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All Journal HAYATI Journal of Biosciences Medical Journal of Indonesia Padjadjaran Journal of Dentistry Paediatrica Indonesiana Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Jamu Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Muhammadiyah Journal of Geriatric Cermin Dunia Kedokteran Indonesian Journal of Jamu

Nafrialdi Nafrialdi

Department Of Pharmacology And Therapeutics, University Of Indonesia Medical School/ Dr. Cipto Mangunkusumo Hospital, Jakarta.

Author-ID : 327554

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

Published : 27 Documents Claim Missing Document

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1 2 3

Editorial Note Nafrialdi, Nafrialdi
Medical Journal of Indonesia Vol 16, No 4 (2007): October-December
Publisher : Faculty of Medicine Universitas Indonesia

[No abstract Available]

A survey on the appropriateness of drug therapy in patients with renal dysfunction at the Internal Medicine Ward FMUI/Dr. Cipto Mangunkusumo Hospital Soetikno, Vivian; Effendi, Imam; Nafrialdi, Nafrialdi; Setiabudy, Rianto
Medical Journal of Indonesia Vol 18, No 2 (2009): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Aim Dose adjusment and drug selection is important in patient with renal dysfuction.This study was aimed to assess the accuracy of dose adjustment and drug selection for renal dysfunction patient at the Internal Medicine Ward FMUI/Dr. Cipto Mangunkusumo Hospital, Jakarta.Methods Patients â¥ 18 years old with estimated creatinine clearance < 60 mL/minute based on Cockroft-Gault formula were included in this study. The drugs assessed were those excreted by the kidney or having nephrotoxic effect. The appropriateness of drug selection is assessed based on the preserce or not contraindication or potential of drug-drug interaction. The accuracy of dose adjustment were assessed based on information available in various textbooks, literatures, and drug brochures. Data were collected between May to July 2007.Results Data obtained from 43 patients met the inclusion criterias demonstrated that 164 out of 385 drug prescriptions were mainly eliminated by the kidney or have nephrotoxic characteristic. Out of 164 drug prescriptions, 142 (86.5%) were appropriately adjusted, while the other 22 (13.5%) were inappropriately adjusted for the dose. There was only one contraindication for the usage of the drug and 15.1% potentially drug interaction.Conclusion Dose adjustment and drug selections in patients with renal dysfunction at the Internal Medicine Ward FMUI/Dr. Cipto Mangunkusumo Hospital are conducted appropriately. (Med J Indones 2009; 18: 108-13)Key words: renal dysfunction, drug interaction, contraindication, dose adjusment

Incretin-based therapies for type 2 diabetes mellitus in Asian patients: Analysis of clinical trials Louisa, Melva; Takeuchi, Madoka; Takeuchi, Masahiro; Nafrialdi, Nafrialdi; Setiabudy, Rianto
Medical Journal of Indonesia Vol 19, No 3 (2010): August
Publisher : Faculty of Medicine Universitas Indonesia

Aim To review the effi cacy and safety data on incretin-based therapies currently available (exenatide, liraglutide, sitagliptin, vildagliptin) for the treatment of type 2 diabetes mellitus in Asian population.Methods We conducted Medline search of all relevant randomized clinical trials of incretin-based therapies for type 2 diabetes mellitus in Asian populations. Data pertinent to the efficacy and safety of GLP-1 mimetics and DPP-4 inhibitors were extracted and used.Results We found 14 randomized controlled trials of incretin based-therapy which included 3567 type 2 diabetes mellitus in Asian population (Japanese, Chinese, Korean, Indian). It was shown that incretin-based therapies improved HbA1c at higher extent (up to -1.42% in exenatide 10 mcg bid, -1.85% for liraglutide 0.9 mg qd, -1.4% for sitagliptin 100 mg and -1.4% for vildagliptin 50 mg bid) compared to the effects observed in studies with Caucasian population, with comparable safety profile.Conclusion The efficacy of incretin-based therapies in Asian patients improved glycemic parameters in a higher magnitude on some glycemic parameters compared with those in Caucasian population. These results indicate that incretin-based therapies may be more effective in Asian population than in Caucasian. (Med J Indones 2010; 19: 205-12)Key words: exenatide, incretin, liraglutide, sitagliptin, type-2 diabetes, vildagliptin

Telmisartan inhibits the progression of cardiomyopathy in daunorubicin treated rats: the role of advanced glycation end products Arozal, Wawaimuli; Watanabe, Kenichi; Veeraveedu, Punniyakoti T.; Ma, Meilei; Nafrialdi, Nafrialdi
Medical Journal of Indonesia Vol 20, No 4 (2011): November
Publisher : Faculty of Medicine Universitas Indonesia

Background: Anthracyclines have been reported to induceÂ cardiotoxicity through mechanisms involving formation ofÂ advanced glycation end-products (AGEs), including pentosidine and NÑ-(carboxymethyl) lysine (CML). We investigated theÂ potential utility of telmisartan (TML), an angiotensin II receptor antagonists (ARB) on anthracycline-induced cardiotoxicity.Methods: Three groups of Sprague-Dawley rats were treated as follows: The first group received daunorubicin (DNR) 3 mg/kgBW every alternating day to reach a cumulative dose of 9 mg/kg DNR . The second group received DNR plus TLM at a dose10 mg/kgBW, by oral gavage for 6 weeks, and the third group served as control group (CTL) which only received vehicle of DNR. Mean blood pressure (MBP) peak left ventricular pressure (LVP), LV end-diastolic pressure (LVEDP), and intra-ventricularÂ contractility (Â±dP/dt) were recorded by using Powerlab instrumentation. Ejection fraction (EF), and fractional shortening (FS) were measured by echocardiography. Expression of receptor of AGE (RAGE), pentosidine and CML were measured byÂ immunohistochemistry and Western blot in LV tissue.Results: DNR treatment was associated with significantÂ weakening of some hemodynamic parameters which couldbe reversed by TML (LVP: 124.3 Â± 6.0; 111 Â± 7; and 115.1 Â± 5.4 mmHg, respectively in CTL, DNR and DNR-TLM groups; LVEDP: 7.5 Â± 0.9; 10.7 Â± 0.3; 8.7 Â± 0.4 mmHg, respectively; +dP/dt: 6813 Â± 541; 4800 Â± 345; 5950 Â± 398 mmHg/s, respectively). The same phenomenons were also observed on echocardiographic parameters (EF: 78.9 Â± 1.8; 59.6 Â± 1.4; 76.2 Â± 2.75 %, resepectively; FS: 42.8 Â± 1.7; 29.1 Â± 1.3; 41 Â± 2.7 %) respectively. Expression of RAGE as well as pentosidine and CML were increased in DNR-rats. TML treatment ameliorated these changes.Conclusion: These results suggested the role of AGE formation in DNR-induced cardiotoxicity and telmisartan could inhibit the progression of cardiac toxicity at least in part by reduction RAGE expressiom. (Med J Indones 2011; 20:255-62)Keywords: advanced glycation end product, anthracyline, cardiotoxicity, daunorubicin, telmisartan

Primaquine decreased plasma concentration of ritonavir: single- and repeated-dose study in Sprague Dawley rats Louisa, Melva; Soetikno, Vivian; Nafrialdi, Nafrialdi; Setiabudy, Rianto; Suyatna, Frans D.
Medical Journal of Indonesia Vol 20, No 3 (2011): August
Publisher : Faculty of Medicine Universitas Indonesia

Background: The present study was aimed to explore the effects of ritonavir and primaquine combination given as a singledoseÂ or repeated-dose compared to ritonavir alone on ritonavir plasma concentration in the rats.Methods: In single-dose study, 30 male Spraque Dawley rats were randomly allocated to receive ritonavir 20 mg/kg BW orÂ ritonavir 20 mg/kg BW + primaquine 1.2 mg/kg BW or ritonavir 20 mg/kg BW + ketokonazole 10 mg/kg BW. KetokonazoleÂ was used as positive control of ritonavir metabolism inhibitor. In the repeated-dose study, thirty Spraque Dawley male ratsÂ were randomly allocated to receive ritonavir 20 mg/kg BW/day or ritonavir 20 mg/kg BW/day + primaquine 1.2 mg/kg BW/day or ritonavir 20 mg/kg BW/day + rifampicin 100 mg/kg BW/day. Rifampicin was used as a positive control of ritonavirÂ metabolism inducer.Results: In the single-dose study, ketokonazole increased the area under the plasma concentration (AUC) of ritonavir (â114.8%, p< 0.05), while primaquine tended to decrease the AUC of ritonavir (â 32.6%, p> 0.05). Repeated-dose studyÂ showed that rifampicin decreases the AUC of ritonavir (â 42.8%, p< 0.001), and primaquine decreased the AUC of ritonavirÂ plasma concentration (â 46.6%, p< 0.001).Conclusion: Concomitant administration of primaquine and ritonavir decreases the AUC of ritonavir. This effect may resultÂ in the insufficient concentration of ritonavir as anti-HIV, which may lead to treatment failure with ritonavir. (Med J IndonesÂ 2011; 20:190-4)Keywords: drug interaction, metabolism, primaquine, ritonavir

Takotsubo cardiomyopathy and the hope of specific biomarker Nafrialdi, Nafrialdi
Medical Journal of Indonesia Vol 24, No 1 (2015): March
Publisher : Faculty of Medicine Universitas Indonesia

[No abstract available]

Determination of.TGFÎ²1Â activity in placental extracts Suyatna, F. D.; Nafrialdi, Nafrialdi
Medical Journal of Indonesia Vol 7, No 3 (1998): July-September
Publisher : Faculty of Medicine Universitas Indonesia

[no abstract available]

Squamous cell carcinoma of the tongue in Sprague-Dawley rats using 4-nitroquinoline 1-oxide model Erfan, Erni; N., Nafrialdi; Ekawuyung, Puspita
Padjadjaran Journal of Dentistry Vol 28, No 1 (2016): March
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Background. 4-nitroquinoline 1-oxide (4NQO) is a water soluble carcinogen which is often used to induce cancer in oral cavity. Objective. The purpose of this study was to know the incidence of histopathological lesions in the tongue of rats after administration of 4-nitroquinoline 1-oxide (4NQO) for a model of oral carcinogenesis in the animal experimental laboratory. Materials and Methods. This study was conducted in the Department ofÂ Pathological Anatomy, Faculty of Medicine, University of Indonesia (FMUI). 4NQO (30 ppm) was administered by drinking water ad libitum to the Sprague Dawley (SD) rats during different time inductions (4-9 and 36-46 weeks). The present of tumor in oral cavity of the 4NQO-treated rats were observed macroscopically and microscopically. Tumor volume were measured based on the formula established by G. Carlsson. The degree of histological changes was determined according to observation towards their Hematoxylin and Eosin (HE) staining results.Â Results. Dysplasia and invasive squamous cell carcinoma (SCC) were respectively found in the tongue of the group given 4NQO for 4-9 and 36-46 weeks. The tongue from rats (4NQO for 36-46 weeks) exhibited whitish protuberant nodular lesions with the longest diameter was 17 mm. The histopathological lesion incidences for dysplasia and invasive SCC respectively were 25% (5/20) and 75% (15/20). The rats had tumor in their tongues with variation of degree alteration which proportional to the induction time.Â The extension of 4NQO induction time increasing the degree of change in the tumor. Conclusion. 4NQO represents a good model of carcinoma of tongue and gives consistence results with histological changes degree being related to duration of exposure.

A cost-effectiveness and safety analysis of dual antiplatelet therapy comparing aspirin–clopidogrel to aspirin–ticagrelor in patients with acute coronary syndrome Nafrialdi, Nafrialdi; Handini, Novita M.; Instiaty, Instiaty; Wijaya, Ika P.
Medical Journal of Indonesia Vol 27, No 4 (2018): December
Publisher : Faculty of Medicine Universitas Indonesia

Background: Dual antiplatelet therapy (DAPT) using either an aspirin–clopidogrel (A–C) combination or aspirin–ticagrelor (A–T) combination has become the standard therapy for acute coronary syndrome (ACS). Ticagrelor shows better pharmacokinetic profiles but is more expensive. This study aimed to compare cost-effectiveness and safety profiles of A–C versus A–T in patients with ACS.Methods: This was a retrospective cohort study of ACS patient at the Cipto Mangunkusumo Hospital between 2014 and 2016. ACS patients treated for the first time with A–T or A–C were included. Occurrence of major adverse cardiovascular events (MACE) within 3, 6, 9, and 12 months were used as effectiveness outcomes, while safety outcomes were measured based on the incidence of adverse drug reactions (major and minor bleeding, dyspnea, and hyperuricemia). Cost-effectiveness analysis was presented as incremental cost-effectiveness ratio (ICER).Results: Data records obtained from 123 ACS patients treated with A–C and 57 ACS patients treated with A–T were evaluated. Within the first three months, the MACE rate was 15.8% in the A–T group and 31.7% in the A–C group (RR: 0.498, 95% CI: 0.259–0.957, p=0.039). There was no statistically significant difference observed in the number of MACE between groups after 6, 9, and 12 months. The A–T group had a higher incidence of major bleeding (melena) than the A–C group (5.3% vs 1.62%, p=0.681), especially in geriatric patients. Minor bleeding was observed in three patients of the A–C group, but in none of the patients in the A–T group. The cost of ICER was IDR 279,438, indicating the additional cost needed for avoiding MACE within 3 months, if A–T was used.Conclusion: The aspirin–ticagrelor combination is a clinically superior and cost-effective option for MACE prevention among ACS patients, especially during the first three months of DAPT, with a slight but not significantly higher major bleeding risk when compared to the aspirin–clopidogrel combination.

Increased vimentin mRNA expression in MCF-7 breast cancer cell line after repeated endoxifen-treatment Paramita, Paramita; Louisa, Melva; Nafrialdi, Nafrialdi
Medical Journal of Indonesia Vol 25, No 4 (2016): December
Publisher : Faculty of Medicine Universitas Indonesia

Background: Epithelial mesenchymal transition (EMT) plays a significant role in the development of cancer cell resistance to drugs. Vimentin, a type III intermediate filament protein, is a marker of EMT. Vimentin's over-expression in cancer correlates well with increased tumor growth, change in cell shape and poor prognosis. Endoxifen is an active metabolite of tamoxifen and has become a new potent agent in the treatment of breast cancer. This is a study that aimed to investigate the effect of endoxifen exposure with or without estradiol on cell viability, cell morphology and EMT progression through the analysis of vimentin mRNA expression after 4-week treatment.Methods: Endoxifen, 100 nM or 1,000 nM, with or without beta-estradiol were given repeatedly to MCF-7 cells. Cells treated with dimethyl sulfoxide (DMSO) 0.001% were used as control. After 2- and 4-week exposure, the cells were counted, analyzed for mRNA vimentin expression, and observed for morphological changes.Results: Compared to control, there were significant decreases in vimentin mRNA expressions in endoxifen and endoxifen+β-estradiol treated cells after 2-weeks, which then significantly increased after 4-week compared with the 2-week exposure. We found no change in morphology of MCF-7 cells.Conclusion: Repeated exposure of endoxifen might induce EMT progression through increased expression of vimentin in MCF-7 breast cancer cell line.

Co-Authors -, Paramita Agatha Grace Ali Sulaiman Arini Setiawati Dewi Sharon Simorangkir Dewi, Yulia Ratna Ening Krisnuhoni Erni Erfan, Erni Eziefule, Oluebube Magnificient F. D. Suyatna Felix F. Widjaja Femmi Dwinda Agustini Frans D. Suyatna Gayatri, Anggi Handini, Novita M. Helyanna Helyanna, Helyanna Imam Effendi Indah D Dewijanti Instiaty, Instiaty Irsan Hasan Isnani A.S. Suryono Joedo Prihartono Kenichi Watanabe Laurentius A Lesmana, Laurentius A Lukman H. Makmun M. Zaim Madoka Takeuchi Maemun, Siti Masahiro Takeuchi Meilei Ma Melva Louisa Mulyadi Djer Nabillah, Deya Adiby Nina Mariana, Nina Paramita, Paramita Pradana Soewondo Punniyakoti T. Veeraveedu Purwantyastuti Purwantyastuti Purwita Wijaya Laksmi Puspita Eka Wuyung Puspita Ekawuyung, Puspita Pustika Amalia Wahidiyat Rachman, Andika Raymond R. Tjandrawinata Rianto Setiabudy Rino Alvani Gani Sake Juli Martina Saut Horas Hatoguan Nababan SEPTELIA INAWATI WANANDI Seruni Tyas Khairunissa Setiabudy, Rahajuningsih D Setyawati, Rumaisah Siti Setiati Soni Siswanto Syarifah Dewi Theresia G Kurniawan, Theresia G Tirza Z Tamin Tri Yuliani Vetnizah Juniantito Vivian Soetikno Vivian Soetikno Vivian Soetikno Wasilah Rochmah Wawaimuli Arozal Wawaimuli Arozal Wawaimuli Arozal Wijaya, Ika P. Wijaya, Surya Oto

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