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All Journal Sains Natural: Journal of Biology and Chemistry Jurnal Farmasi Indonesia JKPK (Jurnal Kimia dan Pendidikan Kimia) Jurnal Ners International Journal Of Science, Technology & Management (IJSTM) JUKESHUM: Jurnal Pengabdian Masyarakat International Archives of Medical Sciences and Public Health Jurnal Farmanesia Jurnal Pengabdian Masyarakat Tjut Nyak Dhien Journal of Pharmaceutical and Sciences. Jurnal Pengabdian Masyarakat Ilmu Kesehatan Media Penelitian dan Pengembangan Kesehatan Ulil Albab
Rida Evalina Tarigan
Institut Kesehatan Helvetia
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Antibacterial Activity of Ag-Hidroxyapatite Composite of Bone-in Tuna (Thunnus albacores) Against Streptococcus mutans Hendri Faisal; Rida Evalina Tarigan; Julkardo Lase
JURNAL SAINS NATURAL Vol. 12 No. 2 (2022): Sains Natural
Publisher : Universitas Nusa Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (517.272 KB) | DOI: 10.31938/jsn.v12i2.378

Abstract

Calcium from fish bones have not been widely used for human needs. Calcium in the medical field is used as a hydroxyapatite compound, such as in the manufacture of bones and dentures, as an additive in the manufacture of toothpaste, and usage in drug delivery. This study aims to determine whether the Ag-Hydroxyapatite composite has an inhibitory capability against Streptococcus mutans bacteria. This research is an experimental study through laboratory testing by synthesizing Ag-Hydroxyapatite from tuna fish bones (Thunnus albacores) and testing its antibacterial activity against Streptococcus mutans bacteria. The results showed that the tuna fish bone samples formed hydroxyapatite compounds and the results of the Ag-Hydroxyapatite composite had antibacterial activity against Streptococcus mutans bacteria, the statistical test results showed a significant difference from the negative control group. Ag-hydroxyapatite composite has antibacterial activity against Streptococcus mutansKeywords: Tuna (Thunnus albacores); Hydroxyapatite; Argentum; Antibacterial; Streptococcus mutans ABSTRAKUji Aktivitas Antibakteri Komposit Ag-Hidroksidaapatit dari Tulang Ikan Tuna (Thunnus albacores) terhadap Streptococcus mutansKalsium dari tulang ikan, belum banyak dimanfaatkan untuk kebutuhan manusia. Kalsium dalam dunia medis dimanfaatkan menjadi senyawa Hidroksiapatit. seperti pada pembuatan tulang dan gigi palsu, sebagai bahan tambahan dalam pembuatan pasta gigi dan juga digunakan sebagai penghantar obat. Penelitian ini bertujuan untuk mengetahui apakah komposit Ag-Hidroksiapatit memiliki daya hambat terhadap bakteri Streptococcus mutans. Penelitian ini merupakan penelitian yang bersifat eksperimental melalui pengujian laboratorium dengan mensintesis Ag-Hidroksiapatit dari tulang ikan tuna (Thunnus albacores) dan menguji aktivitas antibakteri terhadap bakteri Streptococcus mutans. Hasil penelitian menunjukan bahwa dari sampel tulang ikan tuna terbentuk senyawa Hidroksiapatit dan hasil komposit Ag-Hidroksiapatit memiliki aktifitas antibakteri terhadap bakteri Streptococcus mutans, hasil uji statistik menunjukkan adanya perbedaan signifikan terhadap kelompok kontrol negatif.  Komposit Ag-hidrokiapatit memiliki aktifitas antibakteri terhadap bakteri Streptococcus mutansKeywords: Tuna (Thunnus albacores); Hydroxyapatite; Argentum; Antibacterial; Streptococcus mutans
ANALISIS KANDUNGAN VITAMIN C PADA BUAH STROBERI (Fragaria x ananassa Duschesne) SECARA SPEKTROFOTOMETRI ULTRAVIOLET (UV) Denny Satria; Rida Evalina Tarigan
Jurnal Farmanesia Vol 4 No 1 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (160.107 KB)

Abstract

Vitamin C merupakan salah satu vitamin yang terbuat dari turunan heksosa yang larut dalam air dan mudah teroksidasi. Vitamin C juga merupakan salah satu vitamin yang diperlukan oleh tubuh yang berfungsi untuk meningkatkan sistem imunitas tubuh. Untuk melengkapi kebutuhan akan vitamin C, sebagai salah satu sumber vitamin C adalah buah stroberi. Penelitian ini bertujuan untuk mengetahui perbedaan kadar vitamin C yang terdapat dalam buah stroberi (Fragaria x ananassa Duschesne) yang diperoleh dari pasar tradisional dan pasar modern. Sampel yang digunakan adalah buah stroberi yang diperoleh dari pasar tradisional dan pasar pasar modern di Kota Medan. Analisis kandungan vitamin C dilakukan dengan metode spektrofotometri ultraviolet. Hasil penenelitian menunjukkan bahwa kandungan vitamin C pada sampel buah Stroberi pasar modern Berastagi Supermarket sebesar 54,92 mg/100g, Palangkaraya Supermarket sebesar 53,62 mg/100g, dan Transmart Supermarket sebesar 54,68 mg/100g. Dari pasar tradisional, Pasar Rame sebesar 28,07 mg/100g, Pusat Pasar sebesar 30,28 mg/100g,dan Pasar Induk sebesar 28,05 mg/100g.Kesimpulan penelitian ini menyatakan bahwa kandungan vitamin C dalam buah stroberi yang diperoleh dari pasar modern lebih tinggi dibandingkan dengan pasar tradisional
ANALISIS KANDUNGAN VITAMIN C PADA BUAH STROBERI (Fragaria x ananassa Duschesne) SECARA SPEKTROFOTOMETRI ULTRAVIOLET (UV) Denny Satria; Rida Evalina Tarigan
Jurnal Farmanesia Vol 2 No 1 (2015): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (53.231 KB)

Abstract

Vitamin C merupakan salah satu vitamin yang terbuat dari turunan heksosa yang larut dalam air dan mudah teroksidasi.Vitamin C juga merupakan salah satu vitamin yang diperlukan oleh tubuh yang berfungsi untuk meningkatkan sistem imunitas tubuh. Untuk melengkapi kebutuhan akan vitamin C, sebagai salah satu sumber vitamin C adalah buah stroberi. Penelitian ini bertujuan untuk mengetahui perbedaan kadar vitamin C yang terdapat dalam buah stroberi (Fragaria x ananassa Duschesne) yang diperoleh dari pasar tradisional dan pasar modern. Sampel yang digunakan adalah buah stroberi yang diperoleh dari pasar tradisional dan pasar pasar modern di Kota Medan.Analisis kandungan vitamin C dilakukan dengan metode spektrofotometri ultraviolet. Hasil penenelitian menunjukkan bahwa kandungan vitamin C pada sampel buah Stroberi pasar modern Berastagi Supermarket sebesar 54,92 mg/100g, Palangkaraya Supermarket sebesar 53,62 mg/100g, dan Transmart Supermarket sebesar 54,68 mg/100g. Dari pasar tradisional, Pasar Rame sebesar 28,07 mg/100g, Pusat Pasar sebesar 30,28 mg/100g,dan Pasar Induk sebesar 28,05 mg/100g.Kesimpulan penelitian ini menyatakan bahwa kandungan vitamin C dalam buah stroberi yang diperoleh dari pasar modern lebih tinggi dibandingkan dengan pasar tradisional
Determination of Isoniazid and Pyridoxine Hydrochloride Levels in Tablets with Ultraviolet Spectrophotometry by Successive Ratio Derivative Rida Evalina Tarigan; Yustifin Sarumaha
International Archives of Medical Sciences and Public Health Vol. 3 No. 1 (2022)
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Isoniazid and pyridoxine hydrochloride are a combination of anti-tuberculosis drugs that are often used as standard therapy. The advantage of this drug combination is to obtain treatment effectiveness and prevent the emergence of resistance. Examination of the quality of medicinal preparations, determination of the content of efficacious substances is an important part so that a reliable analytical method is needed as well as tools and operational costs that are relatively cheaper, easy to implement, but can provide results with good accuracy and precision. This study aims to determine the levels of isoniazid and pyridoxine hydrochloride in tablet preparations using successive ratio derivative ultraviolet spectrophotometry. isoniazid (10 g/mL) was then transformed into derivative 1 at 4. The results showed that the levels of isoniazid 101.4313% and pyridoxine hydrochloride 104.7125%. Based on the results of the research conducted, it can be concluded that the levels of isoniazid and pyridoxine hydrochloride meet the requirements for levels according to the Indonesian Pharmacopoeia Edition VI.
Pengembangan dan Validasi Metode Spektrofotometri Area Under Curve Untuk Campuran Biner Parasetamol dan Ibuprofen Dalam Bentuk Sediaan Tablet Rida Evalina Tarigan; Lutvia Lutvia; Rina Monica Taruliana Sitorus
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1388

Abstract

The combination of paracetamol (PAR) and ibuprofen (IBU) is the most commonly used over-the-counter medication for fever and pain. This study aimed to develop spechtrophotometry method by area under curve to determine the levels of PAR and IBU in tablet dosage form. This method is based on the area under the curve value of each spectrum in various concentrations is calculated to selected wavelength range analysis, with methanol as solvent. Then, this method was applied to determine levels of PAR and IBU in tablet dosage form. The result of this method is the analysis of selected wavelength ranges of PAR and IBU in the wavelength ranges of 244-254 nm and 220-230 nm, respectively. The mean % recoveries were found to be in 99.35% and 99.49% for PAR and IBU, respectively. The method is successfully applied to determine PAR and IBU in tablet dosage form simultaneously and fulfill the validation requirements.
Formulasi sediaan krim lulur dari sari wortel (Daucus carota L.) sebagai anti aging Fahma Shufyani; Muhammad Andry; Rida Evalina Tarigan
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.177

Abstract

Background; Carrots are famous for the high beta carotene content in the fruit along with other vitamins, namely vitamin B and vitamin E. Vitamin E's role in the skin includes antioxidant, maintaining skin moisture, sun protection, and wound healing process. As a natural antioxidant, vitamin E is able to counteract free radicals and oxygen molecules. Objective:  To find out carrot juice (Daucus carota L.) can be formulated as a scrub cream as anti-aging and to find out at what concentration is the most effective in the preparation of carrotle scrub cream (Daucus carota L.) as anti-aging. Methods: This type of research was conducted experimentally. This research includes collecting respondents, measuring moisture content, smoothness, pores, blemishes, and wrinkles on the skin of respondents, making carrot juice, making scrub preparations from carrotle and evaluating preparation tests. Results: The use of scrub cream preparations containing carrotle (Daucus carota L.) concentration of 15% for 4 weeks showed changes in skin condition for the better with increased water content of 19.3 to 40 (107.25%), smoother skin smoothness of 36.3 to 20.6 (43.25%), shrinking pores 64 to 20.6 (67.81%), many blemishes were reduced 51 to 11.3 (77.97%), wrinkles that were reduced on the respondent's skin showed better results obtained, namely changes in wrinkles 45 to 13.6 with a recovery percent of (69.77%). Conclusion: The conclusion of this study is that carrottle (Daucus carota L.) can be formulated as a scrub cream as anti-aging.
Uji efektivitas ekstrak etanol daun senggani (Melastoma malabathricum L.) sebagai antihipertensi pada mencit putih jantan (Mus musculus) Lilik Septiana; Rida Evalina Tarigan; Muhammad Andry; Vannissa Andriani Irawan; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.220

Abstract

Background; Senggani leaves have secondary metabolites that can inhibit the release of aldosterone so that more water is removed from the body and blood pressure will drop. Objectives; The purpose of this study was to determine the effectiveness of the ethanol extract of senggani leaves (Melastoma malabathricum L.) on reducing blood pressure of male white mice (Mus musculus). Method; this research is experimental which includes sampling, sample processing, extract making, simplicia characteristics, preparation of test materials, treatment of test animals and data analysis. The samples used were senggani leaves (Melastoma malabathircum L.). The test animals used were 15 male white mice then divided into 5 groups. Measurement of blood pressure using a blood pressure analyzer with the tail cuff method. The measurement data were then analyzed using a paired t-test with a significance limit of 0.05. Result; showed that the ethanol extract of senggani leaves had antihypertensive effectiveness with the lowest systolic blood pressure measurement results after treatment at EEDS 150 mg/kgBW which was 86.66 mmHg and diastolic blood pressure obtained the lowest after treatment at EEDS 150 mg/KgBW, which was 59 mmHg. . The results of the statistical paired t-test showed that there was an effect of giving the test material EEDS 50 mg/kgBW, EEDS 100 mg/kgBW, EEDS 150 mg/kgBW test for 14 days with p-value <0.05. On diastolic blood pressure, the effect of treatment with the test material on blood pressure was significant at EEDS 150 mg/kgBW with p-value = 0.001. Conclusion; this study was that the administration of the ethanol extract of the leaves of senggani (Melastoma malabathricum L.) could reduce the blood pressure of experimental male mice (Mus musculus). The ethanol extract of senggani leaves (Melastoma malabathricum L.) was effective in lowering blood pressure at a dose of 150 mg.
Pembuatan Sabun Cuci Tangan Cair sebagai Upaya Pencegahan Penyebaran COVID-19 di Desa Bandar Klippa Rida Evalina Tarigan; Evi Ekayanti Ginting; Melia Sari
Jurnal Pengabdian Masyarakat Ilmu Kesehatan Vol 3, No 2 (2022): Edisi Juli
Publisher : LPPM Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/.v3i2.5592

Abstract

COVID-19 dapat menyebar melalui percikan dari hidung atau mulut yang keluar saat penderita COVID-19 batuk, bersin atau berbicara. Percikan-percikan tersebut dapat menempel di benda dan permukaan lainnya di sekitar seperti meja, gagang pintu, dan jika bersalaman atau pegangan tangan. Orang dapat terinfeksi dengan menyentuh benda atau permukaan tersebut, kemudian menyentuh mata, hidung, atau  mulut. World Health Organization (WHO) menganjurkan masyarakat untuk mencuci tangan sedikitnya kurang lebih selama 20 detik dan melakukan cuci tangan secara benar yaitu membersihkan area permukaan tangan, punggung tangan serta sela-sela jari secara menyeluruh. Sabun cair cuci tangan dapat membunuh bakteri, virus dan kuman penyakit sehingga mencegah terinfeksi COVID-19. Tujuan dari pengabdian kepada masyarakat ini adalah pembuatan sabun cuci tangan cair sebagai upaya pencegahan penyebaran COVID-19 di masyarakat. Metode dari pengabdian masyarakat ini adalah dengan pemberikan pengetahuan melalui ceramah dan demonstrasi cara pembuatan sabun cuci tangan cair sebagai upaya pencegahan penyebaran COVID-19. Hasil dari pengabdian masyrakat ini masyarakat di desa Bandar Klippa Kecamatan Percut Sei Tuan Kabupaten Deli Serdang sudah mampu membuat sabun cuci tangan cair sebagai upaya pencegahan penyebaran COVID-19 di masyarakat. Kesimpulan dari pengabdian masyarakat ini adalah masyarakat di Desa Bandar Klippa Kecamatan Percut Sei Tuan Kabupaten Deli Serdang mampu membuat sabun cuci tangan cair sebagai upaya pencegahan penyebaran COVID-19 di masyarakat.
Advanced UV Spectrophotometry-Classical Least Squares Determination of Paracetamol, Phenylpropanolamine HCl, and Chlorpheniramine Maleate in Tablet Dosage Form Tarigan, Rida Evalina; Sajida, Nurul; Surbakti, Chemayanti
International Journal of Science, Technology & Management Vol. 5 No. 4 (2024): July 2024
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v5i4.1150

Abstract

This study aims to develop and validate an advanced UV spectrophotometry- Classical Least Squares (CLS) for the simultaneous determination of Paracetamol (PA), Phenylpropanolamine HCl (PH), and Chlorpheniramine Maleate (CH) in tablet dosage form. The method involves the preparation of standard solutions of the three compounds across their respective concentration ranges 3-9 µg/mL for PA, 170-512 µg/mL for PH, and 7-19 µg/mL for CH. The CLS spectrophotometry UV method was applied to these spectra to construct calibration, which were then used to predict the concentrations of PA, PH, and CH in tablet dosage form. Validation of the method demonstrated excellent linearity, precision, and accuracy, with recovery rates of 99.26% for PA, 100.06% for PH, and 99.41% for CH. Sensitivity analysis revealed Limits of Detection (LOD) of 0.10 µg/mL for PA, 1.20 µg/mL for PH, and 0.30 µg/mL for CH, and Limits of Quantification (LOQ) of 0,30 µg/mL for PA, 4.00 µg/mL for PH, and 1.50 µg/mL for CH. The method’s robustness and reliability make it an excellent choice for routine quality control of these compounds in pharmaceutical tablet formulations.
Analisis Kepuasan Pasien Rawat Jalan Terhadap Layanan Badan Penyelenggara Jaminan Sosial Di Rumah Sakit Umum Tere Margareth Medan Tahun 2023 Siagian, Lenny Tiarmaida; Efendy, Ismail; Tarigan, Rida Evalina
Jurnal Ners Vol. 8 No. 2 (2024): OKTOBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v8i2.26278

Abstract

Rumah sakit memiliki peran yang sangat strategis dalam upaya mempercepat peningkatan derajat kesehatan masyarakat. Terciptanya kualitas pelayanan mutu tentunya akan menciptakan kepuasan terhadap pengguna layanan. Pelayanan dibentuk berdasarkan 5 prinsip Service Quality (Serqual) yaitu Reability,Assurance, Tangible, Emphaty dan Responsives. Dari beberapa hasil studi menyatakan bahwa tingkat kepuasan pasien terhadap beberapa pelayanan di Rumah sakit Indonesia masih cukup rendah. Pada saat melakukan survey awal di Rumah sakit Margareth Medan pada 10 responden didapati hanya 8 yang mengaku puas dengan pelayanan yang menggunakan system jaminan dan 2 diantaranya merasa tidak puas akan hal tersebut,Jenis penelitian ini merupakan survei kuantitatif dengan pendekatan Cross Sectional. Penelitian dilakukan Rumah Sakit Tere Margareth Medan pada tahun 2024. Populasi dalam penelitian ini adalah seluruh pasien yang datang berobat ke Instalasi Rawat Jalan Rumah Sakit Umum Tere Margareth Medan. Sampel dalam penelitian ini ditetapkan menggunakan rumus slovin dimana sampel berjumlah 83 orang.Berdasarkan hasil penelitian diketahui bahwa ada Ada pengaruh kepuasan pasien terhadap variabel yang diteliti dengan melakukan uji Chi-Square, yaitu : Reabillity P value = 0,001, Assurance P value= 0,012, Tangibles P value = 0,001, Empaty P value = 0,003, Responsives P value = 0,001. (< 0,05). Variabel yang paling dominan mempengaruhi kepuasan pasien berdasarkan hasil uji regresi logistik adalah variabel Empaty dengan hasil akhir p Value Sig 0,000 dan Exp(B) atau Odd Ratio tertinggi yaitu 23.658. Kesimpulan dalam penelitian ini yaitu terdapat pengaruh reability, assurance, tangible, empaty dan responsives dengan kepuasan pasien di rumah sakit Tere Margareth Medan tahun 2024. Saran rumah sakit perlu meningkatkan ketepatan waktu, keramahan kesopanan, kebersihan fasilitas umum, rasa peduli yang sama rata serta memberikan informasi yang jelas dan mudah dipahami oleh pasien.
Co-Authors Aqilah Sarah Nabila Denny Satria Devi Moraliza Lubis Dulce Maria Endang Maryanti Evi Ekayanti Ginting Fahma Shufyani Fahma Shufyani Fitri , Khairani Friska Asnita Sari Simarmata Hendri Faisal Ismail Efendy Januariana, Neni Ekowati Julkardo Lase Khairani , Tetty Noverita Khairani, Cut Lilik Septiana Lutvia Lutvia Maryanti, Endang MAYANG SARI Mayang Sari Melia Sari Mendrofa, Ester Lince Fiani Muhammad Amin Nasution Muhammad Andry Muhammad Andry Natasya, Alfa Nurlita Putri Putri Masitah Rina Monica Taruliana Sitorus Sajida, Nurul Siagian, Lenny Tiarmaida Siti Aisyah Surbakti, Chemayanti Syati Manaharawan Siregar Syati Manaharawan Siregar Tri Mayanti Vannissa Andriani Irawan Yustifin Sarumaha