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All Journal Majalah Obat Tradisional Lumbung Farmasi : Jurnal Ilmu Kefarmasian
Moch Saiful Bachri
Fakultas Farmasi, universitas Ahmad Dahlan
Health Professions Medicine & Pharmacology Public Health

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The Hepatoprotective Effect of Moringa oleifera Leaves on Male Wistar Rat Induced Streptozotocin-Nicotinamide Bachri, Moch Saiful; Nurani, Laela Hayu; Edityaningrum, Citra Ariani; Ma'ruf, Muhammad; Sulistyorini, Dwi Agustin; Amelia, Rizki; Hidayati, Sholihatil; Sulistyawati, Rini; Guntarti, Any
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.90806

Abstract

Diabetes mellitus is a disease characterized by uncontrolled increases in blood sugar levels, which can cause complications in the liver. Disorder liver disease can be seen from the increasing SGOT, SGPT activity, and the number of necrosis cells in the liver. Moringa leaves contain the flavonoid quercetin with antidiabetic and antioxidant activity. This research aimed to determine the effect of administering the ethyl acetate fraction of Moringa leaves on SGOT activity, SGPT, and liver histopathology in rat induced by streptozotocin and nicotinamide. Moringa leaves macerated with 80% ethanol and fractionated with ethyl acetate were used. The research subjects were 30 rats divided into six groups. The rats were induced with streptozotocin at a dose of 65 mg/kgBW and nicotinamide 100 mg/kgBW for five days, then treated for ten days. Serum SGOT and SGPT activity were measured using a Microlab 300 Semi-Automated at a wavelength of 340 nm. Histopathological observations were carried out when the rats were dislocated, their livers were taken, and then preparations were made using Hematoxylin Eosin (HE) staining. Data were analyzed using the SPSS One Way ANOVA method, followed by the Tukey test with a confidence level of 95%. The results of the study showed that administration of Ethyl Acetate Fraction of Moringa oleifera (EA-MO) could reduce the levels of SGOT, SGPT, and the number of liver necrosis cells in rats induced by streptozotocin and nicotinamide.
Aktivitas Antiinflamasi Seduhan Serbuk Bunga Telang (Clitoria ternatea L.) Dengan Metode Stabilisasi Membran Fauziyyah, Khusna; Widyaningsih, Wahyu; Bachri, Moch Saiful; Utami, Dwi
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 6, No 2 (2025): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v6i2.26590

Abstract

Bunga telang (Clitoria ternatea L.) sering digunakan oleh masyarakat untuk keperluan pengobatan tradisional maupun dikonsumsi sebagai minuman yang berkhasiat untuk kesehatan. Bunga ini mengandung zat aktif berupa flavonoid dan antosianin yang berpotensi sebagai antiinflamasi. Penelitian ini bertujuan mengkaji khasiat antiinflamasi seduhan bunga telang (Clitoria ternatea L.) dengan metode stabilisasi membran dan mengukur nilai IC50. Penelitian ini dilakukan dengan metode uji stabilisasi membran sel darah merah secara in vitro. Stabilisasi membran eritrosit secara in vitro dapat memperkirakan aktivitas antiinflamasi suatu senyawa atau ekstrak. Hal ini terjadi karena stabilisasi membran dapat mencegah pelepasan isi lisosom dan mencegah kerusakan jaringan lebih lanjut. Potensi aktivitas antiinflamasi dievaluasi dengan mengukur nilai IC50. Data nilai IC50  dibandingkan dengan standar natrium diklofenak dan analisis statistik dilakukan menggunakan SPSS dengan taraf kepercayaan 95%. Hasil penelitian menunjukkan bahwa bunga telang (Clitoria ternatea L.) positif mengandung flavonoid dan antosianin. IC50 seduhan bunga telang (Clitoria ternatea L.) sebesar 0,2633± 0,01677 mg/mL sedangkan natrium diklofenak sebesar  0,6665 ± 0,004505 mg/mL.  Nilai IC50 pada kedua sampel menunjukkan adanya perbedaan yang bermakna (p<0,05). Seduhan serbuk  bunga telang (Clitoria ternatea L.) memiliki aktivitas stabilisasi membran lebih besar dibandingkan dengan standar natrium diklofenak.
Co-Authors . Nurlaila Any Guntarti Citra Ariani Edityaningrum, Citra Fauziyyah, Khusna Hidayati, Sholihatil Laela Hayu Nurani Muhammad Ma'ruf Muhammad Yusron Maulana El-Yunusi Nita Ratnawati S Rini Sulistyawati Rizki Amelia Sulistyorini, Dwi Agustin Wahyu Widyaningsih