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All Journal Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Jurnal Ilmiah Universitas Batanghari Jambi Syntax Literate : Jurnal Ilmiah Indonesia Jurnal Respirasi (JR) Biomolecular and Health Science Journal Indian Journal of Forensic Medicine & Toxicology

Resti Yudhawati

Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, Universitas Airlangga/Dr. Soetomo General Hospital, Surabaya, Indonesia.

Author-ID : 359632

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Other

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IDENTIFICATION OF INFLUENZA VIRUSES IN HUMAN AND POULTRY IN THE AREA OF LARANGAN WET MARKET SIDOARJO-EAST JAVA, INDONESIA Frederika, Edith; Mareta, Aldise; Poetranto, Djoko; Wulandari, Laksmi; Setyoningrum, Retno Asih; Setyowati, Lucia Landia; Yudhawati, Resti; Soegiarto, Gatot; Yamaoka, Masaoki
Indonesian Journal of Tropical and Infectious Disease Vol 4, No 4 (2013)
Publisher : Institute of Topical Disease

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2006.144 KB)

Background: Influenza is a viral infection that attacks the respiratory system (nose, throat, and lungs) that commonly known as âfluâ. There are 3 types of influenza viruses, such as type A, type B, and type C. Influenza virus type A is the type of virus that can infect both human and animals, virus type B are normally found only in human, and Influenza virus type C can cause mild illness in human and not causing any epidemics or pandemics. Among these 3 types of influenza viruses, only influenza A viruses infect birds, particularly wild bird that are the natural host for all subtypes of influenza A virus. Generally, those wild birds do not get sick when they are infected with influenza virus, unlike chickens or ducks which may die from avian influenza. Aim: In this study, we are identifying the influenza viruses among poultry in Larangan wet market. Method: Around 500 kinds of poultry were examined from cloacal swab. Result: Those samples were restrained with symptoms of suspected H5. The people who worked as the poultry-traders intact with the animal everyday were also examined, by taking nasopharyngeal swab and blood serum. Conclusion: Identification of influenza viruses was obtained to define the type and subtype of influenza virus by PCR.

Profile of Pneumocystis JiroveciiPneumoia in HIV/AIDS Patients in Dr. Soetomo General Hospital of East Java Province Pius Sebastian Ginting; Bramantono; RestiYudhawati Meliana; Musofa Rusli
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 2 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i2.17933

Background: Human immunodeficiency virus (HIV)-infected patients if not treated will experienceacquired immunodeficiency syndrome (AIDS). People with AIDS will suffer opportunistic infection.One of the common opportunistic infections is Pneumocystis jirovecii pneumonia (PCP). PCP is aninfection caused by the fungus Pneumocystis jirovecii which infects patient’s lungs. The purpose of thisstudy is to analyze the profile of HIV/AIDS patients with PCP in Dr. Soetomo Hospital.Methods: This is a retrospective descriptive study based on medical records obtained from the inpatientward of Dr. Soetomo General Hospital Surabaya. A total 21 patients enrolled in this study who met theinclusion criteria. The data are retrospectively described by demographic characteristics, CD4 count,clinical symptoms, blood gas, and lungs radiographic features.Conclusion:Major findings of PCP in HIV/AIDS patients was in the group of age 25-49 years (85,7%),male (85,7%), high school graduate (71,4%), employed and unmarried (66,7%). The most commonclinical symptoms were dyspnea (100%), PaO2 ≥70 mmHg (61,97%), CD4 count <50 cells/μL (76,2%)and the most common radiographic features was bilateral interstitial infiltrates (95,2%).

Viral Profile and Clinical Characteristic in Acute Asthma Exacerbation Patients Resti Yudhawati; Erwin Winaya; Laksmi Wulandari; Aldise M Nastri; Retno A Setyoningrum; Kazufumi Shimizu
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14872

Background: Asthma is a heterogeneous disease characterized by chronic airway inflammation. Thevirus infection in respiratory tract will activate greater pro-inflammatory cytokines in asthma patients.The enhancement of pro-inflammatory cytokines induces various clinical symptoms. This study aims toinvestigate the respiratory virus and clinical characteristics among patients with acute asthma exacerbation.Methods: In this study, subjects were divided into 3 groups based on acute asthma exacerbation triggers.The first group triggered by virus infection; the second group triggered by non-virus infection with ILI; andthe third group without any infection. Nasopharynx or throat swabs were collected to detect any respiratoryvirus. Virus was detected by Multiplex PCR (xTAG Respiratory Viral Panel Fast V2/ LUMINEX)Results: According to PCR examination, the prevalence of virus infection was 46.2%. Only two types ofviruses identified, which were Influenza A virus and Rhinovirus. All patients in the second groups showeda symptom of cough with purulent sputum, while no patients from the other two groups showed similarsymptoms. PEFR and % PEFR prediction of patients with Influenza A virus infection were higher than inRhinovirus infected-patients (210 L/min and 48.6% vs 195 L/min and 45%).Conclusion: Acute asthma exacerbation is one of the most reasons patients came to emergency ward. Themajority of acute asthma exacerbation was caused by infection, and most of it was viral infection. Clinicalsign differs according to the trigger, therefore the use of antibiotics should be avoided, unless there are signsand symptoms of bacterial infections

Capillary Lactate Level in Non-Severe and Severe CommunityAcquired Pneumonia Patients Resti Yudhawati; Kowiy Akbar
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14873

Background: Community-acquired pneumonia is an inflammatory disease of the lung caused bymicroorganisms acquired from a non-hospital environment. The pneumonia severity index and ATS/IDSAseverity criteria are widely used to predict the severity of CAP. Lactate is a biomarker that can be measuredby point-of-care devices that provide results in a short of time. This study aimed to determine the differencein capillary lactate level between non-severe and severe pneumonia to provide an additional method toquickly stratify pneumonia severity and treat it accordingly.Methods: This cross-sectional study was performed in the emergency room of a regional research hospital.The pneumonia diagnosis was determined by the symptoms, physical examination and radiological findings.Capillary lactate level was measured with Accutrend Plus lactate point-of care device. Severity stratificationwas done according to ATS/IDSA criteria. The mean of lactate level in all subjects was 3.40±1.52, in nonsevere pneumonia subgroup was 2.25±0.94, and 4.56±1.01 in severe pneumonia subgroup. Lactate issignificantly higher in severe pneumonia subgroup. The cut-off point of lactate level for severity group was3.2 mmol/L (95.5% sensitivity, 86.4% specificity).Conclusion: The early prediction of CAP severity is essential to determine the need for admission in theintensive care unit and close follow up. The lactate level can be used for immediate severity stratification inemergency departments.

Diabetes Mellitus and History of Tuberculosis Treatment as Risk Factors of Developing Multidrug-Resistant Tuberculosis at TB Polyclinic Dr. Soetomo General Hospital 2019 - 2020 Muhammad Raihan Habibi; Arief Bakhtiar; Danti Nur Indiastuti; Resti Yudhawati Meliana
Jurnal Ilmiah Universitas Batanghari Jambi Vol 22, No 1 (2022): Februari
Publisher : Universitas Batanghari Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33087/jiubj.v22i1.1908

Multidrug-Resistant Tuberculosis (MDR TB) is a condition when Mycobacterium tuberculosis were resistant to Isoniazid and Rifampicin simultaneously, with or without being followed by other first-line Anti-Tuberculosis Drugs. Diabetic patients who also have TB are more susceptible to drug resistance. There is ample evidence noting that a history of previous TB treatment is one of the main factors contributing to the development of MDR TB. This study was a case-control study. The sample of this study was all patients from TB Polyclinic Dr. Soetomo Hospital who were diagnosed with pulmonary TB by pulmonologists on January 1, 2019 – December 31, 2020, who met the inclusion criteria. The data obtained were analyzed using the IBM SPSS Statistics 23 application with a binary logistic regression test.There were 178 samples of this study. MDR TB (65.8%) was the dominant resistance type in Drug-Resistant Tuberculosis (DR TB) patients. Patients with DM were 2.2 times more likely to develop MDR TB than patients without DM. Patients with histories of previous tuberculosis (TB) treatment tended to be three times more likely to develop MDR TB than new patients. Other factors such as age, sex, BMI, history of alcohol consumption, and history of smoking did not show a significant relationship with the incidence of MDR TB. Diabetes Mellitus comorbidity and history of previous Tuberculosis treatment were significant risk factors for developing MDR TB.

Primary Pulmonary Lymphoma with Superior Vena Cava Syndrome Alfian Nur Rosyid; Resti Yudhawati Meliana
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Primary Pulmonary Lymphoma (PPL) is a clonal proliferation of lymphoid cells that involve one or two lungs (parenchyma and or bronchi. PPL is found in approximately 0.4% of all lymphoma cases and 3.6% of NHL cases. Five years survival rate at stage I and II is 90%, and 80% in stage III and IV. A 63-year-old male farmer presented with chief complaint of shortness of breath for one week before admission and preceded by coughing for a month, loss of appetite and night sweating. There was an abnormal physical examination on the right side of the chest with non-tender lymph node enlargements in the right supraclavicular and neck region and superior vena cava syndrome. CT guided FNAB suggesting NHL. Patient was treated with CHOP chemotherapy regiment. However, with high grade lymphoma, patient did not respond well.

The Role of N-Acetyl Sistein in Pulmonary Tuberculosis Resti Yudhawati; Nitya Prasanta
Jurnal Respirasi Vol. 6 No. 1 (2020): January 2020
Publisher : Faculty of Medicine Universitas Airlangga

Pulmonary Tuberculosis is a chronic infection that caused by Mycobacterium tuberculosis (M.tb) infection and it is still the major health problem worldwide. Mycobacterium tuberculosis infection can induce oxidative stress. Some studies has proved that active TB patients have an association with excessive oxidative stress which causes glutathione (GSH) level decrease and free radicals increase. Glutathione (GSH) facilitates the control of M.TB intracellular bacterial growth in macrophages and has direct antimicrobial activity. N-acetylcysteine (NAC) is thiol, a precursor of L-cysteine and glutathione synthesis (GSH) that has been used for decades as a mucolytic agent in the treatment of respiratory diseases. Some studies report beneficial role of NAC as immunomodulator, besides NAC also has anti-inflammatory and antimicrobial effect in TB management.

Biological Therapy for Asthma Resti Yudhawati; Megawati Rif’atyyah Nozomi Guntur
Jurnal Respirasi Vol. 7 No. 1 (2021): January 2021
Publisher : Faculty of Medicine Universitas Airlangga

Asthma is a heterogeneous chronic inflammatory disease in the respiratory tract that leads to recurrent episodic symptoms. Study about the mechanism of pathophysiology and immunology which stimulates chronic inflammation in asthma has been greatly developed. The understanding of inflammation mediator that is predominant on various asthma phenotypes could be useful for development of diagnosis and targeted therapy. Standard asthma therapy administered through the airway has limited effects only in the airway. The knowledge of molecular pathophysiology and immunology of this disease developed interest of the drugs that perform proximally from inflammation process in the airway, in this case is biological therapy. Several biological therapies have been investigated for its efficacy on human, including Anti IgE (Omalizumab), Anti Interleukin-5 (Mepolizumab, Reslizumab, Benralizumab), Anti Interleukin-4/Interleukin-13 (Dupilumab), and Anti Interleukin-17 (Secukinumab and Brodalumab).

Imunopatogenesis Asma: [Immunopathogenesis of Asthma Bronchiale] Resti Yudhawati; Desak Putu Agung Krisdanti
Jurnal Respirasi Vol. 3 No. 1 (2017): Januari 2017
Publisher : Faculty of Medicine Universitas Airlangga

Asthma is a chronic inflammatory disease of the airways characterized by recurrent wheezing, shortness of breath, chest tightness and cough especially at night and or early morning. Airflow resistance in asthma were caused by changes in the airways include bronchoconstriction, airway edema, hyperresponsiveness and airway remodeling. The inflammatory response in asthma patients varies among individuals, whether it can be immediate or late (slow-type) response. Different types of cells are known to play role in this process, especially mast cells, eosinophils, T lymphocytes, macrophages, neutrophils and epithelial cells. Degranulation of mast cells in the airways release inflammatory mediators and various metabolites that directly lead to smooth muscle hypersponsive resulting in airway obstruction. While eosinophil cells, mast cells and lymphocytes associated with slow-type responses, will release various mediators including leukotriene, prostaglandins and a number of proinflammatory cytokines. Type 2 immune response in the lower respiratory tract is a central immunologic process in asthma. This type 2 immune response is mediated by Th2 cells of CD4 + and IgE. The CD4 + Th2 cell is characterized by the large amount of transacting T-cell-specific transcription factor GATA-3 and the secretion of type 2 cytokines (IL-4, IL-5, IL-9 and IL-13). Excessive type 2 cytokines in the lower airway will trigger IgE-mediated hypersensitivity, epithelial cell activation, inflammatory cell inflation mediation into the airways, and cause remodeling responses in the epithelium and subepithelial matrices. This inflammatory cascade of type 2 cytokines is the pathological basis of the main symptoms of asthma.

Hubungan Kadar Interleukin-10 dan Tuberkulosis Multi-Drug Resistant: [Interleukin-6 Serum Level in Multidrug-Resistant Tuberculosis] Nurjanah Lihawa; Resti Yudhawati
Jurnal Respirasi Vol. 1 No. 2 (2015): Mei 2015
Publisher : Faculty of Medicine Universitas Airlangga

Background: Prevalence of multi-drug resistant tuberculosis (MDR-TB) is increased by the time. In Indonesia, there were an estimated 1.9% of new cases and 12% of previously treated cases. Protection against Mycobacterium tuberculosis is dependent on Th1 cell CD4+ that produced pro-inflammatory cytokines such as IFN-γ and TNF-α. T cell regulators (Tregs) produced IL-10 as anti- inflammatory cytokine is against the function of those pro-inflammatory cytokines. It is believed that immune suppression is responsible for MDR-TB. The previous study showed impaired Th1 responses and enhanced regulatory T-cell levels in circulatory blood of MDR- TB patients. The study of IL-10 represented anti-inflammation cytokine as immune suppression never been conducted in Indonesia. Objective: To analyze relationship between level of interleukin-10 and Multi-drug resistant tuberculosis. Methods: The study was conducted at the outpatient department of MDR-TB and DOTS of Dr. Soetomo hospital in Surabaya. Total sample was 38 of TB patients that consist of 19 MDR-TB patients (secondary resistant) and 19 non-MDR TB patients as control. Results: In this study we found that the median level of IL-10 as 5.7±3.3 pg/mL in the group of MDR-TB patients with minimum level was 1.3 pg/mL and maximum level was 14.0 pg/mL while median level of IL-10 in non-MDR TB patients was 7.0±3.4 pg/mL with 3.2 pg/mL and 16.5 pg/mL, respectively. To analyze correlation between time to first of having TB until became MDR-TB and level of IL-10 by using Pearson’s correlation, we showed that no statistical correlation (p>0.05). According to statistical classification, we found that no statistical correlation between level of IL-10 and the history of treatment in MDR-TB patients (p>0.05). Data showed that all the history of treatment classification dominated by MDR-TB patients with the low level of IL-10. We also found that no statistical difference with the level of IL-10 in MDR- TB and non-MDR TB patients (p>0.05) although in descriptive state we found the level of IL-10 was higher in non-MDR TB patients. And also there was no relationship between level of IL-10 and MDR-TB (p>0.05). It could be explained that the host factor was not involved and in the other side we still not known the factor of agents, yet. The low level of IL-10 that was observed in this study could be interfering by the strain of M.tb which not assessed in this study. Conclusion: In this study we found that level of IL-10 is not increase in MDR-TB patients and there was no relationship between level of IL-10 and MDR-TB (p>0.05).

Co-Authors Aldise M Nastri Aldise Mareta Nastri Aldise Mareta, Aldise Atik, Nurul Ayurveda Zaynabila Heriqbaldi Bakhtiar, Arief Bakhtiar, Arief Bramantono Bramantono, Bramantono Desak Putu Agung Krisdanti Djoko Poetranto, Djoko Edith Frederika, Edith Emmanuel Djoko Poetranto Erwin Winaya Febriani, Anna Gatot Soegiarto Hariputri, Wulan Rahmawati Indiastuti, Danti Nur Indrawanto, Dwi Wahyu Johanes Nugroho Kazufumi Shimizu Kowiy Akbar Kusmiati, Tutik Laksmi Wulandari Landia Setiawati Lucia Landia Setyowati, Lucia Landia Luh Ade Wilan Krisna Masaoki Yamaoka Masaoki Yamaoka, Masaoki Megawati Rif’atyyah Nozomi Guntur Mochammad Afif Ziaulhaq Muhammad Jusuf Wibisono, Muhammad Jusuf Muhammad Raihan Habibi Musofa Rusli Ni Made Mertaniasih Nitya Prasanta Novananda, Donny Ardika Nurjanah Lihawa Permatasari, Ariani Pius Sebastian Ginting Rebekah Setiabudi, Rebekah Retno A Setyoningrum Retno Asih Retno Asih Setyoningrum Riyanto, Shandy Billy Rosyid, Alfian Nur Semedi, Bambang Pudjo Setiawati, Rosy Soedarsono Soedarsono Syafa'ah, Irmi Syafa’ah, Irmi Tafana Fadhillah Laili Thendeyas, Richar Tomy Wati, Farah Fatma Whendy Wijaksono Yuyus Dwi Prasetiyo

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