Article Per Year (5 Year)
p-Index From 2020 - 2025
0.659
P-Index
This Author published in this journals
All Journal VALENSI Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Penelitian dan Karya Ilmiah Lembaga Penelitian Universitas Trisakti
Wulansari, Laela
Unknown Affiliation
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Transportation Veterinary Other

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Antioxidant Capacity, Phytochemical Profile, and Clustering of Pomegranate (Punica granatum L.) Peel Extracts Using Different Solvent Extraction Rafi, Mohamad; Wulansari, Laela; Septaningsih, Dewi Anggraini; Purnomo, Tsania Firqin; Auliatifani, Reza; Khaydanur, Khaydanur; Ilmiawati, Auliya; Yulianti, Wina; Nengsih, Nunuk Kurniati; Suparto, Irma Herawati; Kusuma, Wisnu Ananta
Journal of Tropical Life Science Vol 11, No 3 (2021)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pomegranate has valuable nutritional content and contains various bioactive compounds, one found in the fruit's peel. The utilization of these bioactive compounds could be used as herbal medicines and supplements, such as antioxidants. This study aimed to determine the antioxidant capacity, phytochemical profile, and pomegranate peel extract grouping using different extracting solvents. The three extracting solvents used were water, 70% ethanol, and ethanol p.a. Antioxidant capacity of the three extracts was measured using the DPPH and CUPRAC methods. We also determined the total phenolic and flavonoid levels and the TLC fingerprint analysis and FTIR spectrum of the pomegranate peel extracts. The 70% ethanol extract owned the largest antioxidant capacity than the other two extracts with a value of 358.67 and 2981.59 µmol trolox/g dried sample using the DPPH and CUPRAC methods, respectively. The three pomegranate peel extracts' total phenolic and flavonoid levels ranged from 287.26–1068.81 mg GAE/g dried sample and 0.24-0.75 mg QE/g dried sample. TLC fingerprint analysis of pomegranate peel extract yielded 2, 6, and 6 bands for water extract, 70% ethanol, and p.a ethanol, respectively. The three extracts can be grouped based on FTIR spectrum data using principal component analysis using three principal components with a total variance of 93%. The results obtained show that using different extracting solvents provides different antioxidant capacities and phytochemical profiles.
PENENTUAN JENIS PELARUT TERBAIK TERHADAP KADAR EURYCUMANONE PADA EKSTRAKSI AKAR PASAK BUMI (EURYCOMA LONGIFOLIA JACK) Setyaningrum, Dyah; Wulansari, Laela; Andayani, Andayani; Shihran, Laviany Putri; Fauziyyah, Isra; malik, kirana
JURNAL PENELITIAN DAN KARYA ILMIAH LEMBAGA PENELITIAN UNIVERSITAS TRISAKTI Volume 8, Nomor 2, Juli 2023
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/pdk.v8i2.17217

Abstract

Pasak bumi (Eurycoma longifolia Jack) adalah salah satu tanaman herbal dari negara-negara Asia Tenggara yaitu Indonesia, Malaysia, dan Vietnam. Bagian tanaman yang memiliki khasiat adalah bagian daun, akar dan batang. Berbagai macam senyawa kimia telah diisolasi dan dikarakterisasi dari Eurycoma longifolia, serta diketahui memiliki berbagai efek yang menguntungkan seperti male fertility enhancement effect, antimalarial effect, cytotoxic and anti-proliferative effect, antimicrobial effects, anti-inflammatory effects, anti-anxiolytic, anti diabetic, osteoporosis preventive effect, ameliorative effect, ergoganic effect, insecticidal effects, muscular effect, antiulcer effect dan anti-rheumatism effect. Tanaman ini sangat potensial untuk digunakan dalam produk farmasi herbal. Komposisi senyawa kimia dari tumbuhan adalah esensial untuk penentuan kualitas, keamanan dan efektifitas dari produk herbal. Penelitian ini dilakukan untuk mengetahui kandungan eurycomanone pada ekstrak akar pasak bumi, serta mengetahui pelarut terbaik dalam proses ekstraksi dari akar pasak bumi yang menghasilkan kadar eurycomanone tertinggi. Metode pembuatan ekstrak dengan cara melakukan maserasi simplisia akar pasak bumi menggunakan pelarut etanol 30%, etanol 70%, etanol 96%, n-heksana, etilsetat dan air. Tahap awal penelitian dimulai dengan melakukan uji fitokimia dan uji kadar air pada simplisa. Selanjutnya pada masing-masing ekstrak dilakukan uji toksisitas terhadap larva udang serta penentuan kadar eurycomanone dengan High-performance liquid chromatography (HPLC). Hasil rendemen ekstrak pasak bumi tertinggi terdapat pada ekstrak dengan menggunakan pelarut etanol 70% sebesar 3.41 g. Hasil pengujian fitokimia simplisia pasak bumi mengandung flavonoid dan saponin. Toksisitas tertinggi terdapat pada ekstrak dengan menggunakan pelarut etilasetat dengan nilai LC50 sebesar 201.28 ppm. Ekstrak pasak bumi dengan pelarut etanol 70% memiliki kadar eurycomanone tertinggi yaitu 53.42 mg/g.
TLC Fingerprint Analysis and Evaluation of α-Glucosidase Inhibitory and Free Radical Scavenging Activity of Justicia gendarussa from Different Growth Locations Wulansari, Laela; Wahyuni, Wulan Tri; Nurcholis, Waras; Rafi, Mohamad
Jurnal Kimia Valensi Vol. 11 No. 1 (2025): Jurnal Kimia VALENSI
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i1.43662

Abstract

Justicia gendarussa is known to have antioxidant and antidiabetic properties, which are related to the composition and concentration of its metabolites and influenced by differences in growth location. This study aims to evaluate changes in metabolite profiles and biological activities, such as the inhibition of α-glucosidase and free radical scavenging in J. gendarussa genotypes from Bogor, Cianjur, and Sukabumi. Changes in metabolite profiles were assessed using thin-layer chromatography (TLC) fingerprint analysis combined with principal component analysis (PCA). Bioautography TLC using DPPH was performed to confirm the presence of antioxidant compounds. In the TLC fingerprint analysis of J. gendarussa, we obtained 14 bands with good resolution. PCA successfully grouped J. gendarussa extracts based on growth location. The percentage of α-glucosidase inhibitory and free radical scavenging activity was significantly different, with the highest percentage of inhibition of α-glucosidase shown by the IIIS genotype (99.23%) and the highest free radical scavenging (91.35%) demonstrated by the IIB genotype. The results of TLC bioautography confirmed the presence of antioxidant compounds in J. gendarussa represented by bands with Rf 0.04, 0.32, and 0.80. This study concludes that growth location differences influence the variations in metabolite profiles, α-glucosidase inhibitory activity, and free radical scavenging activity of J. gendarussa genotypes.
Co-Authors Andayani Andayani Auliatifani, Reza Auliya Ilmiawati Fauziyyah, Isra Irma Herawati Suparto Khaydanur, Khaydanur M. Rafi Malik, Kirana Mohamad Rafi Nengsih, Nunuk Kurniati Purnomo, Tsania Firqin Septaningsih, Dewi Anggraini Shihran, Laviany Putri Siti Helmyati Waras Nurcholis Wina Yulianti Wisnu Ananta Kusuma Wulan Tri Wahyuni