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All Journal Jurnal Anestesiologi Indonesia Jurnal Anestesi Perioperatif Jurnal Kesehatan Medula Majalah Anestesia dan Critical Care Jurnal Anestesi Obstetri Indonesia Jurnal Neuroanestesi Indonesia Majalah Anestesia & Critical Care (MACC)

Syafruddin Gaus

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Author-ID : 268847

Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Efek Kombinasi Epidural dan Obat Anti-inflamasi Nonsteroid terhadap Nyeri dan Kadar Prostaglandin Gaus, Syafruddin; Patellongi, Ilham Jaya; Budianto, Jeffri; Ahmad, Muh. Ramli
Jurnal Anestesi Perioperatif Vol 6, No 1 (2018)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Kombinasi analgesia epidural (AE) dengan obat anti-inflamasi nonsteroid (OAINS) seperti ketorolak dan parecoxib sebagai analgesia preventif diperlukan untuk mengurangi nyeri pascabedah. Penelitian ini bertujuan mengetahui efek OAINS sebagai analgesia preventif pada pascabedah laparatomi ginekologi berdasar atas perubahan kadar prostaglandin-E2 (PGE2) dan intensitas nyeri. Penelitian bersifat eksperimental acak tersamar ganda dengan jumlah sampel 60 pasien. Penelitian dilakukan di RSUP Dr. Wahidin Sudirohusodo Makasar bulan MaretâJuni 2017. status fisik 1 dan 2 menjalani laparatomi ginekologi dengan anestesi epidural. Subjek dibagi 3 kelompok, yaitu ketorolak (K) 0,5 mg/kgBB intravena, parecoxib (P) 40 mg intravena, dan plasebo (N) NaCl 0,9% 2 mL yang diberikan 30 menit sebelum insisi, 8 jam, dan 16 jam pascabedah. Data dianalisis dengan uji one-way ANOVA, uji Exact Fischer, uji Mann-Whitney U pada batas kemaknaan Î±=5%. NRS=1 pada kelompok K dan P saat insisi hingga 16 jam pascabedah dan berbeda signifikan (p<0,05) dengan kelompok N; 15% mengalami peningkatan intensitas nyeri (NRS=2) 8 jam pascabedah. Kadar PGE2 pada plasebo paling tinggi (439,7Â±35,1; 481,7Â±60,1; 565,1Â±58,7), berbeda signifikan (p<0,05) dengan parecoxib (230,7Â±19,5; 221,4Â±16,4; 201,1Â±18,1). Ketorolak berada di antara keduanya. Simpulan, parecoxib dan ketorolak sebagai analgesia preventif yang dikombinasi AE pada pasien bedah laparatomi ginekologi dapat menekan nyeri dan mengurangi produksi PGE2. Efek parecoxib lebih kuat daripada ketorolak mengurangi produksi PGE2, tetapi sama kuatnya dalam menekan intensitas nyeri pascabedah laparatomi ginekologi.Kata kunci: Analgesia epidural, ketorolak, laparatomi ginekologi, parecoxib, PGE2

Perbandingan Efek Analgesia Pascabedah dan Stabilitas Kadar Gula Darah antara Bupivakain 0,5% 7,5 mg + Klonidin 30 mg dengan Bupivakain 0,5% 7,5 mg + Fentanil 25 mg Intratekal Pasien yang Menjalani Seksio Sesarea , Masrianil; Wahab, Abdul; Gaus, Syafruddin; Ahmad, Muhammad Ramli; Seweng, Arifin
Majalah Anestesia dan Critical Care Vol 32 No 1 (2014): Februari
Publisher : Perdatin Pusat

Show Abstract | Download Original | Original Source | Check in Google Scholar

Penelitian ini bertujuan membandingkan efek analgesia pascabedah dan stabilitas kadar gula darah antara bupivakain 0,5% 7,5 mg+klonidin 30 μg dengan bupivakain 0,5% 7,5 mg+fent anil 25 μg intratekal pada pasien yang menjalani seksio sesaria. Penelitian ini menggunakan metode uji klinis acak tersamar tunggal dengan 50 sampel di Rumah Sakit Fatimah Makassar dan jejaringnya. Pemeriksaan kadar gula darah dilakukan sebelum spinal, 10 menit setelah operasi dan 1 jam setelah operasi selesai. Data dianalisis dengan menggunakan sistem Statistical Package for the Social Scien Tu program (SPSS). Hasil penelitian menunjukkan bahwa durasi analgesia kelompok bupivakain klonidin (BK) (322,08±34,53) menit lebih lama dibandingkan kelompok bupivakain fentanil (186,72±16,45) menit, secara statistik dinyatakan bermakna (p<0,05). Perbandingan kadar gula darah (GD) kelompok BF dan BK menghasilkan kadar GD yang stabil yaitu kelompok BF menghasilkan kadar GD sebelum spinal (122,40±18,34) mg/dl, 10 menit setelah operasi dimulai (114,88±23,31) mg/dl, dan 1 jam post operatif (128,04±21,91) mg/dl, sedangkan pada kelompok BK menghasilkan kadar GD sebelum spinal (118,96±15,99) mg/dl, 10 menit setelah operasi mulai (109,48±10,08)mg/dl,1 jam setelah operasi selesai (122,24±18,14) mg/dl. Secara statistik perbandingan rata-rata GD kedua kelompok tidak bermakna pada kedua kelompok (p>0,05). Kata kunci: Bupivakain, efek analgesia pascabedah, fentanil, kadar gula darah, klonidin, seksio sesarea The Comparison of The Analgesic Post Operatif and Blood Glucose Stability Effects Between Bupivacain 0,5% 7,5 mg + Clonidin 30 mg and Bupivacain 0,5% 7,5 mg + Fentanyl 25 mg Intrathecal in Patients Undergoing Caesarean Section The study aims to compare the effect of bupivacaine 0,5% 7,5 mg+clonidin 30 μg and bupivacaine 0,5% 7,5 mg+Fentanyl 25 μg on the analgesia and blood glucose stability of the intrathecal patient during caesarean section. This study used single-blind method and 50 samples in Fatimah Maternity Hospital in Makassar and its networking maternity hospitals. Blood glucose examination was made before spinal, 10 minutes after operation and 1 hour after the operation. The data were analysed with SPSS program. The result indicates that the duration of analgesia in Bupivacaine Clonidin group (BK) (322.08±34,53) minute longer than Bupivacaine Fentanyl group (BF) (186.72±16,45) minute. The difference is statistically significant (p<0,05). The comparison of both blood glucoses indicates stable blood glucose levels (BG). In the group of BF, the glucose level before spinal (122.40±18.34) mg/dL, 10 minutes after operation (114.88±23.31)mg/dL, and 1 hour after operation (128.04±21.91) mg/dL. In the group of BK, the glucose level before spinal (118.96±15.99)mg/dl, 10 minutes after operation (109.48±10.08 )mg/dL, and 1 hour after operation (122.24±18.14) mg/dL. The comparison between the average of both groups blood glucose is statistically insignificant (p>0.05). Key words: Analgesic post operatif, blood glucose level, bupivacain, clonidine, fentanyl, caesarean section Reference Agrawal A. Comparison of intrathecal fentanyl in addition to bupivacaine for caesarean section under spinal anaesthesia. J Anaesth Clin Pharmacol. 2009;25(2):154-6. Bhure A. Kalita N, Ingley D, Gadkari CP. Comparative study of intrathecal hyperbaric bupivacaine with clonidine, fentanyl and midazolam for quality of anaesthesia and duration of post operative pain relief in patients undergoing elective caesarean section. People Journal of Sciene Research. 2012;5(1):19–23. Bhushan S B, Suresh J S, Vinayak SR , & Lakhe, J.N. Comparison of different doses of clonidine as an adjuvant to intrathecal bupivacaine for spinal anesthesia and postoperative analgesia in patients undergoing caesarian section. Anaesth, Pain & Intensive care. 2012;16(3):266–72 Bintaro A , Pryambhodo, Susilo. Keefektifan anestesi spinal menggunakan bupivakain 0,5% hiperbarik 7,5 mg ditambah fentanil 25 mcg dibandingkan dengan bupivakain 0,5% hiperbarik 12,5 mg pada bedah sesar. Anestesia & critical care. 2010;28:9–17. Biswas B N, Rudra, A, & Bose, B K. Intrathecal fentanyl with hyperbaric bupivacaine improves analgesia during caesarean delivery and in early post-operative period. Indian J Anaesth. 2002;46(6):469–72. Bogra J, Arora N, Srivastava P. Synergis effect of intrathecal fentanil and bupivacaine in spinal anesthesia for cesarean section. BMC Anesthesiol. 2005;5:5. Bouwmeester N.J. Hormonal and metabolic stress responses after major surgery in children aged 0–3 years: a double-blind, randomized trial comparing the effects of continous versus intermitten morphine. Br J Anaesth.2001;87:390–9. Dobrydnjov I Axelsson, K., Matthiesen P, Klockhoff H., Holmstrom, B. Clonidine combined with small-dose bupivacaine during spinal anesthesia for inguinal hernioraphy: a randomized double blinded study. Anesth Analg. 2003;96:1496-503. Ganong WL. Review of medical physiology. Edisi ke-20. New York:McGraw-Hill, 2001. hlm. 322–43. Hayashi Y Maze, M. Alpha drenoceptor agonists and anaesthesia. Br J Anaesthesia.1998;71:108–18. Hocking G ,Wildsmith J.A. Intrathecal drug spread. British J Anesth. 2004; 93(4):568–78. Prasetyo A H. Efek Klonidin sebagai ajuvan anestesi spinal terhadap kadar glukosa darah [Tesis]. Surakarta. 2011. Stoelting R K,Hillier, S.C. Pharmacology & physiology in anesthetic practice. Edisi ke-4. Philadelphia: Lippincott Williams & Wilkins. Hlm.190. Vadivelu N, Whithney, C J, Sinatra R.S. Pain pathway and acute pain processing. Dalam : Sinatra R S, Leon C O, Ginsberg, B, & Viscusi, E.R., penyuntingAcute pain management. New York: Cambridge University Press, 2009. hlm. 3–12.

Efek Kombinasi Epidural dan Obat Anti-inflamasi Nonsteroid terhadap Nyeri dan Kadar Prostaglandin Jeffri Budianto; Muh. Ramli Ahmad; Syafruddin Gaus; Ilham Jaya Patellongi
Jurnal Anestesi Perioperatif Vol 6, No 1 (2018)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Kombinasi analgesia epidural (AE) dengan obat anti-inflamasi nonsteroid (OAINS) seperti ketorolak dan parecoxib sebagai analgesia preventif diperlukan untuk mengurangi nyeri pascabedah. Penelitian ini bertujuan mengetahui efek OAINS sebagai analgesia preventif pada pascabedah laparatomi ginekologi berdasar atas perubahan kadar prostaglandin-E2 (PGE2) dan intensitas nyeri. Penelitian bersifat eksperimental acak tersamar ganda dengan jumlah sampel 60 pasien. Penelitian dilakukan di RSUP Dr. Wahidin Sudirohusodo Makasar bulan Maret–Juni 2017. status fisik 1 dan 2 menjalani laparatomi ginekologi dengan anestesi epidural. Subjek dibagi 3 kelompok, yaitu ketorolak (K) 0,5 mg/kgBB intravena, parecoxib (P) 40 mg intravena, dan plasebo (N) NaCl 0,9% 2 mL yang diberikan 30 menit sebelum insisi, 8 jam, dan 16 jam pascabedah. Data dianalisis dengan uji one-way ANOVA, uji Exact Fischer, uji Mann-Whitney U pada batas kemaknaan α=5%. NRS=1 pada kelompok K dan P saat insisi hingga 16 jam pascabedah dan berbeda signifikan (p<0,05) dengan kelompok N; 15% mengalami peningkatan intensitas nyeri (NRS=2) 8 jam pascabedah. Kadar PGE2 pada plasebo paling tinggi (439,7±35,1; 481,7±60,1; 565,1±58,7), berbeda signifikan (p<0,05) dengan parecoxib (230,7±19,5; 221,4±16,4; 201,1±18,1). Ketorolak berada di antara keduanya. Simpulan, parecoxib dan ketorolak sebagai analgesia preventif yang dikombinasi AE pada pasien bedah laparatomi ginekologi dapat menekan nyeri dan mengurangi produksi PGE2. Efek parecoxib lebih kuat daripada ketorolak mengurangi produksi PGE2, tetapi sama kuatnya dalam menekan intensitas nyeri pascabedah laparatomi ginekologi.Kata kunci: Analgesia epidural, ketorolak, laparatomi ginekologi, parecoxib, PGE2

Perbandingan Skor Insersi LMA antara Pemberian Petidin-propofol dan Fentanil-propofol Intravena Agussalim Ali; Syafruddin Gaus; Muhammad Ramli Ahmad
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 8, No 1 (2020)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v8i1.15025

ABSTRAKLatar Belakang Pemberian adjuvan seperti opioid, lidokain, midazolam dan pelumpuh otot dosis kecil bersama propofol mampu meningkatkan keberhasilan insersi LMA. Petidin adalah opioid yang memiliki aktivitas seperti anestetik lokal dengan harga relatif murah dibanding opioid lain. Tujuan penelitian Membandingkan skor insersi LMA antara antara pemberian petidin-propofol intravena dengan fentanil-propofol intravena.Metode Lima puluh empat pasien ASA PS 1 dan 2 dengan rentang umur 17-60 tahun, BMI 18,5-30 kg/m2 dan mallampati I-II yang direncanakan operasi elektif dengan prosedur GA-LMA diacak kedalam 2 grup dengan menggunakan desain acak tersamar ganda. Grup P mendapatkan petidin 1 mg/kgBB 10 menit sebelum induksi dan grup F mendapatkan fentanil 1 µg/kgBB 3 menit sebelum induksi. Induksi menggunakan propofol 2 mg/kgBB selama 60 detik. Ventilasi dengan oksigen 100% melalui sungkup muka selama 60 detik dilakukan setelah refleks bulu mata hilang, selanjutnya dilakukan insersi LMA dan penilaian skor insersi LMA berdasarkan Lund & Stovener (gerakan anggota tubuh, laringospasme, menelan, batuk dan tersedak).Hasil Skor insersi LMA sangat memuaskan pada kelompok P lebih kecil dibandingkan kelompok F (29,6% vs 48,1%), namun tidak bermakna setelah uji statistik Chi-Square (p=0,264).Simpulan Skor insersi LMA dengan pemberian petidin-propofol intravena samabaiknya dengan pemberian fentanil-propofol intravena.Kata kunci :laryngeal mask airway, fentanyl, petidin, , propofol,

Perbandingan Kadar Laktat Antara Propofol-Fentanil dengan Isofluran-Fentanil Pada Operasi Kraniotomi Cedera Otak Sedang; Harsakti Rasyid; Husni Tanra; Syafruddin Gaus; Ilhamjaya P
JAI (Jurnal Anestesiologi Indonesia) Vol 6, No 1 (2014): Jurnal Anestesiologi Indonesia
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif

Latar Belakang : Cedera otak menimbulkan gangguan beberapa sistem tubuh dan sering menyebabkan iskemia. Laktat terbentuk dari metabolisme anaerob glukosa otak akibat kurangnya oksigen.Tujuan : Membandingkan kadar laktat antara propofol-fentanil dengan isofluran-fentanil pada operasi kraniotomi cedera kepala sedang.Metode : Dilakukan penelitian eksperimental secara acak tersamar tunggal terhadap 42 pasien yang menjalani prosedur kraniotomi cedera kepala sedang. Subyek penelitian dibagi dalam dua kelompok, kelompok pertama mendapat pemeliharaan anestesi propofol 6 mg/kgBB/jam dan fentanil 1 mcg/kgBB/jam (n=21), sementara kelompok kedua mendapat pemeliharaan isofluran 1 vol% dan fentanil 1 mcg/kgBB/jam (n=21). Dilakukan pemeriksaan kadar laktat vena pra bedah, setelah intubasi, setelah kraniotomi, dan setelah ekstubasi. Data diuji berdasarkan Shapiro Wilk, bila distribusi data normal diuji dengan independent T test dan bila distribusi tidak normal dilakukan transformasi data dengan fungsi log. Tingkat kepercayaan 95% dengan kemaknaan p<0,05.Hasil : Hasil penelitian menunjukkan kadar laktat pada pemeliharaan anestesi propofol 6 mg/kgBB/jam dan fentanil 1 mcg/kgBB/jam lebih rendah setelah intubasi, setelah kraniotomi, dan setelah ekstubasi dan secara statistik bermakna (p<0,05) dsbanding pemeliharaan isofluran 1 vol% dan fentanil 1 mcg/kgBB/jam.Kesimpulan : Kadar laktat pada operasi kraniotomi cedera otak sedang dengan pemeliharaan anestesi propofol-fentanil lebih rendah dibanding kadar laktat dengan pemeliharaan anestesi isofluran-fentanil. Propofol dan fentanil dapat dijadikan pemeliharaan anestesi bedah saraf traumatik.

Perbandingan Tiga Dosis Gabapentin Oral terhadap Nyeri Pascabedah, Sedasi, dan Mual-Muntah pada Histerektomi Total dengan Anestesi Spinal Rakhmat Ilhamsyah; Syafruddin Gaus; Faisal Muchtar; Abdul Wahab
Jurnal Anestesi Obstetri Indonesia Vol 4 No 1 (2021): Maret
Publisher : Indonesian Society of Obstetric Anesthesia and Critical Care (INA-SOACC)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47507/obstetri.v4i1.62

Latar Belakang: Gabapentin dapat mencegah nyeri nosiseptif, nyeri neuropatik, inflamasi akut dan mengurangi nyeri pasca operasi. Tujuan: penelitian ini membandingkan tiga dosis gabapentin oral pada operasi histerektomi total dengan anestesi spinal untuk efeknya pada sedasi, mual-muntah, dan nyeri pascabedahSubjek dan Metode: Desain yang digunakan pada penelitian ini adalah uji klinis acak tersamar tunggal. Sampel terbagi dalam kelompok G600: gabapentin 600 mg, kelompok G750 gabapentin 750 mg dan kelompok G900: gabapentin 900 mg dengan jumlah sampel masing-masing 14 orang. Data dianalisis menggunakan uji statistik uji Mann Whitney U.Hasil: Perbandingan analgesik tambahan pascabedah kelompok G600 membutuhkan lebih banyak analgesik tambahan dibanding kelompok G750 (p = 0,021) dan begitu juga untuk kelompok G750 dibanding kelompok G900(p = 0,004). Perbandingan kelompok G600 dan G750 untuk skor sedasi dan agitasi Richmond berbeda bermakna pada jam ke-3,6, dan 9 (nilai p 0,004; 0,007; dan 0,03) dan kelompok G600 dan G900 juga berbeda bermakna pada jam ke-3,6, dan 9 (p = 0,007). Untuk post operative nausea and vomiting (PONV) terdapat perbedaan bermakna antara kelompok G600 dan G900 dan juga antara kelompok G750 dan G900 (p = 0,043). Simpulan: Pemberian gabapentin oral 900 mg memberikan total rescue analgetik paling sedikit dibanding dengan pemberian gabapentin 600 mg dan 750 mg. Ketiga kelompok gabapentin mengalami efek samping sedasi ringan. Kejadian PONV paling rendah pada kelompok gabapentin 900 mg. Comparison Between Three Doses of Oral Gabapentin Against Postoperative Pain, Sedation, and Nausea-Vomiting in Total Hysterectomy with Spinal Anesthesia Abstract Background: Gabapentin can prevent nociceptive pain, neuropathic pain, acute inflammation and reduce postoperative painObjective: this study aimed to compare three doses of oral gabapentin in total hysterectomy with spinal anesthesia for its effect on sedation, postoperative nausea and vomiting, and post operative painSubject and Method: This study was a single blind randomized clinical trial. Samples were divided into groups of G600: gabapentin 600 mg, group G750 gabapentin 750 mg and group G900: gabapentin 900 mg with the number of samples was 14 people each. Data were analyzed using statistical analysis using the Mann Whitney U test.Results: Comparison of postoperative adjunctive analgesics in the G600 group required more additional analgesics than the G750 group (p = 0.021) and likewise for the G750 group compared to the G900 group (p = 0.004). Comparison of the G600 and G750 groups for sedation and agitation scores for Richmond was significantly different at the 3.6 and 9 hours (p value 0.004; 0.007; and 0.03) and the G600 and G900 groups were also significantly different at the 3.6 hour, and 9 (p = 0.007). For post operative nausea and vomiting (PONV), there were significant differences between the G600 and G900 groups and also between the G750 and G900 groups (p = 0.043).Conclusion: Gabapentin oral 900 mg with the least total analgesic rescue compared to gabapentin 600 mg and 750 mg. All three gabapentin groups experienced mild side effects of sedation. The lowest incidence of PONV was in the gabapentin 900 mg group

COMPARISON OF TWO DIFFERENT DOSAGES OF COMBINATION OF INTRAVENOUS GRANISETRON WITH INTRAVENOUS DEXAMETHASONE AS A PROPHYLAXIS FOR NAUSEA AND VOMITING IN CAESAREAN SECTION WITH SUBARACHNOID BLOCK Irfan Faisal Sjattar; Syafruddin Gaus; Andi Salahuddin; Arifin Seweng
Jurnal Kesehatan Vol 15 No 1 (2022): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v15i1.25811

Granisetron can be used to treat and prevent nausea and vomiting in patients receiving chemotherapy or radiotherapy, as well as during or after surgery. To compare the effects of two doses of intravenous granisetron on nausea and vomiting in Caesarean section with subarachnoid block. This study was a randomized double-blind clinical trial. Subjects were randomized into two groups: Granisetron 10 mcg/kg (GD10) and granisetron 25 mcg/kg (GD25). Dexamethasone 0.1 mg/kg was also administered to all subjects. A total of 21 subjects were included for each group. Data was analyzed using Mann Whitney U test. The results When comparing the incidence of nausea and vomiting in the GD10 and GD25 groups, there was a significant difference in the incidence of nausea (p = 0.001). In the GD10 group, there were nine participants who experienced nausea, whereas the GD25 group had none. Neither of the groups experienced vomiting, hence no additional therapy given to both groups. Granisetron is a selective 5-HT3 receptor antagonist and an effective antiemetic during and after neuraxial anesthesia for Caesarean section. The combination of granisetron and dexamethasone has been reported to be more potent than granisetron alone. Administration of granisetron 25 mcg/kg had a positive impact on patients, with no incidence of nausea and vomiting compared to administration of granisetron 10 mcg/kg.

COMPARISON OF MULTIMODAL ANALGESIA FOR PAIN CONTROL AND MEASURING INFLAMMATION LEVELS USING PARACETAMOL WITH VARIOUS DOSAGE OF IBUPROPHENE IN CAESARIAN SURGICAL PATIENTS Yudhitya Afif; Syafruddin Gaus; Alamsyah Ambo
Jurnal Kesehatan Vol 15 No 1 (2022): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v15i1.27753

The concept of multimodal analgesia in the treatment of postoperative pain has been around for a long time. Various drugs have been used to control pain after cesarean section (SC). The purpose of this study was to compare the combination of paracetamol with ibuprofen at various doses as multimodal analgesia and to measure levels of Interleukin-6 (IL-6) as a marker of inflammation in CS surgical patients. Methods this study was a single-blind experimental study. A total of 40 patients who underwent SC surgery under spinal anesthesia using hyperbaric Bupivacaine 0.5% 8 mg were divided into 2 groups, namely IBU4 group (paracetamol 750 mg and ibuprofen 400 mg), and IBU8 (paracetamol 750 mg and ibuprofen 800 mg) given intravenously 1 hour preoperatively, and every 6 hours for 24 hours. Then the degree of pain was assessed at rest and moving using a Numeric Rating Score (NRS) at 2, 4, 6, 12, and 24 hours postoperatively, and IL-6 levels were measured 1 hour preoperatively, 6 and 12 hours postoperatively. Calculate the amount of fentanyl given for rescue. Then repeated ANOVA, paired t-test, and chi-square analysis were performed using SPSS 21 for Windows. The results are declared meaningful if the p-value < 0.05. The results the IBU8 group showed lower values of the silent NRS, motion NRS, and IL-6 levels than the IBU4 group; this difference was significant with a value (p<0.05). All patients in the IBU8 group also did not require rescue fentanyl (p<0.05). The combination of paracetamol 750 mg and ibuprofen 800 mg showed the best results on NRS values, IL-6, and CRP levels for postoperative pain management SC without the need for rescue fentanyl and side effects.

EFFECT OF CRYSTALLOID FLUID LOADING AND VASOPRESSOR PRE-TREATMENT ON THE TIME OF BLOOD PRESSURE DROP IN CESAREAN SECTION WITH SUBARACHNOID BLOCK Muhammad Irfan Djafar; Andi Salahuddin; Syafruddin Gaus
Jurnal Kesehatan Vol 15 No 1 (2022): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v15i1.27761

Caesarean section (SC) is the most frequently performed surgery in obstetrics. Subarachnoid block (SAB) and epidural block are the most widely used anesthetic techniques in CS surgery. Objectives To analyze the effect of loading crystalloid fluid and administration of vasopressors on the time of occurrence of a decrease in blood pressure in SC with SAB anesthesia. Method single-blind randomized controlled clinical trial consisting of 2 treatment groups, namely crystalloid fluid loading and vasopressor pre-treatment. The Results There was a significant difference in mean blood pressure between the crystalloid group and the vasopressor group at 2 to 8 minutes (p<0.05). The average systolic blood pressure for 46 minutes in the three groups showed that the decrease in blood pressure occurred first in the crystalloid group compared to the vasopressor group, and hypotension occurred at 5 minutes in the crystalloid group. After the first 10 minutes, average blood pressure tends to be relatively stable. There was a significant difference in the incidence of hypotension, which occurred more in the crystalloid group, which was 9 or 45%, the vasopressor group with hypotension was 2 or 10% (p<0.05). The incidence of decreased blood pressure was found to be more common with crystalloid loading than with vasopressor pretreatment, in accordance with the findings of previous studies. The incidence of decreased blood pressure in SC with SAB anesthesia was faster and more common with loading crystalloids than pretreatment with vasopressors. Administration of vasopressor pretreatment has been shown to prevent the incidence of a decreased blood pressure in SAB anesthesia.

COMPARISON OF THE EFFECTS OF PRE-EMPTIF ANALGESIA PREGABALINE 75 WITH 150 MG ON THE GRADE OF PAIN AND CAESARIAN SECTION SEDATION SCORE WITH SUBARAKHNOID BLOCK Ardiansyah Siradjuddin; Muhammad Ramli Achmad; Syafruddin Gaus
Jurnal Kesehatan Vol 15 No 1 (2022): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v15i1.27762

In recent years, many studies have been carried out on the pre-emptive analgesia of pregabalin for various types of surgery with varying results. Preemptive analgesia in caesarean section (SC) usually uses pregabalin at a dose of 150 mg, and there have been no studies using low doses (75 mg) Objective This study aimed to determine the effects of pregabalin 75 mg vs 150 mg doses for controlled pain, their sedation score in patients after C-section under spinal anesthesia. Methods This study was a double-blind randomized trial study examining 20 samples of patients who underwent elective C-sections under spinal anesthesia and divided into 2 equal groups, P75 (who received oral pregabalin 75 mg) and P150 (who received pregabalin 150 mg). The Results There were no significant differences in NRS between the 75 vs 150 mg group (p>0.05), and there were significant differences in Ramsay sedation score between the 75 vs 150 mg group on 2 and 6 hours after surgery(p<0.05) and there were no significant differences about the need for fentanyl rescue between 75 vs 150 mg group (p>0.05). Pregabalin has an opioid-sparing effect and larger doses of pregabalin may increase its efficacy. The sedative effect that arises is due to the mechanism of action of pregabalin which binds potently to the 2δ subunit calcium channel and modulates calcium influx at nerve endings, thereby reducing the release of several excitatory neurotransmitters (glutamate), such as the mechanism of action of various intravenous and inhaled anesthetic agents. Preemptive administration of pregabalin 75 mg is recommended for C-section surgery because it might reduce NRS and the need for fentanyl rescue with minimal sedation side effects.

Co-Authors , Masrianil A.A. Ketut Agung Cahyawan W A.M. Takdir Musba Abdul Wahab Adil, Andi Agussalim Ali Ahmad, Muh. Ramli Alamsyah Ambo Alamsyah Ambo Ala Husain Andi Adil Andi Muhammad Takdir Musba Andi Salahuddin Andi Salahuddin Ardiansyah Siradjuddin Arifin Seweng Arifin Seweng Aulyan Syah, Bau Indah Bambang J Oetoro Bambang J. Oetoro Bambang J. Oetoro Bambang J. Oetoro Bangun, Chrismas Gideon Budianto, Jeffri Charles Wijaya Tan Chrismas Gideon Bangun Datu, Madonna Damayanthie Dewi Yulianti Bisri Dhania Anindita Santosa Endah Permatasari Faisal Muchtar Firdaus, Riyadh Harahap, M Sofyan Harsakti Rasyid Hisbullah Husain, Alamsyah Ambo Ala Husni Tanra Ida Bagus Krisna Jaya Sutawan Ilham Jaya Patellongi Ilhamjaya Patellongi Irfan Faisal Sjattar Irina, Sinta Isbul Isbul Jeffri Budianto Kristiono, Evan Kulsum Kulsum Muh. Ramli Ahmad Muh. Ramli Ahmad Muhammad Irfan Djafar Muhammad Ramli Achmad Muhammad Ramli Ahmad Muhammad Ramli Ahmad Musba, A. M. Takdir Nur Surya Wirawan Nurdin, Haizah Oetoro, Bambang J Oetoro, Bambang J. Patellongi, Ilham Jaya Permatasari, Endah Prawira, Lienardy Rakhmat Ilhamsyah RATNAWATI Ratnawati Ratnawati Rose Mafiana Rr Sinta Irina Rum, Muhammad Salahuddin, Andi Saleh, Siti Chasnak Santosa, Dhania Anindita Satya Nugraha, Eva Siti Chasnak Saleh Sri Rahardjo Syafri Kamsul Arif Tatang Bisri Tatang Bisri Widiastuti, Monika Winanda, Haris Yudhitya Afif

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