dieksplorasi secara mendalam, terdapat pemikiran bahwa mekanismenya terkait dengan kerusakan oksidatif yang berhubungan dengan produksi reactive oxygen species (ROS). Diketahui bahwa hormon estrogen dan metabolitnya dapat memproduksi ROS, untuk itu perlu dianalisis seberapa jauh keterlibatan estrogen (17β-estradiol) dalam patomekanisme penyakit ini melalui pengukuran total ROS. Penelitian ini dilaksanakan secara eksperimental dengan menggunakan randomized group control design. Rancangan percobaan yang digunakan adalah rancangan acak lengkap dengan 1 kelompok perlakuan, yaitu kelompok kultur jaringan mola hydatidosa yang mendapat suplementasi estrogen (17β-estradiol) dalam 4 dosis (5 mg/ml, 10 mg/ml, 20 mg/ml, 40 mg/ml) dan tanpa suplementasi. Dari hasil penelitian didapatkan perbedaan sangat bermakna kadar ROS antara kelompok kontrol dengan kelompok 17β-estradiol 5 mg/ml dan 17β-estradiol 40 mg/ml (p = 0,000 < 0,05), antara kelompok perlakuan 17β-estradiol 10 mg/ml dan 17β-estradiol 40 mg/ml (p = 0,000 < 0,05) dan antara kelompok perlakuan 17β-estradiol 20 mg/ml dan kelompok perlakuan 17β-estradiol 40 mg/ml (p = 0,000 < 0,05). Disimpulkan bahwa pemberian 17β-estradiol 20 mg/ml dan 40 mg/ml mempengaruhi produksi total ROS pada kultur jaringan mola hydatidosa. 
Effect of Nanocurcumin in Combination with Methotrexate on Telomerase Activity, NF-kb Expression, and Proliferation Index of Bewo Choriocarcinoma Cells: Pengaruh Kombinasi Nanokurkumin dengan Methotrexate terhadap Aktivitas Telomerase, Ekspresi NF-kb, dan Indeks Proliferasi Sel Koriokarsinoma Bewo Subandi Subandi; Sigit Purbadi
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 2 April 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i2.1733

Abstract

Laporan Kasus Kanker Endometrium Tipe Sekretori: Kasus Jarang Subandi Subandi
Journal of Issues in Midwifery Vol. 7 No. 1 (2023): Volume 7 No 1
Publisher : Journal of Issues in Midwifery

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.JOIM.2023.007.01.5

Abstract

Endometrial cancer is the most common gynecological cancer in developed countries, second most in poor countries and developing countries after cervical cancer. Most endometrial cancer patients come with complaints of bleeding and come at an early stage. It’s important to make the right diagnosis to determine the appropriate treatment. Treatment depends on the stage determined by surgery. After surgery, the patient’s risk was classified as low, moderate, or high risk. This risk is determined by stage, cell type, differentiation, involvement of blood vessels and lymph vessels. From these risk factors, it is determined whether or not additional postoperative therapy is needed in the form of radiation or chemotherapy. Secretory type of endometrial cancer is a rare endometrial malignancy. This case’s population is 1-2% of all endometrial cancer. Histologically, this type of cancer belongs to type one. We report a secretory type of endometrial cancer case in a 41-year-old woman with a complaint of irregular menstruation, and a total hysterectomy, bilateral salpingo oophorectomy, bilateral pelvic lymphadenectomy and para-aortic lymphadenectomy was done. Histologically, secretory carcinoma must be separated from carcinoma clear cell to determine the prognosis.
Nano-curcumin in the decrease of proteinuria in white rats (Rattus norvegicus) with preeclampsia Subandi; Sahara, Aulia Ilma; Nurdiana
Majalah Obstetri & Ginekologi Vol. 32 No. 1 (2024): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V32I12024.8-13

Abstract

HIGHLIGHTS The size of curcumin was modified to nano scale in order to enhance its bioavailability and facilitate its absorption in the body. As a herbal medicine, nano-curcumin has the ability to reduce proteinuria and serve as a preventive measure against preeclampsia.   ABSTRACT Objective: Since preeclampsia is one of the most serious hypertensive disorders in pregnancy, as it occurs in 5-7% of all pregnancies, and causes around 70,000 maternal deaths and 500,000 fetal deaths worldwide each year, this study aimed to determine the effect of nano-curcumin on proteinuria in pregnant white rats (Rattus norvegicus) with preeclampsia. Materials and Methods: In this study, 24 white rats (Rattus norvegicus) were randomly selected and divided into six groups. Inclusion criteria included healthy rats aged 8 weeks or older, with normal blood pressure and weight, while exclusion criteria included sick, deceased, or prematurely birthing rats, and those with high blood pressure. Treatment, administered over six days from gestational days 13-18, involved L-NAME and nano-curcumin injections. Groups included K- (no treatment) and K+, P1, P2, P3, and P4 (treated with L-NAME and varying nano-curcumin doses). Blood pressure and proteinuria were evaluated on gestation days 12, 15, and 19 to confirm the preeclampsia model and assess nano-curcumin's effect on proteinuria. Urine collected over 24 hours in metabolic cages preceded the rats' termination. Data analysis utilized IBM SPSS version 23, including the Shapiro-Wilk test, parametric independent sample t-tests, One-Way ANOVA tests, and LSD post-hoc tests to identify group differences.   Results: The results of this study showed that nano-curcumin had the effect of reducing proteinuria in white rats with preeclampsia. The significant results of the One-Way Anova test was p=0.001 (p <0.05) and the LSD post-hoc test revealed that the effective dose was 25 mg/ml. It was found that higher nano-curcumin dose had a higher average of proteinuria. Conclusion: Nano-curcumin can affect proteinuria in preeclampsia. The most effective dose is 25 mg/ml.
The Effects of Black Garlic on Ovarian Malondialdehyde, Oviduct Muscle, and Endometrial Arterioles in Smoke-Exposed Rats Noni Fidya Ayu Anandasari; Novalia Kridayanti; Ni Ketut Devy Kaspirayanthi; Tatit Nurseta; Tri Yudani Mardining Raras; Husnul Khotimah; Subandi Reksohusodo; Kenty Wantri Anita; Hendy Setyo Yudhanto
JURNAL INFO KESEHATAN Vol 22 No 2 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Politeknik Kesehatan Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss2.1533

Abstract

The effect of cigarette smoke exposure on reproductive health has been widely studied, showing various physiological disorders induced by free radicals and oxidative stress. This study aimed to assess the protective effect of ethanol extract of black garlic (Allium sativum) on some reproductive parameters of female rats Rattus norvegicus exposed to subacute cigarette smoke. A proper experimental method with a post-test-only control group design was used, involving 25 rats divided into five groups with three different doses of the extract. The rats were exposed to cigarette smoke and then treated for 28 days. Results showed a significant decrease in ovarian Malondialdehyde levels and increased fallopian tube smooth muscle thickness in the extract-treated group. In addition, black garlic extract successfully increased the number of endometrial arterioles in the group exposed to cigarette smoke and extract, in contrast to the group exposed to cigarette smoke only. This study concludes that black garlic extract has the potential to be a protective agent against oxidative damage in the reproductive system of rats exposed to cigarette smoke, with effectiveness that depends on the dose of extract given. Further studies should investigate the long-term effects and optimal dosing of black garlic extract in humans. Additionally, exploring the molecular mechanisms behind its protective properties could enhance its application in reproductive health management.                 
Analysis of the Effect of Black Garlic (Allium sativum) Extract on Ovarian Follicular Atresia, Endometrial VEGF Expression, and Fallopian Tube Epithelial Cell Count in Rats (Rattus norvegicus) Exposed to Cigarette Smoke Novalia Kridayanti; Noni Fidya Ayu Anandasari; Ni Ketut Devy Kaspirayanthi; Tatit Nurseta; Tri Yudani Mardining Raras; Husnul Khotimah; Subandi Reksohusodo; Aina Angelica; Kenty Wantri Anita; Hendy Setyo Yudhanto
JURNAL INFO KESEHATAN Vol 22 No 2 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Politeknik Kesehatan Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss2.1535

Abstract

Cigarette smoke exposure significantly impairs reproductive function in Rattus norvegicus. This study evaluated the protective effects of black garlic extract against such damage. Using a post-test-only control group design, 25 female Wistar rats were divided into five groups and exposed to cigarette smoke with or without varying doses of black garlic extract. After four weeks, results indicated that black garlic extract significantly increased Vascular Endothelial Growth Factor expression, enhanced fallopian tube secretory epithelial cell counts, and reduced ovarian follicular atresia in rats exposed to cigarette smoke. The group receiving 50 mg/kgBW of black garlic extract showed the most significant improvements. Statistical analysis, including One-way ANOVA, revealed significant differences between groups. Normality was assessed using the Shapiro-Wilk test, and homogeneity was confirmed with the Levene test. Significant decreases in ovarian follicular atresia (p < 0.05) and increases in Vascular Endothelial Growth Factor expression (p < 0.05) and secretory epithelial cell counts (p < 0.05) were observed in the 50 mg/kgBW treatment group compared to controls. In conclusion, black garlic extract offers dose-dependent protection against cigarette smoke-induced reproductive damage, with 50 mg/kgBW being the optimal dose. Further research should explore molecular mechanisms, long-term toxicity, and clinical applications in humans.              
Co-Authors AA Sudharmawan, AA Abd. Rasyid Syamsuri Aina Angelica Anandasari , Noni Fidya Ayu Anandasari, Noni Fidya Ayu Andriani, Lela Dwi Angelica, Aina Anisa Setyowati Aris Widayati Astri Proborini Bambang Rahardjo DEWI ARIANI Dewi Azar Nuria Wardani Dian Hanifarizani, Rahma Gusti, Kharisma Ciptaning Hendy Setyo Yudhanto Hikmawan Wahyu Sulistomo Husnul Khotimah Ihda Dian Kusuma Ihda Dian Kusuma Ita Sulistiani Kaspirayanthi, Ni Ketut Devy Kenty Wantri Anita Kenty Wantri Anita, Kenty Wantri Kharisma Ciptaning Gusti Kridayanti, Novalia Maharani, Wening Pangesthi Melani Chysti Situmorang Nasution, Annio Indah Lestari Ni Ketut Devy Kaspirayanthi Noni Fidya Ayu Anandasari Novalia Kridayanti Nurdiana Nurdiana Nurdiana Nurdiana Nurdiana Rismaina Putri Safitri, Risma Andani Ayu Sahara, Aulia Ilma Savitri, Faradea Ubaidurrohmah Setyowati, Anisa Sigit Purbadi Silvani, Yulia Sisca Dewi Karlina, Sisca Dewi Situmorang, Melani Chysti Sulistiani, Ita Sulistomo, Hikmawan Wahyu Tatit Nurseta Tatit Nurseta Tri Yudani Mardining Raras Tri Yudani MR Wardani, Dewi Azar Nuria Wati, Linda Ratna Yudhanto, Hendy Setyo