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All Journal eJournal Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Rolan Sitompul
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Measuring HBsAg and HBV DNA Levels in Cilegon Rolan Sitompul; Martono Roni; Unggul Budihusodo
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 10, NUMBER 3, December 2009
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/103200999-104

Abstract

Background: Implication of measuring HBsAg level is still not recognized well. The aim of this study to recognize the correlation of serum HBsAg level and serum HBV DNA level between in HBeAg positive patients and HBeAg negative patients. Method: Quantitative serum HBV DNA were collected retrospectively between January 2006 and May 2009. We stratified the patients into four groups, that were; HBeAg positive and (a) ALT 2 x upper limited normal (UNL) (group A),( b) ALT 2 x UNL (group B), HBeAg negative and:( a) ALT 2 x UNL (group C) (b) ALT 2 x UNL (group D). We studied the correlation of serum HBsAg and HBV DNA level in each group. In addition, we also studied the accuracy of HBsAg titers to predict serum HBV DNA levels in each group by using receiver operating characteristic (ROC) curve analysis. Results: Eighty nine patients were recruited in this study. Most of them 63 (70%) were male; the mean age of the patients was 38.49 ± 11.21 years. The number of patients with HBeAg positive and negative were 28 and 61 respectively. Based on the group stratification, the A, B, C and D groups we found 16, 12, 11, 50 respectively. There was a positive correlation between HBsAg titers and HBV DNA level in HBeAg positive patients but it was statistically not significant. Similar result was also found in HBeAg negative patients. There were positive correlation in group A, C, and D but they were not statistically significant. In group B the correlation was negative (r = -0.40). We found 100% sensitivity and 100% specificity of predicting serum HBV DNA levels in group A with HBsAg cut-off level of 7.91 IU/mL and baseline serum HBV DNA cut-off level 20,000 IU/mL. In group B, C and D the accuracy to predict serum HBV DNA level were not so good . Conclusion: There were positive correlation between HBsAg titers and HBV DNA levels in HBeAg positive and HBeAg negative patients as demonstrated in the three group stratification; however, the correlation was negative in group HBeAg positive and ALT 2 x UNL. We found excellent (100%) specificity and sensitivity for predicting serum HBV DNA level in group HBeAg positive and ALT 2 x UNL with HBsAg cut-off level 7.91 IU/mL and baseline serum HBV DNA cut-off level 20,000 IU/mL; while in other groups, the correlation were not so good.   Keywords: serum HBsAg level, serum HBV DNA level, hepatitis B, correlation
Post-Endoscopic Retrograde Cholangiopancreatography Complications at Dr. Cipto Mangunkusumo General Hospital Rolan Sitompul; Achmad Fauzi; Dadang Makmun; Murdani Abdulah; Ari Fahrial Syam; Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 10, ISSUE 2, August 2009
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/102200941-45

Abstract

Background: This study retrospectively evaluated post-endoscopic retrograde cholangiopancreatography (ERCP) complications at Cipto Mangunkusumo hospital in order to improve management of a subsequent prospective study of post-ERCP complications.Method: The indications, findings, diagnostic or therapeutic procedure, cannulation, devices used during the procedure, and complications of patients treated consecutively with ERCP between January 2004 and November 2008 were evaluated retrospectively.Results: Of 176 ERCP patients who were initially evaluated, 38% had undergone diagnostic ERCP and 62% therapeutic ERCP. The median age of the patients was 49 years (range 18–80 years); 95 (53.9%) were male. Only 54 of these 176 procedures could be evaluated for post-ERCP complications. A computed tomographic abdominal scan or magnetic resonance cholangio-pancreatography was performed in 23 (42.6%) patients and a biliary sphincterotomy in 14 (25.9%) patients. The overall complication rate was 33.3%: 14.8% after diagnostic ERCP and 18.5% after therapeutic ERCP. The complications after diagnostic ERCP were pancreatitis in 3 (15%) patients, cholangitis in 3 (15%) patients, hemorrhage in 1 (5%) patient, pancreatitis and hemorrhage in 1 (5%) patient; the complications after therapeutic ERCP were pancreatitis in 6 (17.6%) patients, cholangitis in 3 (8.8%) patients, hemorrhage in none, and concomitant pancreatitis with hemorrhage in 1 (2.9%) patient. No significant difference was observed between the complication rates and the type of ERCP performed.Conclusion: There were no differences in the complications after diagnostic and therapeutic ERCP. As our study shows the post-ERCP complication rate to be higher than those of other large retrospective and prospective studies, we must evaluate it in a prospective study.Keywords: post-ERCP, complications, therapeutic ERCP, diagnostic ERCP
Sindrom Paraneoplastik pada Kanker Paru Salsabila, Nahri; Sari, Elsa P.; Drajat, Rizki; Sitompul, Rolan
eJournal Kedokteran Indonesia Vol. 12 No. 3 (2024): Vol. 12 No. 3 - Desember 2024
Publisher : Faculty of Medicine Universitas Indonesia

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Abstract

Kanker paru memiliki angka kematian tertinggi akibat keganasan di Indonesia dengan angka kejadian pada laki-laki lebih tinggi dibandingkan Perempuan dan Sepuluh persen penderitanya mengalami sindrom paraneoplastik. Sindrom paraneoplatik merupakan respon tubuh terhadap suatu keganasan yang tidak secara langsung berhubungan dengan tumor primer serta metastasenya yang melibatkan sistem endokrin, dematologi, hematologi, nefrologi, oftalmik, reumatologi, neurologi. Histologi dari kanker paru mempengaruhi jenis sindrom paraneoplastik, dua tersering yaitu Humoral hypercalcaemia of malignancy (HHM) pada tipe karsinoma sel skuamosa dan Syndrome of innappropriate antiduiretic hormone (SIADH) pada tipe small cell lung cancer (SCLC). Artikel ini bertujuan untuk mengkaji jenis-jenis sindrom paraneoplastik pada kanker paru, mekanisme patofisiologi, serta pengaruhnya terhadap diagnosis, prognosis. Pengetahuan yang mendalam mengenai hubungan antara histologi kanker paru dengan jenis sindrom paraneoplastik dapat membantu tenaga medis dalam mendeteksi dini, memberikan pengobatan yang tepat, dan meningkatkan kualitas hidup pasien secara keseluruhan. .Penanganan segera setelah munculnya sindrom paraneoplastik dapat memberikan dampak yang lebih baik seperti memperpanjang tingkat kelangsungan hidup dan meningkatkan kualitas hidup.
Co-Authors ACHMAD FAUZI Achmad Fauzi Ari Fahrial Syam Dadang Makmun Drajat, Rizki Marcellus Simadibrata Marcellus Simadibrata Martono Roni Murdani Abdulah Salsabila, Nahri Sari, Elsa P. Unggul Budihusodo