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All Journal Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Pengabdian Masyarakat (ABDIRA) JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Indonesian Journal on Medical Science (IJMS) Jurnal Sains dan Kesehatan
Sawal, Rizky Ardian Hartanto
Sekolah Tinggi Ilmu Farmasi Nusaputera
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Aktivitas Antihiperglikemik Fraksi-Fraksi Ekstrak Etanol Daun Genjer (L. flava) pada Tikus Diabetes Nefropati Yithro Serang; Yahya Febrianto; Rizky Ardian Hartanto Sawal
JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Vol 6, No 2 (2021)
Publisher : Prodi Kesehatan Masyarakat Fakultas Kesehatan Masyarakat UIN Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (707.179 KB) | DOI: 10.30829/jumantik.v6i2.8451

Abstract

Diabetes mellitus (DM) type 2 can cause complications such as diabetic nephropathy (DN). Genjer leaf (L. flava) can be used as a treatment on the conditions of this study. This research purpose is to know antihyperglikemi activity fractions-fraction ethanol extracts of Africa leaves, repair and regeneration kidney function. This research used 35 white male wistar rats conditioned DM type 2 for 24 days. Rats were divided into 7 groups, group I, group II negative control using STZ-NA 65 mg/kg and 230 mg/kg, group III positive control with glibenklamid 0.45 mg/kg, Group IV ethanol extracts of africa leaves 400 mg/kg, Group V fraction n-heksan 100 mg/kg BB, Group VI fraction of ethyl acetate 100 mg/kg, and Group VII water fraction 100 mg/kg. Data analysis using ANOVA test followed LSD Post Hoc. The results showed that administering fraction-fraction of ethanolic extract of genjer leaf (L. flava) at doses 100 mg/kg BB can lower glucose levels on rat with diabetic nephropathy
Penyuluhan Manfaat Umbi Lokal Canna Edulis Kerr di Masyarakat Ferika Indrasari; Metrikana Novembrina; Rizky Ardian Hartanto Sawal
Jurnal Pengabdian Masyarakat (ABDIRA) Vol 2, No 3 (2022): Abdira, Juli
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdira.v2i3.186

Abstract

Dependence on rice and wheat can be maintained or reduced by increasing the diet through changing the image of tubers such as the local tuber Canna Edulis Kerr. The purpose of service is to improve food security in the community. The method of implementing the activity is counseling using power point media. The results of the activity went well from licensing to the end of the activity. Conclusion Participants get direct benefits related to counseling the benefits of local tuber Canna edulis kerr in the community.
PENGARUH EKSTRAK ETANOL DAN FRAKSI n-HEKSANA BUAH TAKOKAK (Solanum torvum Sw.) TERHADAP RESPON IMUN SELULER PADA MENCIT PUTIH JANTAN Balb/c DENGAN UJI DELAYED-TYPE HYPERSENSITIVITY (DTH) Rizky Ardian Hartanto Sawal; Jason Merari Peranginangin; Reslely Harjanti
Jurnal Farmasi & Sains Indonesia Vol 2 No 1 (2019)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

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Abstract

Buah takokak (Solanum torvum Sw.) mengandung senyawa flavonoid dan steroid yang diharapkan mampu memodulasi sistem imun tubuh. Penelitian ini dilakukan untuk mengetahui dan membuktikan pengaruh ekstrak etanol dan fraksi n-heksana buah takokak dan dosis efektif terhadap respon imun seluler dengan parameter perubahan ketebalan kaki kanan mencit. Penelitian ini menggunakan sebanyak 45 ekor hewan uji mencit dan dibagi dalam 9 kelompok yaitu kontrol negatif (CMC 0,5%), kontrol positif imunostimulan (stimuno), kontrol positif imunosupresan, dosis ekstrak etanol buah takokak 75 mg/kg BB, 150 mg/kg BB, dan 400 mg/kg BB, dan dosis fraksi n-heksana buah takokak 20 mg/kg BB, 40 mg/kg BB, dan 80 mg/kg BB. Setiap mencit disensitisasikan dengan SDMD 20% 0,1 ml secara i.p. kemudian diberikan perlakuan sesuai dengan kelompok masing-masing selama 7 hari. Pada hari ke-6 ketebalan kaki kanan mencit diukur dengan menggunakan jangka sorong lalu diinjeksi dengan SDMD 1% 0,02 ml secara s.c. pada telapak kaki kanan. Ketebalan kaki kanan mencit diukur kembali setelah 24 jam untuk mengetahui respon DTH. Data yang diperoleh dianalisis menggunakan one-way ANOVA. Hasil penelitian menunjukkan bahwa ekstrak etanol buah takokak dengan dosis 150 mg/kg BB dan 300 mg/kg BB dapat meningkatkan sistem imun seluler masing-masing sebesar 55,41 ± 2,5790 dan 57,51 ± 3,6908. Fraksi n-heksana buah takokak dengan dosis 20 mg/kg BB, 40 mg/kg BB, dan 80 mg/kg BB mampu menekan respon imun seluler masing-masing sebesar 30,42 ± 4,7043, 30,03 ± 5,0101 dan 25,72 ± 6,1311.
PENETAPAN KADAR SENYAWA FLAVONOID TOTAL DALAM FRAKSI-FRAKSI SIRIH MERAH (Piper Crocatum Ruiz & Pav) Rizky Ardian Hartanto Sawal; Windarsih Sutrisna
Jurnal Farmasi & Sains Indonesia Vol 2 No 2 (2019)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

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Abstract

Sirih merah adalah salah satu tumbuhan obat yang kini banyak juga ditanam sebagai tanaman hias. Penggunaan sirih merah secara tradisional dimanfaatkan dalam menyembuhkan penyakit seperti sariawan dan sakit gigi. Tujuan peneltian ini adalah untuk melakukan penetapan kadar flavonoid total dalam fraksi-fraksi daun sirih merah (Piper Crocatum Ruiz &Pav). Metode penelitian yang digunakan untuk pembuatan ekstrak adalah remaserasi menggunakan pelarut etanol 96%, fraksinasi dengan cair-cai menggunakan n-Heksana, etil asetat dan air. Analisa data pada penelitian ini menggunakan metode spektrofotometri untuk mengetahui kadar kandungan flavonoid total dalam fraksi-fraksi sirih merah (Piper Crocatum Ruiz & Pav). Hasil spektrofotometri dengan menggunakkan panjang gelombang430,1 nm, kadar flavonoid tertinggi berada pada kelompok A sebesar 182,98 mg QE/g ekstrak mempunyai ppm 19,03. Kelompok B sebesar 133,84 mg QE/g ekstrak dengan ppm 19,03 dan kelompok C sebesar 64,77 mg QE/g ekstrak dengan ppm 6,737.
Pengaruh Metode Maserasi Konvensional dan Berbantu Gelombang Mikro Terhadap Penapisan Fitokimia dan Standardisasi Ekstrak Peperomia pellucida L. Priamsari, Margareta Retno; Kamila, Iffa; Sawal, Rizky Ardian Hartanto
Indonesian Journal on Medical Science Vol 11 No 2 (2024): IJMS 2024
Publisher : Unit Penelitian dan Pengabdian Masyarakat Politeknik Kesehatan Bhakti Mulial

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70050/ijms.v11i2.465

Abstract

Suruhan (Peperomia pellucida L.) is a medicinal plant with many benefits. The efficacy of medicinal plants is related to the results of phytochemical screening and standardization, which are reflected in the quality of the extracts produced. This study aims to assess the impact of extraction methods on the phytochemical screening profile and standardization of suruhan leaf extract. The samples were extracted using the maceration and microwave assisted extraction (MAE) method with 96% ethanol solvent. Next, phytochemical screening and standardization were carried out on both powder and extract. The data obtained was then analyzed descriptively. The results of phytochemical screening from both the maceration and MAE methods show that suruhan leaf extract contains flavonoids, saponins, phenols, tannins, steroids, triterpenoids and glycosides. The results of standardization of leaf extracts using the maceration method obtained water soluble essence content of 2.15%, ethanol dissolved essence content of 67.31%, drying loss of 9.68%, ash content of 37.2988%, specific gravity of 0.9805 g/mL, and Pb metal contamination 0.000 mg/L. Meanwhile, the results of standardization of the leaf extract ordered by the MAE method obtained a water soluble essence content of 30.06%, an ethanol dissolved essence content of 33.84%, a drying loss of 9.52%, an ash content of 38.1392%, a specific gravity of 0.8273 g/mL , and Pb metal contamination 0.061 mg/L.
Pengaruh Kombinasi Ekstrak Daun Mengkudu (Morinda citrifolia L.) dan Daun Alpukat (Persea americana Mill.) terhadap Staphylococcus aureus: Effect of Combination of Noni Leaf Extract (Morinda citrifolia L.) and Avocado Leaves (Persea americana Mill.) on Staphylococcus aureus Sawal, Rizky Ardian Hartanto; Priamsari, Margaretha Retno; Bulu, Atalia Tamo Ina; Wulandari, Dwi
Jurnal Sains dan Kesehatan Vol. 6 No. 6 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i6.2397

Abstract

Noni leaves (Morinda citrifolia L.) and avocado leaves (Persea americana Mill.) contain various phytochemical compounds for their antimicrobial properties. This study aims to evaluate the potential of a combination of extracts from these leaves in inhibiting the growth of Staphylococcus aureus bacteria. The maceration method was used to extract both leaves with 70% ethanol solvent, followed by phytochemical screening through tube tests and TLC. Antibacterial activity was evaluated using the well method on NA media. Concentration variations of noni and avocado leaf extracts were done in ratios of 0:100, 100:0, 50:50, 25:75, and 75:25, with positive controls using amoxicillin and negative controls using DMSO. The results showed that single extracts were most effective at pure concentrations, while the best combination extract was observed at a ratio of 75:25. However, significant differences were noted between the effects of single extracts and combinations, indicating that the combination extract has potential antibacterial activity. Keywords:          Morinda citrifolia L., Persea americana Mill., Wells, antibacterial, Staphylococcus aureus   Abstrak Daun mengkudu (Morinda citrifolia L.) dan daun alpukat (Persea americana Mill.) mengandung sejumlah senyawa fitokimia seperti flavonoid, saponin, tanin, alkaloid, dan lainnya yang dikenal memiliki sifat antimikroba. Penelitian ini bertujuan untuk mengevaluasi potensi kombinasi ekstrak kedua daun tersebut dalam menghambat pertumbuhan bakteri Staphylococcus aureus. Metode maserasi digunakan untuk mengekstraksi kedua daun dengan pelarut etanol 70%, diikuti oleh skrining fitokimia melalui uji tabung dan uji KLT. Aktivitas antibakteri dievaluasi menggunakan metode sumuran pada media NA. Variasi konsentrasi ekstrak daun mengkudu dan alpukat dilakukan dalam rasio 0:100, 100:0, 50:50, 25:75, dan 75:25, dengan kontrol positif menggunakan amoksisilin dan kontrol negatif menggunakan DMSO. Hasilnya menunjukkan bahwa ekstrak tunggal paling efektif pada konsentrasi murni, sementara kombinasi ekstrak terbaik terlihat pada rasio 75:25. Meskipun demikian, perbedaan signifikan terlihat antara efek ekstrak tunggal dan kombinasi, menunjukkan bahwa kombinasi ekstrak tersebut tetap memiliki aktivitas antibakteri yang potensial. Kata Kunci:         Morinda citrifolia L., Persea americana Mill., Sumuran, antibakteri, Staphylococcus aureus
Aktivitas Ekstrak Etanol Daun Akar Kucing (Acalypha indica L.) Sebagai Pengawet Alami Pada Buah Tomat (Lycopersium esculentum Mill.) Solichah, Ayu Ina; Sawal, Rizky Ardian Hartanto; Auliya, Fitri
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p120-125

Abstract

The presence of preservatives in food is a common thing to extend the shelf life of foods. The bad effects appliying chemical preservatives cause both environmental pollution and health disturbing. Consuming chemical preservatives for a long time will will cause cancer. Natural preservatives is needed to reducing the bad effects. One of the Plants can be applied as natural preservatives is cat root leaves (Acalypha indica L. The study aims were to determine the activity and effective concentration of cat root leaf extract as a natural preservative on tomatoes and to identify the its phytochemical content. Activity of cat root leaf extract as a preservative was subjected by organoleptic, meanwhile the phytochemical content by tube-test. The results showed 8% cat root leaf extract effective as natural preservative according to organoleptic observation with observed time for 20 days. The result of tube-test showed cat root leaf extract contain compounds likes alkaloid, flavonoid, saponin, tannin, and terpenoid.
Evaluasi Potensi Ekstrak Etanol Daun Kencur (Kaempferia galanga L.) sebagai Antimikroba terhadap Propionibacterium acnes melalui Teknik Disk Diffusion Sawal, Rizky Ardian Hartanto; Rahayu, Noel Asri
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p193-199

Abstract

The galangal plant, which many people still don't know about, has a variety of interesting benefits. Among other things, kencur leaves contain chemical compounds such as flavonoids and essential oils which have antimicrobial properties. This study aims to activate the antibacterial activity of ethanol extract of kencur leaves against Propionibacterium acnes, as well as to measure how effective it is at different concentrations. The extraction process uses 96% ethanol solvent with the Remaceration method, which is then accompanied by phytochemical screening and TLC tests to strengthen the results. Antibacterial activity tests were carried out using the disc diffusion method at concentrations of 0.3%, 0.6%, 1.2% and 2.4%. The results show the inhibition zone at each concentration, namely 6.86 mm, 8.4 mm, 9.8 mm, and 10.96 mm. Phytochemical analysis identified secondary metabolite compounds such as tannins, saponins and flavonoids with Rf values of 0.925 each; 0.825; and 0.8125. Statistical analysis showed a significant difference between concentrations of 0.3% and 1.2%.
Perbandingan Kadar Total Flavonoid Ekstrak Daun Ketapang (Terminalia catappa L) berdasarkan Kekeringan Simplisia dengan Metode Spektrofotometri UV-Vis Pratiwi, Anastasia Eka; Bulu, Atalia Tamo Ina; Sawal, Rizky Ardian Hartanto; Pitarisa, Agustina Putri
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p203-209

Abstract

Traditional treatment remains one of the widely used treatment methods to this day. One of the plants with potential as conventional medicine is the Ketapang leaf (Terminalia catappa L), which belongs to the Combretaceae family. Ketapang leaves contain various compounds such as flavonoids, alkaloids, tannins, and saponins, with flavonoids known for their high antioxidant properties. This study aims to compare the total flavonoid content in fresh and dried Ketapang leaf extracts. The extraction method used is maceration with 96% ethanol solvent. Evaluation includes organoleptic tests, moisture content, drying shrinkage, phytochemical screening, and thin-layer chromatography (TLC). Total flavonoid content testing is conducted using the colorimetric method with UV-Vis spectrophotometry at a wavelength of 430 nm, with quercetin as the standard. The results show that the yield of fresh Ketapang leaves was 8.74% w/w, while dried Ketapang leaves were 8.40% w/w. In the TLC tested, the Rf values of fresh and dried Ketapang leaf extracts were 0.95 and 0.94, respectively. The total flavonoid content in fresh Ketapang leaf extract was 24.19 mgQE/gram, while for dried Ketapang leaf extract it was 16.84 mgQE/gram. Statistical analysis with an independent sample t-test showed a significant difference (p<0.05) between fresh and dried Ketapang leaf extracts.
Co-Authors Agustina Putri Pitarisa Anastasia Eka Pratiwi Atalia Tamo Ina Bulu Auliya, Fitri Ayu Ina Solichah Bulu, Atalia Tamo Ina Dwi Wulandari Ferika Indrasari Fitri Auliya Jason Merari Peranginangin Kamila, Iffa Margareta Retno Priamsari Metrikana Novembrina Noel Asri Rahayu Pitarisa, Agustina Putri Pratiwi, Anastasia Eka Priamsari, Margaretha Retno Rahayu, Noel Asri Reslely Harjanti Solichah, Ayu Ina Windarsih Sutrisna Windarsih Sutrisna Yahya Febrianto Yithro Serang